ライフサイエンスコーパス: loop

1 ssential for catalysis (i.e. the "activation loop").

2 omatid cohesion) and within chromosomes (DNA looping).

3 172 phosphorylation in the kinase activation loop.

4 10 helix, and a recently evolved tri-proline loop.

5 malization, indicating a mutually regulatory loop.

6 cohesin and monitor the re-formation of each loop.

7 s, as well as for the TARP extracellular EX2 loop.

8 ypothalamus-pituitary-ovary feedback control loop.

9 dephosphorylation of MST2 at the activation loop.

10 the SNARE complex and its N-terminal apolar loop.

11 he [Formula: see text]2-[Formula: see text]2 loop.

12 ine (T) and a tyrosine (Y) in its activation loop.

13 circadian transcription/translation feedback loop.

14 s a YAP-regulated gene that forms a feedback loop.

15 pressor of miR-146a, suggesting an autocrine loop.

16 ity and initiation of this positive feedback loop.

17 riable, unknown input signals via a feedback loop.

18 the CDR3beta loop, as well as the CDR3alpha loop.

19 ne semimetals forms a one-dimensional closed loop.

20 sition with respect to the positive feedback loop.

21 t-discovery and materials-by-design feedback loop.

22 itors MLN8054 and CD532 favors an inactive T-loop.

23 and stimulates the activity of RNaseH1 on R loops.

24 tes, report on the mobility of the connected loops.

25 collisions leading to genome-destabilizing R-loops.

26 cripts containing 5' MS2 and 3' PP7 RNA stem loops.

27 ll biochemically established properties of R-loops.

28 rates for the formation of transcriptional R-loops.

29 of CaM by stabilizing the two Ca(2+) binding loops.

30 ning in areas of intact glomerular capillary loops.

31 ons specifically involved in CEA-DA-striatal loops.

32 rates the recognition of unbranched RNA stem loops.

33 is related to the existence of sessile Frank loops.

34 he release of paused RNAPII via 3D chromatin looping.

35 rough diverse mechanisms including chromatin looping.

36 e helps transmit the cholesterol signal from loop 1 to loop 7, thereby allowing separation of the loo

37 he intervening polytopic sequence separating loops 1 and 7.

38 ay be due to a "lid" formed by extracellular loop 2 (EL2) at the entrance to the binding pocket.

39 n: 19.3 +/- 2 mm Hg, decision assist, closed loop: 24 +/- 0.4 mm Hg; p < 0.05) and hemoglobin concent

40 RIL) fusion (A2AR-BRIL) in the intracellular loop 3 (ICL3) was crystallized in detergent micelles usi

41 (bolus resuscitation: 57 +/- 2 mm Hg, closed loop: 69 +/- 4 mm Hg; p = 0.036).

42 ansmit the cholesterol signal from loop 1 to loop 7, thereby allowing separation of the loops and fac

43 h ligand binding to the lectin domain closes loop 83-89 around the Ca(2+) coordination site, enabling

44 structure is a transition intermediate where loop 83-89 closes to engage Ca(2+) and mannose without t

45 Stem-loop A (SLA), a part of the viral 5' untranslated region

46 AL act as part of an incoherent feed-forward loop, a network motif where two interconnected pathways

47 R-loops accumulate in nucleoli during RNA polymerase I (RN

48 Here we show that R-loops accumulate preferentially in breast luminal epithe

49 ia coli or Saccharomyces cerevisiae caused R-loop accumulation along rDNA.

50 Loss of either RNase H1 or Top1 caused R-loop accumulation, and the accumulation of R-loops was e

51 was combined with the analysis of RANK/RANKL loop activation in the leukemic clone, given recent repo

52 ple tetrahydrofuranyl abasic sites replacing loop adenines (A/AP) and tetrad guanines (G/AP) in quadr

53 are main-chain conformational differences in loops adjacent to the active site that include the exten

54 s, and the addition of the DHPR alpha1s I-II loop (alpha-interaction domain) peptide stabilized both

55 Besides IL-6, this autorine loop also drove the production of other key inflammatory

56 occupancy rewire DNA cleavage sites to novel loop anchors.

57 ne or two TSSs and are enriched at chromatin loop anchors.

58 Glutamate E153 on the E-loop and arginine R210 on the adjacent subunit's backbon

59 n pumps, continuous glucose monitors, closed-loop and artificial pancreas systems) have been the subj

60 to 5'-ACCCC-3' ablates base stacking in the loop and globally reorients the SLII structure.

61 beta-strand is retracted to extend the Ser65 loop and shorten the C-terminal tail.

62 educe exposure of non-nAb epitopes in the V3-loop and trimer base, minimize both CD4 reactivity and C

63 on of YY1 protein disrupts enhancer-promoter looping and gene expression.

64 possess one nucleotide in each of the three loops and a core built of an even number of base pairs.

65 rine proteases have flexible surface-exposed loops and are known to adopt higher and lower activity c

66 islands, together with the accumulation of R-loops and cytosolic ssDNA.

67 Significantly, increased cellular load of R-loops and DSBs, which are normalized on RNaseH1-mediated

68 o loop 7, thereby allowing separation of the loops and facilitating the feedback inhibition of choles

69 Yeast lacking SGS1 accumulate R-loops and gamma-H2A at sites of Sgs1 binding, replicatio

70 r differences arise from transiently forming loops and hairpins within 30 nucleotides of the break.

71 he nanoparticle-wrapping polymer are mobile (loops and tails) versus immobile (trains).

72 by cytosine deamination of DNA engaged in R-loops and the other by MutLgamma cleavage.

73 ch to identify residues in the extracellular loops and transmembrane segments of hERG1 that might int

74 to the penultimate helix, the extended Omega-loop, and a beta-hairpin turn of the Phy-specific domain

75 in the subthalamic-globus pallidus feedback loop, and occur during movement.

76 70) of the conserved FPF sequence of the Cys loop, and that these interactions affect potentiating ef

77 e and stability of the intervening chromatin loops, and use it to demonstrate that malignant transfor

78 ress neuronal function for adaptive feedback-loop applications in the future.

79 and in neuro-engineering to implement closed-loop applications.

80 utagenesis studies indicated these predicted loops are almost exclusively where functionally importan

81 In intron-containing genes, R-loops are bounded between the transcription start site a

82 R-loops are known to interfere with replication forks, and

83 s been proposed to possess a unique "hairpin-loop" arrangement, which is hypothesized to aid in the o

84 These data identified the IL-4/CXCL12 loop as a previously unrecognized pathway involved in ly

85 utants to translation inhibition points to R-loops as precursors for R-lesions.

86 on could alter the structure of the CDR3beta loop, as well as the CDR3alpha loop.

87 lower under bolus resuscitation than closed loop at 20 minutes (bolus resuscitation: 57 +/- 2 mm Hg,

88 located within or directly adjacent to CDR3 loop at the dimer interface, which remarkably include bo

89 ement in human upright walking with a closed-loop BCI has not been investigated.

90 iruses contain an insertion in the 150-loop (loop beginning at position 150) of the receptor-binding

91 d SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 b

92 ar dynamics simulations, we demonstrate that loops both adjacent and non-adjacent to the epitope loop

93 as been proposed that cohesin forms TADs and loops by extruding chromatin loops until it encounters C

94 We obtained evidence that chromosomal looping, bypassing 1524 kb of linear genome, connects Au

95 oth adjacent and non-adjacent to the epitope loop can enhance or diminish antibody binding, a phenoty

96 In migrating cells, feedback loops can amplify stochastic fluctuations in actin dynam

97 ssed by forces above 1 pN, consistent with a loop-capture mechanism for initial binding and compactio

98 Here a closed-loop cavitation controlling paradigm that sustains stabl

99 Unlike the other five CDR loops, CDR H3 does not adopt canonical conformations and

100 As an exception, training on closed-loop (CL) sensorimotor interfaces, such as action video

101 n the nanocrystalline grain size regime, but loop coalescence in the ultra-fine grain size regime.

102 s subgroup and a unique insertion in the 260-loop compared to any other subtype.

103 2 shifts the equilibrium towards an active T-loop conformation whereas addition of the inhibitors MLN

104 lity is associated with two distinct sets of loop conformations, each essential for one function.

105 In bulge-stem-loop constructs of HIV-1 transactivation response elemen

106 domain linked by a large extended connector loop containing a conserved trio of aromatic residues.

107 interaction with hERG mutations in the pore loop containing G604 or with common TdP-related blockers

108 This loop contains a functionally critical Tyr at position 71

109 ition studies further demonstrate that these loops could serve as excellent targets for designing ant

110 new missense mutations in the MET activation loop, critical for binding to crizotinib, upon clinical

111 In this model, a loop defined by the SCI's B and C domains encircles the

112 To examine the validity of such trends, loop density and area for different grains at various ir

113 ata suggest that administration of high-dose loop diuretics to patients with HF yields meaningful inc

114 The second extracellular loop domain (E2) is primarily responsible for this adhes

115 on of activating epigenetic marks across the loop domain, plausibly facilitating phase separation.

116 All loop domains are eliminated, but neither compartment dom

117 "Loop domains" form because of tethering between two loci

118 rge enough group size, they enter a feedback loop - driving shellfish prey size down with attendant c

119 Additionally, L1 loop dynamics of fl-p53 in the presence of DNA is reveal

120 of the kinase is embellished by a unique 'G-loop' element that accounts for guanine nucleotide speci

121 oretical analyses, we find that a hysteresis loop emerges in the system.

122 sib]), interrupts a double-negative feedback loop, enhancing GC-regulated transcription to synergisti

123 R-loop preventing factor, is decreased at R-loop-enriched regions of IFNG and TBX21 (TH1 genes) in T

124 tant phylogenetic distribution implies these loops evolved independently, but their structural simila

125 Thus a mutually reinforcing feedback loop exists between telomere capping and Wnt signalling,

126 the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner

127 d slow "creeping" dynamics consistent with a loop-extrusion mechanism.

128 dulate PON1's active site shape, volume, and loop flexibility, their largest effect is in altering th

129 ly unique in that they lack an electrostatic loop for substrate guidance and have an unusual open-acc

130 urements reveal opening up of the hysteresis loop for {CrTb6 } and {CrHo6 } molecules at low temperat

131 PFM hysteresis loops for the bubble domains reveal that they undergo an

132 kage at expanded CAG repeats occurs due to R-loop formation and reveal two mechanisms for CAG repeat

133 ) flanking the target site, and subsequent R-loop formation and strand scission are driven by complem

134 H-based approach; this reveals predominant R-loop formation near gene promoters with strong G/C skew

135 GB gene is regulated by a cell type-specific loop formed between its promoter and the novel DRE.

136 Two auxiliary negative feedback loops, from ERK to MEK and RAF, placed downstream of the

137 s (resonance "strength") rises profoundly as loop gain rises toward 1.

138 cose range was 59.8% (SD 18.7) in the closed-loop group and 38.1% (16.7) in the control group (differ

139 the category of representations of the based loop group is a bicommutant category.

140 agenesis indicates that tyrosine 645 in this loop has an important role in the selective binding of s

141 The transcription factor (TF) basic/Helix-Loop-Helix (bHLH) is important for plant growth, develop

142 ing an anther-specific predicted basic helix-loop-helix (bHLH) transcription factor required for tape

143 ifferential up-regulation of two basic helix-loop-helix (bHLH) transcription factors with predicted e

144 Here, we identify a network of helix-loop-helix (HLH) transcriptional regulators controlled b

145 The spermatogenesis/oogenesis helix-loop-helix (SOHLH) proteins SOHLH1 and SOHLH2 play impor

146 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CL

147 DEFECTIVE-SIX LIKE (RSL) class I basic helix-loop-helix proteins are expressed in future root hair ce

148 s, we discovered that the Id family of helix-loop-helix proteins is both necessary and sufficient to

149 RACE identified the prooncogenic basic helix-loop-helix transcription factor ID1 as an IRE1alpha RNas

150 ibitor of differentiation 1 (Id1) is a helix-loop-helix transcription factor that plays an important

151 d MPK6 can phosphorylate ICE1, a basic-helix-loop-helix transcription factor that regulates the expre

152 Homeodomain and basic helix-loop-helix transcription factors are required for retino

153 obstruction (SBO), mushroom sign, clustered loops, hurricane eye, small bowel behind the superior me

154 to a serine-to-proline mutation, locking the loop in a conformation that sterically blocks binding an

155 of input tracts in the striatal associative loop in chronic schizophrenia patients and healthy contr

156 primary function of the interlocked feedback loop in Drosophila is to drive rhythmic transcription re

157 A secondary analysis loop in EoE patients defined an IGHE score of >/=37.5 fo

158 53, defining an additional negative feedback loop in the p53 network.

159 The flexible Ser65 loop in the Ub-CR conformation contacts the activation s

160 ropose the presence of an autocrine feedback loop in which Klotho senses the need for FGF23.

161 omic force microscopy show that TFAM creates loops in a discrete region, the formation of which corre

162 enriches in nucleoli and co-localizes with R-loops in cultured human cells.

163 l role for functional information-processing loops in optimizing saccade generation in dynamic enviro

164 trait loci, and by allele-specific enhancer loops in patient-derived primary cells.

165 HDX analysis demonstrates that two basic loops in the mVP40 C-terminal domain make important cont

166 To enable precision analysis of R-loops in vivo, we develop an RNase-H-based approach; thi

167 inine(172), located in the 2nd extracellular loop, in the action of decanoic acid but not of 3,3'-dii

168 hat DNMT1 and KIT form a positive regulatory loop, in which ectopic DNMT1 expression increases, where

169 urbation experiments further indicate that R-loop induction correlates to transcriptional pausing.

170 estigate whether day-and-night hybrid closed-loop insulin delivery can improve glucose control while

171 on RNaseH1-mediated suppression of ectopic R-loops, inversely correlates with disease severity scores

172 aling through a negative feedback regulation loop involving down-regulation of TLR4, IRAK1, and NF-ka

173 demonstrate a deleterious positive feedback loop involving elevated intracellular calcium and enhanc

174 A positive feedback loop involving RAS and SOS, which leads to bistability a

175 An R-loop is a DNA:RNA hybrid formed during transcription whe

176 The fusion loop is also a target of pan-flavivirus antibodies that

177 hat is consistent with the notion that the S-loop is critical for cofactor binding, allosteric activa

178 suggest that the subiculum-containing detour loop is dedicated to meet the requirements associated wi

179 The observation that the alpha4 E loop is involved suggests that physostigmine interacts w

180 The interpretation that the loop is relocated by pressure was validated by site-dire

181 of which correlates with activation of HSP1; looping is lost in tail-deleted TFAM.

182 Therefore, "antiparallel" looping is observed in a single-molecule time trajectory

183 e site, and rearrangement of the surrounding loops is required for binding to substrate ssDNA.

184 ing thymidine nucleotides to lock in i-motif loop lengths support the conclusion that the most stable

185 ified within the epitopes in the EDII fusion loop likely explain the sequence and antigenic conservat

186 H15 viruses contain an insertion in the 150-loop (loop beginning at position 150) of the receptor-bi

187 tasis and cybernetics, the inference-control loop, may be used to guide differential diagnosis in com

188 three general forms of planar network-random loops, mazes and trees-on the surface of self-assembled

189 Thus, we identify tDNAs as a new source of R-loop-mediated DNA damage.

190 Loop-mediated isothermal amplification (LAMP) is a DNA a

191 One of these loops mediates viral attachment, and the other participa

192 on acting effectively in a positive feedback loop, mediating a subsequent surge in procoagulant activ

193 lly triggered stimuli to flies in a feedback-loop mode, and are highly customizable and open source.

194 peripheral element of the RNA that forms a T-loop module and a subset of nucleotides in the cobalamin

195 that BMP signaling plays a critical role in looping morphogenesis of the avian small intestine.

196 e, coupled to an outward motion of the M2-M3 loop near the channel gate.

197 Zinc SBPs are characterized by a flexible loop near the high-affinity zinc-binding site.

198 n (e.g., retinal prostheses), and for closed-loop neural stimulation at a much larger scale than curr

199 is sufficient for long-range promoter-Ebeta looping, nucleosome clearance, and robust transcription

200 uction, large transitions of the beta8-beta9 loop occur in response to neurotransmitter binding.

201 d that the xRRM of LARP7 binds to the 3 stem loop of 7SK and inhibits the methyltransferase activity

202 nity, as revealed by engineering the binding loop of aprotinin, a small protein with high affinity fo

203 specificity through interactions with the L1 loop of CENP-A, stabilized by electrostatic interactions

204 ed based on the sonic hedgehog (Shh)-binding loop of hedgehog-interacting protein (HHIP) and subjecte

205 t decrease in THP-, NKCC2- and AQP1-positive loop of Henle nephron segments in mutant DeltaSRM kidney

206 ases in sodium exit from the proximal tubule/loop of Henle.

207 ss-response pathways by mediating a feedback loop of p38-p53 signaling, thereby contributing to growt

208 utation of D836 to alanine in the activation loop of phosphorylation site mutants nearly completely a

209 G to A substitution present in the terminal loop of pri-mir-30c-1 in breast and gastric cancer patie

210 ubstrate degradation is ensured by the Ins-1 loop of Rpn11, which controls ubiquitin access to its ca

211 irst enzymatic reaction of the amplification loop of the alternative pathway.

212 iral matrix and at the Cyclophilin A binding loop of the capsid.

213 n 25S ribosomal RNA (rRNA) adjacent to the c loop of the expansion segment 7 (ES7), a putative regula

214 The extended 150-loop of the H15 HA retains the conserved conformation as

215 The functionally important switch loop of the trimeric multidrug transporter AcrB separate

216 vealed well-ordered conformations for the EF loop of VP2, the GH loop of VP3, and the N-terminal exte

217 conformations for the EF loop of VP2, the GH loop of VP3, and the N-terminal extensions of VP1 and VP

218 The DII and DIV S3-S4 loops of NaV channel voltage sensors are important for t

219 structure and dynamics of the extracellular loops of OprH show distinct behaviors in different LPS e

220 the presence of ubiquitin, two interhelical loops of the C-terminal four-helix bundle appear to pene

221 -long surface protrusions that are formed by loops of the major capsid protein.

222 -linked ubiquitin chains with two N-terminal loops of Ufd2p.

223 The conformation of the activation loop (T-loop) of protein kinases underlies enzymatic activity an

224 , it remains unknown whether such regulatory loops operate also in non-transformed cells.

225 ing this spatiotemporal dynamic using closed-loop optogenetic stimulation is sufficient to increase m

226 c state and locations of unreliable/flexible loops or termini.

227 a-sheet structure between the Ca(2+) binding loops particularly at C-domain of CaM, enabling Ca(2+) r

228 participant withdrew during the first closed-loop period because of dissatisfaction with study device

229 We identify, for the first time, S-loop phosphorylation as a novel, critical regulator of e

230 However, activation loop phosphorylation occurs via a noncanonical two-step

231 The P-loop phosphotransferase fold of the kinase is embellishe

232 Although R-loops play important roles in gene expression and recomb

233 able, and separate exchanges of the stem and loop portions were likewise well tolerated.

234 gp120, and utilized continuum solvent-based loop prediction protocols to improve sampling.

235 h contains a conserved C-terminal structural loop, preferentially binds to and fills-in short gapped

236 PL and PDS5 proteins, cohesin forms extended loops, presumably by passing CTCF sites, accumulates in

237 increased, and that of topoisomerase 1, an R-loop preventing factor, is decreased at R-loop-enriched

238 to the active site that include the extended loop prior to the penultimate helix, the extended Omega-

239 via low-valence linkages between disordered loops protruding from the protein surface.

240 eads to the proper orientation of a flexible loop proximal to the dimer-dimer interface that is essen

241 cin which transiently stabilized nucleolar R-loops recruited RNase H1 to the nucleoli.

242 ly reducing faradaic energy losses in closed-loop RED systems.

243 y MpPR-1 requires the presence of a flexible loop region containing aromatic amino acids, the caveoli

244 the presence of a 22-amino-acid N-terminal 'loop' region and its catalytic activity.

245 binds in an orientation that disrupts the BC-loop regions at the P450 dimer interface and results in

246 Each monomer has flexible loop regions linking the core alpha-beta-alpha sandwich

247 id substitutions lie in two highly conserved loop regions of uS12 with known roles in maintaining the

248 ompanied by loss of flexibility of two helix/loop regions, as well as of the C-terminal helix; (iii)

249 with only some minor differences in surface loop regions.

250 inhibition by small peptides that mimic the loop residues.

251 nd mRNA profiling using high throughput stem-loop reverse-transcriptase quantitative polymerase chain

252 Protein loops show rich conformational dynamics properties on a

253 a serine residue lying within the activation loop signature sequence S-E-G.

254 We used closed-loop SPW-R detection at goal locations to trigger optoge

255 nd Rrm3 binding to tDNAs is increased upon R-loop stabilization.

256 t is now used to investigate adaptive closed-loop stimulation in first studies.

257 The noise-enhancing effect of the stem-loop structure also remains operational when combined wi

258 600 base pairs downstream of UAS1) through a loop structure that brings UAS1 and UAS2 into spatially

259 2 in shelterin remodels telomeres into the t-loop structure, thereby hiding telomere ends from double

260 troduces a hierarchy among negative feedback loops, such that the effect of a negative feedback depen

261 The conformation of the activation loop (T-loop) of protein kinases underlies enzymatic act

262 as PB insertion encompasses larger chromatin loops termed topologically associating domains.

263 To further explore the translation of closed-loop TES for treatment of epilepsy, we show here for the

264 for the first time that unsupervised closed-loop TES in rats can consistently interrupt seizures for

265 inputs, is nested within a negative feedback loop that encompasses RAS and RAF, MEK, and ERK that inh

266 cyte posterior, creating a positive feedback loop that increases the length and persistence of the po

267 res reveal that G4 recognizes a glycosylated loop that is variable among coronaviruses and they defin

268 ue 137 and that residues 90-125 form a novel loop that links Sac3 to Thp1.

269 esults demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1-

270 bone cells is part of an autocrine feedback loop that regulates FGF23 expression during renal failur

271 nt of P-TEFb, generating a positive feedback loop that sustains transcription.

272 These principles include positive feedback loops that are required to destabilize a spatially unifo

273 GRN characterized by interlaced feed-forward loops that link developmental regulators with biosynthet

274 uggest this may represent one of the control loops that sense the ratio of photorespiratory to photos

275 in-a cationic patch and a unique hydrophobic loop-that are essential for accessing SM in bile salt mi

276 terial by including defect lines-dislocation loops-that are unique to three dimensions.

277 In the alternative "parallel" loop, the expected distance between the dyes is outside

278 wever, PKCdelta is unique in that activation loop (Thr(507)) phosphorylation is not required for cata

279 or betaEST and dFBr communicate with the Cys loop, through interactions between the last residue of p

280 , mevalonate created a positive feed-forward loop to activate MYC signaling via induction of miR-33b.

281 AR signaling and acts in a negative feedback loop to block AR function.

282 that miR-323-3p acts in a negative feedback loop to control the production of IL-22 in IL-22/IL-17-p

283 The molecule is initiating a feedback loop to enable its own movement.

284 MYC ESE looping to the transcriptional stat site of MYC was depe

285 l measurements of a ferroelectric hysteresis loop, to prove ferroelectricity's hallmark switchable po

286 MCM pore loops touch both the Watson and Crick strands, constrain

287 g double-strand breaks (DSBs) via a feedback loop triggered by crossover designation in C. elegans.

288 forms TADs and loops by extruding chromatin loops until it encounters CTCF, but direct evidence for

289 tic peptide corresponding to the HAP2 fusion loop was found to interact directly with model membranes

290 loop accumulation, and the accumulation of R-loops was exacerbated when both proteins were depleted.

291 By varying the strength of the loop, we analyze the precision of the first- and second-

292 this speckle wavemeter as part of a feedback loop, we stabilize a 780 nm diode laser to achieve a lin

293 esting MLV prefers smaller promoter-enhancer loops, whereas PB insertion encompasses larger chromatin

294 ransferase p300 acetylated in its activation loop, which could explain self-acetylation as an importa

295 R loops, which are mainly co-transcriptional, abundant RNA

296 e helicases is suppressed by destabilizing R-loops while Pif1 and Rrm3 binding to tDNAs is increased

297 This mechanism, which employs recurrent loops with an angular shift, bears a resemblance to thos

298 We identified a feedback loop within the NANCI (Nkx2.1-associated noncoding inter

299 eveals a dramatic conformational change in a loop within the PL-2 epitope due to a serine-to-proline

300 residues in a flexible disordered activation loop yields precise control of signal transduction.