ライフサイエンスコーパス: long-lasting

1 icating that the effects of TB treatment are long lasting.

2 urrence (FCR) is prevalent, distressing, and long lasting.

3 w days, chronic joint and muscle pain can be long lasting.

4 ic stacking interactions are stabilizing and long lasting.

5 ession in the face of an infection, are also long-lasting.

6 l development and can, when disturbed, cause long-lasting abnormalities of GI function.

7 d phosphorylation of the FRQ protein and the long-lasting accumulation of FRQ in the nucleus were in

8 ntributing more in CA3, but with delayed and long-lasting accumulation of Zn(2+) within mitochondria

9 1 triggering in MDM caused a more potent and long-lasting activation of the signaling axis involving

10 xpression of long-term potentiation (LTP), a long-lasting, activity-dependent strengthening of synapt

11 drives changes in gene expression to promote long lasting adaptations of neuronal structure and funct

12 peripheral macrophage infiltration initiates long-lasting adaptive immune responses after TBI.

13 V only develop mild symptoms associated with long-lasting adaptive immunity.

14 egulatory T cell (Treg) depletion results in long-lasting AIG associated with both H(+)K(+)ATPase and

15 e Spiegelmer emapticap pegol (NOX-E36) shows long-lasting albuminuria-reducing effects in diabetic ne

16 that CHMI leads to previously unappreciated long-lasting alterations in the human innate-like lympho

17 f post-transplantation host rejection is not long lasting and can have systemic effects.

18 pertussis induced by infection is considered long lasting and effective at preventing reinfection.

19 This rate-adaptive behaviour is long lasting and transferable to the surrounding cardiom

20 ssion of these harmful genes, facilitating a long-lasting and benign association.

21 adjuvants is an important method to develop long-lasting and efficient vaccines against rabies.

22 occupancy and initiation of transcription to long-lasting and heritable epigenetic marks such as DNA

23 to form long-term memories, can exert such a long-lasting and important influence.

24 -fuel technology is the design of efficient, long-lasting and low-cost photoelectrochemical cells, wh

25 This faster onset would result in a long-lasting and meaningful memory trace for the event b

26 ith C. rodentium, and that these effects are long-lasting and not attenuated by probiotic L. reuteri.

27 ion through H3K9 during cocaine use can have long-lasting and unexpected negative consequences on beh

28 al whether the improvement is short-lived or long-lasting, and additionally what accounts for this im

29 only, temporally constrained, cue-specific, long-lasting, and persist following extended cocaine acc

30 is salience reduction was stimulus-specific, long-lasting, and specific to learning about, or respond

31 ed gastric emptying also indicate a safe and long-lasting antagonistic effect.

32 Because OxPAPC exhibits long-lasting anti-inflammatory and lung-protective effec

33 may provide the foundation for complete and long-lasting anti-influenza immunity.

34 represent a new class of rapidly-acting and long-lasting antidepressants.

35 orporation of AgBr/NPVP conferred strong and long-lasting antifungal effects against Candida albicans

36 e (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the

37 Strong and long-lasting antigen-specific T cell responses are criti

38 Here we show that long-lasting antihyperalgesia produced by BMSCs required

39 -Ile-Lys-NH2) to mice resulted in potent and long lasting antinociception in the tail-flick test, ind

40 ablished prostate cancers and development of long-lasting antitumor immune memory, which was primaril

41 resented in the safe context, rats entered a long-lasting, anxiety-like state characterized by increa

42 ositive effects of antibody therapeutics are long-lasting, any acute adverse events or chronic negati

43 g taking and seeking and leads to potent and long-lasting associations between the rewarding effects

44 We show that long-lasting attenuation of PKD in the juvenile cystic k

45 e nematode Caenorhabditis elegans leads to a long-lasting aversion that requires distinct sets of neu

46 idence shows that it is also associated with long-lasting behavioral and neuronal changes.

47 Early life experiences can have long-lasting behavioral consequences because they are en

48 that a short immunization regimen can have a long-lasting beneficial effect.

49 oid hormone, 17beta-estradiol (E2) can exert long-lasting beneficial effects upon axonal health, syna

50 d for the first 3-months after BCCAO exerted long-lasting beneficial effects, including significant n

51 ity of young individuals can causally induce long-lasting beneficial systemic effects that lead to li

52 consequences of stressor exposure, including long-lasting biases towards habit-based responding in a

53 from the plant apoplast during an unusually long-lasting biotrophic stage.

54 The effects of estrogen are long-lasting; bone marrow-derived macrophages from ovari

55 For long-lasting Ca release events, opening events within th

56 posure to the neuropeptide kisspeptin-evoked long-lasting Ca(2+) plateaus that persisted for tens of

57 Sustained contacts result in long-lasting calcium activity and NFAT translocation, a

58 magnitude and that extreme droughts may have long-lasting carbon feedbacks in grassland ecosystems.

59 microlesions" causing considerable acute and long-lasting cardiac damage.

60 ory response in breast tumors able to induce long-lasting CD8(+) T cell-dependent antitumor immunity.

61 Nicotine and stress concur to induce long-lasting cellular adaptations within the dopamine (D

62 recruited MRL.Fas(lpr) T cells establishing long-lasting cellular contacts by enhancing T cell VCAM-

63 st stimulation of alphaT3-1 cells indicating long-lasting cellular effects.

64 The long lasting change in intrinsic neuronal excitability i

65 onic kidney 293 cells, it was shown that the long lasting change in intrinsic neuronal excitability i

66 s within astrocytes were responsible for the long-lasting change in arteriole diameter caused by thet

67 heR binding interaction appears to promote a long-lasting change in receptor molecules, either a cova

68 inges on brain functions requiring adaptive, long-lasting changes by coordinating transcriptional cas

69 awareness, but is not sufficient to produce long-lasting changes in behaviour.

70 We show that iuGC-rats have long-lasting changes in cholinergic markers in the LDT,

71 in the cochlear nucleus could explain these long-lasting changes in hearing processing.

72 gnitive functions and suggest mechanisms for long-lasting changes in memory due to network-targeted s

73 Sensory experience evokes long-lasting changes in neural circuits through activity

74 How experiences during development cause long-lasting changes in sensory circuits and affect beha

75 ing and that altering such activity produces long-lasting changes in subsequent measures of cocaine c

76 is known about the mechanism regulating such long-lasting changes in synaptic strength.

77 he BNST is modulated by stress, resulting in long-lasting changes in the circuit and behavioral state

78 A recent body of literature suggests that long-lasting changes in the epigenome may be a mechanism

79 rolide course, given early in life, leads to long-lasting changes in the gut microbiota and immune sy

80 th seizures and interictal spikes may induce long-lasting changes in the human brain that can be sens

81 n-infecting Plasmodium species can establish long-lasting chronic infections(1-5), creating an infect

82 us perceptions, takotsubo cardiomyopathy has long-lasting clinical consequences, including demonstrab

83 ongue disorder (GPTD) is a newly discovered, long-lasting clinical disorder that may develop in organ

84 bination regimens, have produced durable and long-lasting clinical responses in a subset of metastati

85 M-1) and ICAM-2 on B cells are essential for long-lasting cognate Tfh-B cell interactions and efficie

86 However, clinical reports of long-lasting cognitive deficits, particularly in subject

87 s C. muridarum can spread to and establish a long-lasting colonization in the mouse gastrointestinal

88 to the gastrointestinal tract, establishing long-lasting colonization.

89 indicate that inhibition of NPM-ALK induces long-lasting complete remissions in a large subset of he

90 Brief periods of sleep loss have long-lasting consequences such as impaired memory consol

91 Child abuse has devastating and long-lasting consequences, considerably increasing the l

92 at doses that stimulated ERK42/44 corrected long-lasting corticosterone-induced behavioral abnormali

93 satisfy 'drug hunger' through its slow-onset long-lasting DAT inhibitor action, but also render subse

94 the ribosome after translocation has been a long-lasting debate.

95 Strong and long-lasting declines were found for gymnosperms, shade-

96 ReRh lesions to produce (1) a pronounced and long-lasting decrease of place field stability and (2) a

97 This causes a stimulus-specific and long-lasting deficit in the ability of the conditioned s

98 ia reduces sound to the ear, which can cause long-lasting deficits in language skills and verbal prod

99 ine tasks, patients with mTBI may experience long-lasting deficits in regulating inhibitory control w

100 e extracellular matrix remodeling to support long-lasting dendritic spine plasticity.

101 transients in response to odors, triggering long lasting depolarization of olfactory glomeruli.

102 condition imposed by fatiguing stimulation, long-lasting depolarization, or low drug concentrations)

103 ular calcium concentration during a train of long-lasting depolarizations to a maximally activating v

104 ygous mice were hyperexcitable and generated long-lasting depolarizing potentials with bursts of acti

105 glutamatergic inputs onto HIPP cells induces long-lasting-depression (LTD) of synaptic transmission b

106 Drug addiction is a long-lasting disease characterized by compulsive drug in

107 gle exposure of IL-13 may selectively induce long-lasting DNA methylation changes in asthmatic airway

108 l environment and oxygen tension, triggering long-lasting downstream signaling events with effects on

109 , this intervention neutralized an otherwise long-lasting drug-place preference, showing that recodin

110 tic potential characterized by a delayed but long lasting effect.

111 -function, abolishing PRKG1 expression had a long-lasting effect in promoting rod cell survival.

112 rior acoustic context has a large, rapid and long-lasting effect on a basic auditory judgement.

113 intravitreal injection of ranibizumab had a long-lasting effect.

114 Moreover, long-lasting effects from wildfire nullified pulses of s

115 The new chemicals, known as AMFs, have long-lasting effects in promoting stomatal closure and i

116 Wash-out experiments demonstrated that the long-lasting effects induced by GnRH were most likely ca

117 ant population dynamics to water balance and long-lasting effects of disturbance on plant community d

118 ss in early adulthood, which illustrates the long-lasting effects of hydrogen on stress resilience in

119 a sensitive time period when stress can have long-lasting effects on behavior.

120 e to climate extremes, such as drought, with long-lasting effects on both plant and soil communities

121 tional composition in these forests may have long-lasting effects on ecosystem functioning.

122 nt affects DNA methylation, with potentially long-lasting effects on gene expression and disease.

123 n individual's developmental trajectory with long-lasting effects on health.

124 t-induced obesity during puberty imposes its long-lasting effects on sleep-wake behavior.

125 intrauterine and perinatal factors can have long-lasting effects on the retina and the optic nerve.

126 m half-life, allowing infrequent dosing with long-lasting effects.

127 immunotherapy to benefit more patients with long-lasting efficacy.

128 , the greatest challenge is to deliver high, long-lasting electrocatalytic activity while ensuring co

129 ted these phenotypic alterations, suggesting long-lasting epigenetic changes.

130 Early childhood malnutrition entails long-lasting epigenetic signatures associated with liabi

131 particular cytokine response and be cued to long-lasting epigenomic modifications rather than by sho

132 neurons in vivo, resulting in high level and long-lasting expression of the channel selectively in se

133 a2 channels are a novel target to facilitate long-lasting extinction of alcohol-seeking behavior.SIGN

134 Since LSA produces long-lasting firing in the absence of sound, it may be r

135 adiolabeled single-cells into an integrated, long-lasting fluorescence signal.

136 e environment and this sensitisation is very long lasting following agonist removal.

137 Long-lasting forms of long-term potentiation (LTP) repre

138 al key kinases can predict the occurrence of long-lasting forms of LTP for multiple experimental prot

139 is why different molecules are critical for long-lasting forms of LTP induced by diverse experimenta

140 Long-lasting forms of synaptic plasticity and memory req

141 Long-lasting forms of synaptic plasticity that underlie

142 ger people and may result in significant and long-lasting functional disability.

143 i-saccadic orientation discrimination led to long-lasting gains in that task but did not alter the cl

144 k7 deficiency leads to telomere aberrations, long-lasting gammaH2AX and 53BP1 foci, and augmented cel

145 ariatric surgery may achieve better and more long-lasting glycemic control in select patients with ea

146 squito cells elicited rapid (within 4 d) and long-lasting (>290 d) neutralizing antibodies that provi

147 intraperitoneal injection induces rapid and long-lasting (>3 days) nuclear activation of the heat-sh

148 Modern vaccines must be designed to generate long-lasting, high-affinity, and broadly neutralizing Ab

149 converts the low CL signal into a stable and long-lasting, highly intense fluorescence signal.

150 ruption of this sensitive community may have long-lasting host consequences.

151 able, in particular in regions with deep and long-lasting human footprints.

152 crosphere formulation showed more robust and long-lasting humoral immune response compared to a singl

153 es were significantly less likely to develop long-lasting humoral immune responses to DENV, as measur

154 -7 is beneficial for induction of potent and long-lasting humoral immune responses.

155 The mechanisms underlying the maintenance of long-lasting humoral immunity are not well understood.

156 elper cells contribute to the development of long-lasting humoral immunity by germinal center formati

157 long-lived PCs in humans that contribute to long-lasting humoral immunity.

158 ry system of insulin designed by us showed a long-lasting hypoglycemia effect with a faster onset in

159 y after hours, whereas IFN-lambda provides a long-lasting IFN-stimulated gene induction.

160 elicited serotype-specific, protective, and long-lasting IgG antibodies of nanomolar affinity agains

161 te vaccines are an effective way to create a long-lasting immune response against bacteria.

162 immunogenic and have the capacity to elicit long-lasting immune responses.

163 l, and molecular requirements for robust and long-lasting immunity against EBV infection.

164 ng that SYMPHONY treatment induced effective long-lasting immunity against MB49 cancer cells.

165 ed Th2 cells persisted in vivo and conferred long-lasting immunity.

166 ogous protection and, further, establishes a long-lasting immunogenic memory, which determines diseas

167 ty with patient T cells in vitro, suggesting long-lasting immunological memory.

168 infections with placental sequestration have long-lasting impact on infant susceptibility to malaria

169 her rates of CNS morbidities associated with long-lasting impairment of cognitive functions, includin

170 These data demonstrate that cocaine leaves a long-lasting imprint on the dopamine system that is acti

171 n example of how the polio legacy can create long-lasting improvements to public health beyond polio,

172 n of CTDP-32476 alone produced a slow-onset, long-lasting increase in extracellular nucleus accumbens

173 The dominant effect is a presynaptic, long-lasting increase in synaptic strength.

174 nclusion This population-based study shows a long-lasting increased risk for HPV-related carcinomas a

175 Long-lasting inhibition of ENaC-dependent Isc was also p

176 Tp-SP to all women attending ANC, as well as long-lasting insecticidal net distribution targeted towa

177 rs were randomly allocated to receive either long-lasting insecticidal nets (LLINs) alone or LLINs in

178 Long-lasting insecticidal nets (LLINs) and indoor residu

179 Long-lasting insecticidal nets (LLINs) and indoor residu

180 Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) are the primary t

181 has made to malaria control via funding for long-lasting insecticide treated nets (LLINs), indoor re

182 erventions with larviciding, distribution of long-lasting insecticide-treated nets, indoor residual s

183 potent IR antagonist that creates rapid and long-lasting insulin resistance.

184 amically scan MCs, whereas at a later stage, long-lasting interactions predominate.

185 During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh)

186 With emphasizing on persistent long-lasting interactions, an approach is proposed that

187 Our results also highlight an apparent long-lasting intergenerational influence of maternal BMI

188 icles, with Cn being capable of establishing long-lasting latent infections within host macrophages.

189 ing new materials, and molecular probes with long-lasting light emission and imaging capabilities.

190 emporal pattern of synaptic input to achieve long-lasting LTP and memory storage.

191 e beta-adrenergic receptor will likely block long-lasting LTP in response to strong stimulation.

192 Gi-coupled) pathways underpins most forms of long-lasting LTP.

193 Lenalidomide is a suitable candidate for long-lasting maintenance as it is an oral drug, active a

194 howed that Dhb modifications accumulate in a long-lasting manner in Shigella-infected cells, causing

195 m, with increased frequency and intensity of long-lasting MCSs.

196 ystem rapidly transforms current inputs into long-lasting meaningful memories.

197 However, the long-lasting mechanisms that shape risk or resilience fo

198 tion potential-driven eCB release leads to a long-lasting membrane potential hyperpolarization in hip

199 The formation of long-lasting memories requires coordinated changes in ge

200 The formation of long-lasting memories-a process referred to as memory co

201 r data suggest that LAIV vaccination induces long-lasting memory immune responses.

202 synaptic modifications in PL-mPFC and causes long-lasting memory impairments.

203 ating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 expo

204 er reinstates a robust, context-specific and long-lasting memory.

205 a Orb2A protein is required specifically for long-lasting memory.

206 ell transplantation offer an opportunity for long-lasting modification of epileptic circuits.

207 Neuropathic pain involves long-lasting modifications of pain pathways that result

208 , whether chronic or self-limiting, leaves a long-lasting molecular imprint on the bladder tissue tha

209 olamine toxicity that may produce subtle but long-lasting myocardial alterations.

210 For memory to be established in a long-lasting neocortical store, many learning repetition

211 Recent research has identified late-latency, long-lasting neural activity as a robust correlate of co

212 rogenesis but a factor capable of inducing a long-lasting neurogenic enhancement that attenuates age-

213 ease accompanied by a high mortality rate or long-lasting neurologic sequelae.

214 r performance showed comparable improvement, long-lasting neuroplasticity can only be detected in the

215 LSA is induced by long-lasting, or repetitive short-duration, innocuous so

216 al HIV/AIDS Strategy calls for programs with long-lasting outcomes.

217 cterized by high PTEN and low Wip1 levels to long-lasting p53 level oscillations in cells having PTEN

218 ce at mid-gestation resulted in enhanced and long-lasting passive immunity of the offspring, measured

219 Such long-lasting patterning of habitats makes them ideal to

220 pening of mitochondrial high-conductance and long-lasting permeability transition pores (mPTP) causes

221 hat early-life immune activation can lead to long-lasting physiologic perturbations that resemble med

222 esults suggest that early adversity may have long-lasting physiological consequences contributing to

223 gnals at the median eminence (ME) to control long-lasting pituitary hormone rhythms essential for hom

224 l immune responses appeared to be strong and long-lasting, pointing to systemic infection in humans.

225 achieving excellent signal enhancements with long-lasting polarization.

226 m weight loss in patients with psoriasis has long-lasting positive effects on the severity of psorias

227 ng a rodent model of cocaine abuse, we found long-lasting, possibly permanent, cocaine-induced altera

228 -term potentiation, and also interferes with long-lasting potentiation induced either by postsynaptic

229 drenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA

230 ained behavioral responses are mediated by a long-lasting potentiation of the rewarding properties of

231 t the level of the lateral lemniscus, and to long-lasting presynaptic and postsynaptic structural and

232 In 2 murine models we found a long-lasting preventive effect against experimental asth

233 verexpressing IL-7 improved the induction of long-lasting primary and secondary antibody responses po

234 Because of the long-lasting problems that are associated with fetal alc

235 Disadvantages are a long-lasting procedure, and in a few cases potential sys

236 efficiencies in converting harvested wood to long-lasting products and sources of energy, and novel a

237 an infusion of these cells into mice confers long lasting protection against a high dose of BoNT/A.

238 A vaccine that induces broad and long-lasting protection against influenza B viruses is t

239 methasone exposure during pregnancy provides long-lasting protection against the onset and developmen

240 paring effect and significantly enhanced the long-lasting protection of the pH1N1 vaccine.

241 Long-lasting protection resulting from hepatitis B vacci

242 fective vaccine against dengue should elicit long-lasting protective antibody responses to all four s

243 In the current study, we examined the long-lasting protective efficacy of chimeric VLPs (cVLPs

244 a vaccine that elicits broadly reactive and long-lasting protective immune responses.

245 Long lasting pyrethroid treated bednets are the most imp

246 e, an urgent need to develop single-dose and long-lasting rabies vaccines.

247 al cord injury (SCI), astrocytes demonstrate long-lasting reactive changes, which are associated with

248 rizing GABA and p75(NTR) signaling fosters a long-lasting rearrangement of glutamatergic network that

249 tinct pathways, with the potential to induce long-lasting recovery of movement despite the continued

250 burst neural activity produced an unexpected long-lasting reduction in astrocyte free Ca(2+) in the s

251 ex vivo or in vivo neural activity induced a long-lasting reduction in resting free astrocyte Ca(2+)

252 We found that nerve injury in rats induced a long-lasting reduction in the expression level of MORs i

253 Measurement of long-lasting reflex using electromyography, behavioral f

254 nished or regenerated through subduction, or long-lasting regions containing both metallic and silica

255 that neuromodulators can exert powerful and long-lasting regulation of nerve terminal Ca(2+) indepen

256 asement rocks during the Mesozoic and later, long-lasting relative tectonic stability.

257 hydrobiopterin analogue, led to dramatic and long-lasting remission of depression.

258 Current strategies aim for deep and long-lasting remission, with the goal of preventing comp

259 Most patients achieve long-lasting remissions and have excellent overall survi

260 aine, and explains how acute cocaine induces long-lasting remodeling of the mesolimbic DA system.

261 Cancer immunotherapy can induce long lasting responses in patients with metastatic cance

262 leash breaks in the immune system and induce long-lasting responses.

263 last exposure, suggesting the possibility of long-lasting retinal injury and neuronal inflammation af

264 ghlight the clinical potential of developing long-lasting, safe, and versatile gene therapy approache

265 vo and at Day 28 post-mortem) and marked and long-lasting sensorimotor deficits, normobaric oxygen th

266 sive selective neuronal loss associated with long-lasting sensorimotor impairment but normal magnetic

267 In female mice, mating creates a long-lasting sensory memory for the pheromones of the st

268 re infection of the CNS with a high risk for long-lasting sequelae.

269 The capacity to form long-lasting social memories is critical to our health a

270 A vigorous, long-lasting sound-evoked afterdischarge (LSA) is seen i

271 gh, increasing RyR open probability promotes long-lasting sparks by potentiating Ca-induced Ca releas

272 trate theoretically and computationally that long-lasting sparks emerge as a collective dynamical beh

273 U network is monostable and excitable, while long-lasting sparks occur when the network dynamics poss

274 f duration in the range of 10 to 100 ms, but long-lasting sparks with durations of several hundred mi

275 t the mechanisms and conditions that produce long-lasting sparks, demonstrating the existence of an o

276 timal range of RyR open probability favoring long-lasting sparks.

277 ir larger array of target Ags have conferred long-lasting sterilizing protection to humans.

278 ng neurons and neuronal networks may lead to long-lasting structural and functional alterations assoc

279 and 50 million years ago as a consequence of long-lasting subduction systems, unlike those in the sou

280 ate a nongenomic glucocorticoid induction of long-lasting suppression of synaptic inhibition that is

281 Pathogen-infected &CMFDA-labeled MoDCs long-lasting survival was confirmed in a huMoDC reconsti

282 ng disease pathophysiology or simply induces long-lasting symptomatic effects is uncertain.

283 e treatments for patients suffering from the long-lasting symptoms of TBI.

284 ns represent a network state that introduces long-lasting synaptic plasticity in a cell-specific mann

285 er, an acute exposure to cocaine can trigger long-lasting synaptic plasticity in SPNs leading to beha

286 A pivotal feature of long-lasting synaptic plasticity is the localization of

287 ecoding calcium (Ca(2+)) signals to initiate long-lasting synaptic plasticity.

288 How long-lasting T-B interactions and B cell clonal expansio

289 nt of a leprosy-specific vaccine that boosts long-lasting T-cell responses is also a research objecti

290 Here, we evaluate whether a novel potent and long-lasting (t(1/2) >/=7 hours) acylated alpha-CGRP ana

291 py may provide the desired specificity and a long-lasting therapeutic effect by inducing myelin-speci

292 lting in an efficacious, tumor-specific, and long-lasting therapeutic effect.

293 dual inhibition of COX2 and YAP1 elicited a long-lasting therapeutic response by limiting CSC expans

294 onger FAK phosphorylation in cell adhesions, long-lasting trailing ends and slower turnover of focal

295 ity to adult social defeat stress and causes long-lasting transcriptional alterations that prime the

296 ncodes lifelong susceptibility to stress via long-lasting transcriptional programming in VTA mediated

297 low-dose TNF, complete tumor regression and long-lasting tumor immunity were observed, still without

298 ctions of nanoparticles led to effective and long-lasting tumor regression/eradication in subcutaneou

299 Training produced long-lasting upregulation of pERK throughout the PL and

300 roup of Dorothy Hodgkin became interested in long-lasting zinc-insulin crystals for treatment of diab