ライフサイエンスコーパス: long-term use

1 nulocytosis side effects associated with its long term use.

2 developed which would be more applicable for long-term use.

3 t hospital discharge, but few have evaluated long-term use.

4 determine whether this effect persists with long-term use.

5 the significant risks associated with their long-term use.

6 tential harms of HRT, particularly regarding long-term use.

7 reast or endometrium) precludes recommending long-term use.

8 d hormones are effective, side-effects limit long-term use.

9 e, which prevents loss in sensitivity during long-term use.

10 mposite material also make it preferable for long-term use.

11 re especially troubling in children and with long-term use.

12 d as a means to improve biocompatibility for long-term use.

13 adverse events or the risks associated with long-term use.

14 i-inflammatory drugs are not recommended for long-term use.

15 cal effects and biokinetic distribution with long-term use.

16 well short-duration usage measures predicted long-term use.

17 , most present significant side effects over long-term use.

18 es h(-1)), and relatively good stability for long-term use.

19 th limited potential side effects, even with long-term use.

20 are potential complications associated with long-term use.

21 positive airway pressure (CPAP) may predict long-term use.

22 there was no consistent association between long-term use and NHL for all NSAIDs combined, aspirin,

23 tion; however, emerging problems limit their long-term use, and an increasing number of patients inte

24 n skin model, indicated that MB was safe for long-term use, and did not cause irritation even at high

25 ral years is safe and effective, but data on long-term use are limited.

26 ramine was approved in the United States for long-term use as an appetite suppressant until it was re

27 rs are promising anticancer agents but their long-term use at high doses is associated with adverse c

28 y the most apoptosis-resistant cells survive long-term using autophagy-derived nutrients when growth

29 irculatory support systems for short-term or long-term use: bridging to transplant as well as for rec

30 postmenopausal women, is not acceptable for long-term use by many women.

31 g the rate of benzodiazepine use, especially long-term use by older adults, little information is ava

32 here was a significantly increased risk with long-term use compared with never use (for >5 years, HR

33 .99]), whereas the overall OR for cumulative long-term use (continuous or noncontinuous) was close to

34 atment of anxiety disorders but have limited long-term use due to adverse effects.

35 The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was designed to t

36 The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial was designed to t

37 results from the Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial, in which the use

38 bridge to cardiac transplantation, but their long-term use for the purpose of enhancing survival and

39 Continuous long-term use (>/=5 years) of low-dose aspirin was assoc

40 uss the most recent literature regarding the long-term use (>/=52 weeks of follow-up) of antivascular

41 ited States Food and Drug Administration for long-term use in adolescents.

42 t use at least 16 years before diagnosis and long-term use in age-adjusted analyses but not in multiv

43 ods in xenogeneic hosts and are suitable for long-term use in an immunoexclusion device in a discorda

44 Its long-term use in children with renal dysfunction after O

45 ., postoperative) and cancer pain, but their long-term use in chronic pain has met increasing scrutin

46 t or heat-induced defects, thus limiting its long-term use in devices.

47 it may be possible to store donor cells for long-term use in high-risk hosts.

48 ity with PIs could substantially limit their long-term use in highly active ARV therapy.

49 Temsirolimus is designed for long-term use in patients and therefore represents a pos

50 ilotinib is effective and well-tolerated for long-term use in patients with imatinib intolerance.

51 Three medications with approval for long-term use in the treatment of obesity are currently

52 toxicity of CS2 has been documented from its long-term use in the viscose rayon industry.

53 However, information about its long-term use in this population is limited.

54 ropic actions in human myocardium, but their long-term use increases mortality in patients with heart

55 opamine release and neuron activity, whereas long-term use is associated with blunting of the dopamin

56 calcium available for contraction, but their long-term use is associated with increased mortality due

57 immune diseases are limited in efficacy, and long-term use is associated with severe adverse events.

58 s may be used to attenuate chronic pain, but long-term use is complicated by the possible increase in

59 he potential for chronic nephrotoxicity, its long-term use is controversial.

60 a, the need to assess the potential risks of long-term use is essential.

61 However their long-term use is limited because of the development of t

62 allergies or autoimmune diseases), but their long-term use is limited by severe side effects.

63 However, their long-term use is restricted by the occurrence of adverse

64 Despite the popularity of GCs in the clinic, long-term use leads to numerous side effects, driving th

65 in the treatment of chronic pain, but their long-term use leads to the development of physiological

66 With long-term use, levodopa causes motor complications inclu

67 Epidemiological studies indicate that long term use of nonsteroidal anti-inflammatory drugs (N

68 develops as a complication of pacemaker use, long-term use of a central venous catheter (CVC), or can

69 In male physicians aged 65 years or older, long-term use of a daily multivitamin did not provide co

70 Long-term use of a tongue barbell increases the prevalen

71 Long-term use of ACE inhibitors may protect against canc

72 Long-term use of acyclovir for up to 10 years for HSV su

73 Because this is the first case of long-term use of AI vaccines in poultry, the Mexican lin

74 Long-term use of alternate-day, low-dose aspirin may red

75 that may have clinical implications for the long-term use of an L1-virus-like particle-based prophyl

76 These observations support the long-term use of anakinra for the treatment of patients

77 Long-term use of androgen deprivation in prostate cancer

78 cardiovascular morbidity and mortality with long-term use of angiotensin-converting enzyme inhibitor

79 of dexfenfluramine gave rise to widespread, long-term use of anorectics to treat obesity.

80 We report effective long-term use of anti-IL-2 therapy for an autoimmune ind

81 bition accelerates disease, cautions against long-term use of anti-TNF-alpha therapeutics for AD, and

82 is is given to important questions regarding long-term use of anti-TNFalpha therapies.

83 hese findings reinforce the need for prudent long-term use of antibiotics.

84 Until research fully substantiates that the long-term use of antioxidants is safe and effective, the

85 Long-term use of antioxidants such as vitamin C, lutein,

86 Long-term use of aspirin (>5 years: odds ratio = 0.76, 9

87 le clinical data do not support the routine, long-term use of aspirin dosages greater than 75 to 81 m

88 o assist clinicians with decisions regarding long-term use of asthma therapies, including omalizumab.

89 mune effector cells has implications for the long-term use of azathioprine in the management of infla

90 s that are lacking after SCI and restored by long-term use of baclofen.

91 The key factor in long-term use of batteries is the formation of an electr

92 r the current clinical guidelines advocating long-term use of beta-blockers to treat most forms of co

93 Recently published studies confirm that the long-term use of biological agents targeting TNF-alpha i

94 Recently published studies confirm that the long-term use of biologicals targeting tumor necrosis fa

95 t, we did not observe an association between long-term use of bisphosphonates and risk of colorectal

96 to be time-dependent with higher risk after long-term use of bisphosphonates in older MM patients of

97 tatus, smoking, cardiovascular risk factors, long-term use of bronchodilators or steroids for lung di

98 sts about breast cancer risk associated with long-term use of calcium channel blockers (CCBs) or angi

99 The long-term use of calcium channel blockers may be protect

100 tolerance and receptor down-regulation after long-term use of cannabinoids.

101 The long-term use of cannabis, particularly at high intake l

102 is known about the benefits and risks of the long-term use of cardiovascular drugs.

103 We examined the association between long-term use of cholesterol-lowering drugs, predominant

104 E-/- mice has important implications for the long-term use of cholinesterase inhibitors and other cho

105 However, long-term use of CNIs is associated with some degree of

106 Long-term use of combination therapy against human immun

107 Long-term use of corticosteroids can lead to loss of bon

108 Long-term use of corticosteroids is associated with cons

109 Due to concerns regarding the safety of long-term use of COX-2 inhibitors as well as a desire to

110 S and biopsy-proven IgM nephropathy, and (2) long-term use of CsA in moderate doses with closely moni

111 Thus, long-term use of cultures to define homeostasis and woun

112 Long-term use of cyclosporine also is associated with a

113 Long-term use of decongestant nasal spray (alpha adrener

114 onstrate any health concerns associated with long-term use of EC in relatively young users who did no

115 EXTEND demonstrated that long-term use of eltrombopag was effective in maintainin

116 Long-term use of epoprostenol further lowered PVR (-47%

117 Long-term use of G-CSF appears well tolerated and effect

118 Despite long-term use of high doses of atracurium infusion and t

119 nts might develop substantial morbidity from long-term use of high doses of these drugs.

120 e healing in our mouse model is dependent on long-term use of high-dose bisphosphonates, immunosuppre

121 to the growing body of evidence that recent long-term use of HRT is associated with an increased ris

122 and outer retinal involvement in short- and long-term use of hydroxychloroquine before the developme

123 Importance: Retinopathy is a known risk of long-term use of hydroxychloroquine sulfate.

124 The estimated risk reduction for long-term use of ibuprofen (RR, 0.51; CI, 0.28-0.96) was

125 To permit the long-term use of IFN, we propose combining low doses of

126 Long-term use of immunosuppressants is associated with s

127 d because of the hazards associated with the long-term use of immunosuppressive drugs.

128 minate much of the morbidity associated with long-term use of immunosuppressive medication.

129 Long-term use of individual beta-carotene, retinol, and

130 The data indicate caution in the long-term use of inhibition of host cell protein synthes

131 Conclusion Long-term use of insulin glargine is associated with an

132 Long-term use of ISDN/HYD therapy should be associated w

133 ad already developed side effects from their long-term use of L-dopa revealed, in some cases, the pre

134 of antiviral resistance have been found with long-term use of lamivudine, in up to 76% of patients tr

135 Long-term use of lead azide and lead styphnate as primar

136 If long-term use of left ventricular assist devices (LVADs)

137 Long-term use of levodopa is commonly associated with mo

138 We estimated the association between long-term use of lithium (>/=5 years) and risk of upper

139 idemiologic study of the association between long-term use of lithium and risk of upper urinary tract

140 Long-term use of lithium was observed among 0.22% of cas

141 r upper urinary tract cancer associated with long-term use of lithium.

142 a potential mechanistic explanation for why long-term use of low doses of NSAIDs, including aspirin,

143 (VTE) in high-risk patients, but whether the long-term use of low-dose aspirin reduces risk in health

144 Long-term use of low-dose combination OCs did not increa

145 arding disease prognosis and decisions about long-term use of medical, endoscopic, and diet therapies

146 e associated with postoperative symptoms and long-term use of medication.

147 tes of antidepressant use and a reduction in long-term use of minor tranquilizers for up to 2 years,

148 tanding the molecular changes in response to long-term use of morphine is likely to aid in the develo

149 Long-term use of morphine leads to development of antino

150 Long-term use of MTX for JRA does not appear to be assoc

151 Long-term use of multivitamins may substantially reduce

152 Long-term use of nicotine has been linked with self-medi

153 studies and clinical trials demonstrate that long-term use of non-steroidal anti-inflammatory drugs (

154 s of epidemiological studies have shown that long-term use of non-steroidal anti-inflammatory drugs,

155 term, continuous use of low-dose aspirin and long-term use of nonaspirin NSAIDs were associated with

156 ventive agents and difficulties in assessing long-term use of nonprescription medications.

157 Epidemiological studies have shown that long-term use of nonsteroidal anti-inflammatory drugs (N

158 dies suggest reduced AD risk associates with long-term use of nonsteroidal anti-inflammatory drugs (N

159 Epidemiological studies have shown that long-term use of nonsteroidal antiinflammatory drugs (NS

160 The association between long-term use of nonsteroidal antiinflammatory drugs (NS

161 uman epidemiological studies have identified long-term use of NSAIDs as protective against AD.

162 Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced ris

163 t pattern in this research is that continued long-term use of NSAIDs is required for an anticancer ef

164 Long-term use of NSAIDs, especially ASA, is associated w

165 a nationwide analysis of patients in Sweden, long-term use of OCs, particularly the combination type,

166 In light of the increasing long-term use of opiates in chronic pain, in principle,

167 lopment of strategies that could improve the long-term use of opioids for pain.

168 SCD is mostly reliant upon opioids; however, long-term use of opioids is associated with multiple sid

169 Another evolving concern is whether the long-term use of opioids is safe and effective.

170 o functional status markers were improved by long-term use of opioids.

171 Little is known of the risks associated with long-term use of oral bisphosphonates despite their use

172 acquisition decreased with age, income, and long-term use of oral contraceptives and increased with

173 onsistent with the observation in women that long-term use of oral contraceptives or multiple pregnan

174 ncy department, the use of rescue therapy or long-term use of oral corticosteroids, or the dispensing

175 Widespread and long-term use of oral nucleos(t)ide analogs (NAs) to tre

176 egrity in most osteoporotic patients and the long-term use of osteoporosis drugs is controversial.

177 exacerbates pathogenesis and argues against long-term use of pan-anti-TNF-alpha inhibitors for the t

178 ), high levels of physical activity, and the long-term use of pharmacotherapy combined with lifestyle

179 Relative to nondiabetics, the cumulative long-term use of pioglitazone reduced the dementia risk

180 Long-term use of pioglitazone was associated with a lowe

181 The long-term use of plasmapheresis may be a well-tolerated

182 f proton pump inhibitors (PPIs), focusing on long-term use of PPIs for three common indications: gast

183 We hypothesized that long-term use of PPIs is associated with greater microbi

184 In HIV, long-term use of PPIs was associated with increased micr

185 onal studies of outcomes associated with the long-term use of preventive therapies are subject to the

186 atter finding is potentially relevant to the long-term use of protein farnesyltransferase inhibitors,

187 observational studies, between high-dose or long-term use of proton pump inhibitor drugs and certain

188 iew is to evaluate the risks associated with long-term use of proton pump inhibitors (PPIs), focusing

189 to accumulation of the (S)-enantiomer after long-term use of racemic albuterol.

190 No new safety events were identified with long-term use of ranibizumab; rates of SAEs potentially

191 These results support the long-term use of riociguat in patients with pulmonary ar

192 Current long-term use of SSRI (>/=20 prescriptions) was not asso

193 Long-term use of statins among patients with CAD appeare

194 These results suggest that long-term use of statins is unlikely to substantially in

195 PIMs included: long-term use of stimulant laxatives and high-dosages of

196 Then we evaluated the long-term use of subcutaneous ICDs in a pilot study, inv

197 The potential hazards associated with long-term use of such doses should be carefully consider

198 We examined the association between long-term use of supplemental B vitamins on the one-carb

199 The effect that long-term use of suppressive acyclovir (ACV) has on both

200 Long-term use of suppressive prophylactic ACV appears to

201 Long-term use of systemic antifungals is not optimal due

202 The long-term use of tamoxifen and other selective estrogen

203 Long-term use of the CSD lowered end-diastolic and end-s

204 Recently, long-term use of these agents has come under scrutiny du

205 improves cytopenias in 50% of patients, but long-term use of these can lead to toxicity.

206 Unfortunately, the long-term use of these devices is compromised by cellula

207 Furthermore, long-term use of these devices is not associated with in

208 rm trials, the current evidence supports the long-term use of these drugs for the treatment of patien

209 onsteroidal analgesics and opiates; however, long-term use of these drugs is commonly associated with

210 y reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic ev

211 ilar to those in patients on diclofenac with long-term use of these drugs.

212 rdive dystonia may become irreversible after long-term use of these drugs.

213 Studies over the past decade suggest that long-term use of these heparins in both primary and seco

214 ing fetal exposure to drugs and xenobiotics, long-term use of these medications may affect fetal drug

215 Unfortunately, the long-term use of these therapies is complicated by unwan

216 d with GSK2330672 treatment, might limit the long-term use of this drug.

217 Long-term use of topical corticosteroids in skin inflamm

218 and clinical studies have reported that the long-term use of topical medications in chronic ophthalm

219 ment of resistance is the main threat to the long-term use of toxins from Bacillus thuringiensis (Bt)

220 Long-term use of unopposed estrogen is associated with i

221 ator levels in patients with RA, despite the long-term use of various anti-inflammatory drugs, sugges

222 However, long-term use poses adherence challenges, is associated

223 and prostaglandin E2 (PGE2) expression, but long-term use produced significantly higher levels of th

224 however, the apparent benefit decreased with long-term use (relative risk, 0.80; 0.67 to 0.96, after

225 atients who began treatment in recent years, long-term use remains low.

226 ubtedly cause irreversible brain damage with long-term use, the jury is still out on the party drug e

227 is glucocorticoids, their side effects make long-term use undesirable.

228 Obesity medications approved for long-term use, when prescribed with lifestyle interventi

229 cannabinoids has been widely observed after long-term use, with concomitant receptor desensitization

230 ophageal reflux, which are now available for long-term use without medical supervision.