ライフサイエンスコーパス: long-sought

1 oids from their therapeutic effects has been long sought.

2 The long-sought 17 e (-) radical cation of the parent comple

3 crofluidic and nanofluidic technologies have long sought a fast, reliable method to overcome the crea

4 Evolutionary biologists have long sought a way to determine whether a phenotypic diff

5 Ecologists have long sought a way to explain how the remarkable biodiver

6 ue U C-bearing molecules are examples of the long-sought actinide-alkylidynes.

7 le synthesis of aminodiborane will make this long-sought active chemical reagent readily available fo

8 c phospholipase C (PLC), PLCzeta, may be the long sought after [Ca2+]i oscillation-inducing SF.

9 , we suggest that Ded1p may be a part of the long sought after activity shown to promote yeast viral

10 ndez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region

11 they provide experimental confirmation of a long sought after animal model of HDFN.

12 transmembrane aspartic proteinase to be the long sought after beta-secretase.

13 The long sought after but elusive efficient and selective ox

14 gstrom, and ultrafast temporal duration, the long sought after but hitherto unrealized quest for ultr

15 vidence presented here establishes PilZ as a long sought after c-di-GMP-binding domain and YcgR as a

16 control organ size and may, in fact, be the long sought after chalones, or negative growth regulator

17 se results indicate that TORC2 is one of the long sought after cofactors that mediates the differenti

18 ).The generation and characterization of the long sought after ferriheme peroxynitrite complex has be

19 Using this approach, we discovered the long sought after folic acid receptor, fAR1, in D. disco

20 CNS regeneration in higher vertebrates is a long sought after goal in neuroscience.

21 hat may take us one large step closer to the long sought after goal of separating GVL and GVHD.

22 gene, RNASEL, as a strong candidate for the long sought after hereditary prostate cancer 1 (HPC1) al

23 a long Abeta species that is most likely the long sought after intermediate product, Abeta(49), gener

24 It may be the long sought after m-FSHRF.

25 implicated roles for a new protein PIEZO1, a long sought after mammalian mechanosensory protein; GLUT

26 We propose that md-L neurons are long sought after mechanoreceptor cells through which fo

27 n may provide a platform for the design of a long sought after monovalent form of avidin, which would

28 These data provide long sought after near-atomic resolution insights into h

29 ealed by the present study, point toward the long sought after physiological and pathophysiological r

30 critical for NAADP action and is likely the long sought after target channel for NAADP.

31 pore channel (TPC) family in mammals are the long sought after target channels for NAADP.

32 cs to become that enabling technology for so long sought after.

33 mutant p53 using small molecules has been a long sought-after anticancer therapeutic strategy.

34 (HSCs) from renewable cell types has been a long sought-after but elusive goal in regenerative medic

35 identification, and characterization of the long sought-after Criegee intermediate for each system,

36 Thus, we propose that PARI is a long sought-after factor that suppresses inappropriate r

37 Dirac electrons-a mechanism analogous to the long sought-after Higgs mechanism in particle physics.

38 between MSK1, Trim7 and RACO-1 completes the long sought-after mechanism linking growth factor signal

39 scriptional repression of 15-PGDH elucidates long sought-after molecular mechanisms that govern PG ac

40 These results provide support for DEK as a long sought-after oncogene mapping at chromosome 6, with

41 rol of the apoptotic machinery, and reveal a long sought-after oncogenic event conferring sensitivity

42 mics simulations identify the origin of this long sought-after regime as a planar, torsion-free backb

43 box E3:E2~Ub ligase complex and identify the long sought-after source of allostery for RING/U-Box act

44 and indicates that it is a candidate for the long sought-after tubulin tyrosine carboxypeptidase impo

45 urons of the RTN are good candidates for the long sought-after VMS chemoreceptors.

46 The long sought-after, intrinsically short-lived molecule et

47 thylene with functionalized co-monomers is a long-sought-after approach to introducing polyolefin fun

48 The structure reveals the long-sought-after catalytic Phi-clamp and the membrane-s

49 These findings identify a long-sought-after critical component of the nephron stem

50 hemically and thermally stable, yet have the long-sought-after design flexibility offered by function

51 OMM, not BH3-only proteins or p53/Rb, is the long-sought-after direct activator of Bax/Bak following

52 This important work not only identifies a long-sought-after dorsalizing factor but also highlights

53 SO/FAIM3 recently has been identified as the long-sought-after FcR for IgM (FcmuR).

54 SSM electrophysiology provides a long-sought-after functional assay for the ubiquitous am

55 man pluripotent stem cells (PSCs) has been a long-sought-after goal for use in hematopoietic cell pro

56 ired after serial DENV infections has been a long-sought-after goal for vaccination.

57 l greenhouse effect, which may represent the long-sought-after historical analog to the carbon dioxid

58 nse that, with continued study, might reveal long-sought-after keys to achieving CNS repair.

59 DNA structures in mutagenesis and reveal the long-sought-after mechanism of complex mutations that re

60 as developmental signals but also identify a long-sought-after mechanism that initiates Pax6 in placo

61 bolically unstable LBR variants may serve as long-sought-after model substrates enabling previously i

62 s that are missing in chicken, including the long-sought-after nephrin and tumor necrosis factor gene

63 These findings not only identify the long-sought-after osteoclast progenitors but also establ

64 Arabidopsis thaliana UVR8 (AtUVR8) is a long-sought-after photoreceptor that undergoes dimer dis

65 IKK turns out to be the long-sought-after protein kinase that mediates the criti

66 A long-sought-after reactive monophosphine-ligated palladi

67 hat lamin B is a structural component of the long-sought-after spindle matrix that promotes microtubu

68 Our study essentially identifies a long-sought-after structural glass order in hard-sphere

69 For example, recent work suggests that the long-sought-after target of the analgesic acetaminophen

70 o recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cell a

71 in atomic nuclei and is a measurement of the long-sought anapole moment.

72 They could thus provide a long-sought anatomical link for understanding homeostati

73 eukaryotes implicates eukaryotic RtcB as the long-sought animal 3'-P RNA ligase.

74 This finding provides a long-sought answer to the question of how dermal cells m

75 us, the mcDC subset appears to represent the long-sought APC responsible for breaking peripheral tole

76 e analysis suggests that ERH1 may encode the long-sought Arabidopsis functional homolog of yeast and

77 Cellulose has been long sought as a chiral inducer in enantioselective cata

78 This microstructure has been long-sought as it provides an opportunity to incorporate

79 The vPAG dopaminergic cells may provide the long-sought ascending dopaminergic waking influence.

80 ngiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic

81 Rapid, quantitative Western blotting is a long-sought bioanalytical goal in the life sciences.

82 In addition to uncovering a long sought biological function for Old Yellow Enzyme, t

83 terization of a 1,3-dihydro-1,3-azaborine, a long-sought BN isostere of benzene.

84 ent discovery of strigolactones (SLs) as the long-sought branch-inhibiting hormone allowed us to test

85 regulation and on the dephosphorylation of a long sought but still unidentified substrate.

86 nsient scenes at high imaging speed has been long sought by photographers, with early examples being

87 ment, an oxidant was developed such that the long-sought C60.+ ion can be synthesized in solution.

88 assembled by HPV E2 and turns out to be the long sought cellular corepressor that inhibits the expre

89 These results show that BMPs may be the long-sought 'chalone' inhibitors of hair growth postulat

90 transporters, implicating it as (one of) the long-sought Cl-/volume-sensitive kinase(s).

91 at WNK3-SPAK is an integral component of the long-sought "Cl(-)/volume-sensitive kinase" of the catio

92 ear, candidates have been identified for two long-sought classes of molecules, insect odorant recepto

93 We identify Bothrioplanida as the long-sought closest free-living sister group of the para

94 ency and may be relevant to development of a long-sought "cocaine antagonist".

95 The proteins STIM1 and Orai1 are the long sought components of the store-operated channels re

96 e propose that these cells correspond to the long-sought components of the cerebrospinal fluid chemos

97 Our results indicate that PCSK6 is the long-sought corin activator and is important for sodium

98 operated currents and that CRACM1 may be the long-sought CRAC channel.

99 Here we present the long sought crystal structure of the PLB-SERCA complex a

100 We identify this FQHE state as the long-sought CSL with a uniform chiral order spontaneousl

101 The long-sought cubic gauche phase of polymeric nitrogen (cg

102 al efficiencies make them candidates for the long sought de novo methyltransferases.

103 light-emitting diode (spin-OLED) has been a long-sought device within the field of organic spintroni

104 nstein condensate (BEC), which resembles the long-sought Dicke QPT.

105 and the optogenetic repertoire along several long-sought dimensions.

106 Our findings identify Sox5 as the long-sought DNA-binding partner for BMP R-Smads essentia

107 We conclude that IREG1 represents the long-sought duodenal iron export protein and is upregula

108 Our studies identify a long-sought enzyme that plays a critical role in PC remo

109 nin stabilization may be a key player in the long-sought epidermal signal leading to hair development

110 and chronicles, we argue the source of this long-sought eruption is the Samalas volcano, adjacent to

111 Our results provide the long sought evidence for understanding the formation of

112 The results provide long-sought evidence for two evolutionary hypotheses: sp

113 We conclude that Par3 is the long-sought exocyst receptor required for targeted membr

114 Majorana fermions are long-sought exotic particles that are their own antipart

115 This might provide the long-sought experimental basis for a generally accepted

116 These data provide long-sought experimentally derived constraints for high-

117 ayer in antiviral innate immunity provides a long-sought explanation for delayed activities of respec

118 The results provide a long-sought explanation for why PTAP duplications arise

119 e temporal optogenetics control, achieving a long-sought flexibility beyond the means of conventional

120 unctional biology, a linkage scientists have long sought for more complex systems.

121 Thus, we identify the long-sought foreign ligand for this key immunoregulatory

122 e vicinity of the impurity atoms reveals the long-sought four-fold symmetric quasiparticle 'cloud' al

123 Our results suggest that BDNF may perform a long-sought function for a secreted growth factor in med

124 dc48, Ufd1 and Npl4 action not only provides long-sought functions for these specific proteins, but i

125 ite 2 protease (S2P) may be identical to the long sought gamma-secretase.

126 These characteristics indicate that the long-sought gene and polypeptide harboring the FA- and F

127 the lysosomal arylsulfatase G (ARSG) is the long-sought glucosamine-3-O-sulfatase required to comple

128 id microfluidic-based separations has been a long-sought goal for applications in proteomics, genomic

129 rategies for inducing beta-cell expansion, a long-sought goal for diabetes therapy.

130 It has been a long-sought goal in cluster science to discover stable a

131 eration of beta cell endocrine function is a long-sought goal in diabetes research.

132 A long-sought goal in metallic glasses is to impart ductil

133 tal realization of quantum spin liquids is a long-sought goal in physics, as they represent new state

134 sm to achieve orderly recruitment has been a long-sought goal in physiology, medicine and engineering

135 A long-sought goal in structural biology has been the imag

136 onal proteins to specific DNA sequences is a long-sought goal in the study and engineering of biologi

137 k gives a new approach towards achieving the long-sought goal of a predictive capability for bulk met

138 chitecture of bacterial epidemics has been a long-sought goal of infectious disease research.

139 rd's transfer model, we demonstrate that the long-sought goal of predicting solvent-dependent coopera

140 odel and newly determined GTFEs achieves the long-sought goal of predicting urea-dependent cooperativ

141 in seismically active fault zones has been a long-sought goal of seismology.

142 ty in well-defined neuronal populations is a long-sought goal of systems neuroscience.

143 nanophotonics and atomic physics has been a long-sought goal that would open new frontiers for optic

144 constituted synaptic proteins that meets the long-sought goal to produce fast content release in the

145 cally active valence electron densities is a long-sought goal, as these electrons dictate the course

146 inities between antibodies and antigens is a long-sought goal.

147 r principles of synaptic vesicle fusion is a long-sought goal.

148 tron spin using electron spin resonance is a long-sought goal.

149 s) with their physical properties has been a long-sought goal.

150 broad HIV neutralizing activity of the mAbs, long sought goals in HIV vaccine development.

151 through postexposure immunotherapeutics are long-sought goals.

152 h these TMCs as pore-forming subunits of the long-sought hair-cell transduction channel.

153 vity, which is predominantly composed of the long sought heparan sulfate D-glucosaminyl 3-O-sulfotran

154 r magnetic resonance (NMR) spectroscopy have long sought higher magnetic fields to enhance resolution

155 (6)X(6)(-) (X = Cl, Br), allow access to the long sought, highly electrophilic diethylaluminum moiety

156 l of sequence profiles indicated Ac45 as the long-sought human homologue of yeast V-ATPase assembly f

157 Our studies elucidate a long-sought Igh V(D)J recombination control region and i

158 sm exhibited by the material system has been long sought in ophthalmic applications such as photochro

159 n factor 8 or 'myostatin', may be one of the long sought inhibitors that control the growth of indivi

160 A long-sought insight from these results is that during Ho

161 ia diborane (NH(3)BH(2)(mu-H)BH(3), AaDB), a long-sought intermediate proposed for the formation of D

162 pproach has resulted in the isolation of the long sought intermediates, cobalt-precorrin-6A and -6B a

163 The discovery of these long-sought intermediates paves the way for defining the

164 Our data indicate that HCP 1 is the long-sought intestinal heme transporter.

165 be a new mediator of innate immunity and the long-sought iron-regulatory hormone.

166 This study demonstrates that RPE65 is the long-sought isomerohydrolase and fills a major gap in ou

167 TREK-1 as being the major components of the long-sought K(+) channels underlying the passive conduct

168 udy suggests that GRPR+ neurons constitute a long-sought labeled line for itch sensation in the spina

169 These data delineate a long-sought ligand- and ubiquitin-independent mechanism

170 This concordance provides a long-sought link between gamma oscillations, cortical pl

171 -containing nuclear membrane proteins as the long-sought linker between microtubules and the nucleus

172 r, and hence their reorientations embody the long-sought local zero energy modes for the pyrochlore l

173 t can be hypothesized that BMPs might be the long-sought "luteinization inhibitor" in Graafian follic

174 uggest that RhBG homologous proteins are the long sought major ammonium transporters in mammalians.

175 Thus, p62dok appears to be the long-sought major substrate of many tyrosine kinases.

176 e superconductor is predicted to produce the long-sought Majorana quasiparticle excitations.

177 Behavioral scientists have long sought measures of important psychological construc

178 Together, our data provide a long sought mechanism as to how defects in Sac1p overcom

179 In summary, this study has uncovered a long-sought mechanism of HCV cell-culture adaptation and

180 walls of the Golgi yields insights into the long-sought mechanism of transport through this organell

181 Our data provide a long-sought mechanism underlying the resolution of LPS-i

182 nt, with the ultimate goal of unraveling the long-sought mechanisms that support the emerging complex

183 metaphase of meiosis II and seems to be the long-sought mediator of CSF activity.

184 Most recently, two breakthroughs in the long-sought molecular bases of alkane formation and poly

185 Our analysis defines the long-sought molecular function for the zillion different

186 e to induce flowering under LDs, providing a long-sought molecular knob that links developmental agin

187 ce strongly suggests that follistatin is the long-sought mTOR-regulated fusion factor.

188 These findings reveal a long-sought myogenic fusion protein that controls mammal

189 chardt correlator, revealing elements of the long-sought neural substrates of motion detection in the

190 It exploits the long sought non-trivial non-radiating charge-current exc

191 aptive cellular structure is responsible for long-sought non-dissipative (hysteresis-free), linearly

192 hem to design and produce a new polymer is a long-sought objective of polymer scientists.

193 ides in an MHC-like fashion has revealed the long-sought odorants used to recognize the MHC genotype

194 herefore supports a new route to realize the long-sought opportunities offered by molecular structure

195 istinctive macrocyclic environment creates a long-sought opportunity to trap unique organometallic tr

196 y success of bats, and palaeontologists have long sought osteological correlates of echolocation that

197 Determination of the long-sought oxidized desaturase crystal structure facili

198 Elusive diphosphorus tetroxide, the long sought phosphorus analogue of N2O4, is particularly

199 The long-sought platelet growth factor, thrombopoietin, has

200 thus suggest that SRD5A3 is likely to be the long-sought polyprenol reductase and reveal the genetic

201 Neonatologists and pulmonary biologists have long sought preventive treatments for bronchopulmonary d

202 roscopic and kinetic characterization of the long-sought principal intermediate involved in this proc

203 Our findings suggest that corin is the long-sought pro-ANP-converting enzyme and that the corin

204 demonstrate that merging neutron stars are a long-sought production site forging heavy elements by r-

205 ich forms LPA, may form a key element of the long-sought pruritogenic signaling cascade in cholestati

206 etic field and doping, that it cannot be the long-sought pseudogap state.

207 arrangement of FSO(2)N was observed, but the long-sought radical FSO(2) (22%) and traces of SO(2) (3%

208 epresents a molecular "living fossil" of the long-sought RAG transposon.

209 ns (<1 mug/l; nM range), thereby providing a long-sought rationale for their health protecting effect

210 , identify a family of F box proteins as the long-sought receptors for the plant growth hormone auxin

211 GPR107 might be one of the long-sought receptors that associates with G-proteins to

212 in oligodendrocytes, we identify QKI as the long-sought regulator of Neurofascin alternative splicin

213 The long-sought relativistic phenomenon of massless Dirac fe

214 LTP) raises the question whether this is the long-sought resetting mechanism for long-term depression

215 degradation of structured RNA and may be the long sought RNA-degrading complex in the mammalian mitoc

216 her, these data demonstrate that RtcB is the long-sought RNA ligase that catalyzes unconventional RNA

217 ction of the energy state of the cell is the long sought role of MT.

218 Here we describe a long-sought route through ribose aminooxazoline to the p

219 Here we show that activin A is the long-sought second negative muscle regulator.

220 activation of these channels and may be the long sought sensor of calcium store content.

221 Chemists have long sought sequence-controlled synthetic polymers that

222 n Pancrustacea we identify Xenocarida as the long-sought sister group to the Hexapoda, a result confi

223 the course of these studies, we identified a long-sought site of RNase L-mediated cleavage in the 28S

224 ree reconstitution experiment in real time a long-sought SNARE assembly intermediate in which only th

225 ApSOD further provides the structure of a long-sought SOD product complex at 1.35 A resolution, su

226 ochemical platform is anticipated to offer a long sought solution for single-molecule sensing with im

227 This long-sought solution to Darwin's dilemma was set in moti

228 We conclude that a long-sought specific DNA sequence within X-linked genes

229 These results are a long-sought step for the field of regenerative medicine;

230 Thus, rootletin is the long-sought structural component of the ciliary rootlet.

231 This work reveals long-sought structural differences between the pre-accom

232 related and probably indentical to SNT, the long-sought target of FGF and NGF receptors.

233 Thus, vasohibin/SVBP complexes represent long-sought TCP enzymes.

234 Geneticists have long sought the ability to manipulate vertebrate genomes

235 Biologists have long sought the genes that contribute to phenotypic and

236 Abeta1-x peptides and, therefore, has been a long- sought therapeutic target for treatment of AD.

237 Ecologists have long sought to account for the patterns observed in spec

238 of metal-organic frameworks (MOFs) have been long sought to advance the application of MOFs in variou

239 Microbial ecologists have long sought to associate the transformation of compounds

240 Visual neuroscience has long sought to determine the extent to which stimulus-ev

241 Neuroscientists have long sought to elucidate the molecular underpinnings of

242 Population geneticists have long sought to estimate the distribution of selection in

243 Geneticists have long sought to identify the genetic changes that made us

244 New electron-acceptor materials are long sought to overcome the small photovoltage, high-cos

245 Researchers have long sought to structurally characterize dynamic process

246 Neurobiologists have long sought to understand how circuits in the nervous sy

247 Scientists have long sought to understand how vascular networks supply b

248 Evolutionary biologists have long sought to understand the relationship between micro

249 Scientists have long sought to understand what is the origin of egocentr

250 Neurologists have long sought to understand what precipitates individual s

251 Biologists have long sought to understand which genes and what kinds of

252 eukaryotes, with no off-target effects, is a long-sought tool for molecular and systems biologists.

253 f the Kramers point and can be driven to the long-sought topological spin transport regime.

254 thylaniline (DMA) radical cation DMA(.+) , a long-sought transient intermediate, was detected by mass

255 Long-sought transporters involved in mitochondrial calci

256 theory is the most promising approach to the long-sought unified description of the four forces of na

257 all organics, the technique could become the long-sought universal soft ionization method.

258 ented accuracy, thus opening the door to the long-sought "universal model" capable of describing the

259 buted among kingdoms and are proposed as the long-sought vacuolar phytochelatin transporters in plant

260 today monoclonal antibodies have emerged as long-sought vehicles for the targeted delivery of potent

261 The data presented here identify H(v)1 as a long-sought voltage-gated H+ channel and establish H(v)1

262 coding a tumor suppressor protein within the long-sought WT2 locus.