ライフサイエンスコーパス: long-term plasticity

1 y, AMPA receptors regulate genes involved in long-term plasticity.

2 es and an increase in threshold for inducing long-term plasticity.

3 nt molecular cascades for the maintenance of long-term plasticity.

4 for FMRP in synaptic growth, structure, and long-term plasticity.

5 y of transcription factors known to regulate long-term plasticity.

6 ication of cellular properties that underlie long-term plasticity.

7 tablishing a commonality with other forms of long-term plasticity.

8 ivation of specific kinase isoforms sustains long-term plasticity.

9 risynaptic receptors that mediate short- and long-term plasticity.

10 synaptic regulation of synaptic strength and long-term plasticity.

11 uired during the induction and expression of long-term plasticity.

12 ion of Rac1 partially reverses their altered long-term plasticity.

13 active zone protein required for presynaptic long-term plasticity.

14 tsynaptic changes underlying dysfunctions in long-term plasticity.

15 motoneuronal inspiratory drive currents and long-term plasticity.

16 ll as provide an instructive signal to guide long-term plasticity.

17 VR, and suggests that MVR can be modified by long-term plasticity.

18 d, a time of known neuronal vulnerability to long-term plasticity.

19 different capacities for both short-term and long-term plasticities.

20 to be a powerful inducement to compensatory long-term plasticity, a mechanism that can explain the l

21 frontal cortex and working memory but not of long-term plasticity and cytoarchitecture.

22 and potentiation), as well as alterations in long-term plasticity and dendritic spine stability.

23 ted by loss of Epac2 activity; however, both long-term plasticity and forskolin-mediated potentiation

24 population is critical for the formation of long-term plasticity and memory and is achieved by mecha

25 d in regulating gene expression required for long-term plasticity and memory.

26 local translation occurs at synapses during long-term plasticity and requires trans-synaptic signals

27 h their recent or remote use (short-term and long-term plasticity) and the action of extracellular me

28 rain, mediating numerous forms of short- and long-term plasticity, and having strong influences on sy

29 exhibits exquisite temperature sensitivity, long-term plasticity, and the ability to transform therm

30 have shown that even the earliest phases of long-term plasticity are accompanied by the rapid recrui

31 different forms of presynaptic PKA-dependent long-term plasticity are normal.

32 m plasticity) and developmental acclimation (long-term plasticity) are positively correlated, suggest

33 n release probability and altered short- and long-term plasticity as present in RIM1alpha(-/-) mice r

34 This differential effect may be prodromic to long-term plasticity, as postsynaptic sensitivity is mom

35 ase pathways contribute to opposing forms of long-term plasticity at a central synapse.

36 one synapse can facilitate the induction of long-term plasticity at another synapse.

37 support the notion that presynaptic forms of long-term plasticity at excitatory and inhibitory synaps

38 lation of spine actin cytoskeleton and gates long-term plasticity at excitatory synapses in cortical

39 hippocampus-dependent contextual memory and long-term plasticity at mossy fiber synapses.

40 ex spike pattern, and promote short-term and long-term plasticity at parallel fiber synapses in a man

41 IFICANCE STATEMENT Differences in short- and long-term plasticity at Schaffer collateral (SC) synapse

42 Here, we show that long-term plasticity at subthalamo-nigral glutamatergic

43 Bidirectional long-term plasticity at the corticostriatal synapse has

44 These alterations involved localized long-term plasticity because increases were highly selec

45 irs synaptic vesicle priming and presynaptic long-term plasticity, but is not lethal.

46 Excitatory and inhibitory synapses show long-term plasticity, but spike timing-dependent plastic

47 processes in the human neocortex, and their long-term plasticity can alter the discharging cortical

48 tantly, abnormalities in both short-term and long-term plasticity can be reversed by the introduction

49 Long-term plasticity can differ from short-term in recru

50 nhibitory microcircuitry might contribute to long-term plasticity capable of sculpting direct and ind

51 play a role in the neuronal cell damage and long-term plasticity changes associated with SE.

52 y may play a role in epileptogenesis and the long-term plasticity changes associated with the develop

53 opment of symptomatic epilepsy is a model of long-term plasticity changes in the central nervous syst

54 In the cerebellum, for example, long-term plasticity contributes to eyelid conditioning

55 Cortical long-term plasticity depends on firing rate, spike timin

56 esynaptic, protein kinase A (PKA)-dependent, long-term plasticity has been described in numerous brai

57 n of AMPAR synthesis, synaptic function, and long-term plasticity, important for hippocampal-dependen

58 ked if intracellular tetanization can induce long-term plasticity in auditory cortex.

59 ine both the sign and timing requirements of long-term plasticity in interneurons.

60 upled to the production of ATP, and reflects long-term plasticity in metabolic capacity.

61 Moreover, this complex mediates short- and long-term plasticity in response to bursts of action pot

62 owing nicotine treatment during adolescence, long-term plasticity in response to timed presynaptic an

63 Long-term plasticity in sensory systems is usually conce

64 protein kinase A (PKA) triggers presynaptic long-term plasticity in synapses such as cerebellar para

65 eceptor-independent LTD is the major form of long-term plasticity in the anterior cingulate cortex (A

66 This novel form of long-term plasticity in the avian auditory brainstem may

67 patial learning and synaptic integration and long-term plasticity in the distal dendrites of hippocam

68 s of PV-IN microcircuits to input gating and long-term plasticity in the fear system remain unknown.

69 y double knockout (DKO) mice showed abnormal long-term plasticity in the hippocampal CA1 region toget

70 festing in reduced synaptic transmission and long-term plasticity in the hippocampus.

71 eld, can trigger IEG expression required for long-term plasticity in the hippocampus.

72 longed darkness (light-history) may regulate long-term plasticity in the kinetics of the cone-HC path

73 sets the rules for the induction of synaptic long-term plasticity in the LHb.

74 modification of synaptic transmission during long-term plasticity in the mammalian hippocampus remain

75 modification of synaptic transmission during long-term plasticity in the mammalian hippocampus.

76 sis controls neurotransmitter release during long-term plasticity in the mature mammalian brain.

77 Nonetheless, no NA-gated mechanism of long-term plasticity in the OB has ever been directly ob

78 fects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which

79 ic active zone, is essential for presynaptic long-term plasticity in these synapses and is phosphoryl

80 nputs into the NAc, as well as for affecting long-term plasticity in this structure.

81 on) enabling a comparison between short- and long-term plasticity in traits.

82 rmore, activity- and NMDA-receptor-dependent long-term plasticity increased this resonance frequency

83 suitable for controlling the polarity of MF long-term plasticity induced by joint presynaptic and po

84 ver, much less is known about heterosynaptic long-term plasticity induced by mGluRs at inhibitory syn

85 short form]) is an important mediator of the long-term plasticity induced in brain by chronic exposur

86 Hebbian-type long-term plasticity introduces intrinsic positive feedb

87 Modification of synaptic transmission in long-term plasticity is a complex process involving many

88 missed when only postsynaptic expression of long-term plasticity is considered, and suggest an exper

89 receptors (NMDARs) controls the direction of long-term plasticity is currently disputed.

90 by femtosecond laser ablation, we show that long-term plasticity is encoded as shifts in the operati

91 and whether i-LTD, similar to other forms of long-term plasticity, is important for learning and memo

92 CREB-binding protein (CBP) cause deficits in long-term plasticity, learning, and memory.

93 nase C (PKC) contribute to the expression of long-term plasticity, little is known about how constitu

94 memory by prolonging CaMKII activity during long-term plasticity (LTP) and learning but also represe

95 ely prevented the suppression of hippocampal long-term plasticity (LTP) by Abeta.

96 fiber-Purkinje cell synapse and induction of long-term plasticity (LTP) in M1, leading to transient o

97 This mechanism for long-term plasticity may be quite general: cAMP also act

98 eased when PR is elevated by both short- and long-term plasticity mechanisms.

99 enable a direct emulation of both short- and long-term plasticity of biological synapses, representin

100 eurons in the somatosensory cortex triggered long-term plasticity of circuits (LTPc), resulting in th

101 d goal-directed actions, and can also modify long-term plasticity of corticostriatal synapses.

102 pendent asymmetry, as well as for short- and long-term plasticity of electrical synapses.

103 lts reveal a new form of activity-dependent, long-term plasticity of endocannabinoid signaling at per

104 This activity-dependent, long-term plasticity of endocannabinoid signaling was sp

105 mmunity and have recently been implicated in long-term plasticity of excitatory synaptic transmission

106 l a critical role of eCBs in controlling the long-term plasticity of glutamate synapses in VTA DA neu

107 However, their role in modulating the long-term plasticity of glutamate synapses of VTA dopami

108 GABAergic inhibition of principal cells and long-term plasticity of glutamateric recruitment of inhi

109 duction of epileptiform activity, but shifts long-term plasticity of hippocampal synapses in favor of

110 Therefore, we studied long-term plasticity of inhibitory inputs to TC cells in

111 receptor activation elicits a bidirectional long-term plasticity of NMDA receptor-mediated synaptic

112 small RNAs and present a role for miR-124 in long-term plasticity of synapses in the mature nervous s

113 and signaling molecules and thereby support long-term plasticity of synaptic contacts.

114 We demonstrated that such [Mg2+]i-dependent long-term plasticity of the electrical synapse can be ad

115 However, long-term plasticity of the VLE connections and how the

116 on dopamine-dependent shaping of prefrontal long-term plasticity often appear inconsistent and, alto

117 arning and changes in hippocampal short- and long-term plasticity (paired-pulse depression, synaptic

118 e introduce a theoretical framework in which long-term plasticity performs an optimization of the pos

119 nstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain th

120 ular interest, mechanisms of both short- and long-term plasticity remain autonomous at these divergen

121 olecular and cellular events associated with long-term plasticity remain hampered in Drosophila by th

122 Long-term plasticity requires new transcription, indicat

123 ed whether these synapses show mechanisms of long-term plasticity similar to those found at principal

124 s a major regulator of synaptic strength and long-term plasticity, suggesting that O-GlcNAcylation of

125 Here we describe a form of long-term plasticity that regulates the spontaneous firi

126 We investigate dopaminergic modulation of long-term plasticity through a multicompartment Hodgkin-

127 Long-term plasticity typically relies on postsynaptic NM

128 at Schaffer-collateral excitatory terminals, long-term plasticity under various recording conditions

129 anges in synaptic strength may contribute to long-term plasticity underlying classical conditioning.

130 c strength are well established as mediating long-term plasticity underlying learning and memory, but

131 Synapse-specific long-term plasticity underlying memory involves the targ

132 etween GluN2B and alphaCaMKII have a role in long-term plasticity via the control of ERK1/2 signaling

133 dying regulation of Arc, a gene required for long-term plasticity, we uncovered a new role for AMPA r

134 Key features of biological synapses, such as long-term plasticity with heterogeneity, including long-

135 ve degeneration pathways, thereby permitting long-term plasticity without risking neurodegeneration.