ライフサイエンスコーパス: long-lived

1 ndow, while many animals store sperm and are long-lived.

2 s germ-line genes in their somatic cells are long-lived.

3 lls declines with age, naive T cells must be long-lived.

4 s relaxation from initial nonpolar S3(FC) to long-lived (1.3 ns in n-hexane and 3.4 ns in acetonitril

5 and spectroscopic studies suggested that the long-lived (2)D excited states of these complexes corres

6 we propose that the gradual accumulation of long-lived active receptor complexes contributes to the

7 Our findings support the existence of a long-lived, adaptive NK-cell population maintained indep

8 uring development influences the lifespan of long-lived Ames dwarf and normal littermate control mice

9 Interestingly, in long-lived Ames dwarf mice, renal FXR and TGR5 expressio

10 Intermediates are long lived and accumulate progressively, in contrast wit

11 ulting charge-transfer state is surprisingly long lived and leads to efficient electronic relaxation.

12 progenitor (MPP) cell compartment, which is long lived and responsible for dynamically regulating ou

13 We show that, like TfR, Megalin is a long-lived and fast-recycling receptor.

14 Declines in the abundance of long-lived and habitat-forming species on continental sh

15 roblem is most severe when the weak stock is long-lived and has low fecundity and thus requires a ver

16 ct, suggesting that these may be general for long-lived and highly fecund fishes.

17 Crocodiles, as a long-lived and highly fecund species, deviate from the u

18 titioning predicts a population structure of long-lived and highly heterogeneous phenotypes.

19 These results establish the presence of a long-lived and indispensable Krt15+ progenitor cell popu

20 olymer solar cells because these species are long-lived and quench subsequently generated singlet exc

21 arded as energy storage units since they are long-lived and require energy to be formed.

22 Long-lived and self-renewing adult stem cells (SCs) are

23 n myelin sheaths may persist indefinitely in long-lived animal models.

24 Long-lived animals representing distinct longevity pathw

25 development of PNA and provide evidence that long-lived anti-peanut IgE levels may be maintained by l

26 nants and adjuvants in promoting high-titer, long-lived antibody responses against Pfs25.

27 vaccine cargo release was the generation of long-lived antigen-specific CD8(+) T cells that accumula

28 munization, suggesting CD161 is a marker for long-lived antigen-specific memory T cells.

29 As long-lived apex predators, predatory birds represent a s

30 nces produced a demographic explosion of the long-lived ( approximately 120 y old, maximum height of

31 anti-peanut IgE levels may be maintained by long-lived ASCs.

32 of summer insolation, global ice volume and long-lived atmospheric greenhouse gases.

33 ing revealed that the Krt15 promoter marks a long-lived basal cell population able to self-renew, pro

34 rsion to the ground state and formation of a long-lived base-off species with a quantum yield of appr

35 tions, a critical advantage for developing a long-lived battery.

36 ethods were chosen for the separation of the long-lived beta-emitters (129)I, (36)Cl and the alpha-em

37 tions result from closed-open transitions in long-lived bilayer-spanning dimers.

38 bulky C2 substituents can promote stable and long-lived binding events leading to sustained agonist r

39 lication of this HTPS/GOx-based electrode in long-lived biofuel cells and amperometric biosensors.

40 uickly than anchors that form high-affinity, long-lived bonds with matrix, leading to markedly greate

41 equency of antigen-specific plasma cells and long-lived bone marrow plasma cells was detected in the

42 for exogenous antigen or DNA, frequencies of long-lived bone marrow plasma cells were unaffected.

43 entral England, northern Spain, and a major, long-lived but little-documented alabaster trade radiati

44 solved photoconductivity measurements reveal long-lived carriers with microsecond lifetimes in the al

45 to capture leukocytes from flowing blood via long-lived catch-bonds that support slow leukocyte rolli

46 virus persists as integrated proviral DNA in long-lived cells despite years of suppressive antiretrov

47 IV-1 because they do not eliminate a pool of long-lived cells harboring immunologically silent but re

48 op before birth and persist in the tissue as long-lived cells with minimal turnover.

49 lances Th1 and Th2-type immune responses for long-lived cellular and neutralizing humoral immunity ag

50 e mechanism considered to contribute to such long-lived changes is the remodeling of the ionotropic A

51 appear to independently sustain appreciable long-lived charge generation.

52 The long-lived charge separation and ability to accumulate m

53 Presently, long-lived charge traps limit the speed of such detector

54 fer in the solid state and the origin of the long-lived charge-separated state were studied by steady

55 rth-abundant transition-metal complexes with long-lived charge-transfer excited states.

56 s unichromosomal architecture is shared by a long-lived clade of asexual nematodes closely related to

57 d lineage-tracing of Prox1(+) cells revealed long-lived clones during homeostasis and after radiation

58 However, large igneous provinces are long-lived compared to mass extinctions.

59 luences U1 binding at the 5' SS by promoting long-lived complex formation.

60 ounds from biomass burning can be relatively long-lived components in atmospheric aerosols, thus more

61 Long-lived conformational states and their interconversi

62 volutionarily stable N2 -fixing strategy for long-lived conifers.

63 rol over tumor growth have sparked hope that long-lived control of cancer through stimulation of the

64 and carbon isotopes (delta(13)C) measured in long-lived coralline algae demonstrate significant corre

65 habitats - from short-lived phytoplankton to long-lived corals - in response to environmental heterog

66 change, potentially aiding the adaptation of long-lived corals.

67 The surprisingly long-lived CS state, together with its intrinsic hybrid

68 Demonstration of long-lived cytotoxic agents after Pseudomonas infection

69 insulin signalling and accelerates aging of long-lived daf-2 worms fed a high glucose diet.

70 sues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/IGF-1 and glp-1/Notch mutants t

71 s well as the fraction of molecules entering long-lived dark states, resulting in widely different ap

72 e, it is unlikely that DCAM can persist as a long-lived DCAN decomposition product in systems using f

73 l nucleoli and fibrillarin expression, as do long-lived dietary restricted and IRS1 knockout mice.

74 Long-lived dietary restricted fruit flies and insulin-li

75 As nut allergy is likely to be a long-lived disease, nut avoidance advice is the cornerst

76 l-surface engineering strategies that permit long-lived display of well-defined, functionally active

77 otein acceptors of living cells resulting in long-lived display.

78 ii) d(5) complex, and emission occurs from a long-lived doublet ligand-to-metal charge-transfer ((2)L

79 However, in many long-lived ectotherms, selection is expected to remain s

80 HIV-1 envelope (Env) antigens (Ag) for more long-lived, efficacious HIV-1 vaccine-induced B-cell res

81 eous solution do not provide evidence of any long-lived electronic quantum coherence, but confirm the

82 erpreted as direct evidence of exceptionally long-lived electronic quantum coherence.

83 ly QDs, CuFeS2 based nanoparticles exhibit a long-lived emission that is significantly red-shifted co

84 orded in low dielectric media, reveal that a long-lived emissive excimer state appears approximately

85 used nanoparticle carriers by leveraging the long-lived endogenous serum protein albumin as an siRNA

86 The long-lived energetic carriers may enable hot-carrier sol

87 OTA results show that an exceptionally long-lived excited state is formed after photoexcitation

88 le of 26 +/- 6 fs and leaves the system in a long-lived excited state of the metallic phase, driven b

89 ups (PhiF increases from 0.22 to 0.96) while long-lived fluorescence lifetimes were observed between

90 For long-lived forest tree species, the understanding of int

91 oncogene-initiated carcinogenesis instruct a long-lived granuloma-resident macrophage differentiation

92 le in the regulation of larval diapause, the long-lived growth arrest state called dauer arrest, in C

93 Consequently, we find systematic and long-lived growth differences between mother and daughte

94 le haematopoietic compartments, suggesting a long-lived haematopoietic stem and progenitor cell of or

95 near ubiquitous latent skin infection within long-lived hair follicle (HF) keratinocyte stem cells.

96 ally enter either the fully fused state or a long-lived hemifusion intermediate.

97 e that sustained high-eruption discharge and long-lived high-pore pressure in dense granular dispersi

98 ulates and matrix; the popular dogma is that long-lived, high-affinity bonds to both species facilita

99 tantial near-infrared (NIR) absorptivity and long-lived, high-yield triplet excited states is vital f

100 olution, the tube-severing process displayed long-lived, highly constricted prefission intermediates

101 for green turtles, Chelonia mydas, which are long-lived, highly migratory, primarily herbivorous mega

102 perovskites, but it is unclear whether these long-lived hot carriers can migrate long distance for ef

103 Long-lived human plasma cells (PCs) play central roles i

104 These DENV-positive C cases did not elicit long-lived humoral immune responses, despite viremia lev

105 s in B cells that may be targeted to promote long-lived humoral immunity and resistance to malaria.

106 rly B cell activation and the development of long-lived humoral immunity.

107 ant lifelong IgE titers are not sustained by long-lived IgE(+) PCs.

108 iters have been attributed conventionally to long-lived IgE(+) plasma cells (PCs), this has not been

109 ation within germinal centres and persist as long-lived IgG plasma cells in the bone marrow.

110 mmunization, thereby providing the host with long-lived immunological memory.

111 e demonstrate that post-strain stress can be long-lived in cross-linked networks by distributing stre

112 ported that finding and showed the cages are long-lived in solution at room temperature.

113 However, the IIS mutants remained long-lived in the absence of DHR96 and the xenobiotic re

114 ly showed that humanized mice immunized with long-lived induced-dendritic cells loaded with the pp65

115 pulations containing a mixture of short- and long-lived infections promote selection efficiency.

116 ) permanent bleaching, and (vi) formation of long-lived intermediates.

117 , appear indispensable for longevity in many long-lived invertebrate mutants.

118 demographics are generally lacking for many long-lived iteroparous species such as large reptiles.

119 ial pressure of CO2 (PCO2) coinciding with a long-lived lake system in Gale Crater at approximately 3

120 als that strand backbones in open regions of long-lived lambdaPR-discriminator OCs are much more tigh

121 e to the ribosome resolve through relatively long-lived late intermediates wherein peptidyl-tRNA ente

122 A long-lived latent reservoir for HIV-1 persists in CD4(+)

123 ts in viral rebound, attributed to a pool of long-lived, latently infected cells.

124 e efficiency or, equivalently, from high-LMA/long-lived leaves (i.e., evergreen) to low-LMA/short-liv

125 model with two case studies: a short- and a long-lived life history.

126 itive embryonic dorsal aorta establishes the long-lived lineages of smooth muscle cells that make up

127 in or exclusive mode of reproduction in some long-lived lineages.

128 nd maintenance of tissue boundaries involves long-lived, long-ranged mechanical events.

129 des on different timescales by combining the long-lived luminescence of Mn(2+) with the relatively sh

130 ability of EBV to convert human B cells into long-lived lymphoblastoid cell lines (LCLs) in vitro req

131 ocyte survival, and differentiation toward a long-lived M1-like macrophage phenotype.

132 , often associated with large eruptions from long-lived magmatic systems.

133 ife-history traits in natural populations of long-lived mammals.

134 ctive, longitudinal framework, especially in long-lived mammals.

135 oxygen isotope ratios from the shells of the long-lived marine bivalve Arctica islandica (delta(18)O-

136 l reproductive effort in the Weddell seal, a long-lived marine mammal with a protracted period of mat

137 acylated SOD1-CCS heterodimer may serve as a long-lived maturation intermediate in human spinal cord.

138 ical memory T cell signature associated with long-lived memory and have identical proliferative poten

139 gly, rLBNSE-IL-7 improved the percentages of long-lived memory B cells (Bmem) in the draining LNs and

140 reactivity is conferred by allergen-specific long-lived memory B cells that replenish the IgE(+) PC c

141 he early generation of a latent reservoir of long-lived memory CD4(+) T cells bearing replication-com

142 Here we show that long-lived memory CD8 T cells are derived from a subset

143 s can be reversed in cells that develop into long-lived memory CD8 T cells while key effector genes r

144 for NK cells to adapt and differentiate into long-lived memory cells has added further complexity to

145 phenotypic and functional characteristics of long-lived memory cells.

146 Long-lived memory effector phenotype, associated with vi

147 not exist under normal conditions-to provide long-lived memory function, suggesting that quantitative

148 ic emigrants to undergo LIP and convert into long-lived memory T cells.

149 ge, a Plasmodium falciparum gamma-irradiated long-lived merozoite (LLM) line was developed and invest

150 processing history drives the material into long-lived metastable states defined by self-assembled p

151 We have identified three additional long-lived, metastable states from the bin-based model.

152 a correlated, rather than a causal, trait in long-lived mice.

153 Many models suggest that long-lived microtubules along the anticlinal cell wall g

154 We found that neither PIN proteins nor long-lived microtubules along the anticlinal wall predic

155 We considered that long-lived microtubules are acetylated inside their lume

156 Centrioles are composed of long-lived microtubules arranged in nine triplets.

157 Eukaryotic cells rely on long-lived microtubules for intracellular transport and

158 required for the mechanical stabilization of long-lived microtubules in cells.

159 ical resilience to ensure the persistence of long-lived microtubules.

160 t control in an architecture compatible with long-lived microwave cavity-based quantum memories.

161 Long-lived migratory animals must balance the cost of cu

162 Here, we demonstrate that integration of long-lived Mn(2+) upconversion emission and relatively s

163 The formation of a long-lived Mn(III) oxide appears to depend on aqueous Mn

164 Over the last 20 years a number of long-lived mouse mutants have been described, many of wh

165 to the increased lifespan and healthspan of long-lived mouse mutants.

166 ogression in four orthologous, including two long-lived, mouse models of ADPKD.

167 Long-lived murine Plasmodium-specific MBCs consisted of

168 h age in C. elegans, whereas daf-2 and glp-1 long-lived mutants regulate autophagy in distinct spatio

169 required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms.

170 agy appeared active in the intestine of both long-lived mutants, inhibition of intestinal autophagy s

171 razone switch with a phenyl one leads to the long-lived negative photochromic compounds.

172 en by the protein tyrosine kinase Syk; slow, long-lived negative signals driven by the lipid phosphat

173 es give rise to year-to-year shifts in these long-lived NPO anomalies.

174 n 2-methyl-1-(methyl-d)piperidine supports a long-lived nuclear spin state.

175 Long-lived organisms often feature more stringent protei

176 gic and molecular regulation of autophagy in long-lived organisms remains incompletely understood.

177 The establishment of long-lived pathogen-specific T cells is a fundamental pr

178 However, it remains poorly understood how long-lived PCs (LLPCs) are generated and maintained.

179 the existence of memory B-cell-independent, long-lived PCs in humans that contribute to long-lasting

180 Moreover, we found that the long-lived PCs that were elicited by the IL-7-expressing

181 The absence of long-lived PCs was associated with a rapid decline in Ag

182 he TIE checkpoint thus mediates selection of long-lived PCs with limited ER stress supporting high Ig

183 As a result of the presence of the long-lived PCs, it also generated prolonged virus-neutra

184 ducing the pool of bone marrow (BM)-resident long-lived PCs.

185 e complex traits that are hard to improve in long-lived perennials.

186 But in the long-lived periodical cicada Magicicada tredecim, the Ho

187 of the diferrous cluster to O2, CmlI forms a long-lived peroxo intermediate, P, which reacts with NH2

188 m cells (TSCM) retain superior potential for long-lived persistence, but challenges exist in manufact

189 ly, wastewater contains biologically active, long-lived pharmaceuticals, even after treatment.

190 Crystalline or potentially long-lived phases produced in these experiments included

191 Second, we imprint a long-lived phenotype exhibiting improved antitumor activ

192 ural basis for designing photocatalysts with long-lived photo-induced states.

193 The achievement of long-lived photoinduced redox separation lifetimes has l

194 s compound is solution processable, exhibits long-lived photoluminescence, and an optical band gap of

195 e are devices and materials supporting ultra-long-lived photonic and phononic excitations that enable

196 The long-lived photoproduct stores energy in the form of a r

197 effect can play a crucial role for obtaining long-lived photoproducts resulting from multiphoton, mul

198 insects can affect population structure of a long-lived plant.

199 /liposomes induce high levels of bone marrow long-lived plasma cell (LLPC) antibody production.

200 djuvanted vaccines induced antigen-specific, long-lived plasma cells (LLPCs), which persisted in the

201 to the immunoglobulin-secreting activity of long-lived plasma cells (LLPCs).

202 differentiation of memory B cells (MBCs) and long-lived plasma cells (LLPCs).

203 mportantly, these humoral responses generate long-lived plasma cells and generate Abs capable of neut

204 ists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B ce

205 Long-lived plasma cells are critical to humoral immunity

206 On the basis of these results, long-lived plasma cells represent a key cell population

207 Graphene carries long-lived plasmons that are extremely confined and cont

208 This long-lived polarization enables the visualization of the

209 The creation of such hyperpolarized long-lived polarization reflects an important step forwa

210 agnetization states, thus offering a path to long-lived polarization storage.

211 croneedle technology induces mobilization of long lived, poly-functional CD8(+) T cells to peripheral

212 into effector cells, and then contract to a long-lived pool of memory cells after pathogen clearance

213 e BM, diminishing the number of cells in the long-lived pool.

214 Radiolabeling with long-lived positron emission tomography (PET) radionucli

215 e and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throu

216 MX administration induces stage-specific and long-lived pre-erythrocytic protective anti-malarial imm

217 Herein, we have described a long-lived progenitor cell population in the mouse esoph

218 that accompanied the extremely energetic and long-lived prompt gamma-ray emission from GRB 160625B.

219 and the CHIKV DNA vaccine afforded rapid and long-lived protection.

220 n with Staphylococcus aureus does not induce long-lived protective immunity for reasons that are not

221 rintuitively, results show that for a stable long-lived protein, the optimal strategy is to express t

222 ts selectively increase degradation rates of long-lived proteins as they transition from a proliferat

223 Old long-lived proteins contain dehydroalanine (Dha) and deh

224 The degradation of long-lived proteins in the body is an important aspect o

225 The selective degradation of long-lived proteins occurs by the concurrent activation

226 iescent cells avoid the accumulation of aged long-lived proteins that would otherwise result from the

227 nondividing state, there is a propensity for long-lived proteins to become stabilized relative to sho

228 ution is the dominant route of clearance for long-lived proteins whose inherent degradation is slower

229 s biological mechanism allowing recycling of long-lived proteins, abnormal protein aggregates, and da

230 esulting from reduced degradation of overall long-lived proteins.

231 hway (ALP) is involved in the degradation of long-lived proteins.

232 st optomechanical system with a multitude of long-lived (Q > 10(7)) mechanical modes in a phononic-ba

233 We explore the mechanism for the long-lived quantum coherence by considering the discrete

234 In the search for long-lived quantum coherence in spin systems, vanadium(I

235 down of the standard Fermi-liquid picture of long-lived quasiparticles in well-defined band states em

236 kinase-1 (Dclk1) labels a rare population of long-lived, quiescent pancreatic cells.

237 onditions, neither one-photon ionization nor long-lived radical cations are detected for the telomere

238 rates a new approach for storing sunlight as long-lived radicals, and provides the structural basis f

239 approach to managing this highly mobile and long-lived radionuclide is immobilization into micro- an

240 With the prospect of coupling to other long-lived rare-earth spin states, this technique opens

241 n CAP may activate cells in vivo to generate long-lived reactive species such as H2O2, which may trig

242 Photoactivation of these long-lived, reactive states is shown to photosensitize c

243 es with red-shifted absorptions that possess long-lived, redox-active excited states that are useful

244 artificial photosynthetic systems requiring long-lived reduced states to perform multi-electron chem

245 ng a chase, the ratio of a test protein to a long-lived reference protein, a dihydrofolate reductase

246 rocodiles is actually shared by other large, long-lived reptiles: while adult survival rates always h

247 fection, and whether macrophages represent a long-lived reservoir for the virus.

248 HIV infection is incurable due to a long-lived reservoir of HIV(+)memory CD4 T cells, and no

249 A long-lived reservoir of latently infected T cells preven

250 -host quasispecies model that incorporates a long-lived reservoir, which we then nest into an epidemi

251 The existence of long-lived reservoirs of latently infected CD4+ T cells

252 igate serum anti-CT immunoglobulin G1 (IgG1; long-lived response) and immunoglobulin G3 (IgG3; short-

253 replication-competent, latent proviruses in long-lived resting T cells.

254 often due to accumulation of infections with long-lived schistosomes from early life.

255 Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essentia

256 cells (ASCs) are critical effector cells and long-lived sentinels for immune memory.

257 xin2 gene in mice identifies a population of long-lived skeletal cells on the periosteum of long bone

258 In the presence of long-lived slots, the 10(6)-y average power output of th

259 nges in maternal reproductive allocation for long-lived species are a key prediction from life-histor

260 Defense and susceptibility in two long-lived species, GB bristlecone pine (Pinus longaeva)

261 The model is constrained to observations of long-lived species, meteorological parameters, and photo

262 s most sensitive to nonbreeder parameters in long-lived species, when Nnb */Nb *>0, and when individu

263 l to considerably and negatively influence a long-lived species, which might previously have been ass

264 but evidence of such patterns is lacking for long-lived species.

265 ing selection on growth rates over time in a long-lived species.

266 f the approach can also provide insight into long-lived specific water-protein interactions that esca

267 The detection of (19)F-(19)F long-lived states in suitably designed fluorinated spy m

268 The magnetic origin of the long-lived states is confirmed by single-atom electron s

269 cules with CH2D groups exhibiting accessible long-lived states, and to investigate the factors govern

270 to lineages comprising infrequently-dividing long-lived stem cells and frequently-dividing short-live

271 A putative subset of tissue-resident long-lived stem cells is characterized by the ability to

272 eneration of stomach epithelium is driven by long-lived stem cells, but the mechanism that regulates

273 ed malaria exposures would induce protective long-lived sterile immunity targeting pre-erythrocytic s

274 g the WorMotel, we find that short-lived and long-lived strains exhibit patterns of behavioral declin

275 Free Radicals (EPFRs) are newly discovered, long-lived surface bound radicals that form on particula

276 ith key outcomes dependent upon sufficiently long-lived Syk binding events.

277 ymphoid organs are an essential component of long-lived T cell immunity.

278 f memory CD8 T cells is vital for sustaining long-lived T cell-mediated immunity.

279 velength absorbers that efficiently populate long-lived T1 states.

280 pq results in the population of a relatively long-lived (tau = 19 ns) Ru(dpi) --> qdpq(pi*) (3)MLCT e

281 We observe long-lived temporal correlations, experimentally identif

282 replacement histone for damaged histones in long-lived terminally differentiated cells.

283 data suggest that adaptive NK cells are more long-lived than canonical, immunoregulatory NK cells.

284 [(HEB)Re(CO)2(alkane)](+) complexes are more long-lived than the corresponding neutral alkane complex

285 Furthermore, as trees are sessile and long-lived, their responses to climate extremes are subs

286 enter the epidermis and form populations of long-lived tissue-resident memory T (TRM) cells.

287 ferred durable protection to malaria through long-lived tissue-resident T cells and that administrati

288 t, although highly reactive, is sufficiently long-lived to react intermolecularly.

289 d results are relevant for the management of long-lived top predators, including many commercially im

290 n the full-length aCRY revealed an unusually long-lived tyrosyl radical with a lifetime of 2.6 s, whi

291 w resident F4/80(hi)GATA6(+) macrophages are long-lived, undergo non-stochastic self-renewal and reta

292 whole-mount confocal imaging revealed these long-lived unipotent luminal stem cells survive consecut

293 namics for ViBr and AllBr gave evidence of a long-lived vibrationally excited intermediate for both D

294 from the Soufriere Volcanic Center (SVC), a long-lived volcanic complex in the Lesser Antilles arc,

295 ary considerably: tRNAs and rRNAs tend to be long lived while mRNAs tend to be more short lived.

296 emonstrate that the population dynamics of a long-lived, wide-ranging marine predator are associated

297 und that neocortical resident microglia were long-lived, with a median lifetime of well over 15 month

298 tributions of myeloid cells post-injury were long-lived, with recruited monocytes acquiring the distr

299 Long-lived wood products also allowed more regrowth of b

300 Although these long-lived YFV-specific memory CD8 T cells did not expre