ライフサイエンスコーパス: longevity

1 quality, and within-canopy variation in leaf longevity).

2 RNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity.

3 ivate an adaptive stress response to promote longevity.

4 s the risk of many diseases and, ultimately, longevity.

5 make them fit for purpose will increase the longevity.

6 hat may link SES to age-related diseases and longevity.

7 interventions that improve public health and longevity.

8 olite acting on host mitochondria to promote longevity.

9 ychological maternal stress can affect human longevity.

10 of which also demonstrated associations with longevity.

11 ociated with various pathologies and reduced longevity.

12 cardioverter-defibrillators do not increase longevity.

13 s that promote metabolic health and organism longevity.

14 the UPR(mt) to improve metabolic health and longevity.

15 nogaster and Caenorhabditis elegans promotes longevity.

16 ar size varies, but is highly predictive for longevity.

17 ns for islet survival and transplanted graft longevity.

18 , and can promote both stress resistance and longevity.

19 important for RNA quality control to promote longevity.

20 reproductive success, rather than health or longevity.

21 hallenge the universal concept of microglial longevity.

22 ed on high dietary glucose limits C. elegans longevity.

23 ic hydrogen production through the radical's longevity.

24 and CHRNA5) might be causally implicated in longevity.

25 -1/NRF1,2,3 to promote stress resistance and longevity.

26 ents for energy, molecular biosynthesis, and longevity.

27 homeostatic proliferation, maintenance, and longevity.

28 atory influence of the flora on myeloid cell longevity.

29 n (CR) is a feeding paradigm known to extend longevity.

30 e cell wall component of BB68 contributed to longevity.

31 nes and metabolites correlating with species longevity.

32 uding MDL-1/MAD-like HLH factor required for longevity.

33 e training improve cardiovascular health and longevity.

34 1+ cells does not affect their quiescence or longevity.

35 inment are useful in the prediction of human longevity.

36 environmental stress play key roles in human longevity.

37 iated motor symptoms and improved health and longevity.

38 rs between areas with the highest and lowest longevity.

39 t with slow childhood growth and exceptional longevity.

40 ere followed up for mortality predictors and longevity.

41 oint to a role for this protein in promoting longevity.

42 in these cells can alter their function and longevity.

43 d downstream outputs that regulate aging and longevity.

44 elopment, and metabolism to reproduction and longevity.

45 insulin resistance and, conversely, improved longevity.

46 ociated with many health outcomes, including longevity.

47 ity, and is also an important determinant of longevity.

48 s for restorations with potentially enhanced longevity.

49 ir progeny can be a mechanism for modulating longevity.

50 stemic level to ensure organismal health and longevity.

51 icantly reducing lesion burden and extending longevity.

52 of extracellular H2O2 stress on replicative longevity.

53 ities, may impact mitochondrial function and longevity.

54 cal trade-offs that facilitate their greater longevity.

55 in the environmental influence on molecular longevity.

56 n and abrogated the effect of heat stress on longevity.

57 consequences of improved health and extended longevity.

58 ranscript, by daf-2 mutations contributes to longevity.

59 xplains a small fraction of the variances in longevity (5.9%), age at first reproduction (3.7%) and l

60 pecies (ROS) are not the key determinants of longevity, a number of studies have highlighted the key

61 cy at birth in women will be due to enhanced longevity above age 65 years.

62 d substantially across areas; differences in longevity across income groups decreased in some areas a

63 fibroblast profiling captures differences in longevity across mammals at the level of global gene exp

64 We identify lipids associated with species' longevity across the three clades, uncoupled from other

65 as biological links between mood, stress and longevity/aging, that may be biomarkers as well as targe

66 i.e., per-area photosynthetic capacity), and longevity all influence the photosynthetic seasonality o

67 results raise the prospect that variation in longevity and age-related traits could be traced to proc

68 We used data from the Rugao Longevity and Ageing Study, a population-based cohort st

69 The magnitude, longevity and avidity of IgG differed significantly amon

70 sient population dynamics and differences in longevity and behavioural flexibility can help reconcile

71 Our results indicate that increases in longevity and BMI are insufficient to explain the approx

72 seeds revealed that both the acquisition of longevity and dormancy were severely impaired.

73 The longevity and downstream propagation of these effects as

74 he soluble inner matrix through increases in longevity and fecundity.

75 sal associations of triglyceride levels with longevity and frailty in elderly populations.

76 est associations of triglyceride levels with longevity and frailty.

77 While the effects of hypoxia on neutrophil longevity and function have been widely studied, little

78 BP5 have a critical role in the maintenance, longevity and function of CD8(+) TRM cells, and suggest

79 hereby creating the opportunity for extended longevity and good quality of life.

80 towards answering this question, we compared longevity and health of Snuppy, the world's first cloned

81 ishment through low-level viral replication, longevity and homeostatic proliferation of memory T cell

82 us observations on the relationships between longevity and immunity.

83 rmittent silencing dynamics is important for longevity and is dependent on the conserved Sir2 deacety

84 ge at puberty is a predictive factor for sow longevity and lifetime productivity, but not routinely m

85 ual variance in demographic outcomes such as longevity and lifetime reproduction.

86 at small nucleoli are a cellular hallmark of longevity and metabolic health conserved across taxa.

87 sly unidentified molecular mechanism linking longevity and metabolic pathways to neural mechanisms of

88 conditions during development, also modulate longevity and metabolism.

89 an epigenetic mechanism that modulates both longevity and mitochondrial proteostasis throughout life

90 system and is believed to improve the graft longevity and patency rates at distal graft anastomoses.

91 aging reveals deeply conserved mechanisms of longevity and population structure regulation.

92 n, by which IDO is known to influence T cell longevity and proliferation, was not involved in its eff

93 Based on their longevity and proliferative potential, CD4(+) T memory s

94 rturbation, we uncover abundant variation in longevity and reproduction-induced mortality among genot

95 es displayed more than fourfold variation in longevity and reproduction-induced mortality that can be

96 ting that TSCM cells, owing to their extreme longevity and robust potential for immune reconstitution

97 n as in berries, with an important impact on longevity and sensorial characters of wines.

98 splicing homeostasis in dietary restriction longevity and suggest that modulation of specific splice

99 thers have powerful influences on health and longevity and that lacking social connection qualifies a

100 etary history of an animal regulates its own longevity and that of its conspecific neighbours.

101 s stable to shear instability, suggestive of longevity and the ability to carry water far distances w

102 epigenetic contribution to healthy aging and longevity and the molecular basis of the DNA methylation

103 tion of the demethylases potently suppresses longevity and UPR(mt) induction, while gain of function

104 onserved roles of the mammalian orthologs in longevity and UPR(mt) signaling.

105 n efficiencies, (ii) gains in photocatalytic longevity, and (iii) insights into the ET mechanism at t

106 4, higher income was associated with greater longevity, and differences in life expectancy across inc

107 Being taller is associated with enhanced longevity, and higher education and earnings.

108 Autophagy is associated with health and longevity, and is critical for protecting haematopoietic

109 hat include curly hair, infertility, reduced longevity, and kidney abnormalities.

110 tes characterized by function, localization, longevity, and the capacity for self-renewal.

111 Our projections show continued increases in longevity, and the need for careful planning for health

112 ve natural compounds that promote health and longevity, and understanding how they act, will provide

113 mechanism by which H3K4me3 modifiers affect longevity, and whether this mechanism involves metabolic

114 bstantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fit

115 Aging and longevity are controlled by a multiplicity of molecular

116 increased xenobiotic resistance and enhanced longevity are not causally connected.

117 e pressure and exaptation of traits for tree longevity are potential explanations, highlighting the c

118 he main regulators of metabolism, aging, and longevity, are components of the same pathway.

119 molecular mechanisms underlying reproduction-longevity associations remain a matter of debate.

120 need without sacrificing quality of life and longevity because of drug-based immunosuppression.

121 activity in the adult gut achieves the full longevity benefit of systemic TORC1 inhibition.

122 a physiologically low heart rate may confer longevity benefits.

123 Differences in longevity between sexes is a mysterious yet general phen

124 s of absolute and relative brain volume with longevity (both juvenile period and reproductive lifespa

125 ed with antiretroviral therapy have improved longevity but face an elevated risk of myocardial infarc

126 orrelation between antigen-specific IgGs for longevity but not for magnitude and avidity.

127 s have been repeatedly associated with human longevity, but online interactions might have different

128 itochondrial fusion is not a major driver of longevity, but rather is essential to allow the survival

129 s autotoxins can influence the regulation of longevity by other factors including diet, sex, insulin

130 irus and then assessed cellular turnover and longevity by quantifying deuterium dilution kinetics in

131 decreasing costs, and potentially improving longevity by reducing our patients' risk of death and tr

132 is sufficient to extend lifespan; in flies, longevity can be achieved by Pol III inhibition specific

133 k-controlled transcriptional factors and the longevity candidate genes.

134 Of ten pro-longevity chemicals tested, six significantly extend lif

135 sing both simulated and real datasets (Rugao longevity cohort mitochondrial DNA haplogroups and kidne

136 in the body weight, oviposition periods, and longevity compared to controls.

137 quality control process that contributes to longevity conferred by daf-2 mutations.

138 cted to) has been associated with fertility, longevity, disease and information transmission in a ran

139 ired at memory to maintain memory CD8 T-cell longevity, effector function, and Eomes expression.

140 Furthermore, the mitochondrial changes and longevity effects induced by CA are conserved across dif

141 The dramatic longevity-enhancing effect of cold has long been known i

142 identified 6 genetic markers associated with longevity for all 4 antigens, although the expression le

143 valuable opportunities to improve health and longevity for an aging global population.

144 vements in air quality may promote molecular longevity from birth onward.

145 herefore, those at high risk of SCD may gain longevity from successful implantable cardioverter defib

146 ors to contemporary Japan, Sweden, and other longevity frontrunners.

147 g missed out on decades of income growth and longevity gains, low-income Americans are increasingly l

148 and the first to discriminate anti- and pro-longevity genes, revealing new insights on aging-related

149 d triglycerides with two ageing phenotypes - longevity ( >/=95 years) and frailty (modified Fried fra

150 her hand, the biofilm exhibited much greater longevity (>5 days) than the protein-film (<6 h), with t

151 Therapeutic advances, despite improving longevity, have increased the overlap between these dise

152 val, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA).

153 Dampened flow seasonality, increased longevity (i.e., delayed reproduction), and decreased fi

154 Aripiprazole increased longevity in a Drosophila model of Machado-Joseph diseas

155 Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction.

156 We also demonstrate that PACRG promotes longevity in C. elegans by acting upstream of the lifesp

157 Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/

158 ry point for the modulation of autophagy and longevity in C. elegans with conserved effects in the mu

159 ifespan in Drosophila, and can also increase longevity in C. elegans, mice, and possibly humans.

160 Antidepressants have been shown to improve longevity in C. elegans.

161 ectiveness as a mechanism for improving bond longevity in dentin bonding.

162 production drives the evolution of decreased longevity in Drosophila whereas experimental selection f

163 he relationship of TL with these disease and longevity in humans.

164 restriction (CR) retards aging and increases longevity in many animal models.

165 UPS) and autophagy, appear indispensable for longevity in many long-lived invertebrate mutants.

166 Calorie restriction (CR) increases longevity in many species by unknown mechanisms.

167 Autophagy has been linked to longevity in many species, but the underlying mechanisms

168 ) action can produce remarkable extension of longevity in mice.

169 regulator of cellular proteostasis linked to longevity in nematodes, but its biological function in m

170 ifespan, but also with a greater increase in longevity in response to dietary restriction.

171 AMPK/SNF1 also promotes longevity in several model organisms, including yeast.

172 However, little is known about aging and longevity in symmetrically dividing eukaryotic cells bec

173 er environmental signals influence phagocyte longevity in the absence of inflammation remains unknown

174 reased mitochondrial fusion is essential for longevity in the diverse longevity pathways, as inhibiti

175 essful suppression of viremia with increased longevity in the era of combined antiretroviral therapy,

176 t 29 bacterial genes, when deleted, increase longevity in the host Caenorhabditis elegans.

177 How schistosomes maintain their longevity in this immunologically hostile environment is

178 vealing a genetic mechanism for cold-induced longevity in this model organism.

179 re, we investigated how heat stress promotes longevity in yeast.

180 f candidate genes previously implicated with longevity indicates physiological systems may undergo se

181 ike complex (MML-1/MXL-2) to be required for longevity induced by germline removal, as well as by red

182 , whereas genetic loci linked to exceptional longevity influence metabolism.

183 are rapidly ageing, evidence that increasing longevity is being accompanied by an extended period of

184 crose and xenobiotic metabolism pathway with longevity is consistent with the previous results from D

185 ve lifespan) and social group size, although longevity is generally the stronger predictor.

186 hs to expected lifespan.Variability in human longevity is genetically influenced.

187 A key obstacle to achieving optimal longevity is the progressive decline in physiological fu

188 whereas experimental selection for increased longevity leads to changes in reproduction.

189 three UH groups, differing substantially in longevity, lifetime reproductive output, age at first re

190 nd are new attitudes and demand for 'optimal longevity' - living long, but with good health and quali

191 Leaf longevity (LL) varies more than 20-fold in tropical ever

192 ions, and APOE and 5q33.3 were replicated as longevity loci.

193 ntified molecular targets for developing pro-longevity microbes and a bacterial metabolite acting on

194 an extension across mechanistically distinct longevity nematode models.

195 interface between antidepressant effects and longevity, notably pathways involved in drug metabolism/

196 ced expiratory volume, grip strength, HbA1c, longevity, obesity, self-rated health, smoking status, t

197 es are required for the thermoresistance and longevity of animals exposed to hormetic heat shock or H

198 The longevity of asexual clades may be correlated with the m

199 The longevity of both the donor and the cloned dog was close

200 s to advance predictive understanding of the longevity of BPA and its transformation products in envi

201 fidobacterium longum strain BB68 affects the longevity of C. elegans were assessed.

202 es cell size, and suppresses the replicative longevity of cells lacking the Sch9p protein kinase regu

203 a unique opportunity to study the health and longevity of cloned animals compared with their cell don

204 mplies that women's fertility depends on the longevity of cohesin proteins that established cohesion

205 Thus, the longevity of dentin bonding can only be improved with en

206 composite restoration is unsatisfactory, and longevity of dentin bonding is one of the major culprits

207 represent mechanisms responsible for reduced longevity of dwarf mice exposed to GH treatment early in

208 ue to low spatiotemporal resolution and poor longevity of gradients utilizing microfluidic techniques

209 iquid phase, as well as the distribution and longevity of heat.

210 With the improved longevity of HIV-positive individuals, a kidney transpla

211 l of serological memory based upon intrinsic longevity of human plasma cells.

212 olism and the differentiation, function, and longevity of immune cells.

213 Characterising the longevity of immunological memory requires establishing

214 ls produce high condition larvae and rely on longevity of individuals for population persistence and

215 Dietary restriction increases the longevity of many organisms, but the cell signaling and

216 he physical state, spatial distribution, and longevity of melt in the crust.

217 In contrast, SHM reduced the longevity of memory B cells by creating polyreactive spe

218 Thus, BB68 increased the longevity of nematodes by activating the TIR-1 - JNK-1 -

219 f high-resolution data, qualitative metrics, longevity of records, and simultaneous multiwatershed an

220 bjective measure to assess independently the longevity of retinal GT.

221 ding smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2

222 em to improve the operational efficiency and longevity of SOFC-based energy generation systems.

223 ffold were also generally maintained for the longevity of the culture albeit with a higher level of c

224 and surgically related events increases with longevity of the implants.

225 cessary to predict both the severity and the longevity of the resulting environmental impacts.

226 icolour photometric observations confirm the longevity of the secondary variations, which we interpre

227 e next "generation" of learners, so that the longevity of the skill in the population could outlast t

228 e over millions of years and establishes the longevity of these genes in this genus.

229 These studies confirm the persistence and longevity of thin myelin sheaths and the importance of r

230 The association with longevity of three of these four pathways (MAPK; immunit

231 have been developed to improve prognosis and longevity of transplanted teeth with complete root forma

232 ient benefits and its role in prolonging the longevity of treatment programs.

233 due to its impact on the sensory quality and longevity of wines.

234 fusion is necessary, but not sufficient, for longevity of worms with mutations that increase lifespan

235 Genomic analysis of longevity offers the potential to illuminate the biology

236 id composition imbalance, and reduced animal longevity on a high-fat diet.

237 d autophagy pathways-processes implicated in longevity-on learning.

238 OI, and whether this is due to high density, longevity or high annual production in six study species

239 icted triglyceride levels and probability of longevity (OR: 0.61; 95% CI: 0.35, 1.07 per 1 mmol/L inc

240 K; calcium signaling) highly associated with longevity (P </= 0.006) in Han Chinese.

241 autophagic activity, indicating that the two longevity paradigms have distinct effects on autophagy d

242 e developments needed to improve restoration longevity past the average 10 y.

243 We show that diverse longevity pathways exhibit increased levels of elongated

244 Long-lived animals representing distinct longevity pathways exhibit small nucleoli, and decreased

245 nt of target genes involved in key aging and longevity pathways including mTOR, FOXO and MAPK, most o

246 ribute to cell cycle, growth regulation, and longevity pathways to which MRPL12 has been linked.

247 nimal model of aging which shares many major longevity pathways with mammals.

248 on is essential for longevity in the diverse longevity pathways, as inhibiting mitochondrial fusion r

249 imits nucleolar size in the major C. elegans longevity pathways, as part of a convergent mechanism fo

250 rse genetic backgrounds may engage conserved longevity pathways.

251 mals beyond their normal lifespan in diverse longevity pathways.Mitochondria can undergo shape change

252 The longevity phenotype is associated with amelioration of a

253 prone background, Pml(-/-) animals display a longevity phenotype, likely reflecting decreased basal p

254 levels of these genes did not correlate with longevity phenotype.

255 The EFA and longevity phenotypes are ameliorated by a reduction of t

256 ing 58 disease-related GWA studies to derive longevity priors for all HapMap SNPs.

257 etin, vitamin D and resveratrol as potential longevity promoting compounds, along with a series of ex

258 and metformin (an antidiabetic and possible longevity promoting drug).

259 The longevity-promoting benefits of lactobacilli were hypoth

260 Longevity-promoting caloric restriction is thought to tr

261 Distinct longevity-promoting interventions, specifically genetic,

262 evel in mouse liver and tested the impact of longevity-promoting interventions, specifically the Ames

263 er epigenetic aging signatures are slowed by longevity-promoting interventions, we analyzed 28 additi

264 klotho transgene in mdx mice restored their longevity, reduced muscle wasting, improved function and

265 o environmental cues and sexual behaviors in longevity regulation, we examined Caenorhabditis male li

266 Evasion of forkhead box O (FOXO) family of longevity-related transcription factors-mediated growth

267 organisms the underpinnings of cold-induced longevity remain largely mysterious.

268 s between social learning, brain volume, and longevity remain when controlling for maternal investmen

269 entified 11 independent loci associated with longevity replicated in Southern-Northern regions of Chi

270 shape the great amount of variation in plant longevity, reproductive output and growth rate is fundam

271 nfirmed a role for ABI5 in the regulation of longevity, seed degreening, and RFO accumulation, identi

272 ve characteristics such as clonal expansion, longevity, self-renewal, and robust recall responses to

273 INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing t

274 stem to explore the genetic underpinnings of longevity, since its generation time is brief and both t

275 ses with absolute and relative brain volume, longevity (specifically reproductive lifespan), and soci

276 them replicate (5% FDR) in five independent longevity studies combined; all but three are depleted o

277 .2% women, median age 66.5 years) and Leiden Longevity Study (N = 661; 50.5% women, median age 63.1 y

278 cated in 599 Dutch Europeans from the Leiden Longevity Study (p = 0.042) and in 1,173 Europeans of th

279 the Collaborative Breast Cancer and Women's Longevity Study, a population-based prospective observat

280 d data from the Chinese Longitudinal Healthy Longevity Study.

281 on rate of CDPs is inversely correlated with longevity, suggesting the occurrence of still unidentifi

282 onger in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain con

283 ping but distinct phenotype from exceptional longevity that may be enriched with disease-protective g

284 of this key nutrient-signalling network for longevity; the growth-promoting anabolic activity of Pol

285 scovered that five bacterial mutants promote longevity through increased secretion of the polysacchar

286 t, higher income was associated with greater longevity throughout the income distribution.

287 cells maintain developmental plasticity and longevity to provide long-term immunity while other effe

288 These observations may explain the increased longevity typical of endurance athletes despite the pres

289 In contrast with studies of exceptional longevity, usually focused on centenarians, healthy agin

290 , healthy aging is not associated with known longevity variants, but is associated with reduced genet

291 is Intervention Testing Program in assessing longevity variation across 22 Caenorhabditis strains spa

292 Longevity varies among individuals, but how natural gene

293 rified CA polymers are sufficient to promote longevity via ATFS-1, the host UPR(mt)-responsive transc

294 ypes and then animal behavior, pathology and longevity were assessed.

295 andidate genes for mood and stress-modulated longevity were changed in expression in opposite directi

296 of bryozoans (rather than high densities or longevity), which were 2x, 3x and 5x higher than on the

297 a1-1 and bb/eod1-2 leaves showed a prolonged longevity, which was enhanced in the double mutant.

298 DNA, for example, combines remarkable longevity with high data storage densities and has been

299 growth and reproduction trading off against longevity, with trials of calorie restriction underway.

300 rsal trade-off between early growth and tree longevity within a species, although this result may als