ライフサイエンスコーパス: long before

1 introduction into the African population not long before 1959.

2 iles at three stages of disease progression: long before (2 months of age), immediately before (5 mon

3 stors from African Yoruban ancestors started long before 50,000 years ago and give information about

4 in a functional impairment of CD4(+) T cells long before a quantitative decline in circulating CD4(+)

5 f major depression associated with ACS began long before ACS and therefore were not caused by ACS.

6 m signaling and synaptic transmission system long before AD histopathology onset.

7 44 weeks) and is seen throughout the cochlea long before age-related changes in thresholds or hair ce

8 Conversely, thermal preference can arise long before, and remain long after, the harmful effects

9 as evident even at a very early age in mice, long before any clinical symptoms arose.

10 s within an hour or two of cohesin cleavage, long before any decline in ecdysone receptor could be de

11 og, two "utility" species, were domesticated long before any food crops or livestock species, and tha

12 rs coincident with the development of IR and long before any measurable change in carotid intima-medi

13 al evidence of a photo-induced cell response long before any morphological cues.

14 balance and modulate each other's activities long before any mutually exclusive silencing occurs.

15 evident microvascular morphological changes long before any pathological manifestation.

16 f communities and change ecosystem processes long before any species are extirpated from communities.

17 provide a marker to screen cigarette smokers long before any symptoms of bladder cancer are present.

18 concentrations may alter astrocyte function long before any visible symptoms of the disease are obse

19 w that macrophages arrive at the lesion site long before axon fragmentation, much earlier than previo

20 Long before bacteria infected humans, they infected amoe

21 etected in Ca isotope data after about 1 wk, long before bone mineral density has changed enough to b

22 ay have engaged this function independently, long before cadherins arrived on the scene.

23 unity to characterize early arterial disease long before cardiovascular complications present.

24 ction occurs during early-stage HIV disease, long before CD4 T cell counts fall below critical levels

25 Long before chondrogenesis, suc/et-1 mutant embryos have

26 It is highly probable that BCCs enter the BM long before clinical detection.

27 flammatory phenotype in the microvasculature long before clinical disease is evident.

28 t these autoreactive T-cells can be detected long before clinical onset of the disease.

29 ss, which, in nontransplant patients, occurs long before clinical presentation.

30 ble to detect mutations emerging in patients long before clinical relapse.

31 nce: Alzheimer disease (AD) pathology starts long before clinical symptoms manifest, and there is no

32 ng the earliest phases of neurodegeneration, long before commitment to cell death.

33 rdiovascular gender differences are apparent long before CVDs appear in men and women, and improved u

34 ter mitochondrial membrane, which take place long before cytochrome c is released from mitochondria i

35 ersible" DAergic synaptic dysfunction occurs long before DAergic neuron loss.

36 nopause, female mice exhibit ovarian failure long before death because of chronological age and subse

37 We examined how long before death patients enrolled in hospice programs.

38 a predisposition toward cancer development, long before detectable tumors are formed, is a key to th

39 arise early in tumor development, sometimes long before diagnosis.

40 motoneurons that occur by 10 d after birth, long before disease onset.

41 in cell processes as well as the perikaryon long before DNA fragmentation and cell death and therefo

42 ltivated tomatoes, arose in tomato germplasm long before domestication; (4) extant accessions of L. e

43 e cells define the exit points by stage 12+, long before either motor or sensory axons have grown thr

44 underwent receptor-mediated internalization long before endosomal fusion, thus minimizing the surfac

45 ll as advance directives should be addressed long before enteral feeding or assistive ventilatory sup

46 a collapsed at approximately 800 years B.P., long before European contact.

47 mary glands in which cyclin E is deregulated long before evidence of malignancy.

48 d at exocytic sites are associated with DCVs long before exocytosis, and near the time of membrane fu

49 value can also be badly biased when measured long before exposure initiation.

50 oping fetus is exposed to a source of prions long before exposure to the infectious agent during and

51 shows that Solanaceae were well diversified long before final Gondwanan breakup.

52 tively the stem rust resistance protein RPG1 long before haustoria formation.

53 y of human hepatocytes stained HDAg-positive long before HBV spreading was completed, confirming that

54 er, nifII, was expressed in vegetative cells long before heterocysts formed.

55 a critical region for peach evolution since long before human presence, much less agriculture.

56 Long before infants reach, crawl or walk, they explore t

57 replicate and accumulate in lymphoid tissues long before infection spreads to the central nervous sys

58 imonidazole binding significantly at 7 days, long before inflammation and necrosis could be detected.

59 rly in the second and third decades of life, long before ischemic heart disease becomes clinically ap

60 membranes rich in trans-Golgi network (TGN) long before it becomes available for re-esterification a

61 fter treatment, anticipating drug resistance long before it was clinically manifest.

62 seases to be detected at the molecular level long before macroscopic symptoms appear.

63 y very early in the course of SIV infection, long before marked declines in peripheral CD4(+) T cell

64 es (IIS) in epilepsy at just 5 weeks of age, long before memory impairments or beta-amyloid depositio

65 in the common ancestor of fungi and animals long before mesoderm appeared.

66 Long before Meta II decays into the aporeceptor opsin an

67 acute (LPS) and chronic (ethanol) stresses, long before more-dramatic fibrotic changes to the liver

68 Taken together, we have shown that long before morphological changes occur in the shoot api

69 genes that showed marked decreases in levels long before morphological damage could be readily ascert

70 The evidence that the environment acts long before MS becomes clinically evident is well establ

71 r the MBP gene in the early developing brain long before myelination and especially in the pioneer co

72 Mitochondrial fission by NO occurs long before neurite injury and neuronal cell death.

73 date have involved administration of agents long before onset of symptoms, which cannot currently be

74 A discordant origin of traits long before or after the origin of the putative coevolut

75 process, which we term 'cistauosis', appears long before other tauopathy.

76 All reefs were substantially degraded long before outbreaks of coral disease and bleaching.

77 treatment of diabetes and its complications long before overt disease develops.

78 Brown Norway (BN/SsNHsd) rat as a DNA source long before plans for rat genome sequencing had been lau

79 ssure may require reduction of lead exposure long before pregnancy.

80 nity leaders, employee groups and the media, long before protocol implementation, is essential.

81 proliferating human mammary epithelial cells long before senescence.

82 is pathology is manifested in memory defects long before significant plaque deposition.

83 onset of the phenotype, which in turn occurs long before specific neurodegeneration can be detected.

84 As SpOtx appears long before SpGsc transcription is activated, we propose

85 egy, as well as determine the visual outcome long before surgery occurs.

86 ow telomere length regulates gene expression long before telomeres become short enough to produce a D

87 gen-derived as well as environmental signals long before Th17 cells have sensed bacterial invasion.

88 n primary visual and primary auditory cortex long before thalamocortical synapse formation, but that

89 ighly conserved and was probably established long before that of double-stranded DNA viruses infectin

90 but they were likely used in Asian medicine long before that.

91 et of neuromuscular denervation, which began long before the activation of cell death proteins in SOD

92 a common ancestor of great apes and humans, long before the advent of modern humans.

93 d as gain medium for lasers since the 1960s, long before the advent of today's organic electronic dev

94 at M form KSHV likely existed in this region long before the AIDS epidemic.

95 -related decrease in neurogenesis is evident long before the animals become aged.

96 ns form early during the refolding reaction, long before the appearance of native tailspike.

97 esults in the formation of cellular patches, long before the appearance of tumors, that are visualize

98 rsity in chronic infection could be detected long before the appearance of viral escape mutations in

99 eak in sea-ice-related feedbacks that occurs long before the Arctic becomes ice-free in summer.

100 ntigen within 90 min of antigen inoculation, long before the arrival of dendritic cells from skin.

101 olithic technology were active in Madagascar long before the arrival of farmers and herders and befor

102 t with growing evidence that sponges evolved long before the Cambrian explosion approximately 542 mil

103 Long before the cause was discovered, peptic ulcers were

104 losed marine basin, was affected by land use long before the changes of the Industrial Era.

105 nment problem-action selection signals occur long before the consequent dopamine reinforcement signal

106 ls in a species-typical manner might develop long before the coordinated behavior is demanded of the

107 viability as the pH went <6, which happened long before the culture reached saturation.

108 PBC often suffer from a variety of symptoms long before the development of cirrhosis that include is

109 ncing the early growth of transformed cells, long before the development of clinical cancer.

110 ryonic vertebrate heart begins pumping blood long before the development of discernable chambers and

111 e soon after activation of the transgene and long before the development of lung pathology.

112 topoietic stem cells and exhibit dysfunction long before the development of lung pathology.

113 through inflammatory and neuroretinal stages long before the development of vascular lesions represen

114 les can be traced back 5,000 years, or more, long before the development of written traditions.

115 fferences between the sexes begin to develop long before the differentiation of Sertoli cells, includ

116 ementally through mammaliaform evolution and long before the differentiation of the living mammal gro

117 Long before the discovery of cytokines as immune system

118 ore the radiation of the Laverania subgenus, long before the emergence of P. falciparum.

119 a common ancestor that probably existed not long before the emergence of the cartilaginous fish.

120 ches a threshold level (or bound), sometimes long before the end of stimulus.

121 across trials, with most labels stabilizing long before the end of training and then being used cons

122 timulation resting level, which was attained long before the endoplasmic reticulum Ca2+ store had bee

123 nce of the FtsZ1 and FtsZ2 families occurred long before the evolution of land plants, preceding the

124 libut brain already at the time of hatching, long before the eyes are functional.

125 is well established by the day after birth, long before the final target zone is discernible within

126 rged as a stable and widespread way of life, long before the first evidence for domesticated plants o

127 response to stress under normal conditions, long before the formation of a cancerous lesion.

128 m was bioavailable in the mid-Archaean ocean long before the Great Oxidation Event.

129 g ancestral gene resurrection, we show that, long before the hormone evolved, the receptor's affinity

130 isease initiation/progression in human cells long before the induction of a critical DNA damage respo

131 As encoding genes for 5S rRNA was detectable long before the injected DNAs had time to reconstitute i

132 deoxynucleotides into newly synthesized DNA, long before the lack of pyrimidine nucleoside triphospha

133 n medical education implemented in Ann Arbor long before the landmark Flexner Report on Medical Educa

134 iated with pre-angiosperm plants that appear long before the later, iterative associations between an

135 ons resulted in rapid decline of thresholds, long before the loss of most photoreceptors, which was e

136 ecause infected cells express viral antigens long before the macroscopic signs of infection scored in

137 the non-image-forming pathway is functional long before the mainstream image-forming pathway during

138 ersely alter the cardiovascular risk profile long before the manifestation of clinical disease.

139 c responses were demonstrated experimentally long before the mechanisms responsible were elucidated.

140 Long before the morphological effects of NT-3 appeared,

141 ondary structure, but without tight packing, long before the native state.

142 proach to modulate early pathologic pathways long before the occurrence of vision loss among patients

143 vascular hyperpermeability (CVH) was induced long before the onset of angiogenesis in a modified, in

144 nal peak within 15 min after light exposure, long before the onset of cell division.

145 from synapses early in the disease process, long before the onset of classical AD pathology.

146 regnancy, even at 13 to 16 weeks' gestation (long before the onset of clinical disease); their gestat

147 in system-level circuits of the human brain, long before the onset of cognitive symptoms.

148 in aqueous solutions as volume is decreased long before the onset of crystallization by in situ time

149 ic inflammation and autoimmunity in RA begin long before the onset of detectable joint inflammation.

150 metabolic rate for glucose, which may begin long before the onset of histopathological or clinical f

151 ccupied seasonally dry heterogenous habitats long before the onset of late Neogene aridity.

152 ize in most chloroplasts from mature leaves, long before the onset of leaf senescence.

153 aled a marked degeneration of callosal axons long before the onset of motor symptoms.

154 poised in a near-eruptive equilibrium state long before the onset of the 2004-05 eruption.

155 the hallmark of type 2 diabetes and develops long before the onset of the disease.

156 Insulin resistance (IR) is present long before the onset of type 2 diabetes and results not

157 of inflammation, on postimmunization day 5, long before the peak of inflammation on day 14.

158 nd the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of

159 for both targeted and nontargeted infections long before the policy was implemented.

160 Long before the recent thrust of scientific research on

161 ion of HIV-1 in west-central Africa occurred long before the recognized AIDS pandemic.

162 nducible resistance phenotype within 5 days, long before the recommended 14-day extended incubation.

163 nsic feature of the oropharyngeal epithelium long before the region becomes innervated.

164 a time scale of only 1 millisecond, that is, long before the remnant can collapse into a black hole.

165 Although animal breeding was practiced long before the science of genetics and the relevant dis

166 h site the first double-strand break is made long before the second.

167 The ancestral AL gene emerged long before the separation of human and chimpanzee ances

168 rences are most obvious at postnatal day 15, long before the start of the critical period, indicating

169 SC concentration of oral samples was reached long before the sulfide detector fully responded.

170 change projections (sometimes >10 000 muatm) long before the term 'ocean acidification' was coined, w

171 arrest is initiated during a critical period long before the time at which fusion normally occurs.

172 n occurs within 5 minutes after irradiation, long before the translocation of RAP80 to IRIF.

173 rized genetically as regulators of Hox loci, long before their catalytic functions were recognized.

174 ths in intermediate hosts often stop growing long before their growth is limited by host resources, a

175 in the atmosphere was likely to have ceased long before their ultimate disappearance from the rock r

176 that he believed that ancestral forms 'lived long before' their first fossil representatives.

177 ar under selective conditions in some clones long before there is any sign of neoplastic change in th

178 ology has now come of age and it will not be long before these formulations assume a prominent role i

179 Evidence suggests that some flaps become long before they are cleaved, and that this cleavage inv

180 ETR2 mRNAs are expressed in geranium florets long before they are receptive to pollination and transc

181 ation process that is almost two cell cycles long before they become competent to function as microtu

182 ted to become bullwhip neurons are generated long before they begin to differentiate and that their s

183 n members of the same species was recognized long before they could be identified.

184 hemionus) excrete CWD prions in their faeces long before they develop clinical signs of prion disease

185 as mice display various malignant properties long before they develop tumors in vivo.

186 owed their behaviors when they were infants, long before they had been diagnosed as autistic.

187 t adjacent fascicles proximally in the limb, long before they reached the muscle.

188 Long before this goal is achieved, and sometimes at the

189 neage between 230 and 250 million years ago, long before this lineage gave rise to the first birds.

190 18 months; soluble Abeta levels are elevated long before vascular deposition takes place in this mode

191 early during the development of the oocyte, long before vitellogenesis begins.