ライフサイエンスコーパス: loop region

1 conserved sequence associated with the gp41 loop region.

2 the mode of action of these mutations on the loop region.

3 nal change of the Arg residue in the stromal loop region.

4 crystal structure in the conformation of the loop region.

5 t is associated with the membranotropic gp41 loop region.

6 tein family, SRSF2 structure has a longer L3 loop region.

7 exhibits an altered conformation within this loop region.

8 elial stem cells that reside in the cervical loop region.

9 contains three pseudouridine residues in its loop region.

10 with the C5 of its adjacent 3' uracil in the loop region.

11 a single-stranded configuration within the R-loop region.

12 ail sequence and not the inverted-repeat and loop region.

13 ce is demonstrated to be predominantly in DE loop region.

14 protein, specifically, ones containing the D-loop region.

15 llosteric control regulated via the Cbeta FG loop region.

16 ane space (IMS)-exposed charged unstructured loop region.

17 five Rpt subunits, most notably in its pore loop region.

18 gene in the minor arc, and the non-coding D-Loop region.

19 t of the protease and are located in surface loop regions.

20 n of contacting residues located in flexible loop regions.

21 und throughout the conformationally flexible loop regions.

22 t of conformational changes in two conserved loop regions.

23 ate failed to detect exposed thymines in the loop regions.

24 ght to occur via the porin's surface-exposed loop regions.

25 ones often move significantly, especially in loop regions.

26 luctuations are smaller than in the flexible loop regions.

27 docked ligand and the flexible extracellular loop regions.

28 matrix and go between its helices and in its loop regions.

29 erted differentiation of preexisting protein loop regions.

30 o influenced by substitutions in other outer loop regions.

31 alpha-helices, 70% in beta-sheets and 60% in loop regions.

32 ut metal bound are similar but differ in the loop regions.

33 with only some minor differences in surface loop regions.

34 hat assembled CA is dynamic, particularly in loop regions.

35 e of transmembrane helices and intracellular loop regions.

36 lternative protein backbone conformations in loop regions.

37 ependent on the position of the probe in the looped region.

38 We observed that loop regions 1 and 2 play an important role in the survi

39 inside neutrophils and dendritic cells, and loop regions 1 and 3 are needed for survival in macropha

40 Six tandem repeats of this stem-loop region (72 nt) of roX2 were enough for targeting th

41 e of the Arg(13)-Gln(14) peptide bond in the loop region, a catastrophic proteolytic event resulting

42 ace, and here we studied a role of the Ndc80 loop region, a distinct motif looping out from the coile

43 king site consists of side chains from three loop regions (AB, EF and BG) and part of the betaD stran

44 In sum, our data suggest that the loop region acts as a "hinge" around which the bulky hea

45 tant motifs within the N-terminal or central loop region affected crescent maturation and the immatur

46 inding domains) as foreign components to the loop regions allows the formation of active Mg(2+)- or Z

47 native beta-sheet, delimited by unprotected loop regions analogous to those of the native monomeric

48 ucts that were cyclically permuted in the V1 loop region and contained an N-terminal trimerization do

49 nges that instigate movement of the EF helix-loop region and make residues Lys70, Lys76, His88, and H

50 nique charged IgE epitope residues at the L2 loop region and on helix alpha3.

51 re generally very similar except for the A-B loop region and part of helix B (residues 15-31) which c

52 A model involving the movement of the B-C loop region and R108 between the open and closed conform

53 ors for tau exon 10, p68 binding at the stem-loop region and RBM4 interacting with the intronic splic

54 57L increases the flexibility of the motif 2 loop region and specifically A214, which may account for

55 f DHFR engineered within the Met20 catalytic loop region and study the protein's structural motion at

56 tes a reciprocal communication between the W-loop region and the nucleotide binding cleft on actin.

57 t the accessible conformational space of the loop region and thus reduces the entropic cost of KID fo

58 d a diversity of mitochondrial DNA (mtDNA) D-loop region and Y chromosome SNP markers in 25 male and

59 e (nanosecond to picosecond), except for the loop regions and certain helix-helix connections.

60 e secondary structural elements and variable loop regions and evaluate the method's performance in na

61 bserved, such as small inversions in hairpin-loop regions and indels, which were common in intergenic

62 five antiparallel strands separated by three loop regions and one 3 10-helical turn.

63 eractions between specific basic residues in loop regions and phosphate oxygens of the CL head group.

64 rst time includes refined helical bundle and loop regions and reflects a peptide-binding groove withi

65 Therefore, we hypothesize that these loop regions and the flexibility of the P domains play i

66 the presence of a 22-amino-acid N-terminal 'loop' region and its catalytic activity.

67 the alignment, with many in the important A-loop region, and others spread between the N and C lobes

68 RPV1 that are localized in the putative pore-loop region; and activation of TRPV1 by CFA1 is not excl

69 Instead, binding of a conserved loop region appears to compete with dimerization and anc

70 tween them and wild-type RpMatB was within a loop region approximately 23 A from the acetylation site

71 that the long noncoding RNA species in the D-loop region are generated by the extension of H-strand t

72 Afterward, the loop regions are compared one-to-one in accordance with

73 al beta-sheet and flanking alpha-helices and loop regions are formed.

74 h previous reports that amino acids in these loop regions are involved in differentiating AAV recepto

75 The AU element and stem-loop regions are phylogenetically conserved within dusB-

76 ions are strongly temperature-dependent, and loop regions are surprisingly mobile.

77 levels of flexibility, for example, exposed loop regions are usually more flexible than the core reg

78 luctuations in SH3, and in particular the RT loop region, are structurally diverse and are well-appro

79 na mtTyrRSs, highlight flexible terminal and loop regions as major sites for enzyme diversification,

80 and no mutations have been found within the 'loop' region as expected.

81 s, orchestrated by key residues in exofacial loop regions, as well as in membrane-spanning helices.

82 ompanied by loss of flexibility of two helix/loop regions, as well as of the C-terminal helix; (iii)

83 ulation of the channel, are located in the D-loop region at the center of the predicted dimer interfa

84 Structural analysis revealed a loop region at the N terminus as a putative acceptor sub

85 binds in an orientation that disrupts the BC-loop regions at the P450 dimer interface and results in

86 ce of Top2alpha-DNA complexes in the mtDNA D-loop region, at the sites where both ends of 7S DNA are

87 Modeling actin's D-loop region based on our 3.9 A cryoEM reconstruction sug

88 hat the SP-A lectin site and the surrounding loop region become more compact.

89 Guided by structural differences in the loop region between beta4 and beta5 strands, we identifi

90 site is composed of residues in EF4 and the loop region between EF3 and EF4, confirmed by mutagenesi

91 The PIP2 binding site includes the Loop region between Helix2 and Helix3 in the EIAV MA.

92 of the HNP family, with the exception of the loop region between the first and second beta-strands.

93 ntracellular C-terminal domain (CTD) and the loop region between the M1 and M2 helices move during ac

94 of the protein backbone of the so-called 60s loop region between the two flavodoxins.

95 effectors through (i) insertion/deletions in loop regions between alpha-helices, (ii) extensions to t

96 nificant residues are located, namely in the loop regions between helices C and E, E and F, and F and

97 (betaB to betaI) beta-barrel core and large loop regions between the strands which form the capsid s

98 tranded anti-parallel beta-barrel with large loop regions between the strands.

99 nformations of the so-called helix B and rim loop regions, both of which are implicated in interfacia

100 anism that yields functional RNAs from miRNA loop regions, broadening the repertoire of Argonaute-dep

101 tion properties of the H5 hemagglutinin stem loop region by site-directed mutagenesis.

102 Engineering of these loop regions can alter protein stability, substrate bind

103 ut disregard the length details of helix and loop regions, can improve the performance of structure p

104 The Ser(36) is located in a loop region close to the entrance of the proposed substr

105 ls significant structural differences in the loop regions compared with other TIR domain structures.

106 a stem, with fluorophore/quencher pair and a loop region complementary to the desired DNA.

107 A unique loop region comprised of residues (536)Y-N-G-H-P-P(541),

108 conformational difference in the C-terminal loop region (comprising residues 170-176 and 195-206).

109 Here, we have identified the flexible loop region connecting the bulky enzymatically active he

110 peptide) corresponding to the extracellular loop region connecting the S5 and S6 segments of the HER

111 fy an intrinsically unstructured cytoplasmic loop region connecting transmembrane helices 5 and 6 (CL

112 ne helices (TM) 7, 10, and 11 and associated loop regions contain the amino acids that are important

113 y MpPR-1 requires the presence of a flexible loop region containing aromatic amino acids, the caveoli

114 ons of the RNA are important for activation, loop regions contribute as well.

115 s, including the sequences flanking the stem-loop region, contributed to high affinity EWS binding an

116 tyrosine and phenylalanine in the catalytic loop region could serve as a signature residue to reliab

117 easoned that lasso peptides cleaved in their loop region could serve as building blocks for catenanes

118 loops connecting the TMHs, suggesting these loop regions could be involved in gating H(+) release to

119 on of conformational flexibility in terminal loop regions could explain the presence of multiple homo

120 Here, using select loop-region Cys from the single cytoplasmic loop of subu

121 POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulato

122 tify amino acids within the N terminus and a loop region distal to the nucleotide binding pocket of T

123 Mobile loop regions distal to the active site exhibit significa

124 cular basis for the epitope at the disulfide loop region (DLR) of the principal immunodominant domain

125 s pocket as well as the second extracellular loop region (ECL2).

126 ectively incorporated into the extracellular loop regions (ECLs) of GCGR and GLP-1R, two members of c

127 The loop region extended from the compact core in the crysta

128 Thus, the AP site in any loop region facilitates the formation of the propeller l

129 The third inter-repeat loop region (Finger 3 loop) is flexible and may act as a

130 residue Tyr322 became disordered as did the loop region flanking it.

131 whereas the D0 domain of the KIR3DLs binds a loop region flanking the alpha1 helix of the HLA molecul

132 ement for negatively charged residues in the loop regions for divalent ion binding.

133 releasing the Mg(2+) cofactor highlights two loop regions for which fragmentation increases upon UVPD

134 Helix 69 (H69) is a 19-nt stem-loop region from the large subunit ribosomal RNA.

135 yclopropanecarboxylic acid (Ac3c) residue in loop regions greatly enhances the stability of beta-heli

136 Mutations that disrupted the helices, or the loop region, had profound effects on channel gating, shi

137 l CTLD-containing proteins, including a long loop region hydrophobic core associated with calcium-dep

138 icates that phosphorylation of an N-terminal loop region in APC1 is sufficient for binding and activa

139 ervations are consistent with a role for the loop region in cis-CaaD specificity and catalysis, but t

140 s from the conformation of the corresponding loop region in crystal structures of free SNase.

141 Furthermore, the shorter loop region in Mtb DsbF results in a more solvent-expose

142 idation of the model and conformation of the loop region in NKR-P1C were addressed using ion-mobility

143 ate the role of key residues and the 116-128 loop region in substrate binding and turnover.

144 ecifically interacted with the variable-stem-loop region in the 3' NTR and domain IIId of the HCV-IRE

145 Furthermore, a highly acidic loop region in the ARC2 domain and basic patches in the

146 ng to MMRN2 is dependent on a predicted long-loop region in the C-type lectin domain and is abrogated

147 is report, we have identified the MT-LOOP, a loop region in the catalytic domain of MT1-MMP ((163)PYA

148 tability is observed upon modifications of a loop region in the enzyme acylphosphatase and is achieve

149 requires replacement of the three amino acid loop region in the fingers domain of Tgo-Pol with a long

150 s, and it was revealed that the more rigid P-loop region in the G2032R-mutated ROS1 was primarily res

151 nterface but, rather, triggers movement of a loop region in the propeptide that modulates access to t

152 n the proportion of IgG specific for certain loop regions in AMA1 surrounding the binding site of RON

153 ing to interpret the conformation of protein loop regions in terms of single dominant structures.

154 e N terminus of Cullin5 for interaction with loop regions in the first cullin repeat of Cullin5.

155 F causes a structural stabilization of three loop regions in the mature part, possibly through a dire

156 re formed through large, rare motions of the loop regions in trypsin.

157 We conclude that the loop-regions in subunits a and c that are implicated in

158 ences between maize and barley LTP in the AB loop region, in residues at the base of the hydrophobic

159 Meanwhile, the motion of Spy's flexible loop region increases, allowing for better interaction w

160 tenuate microsecond-timescale motions of the loop regions, indicating that preorganization of the met

161 Mutations that restrain the terminal loop region inhibit Drosha processing of primary microRN

162 Our study indicates that the three loop regions interact with the core G-tetrads in a speci

163 hange of up to 38 A in the N terminus, and a loop region involving Tyr(38)-Tyr(39).

164 We therefore propose that the MT-LOOP region is an interface for molecular interactions t

165 i has the following unique features: (i) the loop region is closed by a Watson-Crick base pair betwee

166 In the pH 3.5 structure, the EF helix-loop region is completely disordered.

167 We conclude that a flexible terminal loop region is critical for microRNA processing.

168 ts of a number of short stem-loops where the loop region is disordered.

169 tochondrial 5-methylcytosine levels in the D-loop region is found in the substantia nigra in Parkinso

170 e of the polypeptide sequence, another hinge-loop region is observed between strands beta7 and beta8

171 We also show that this Esa1 Tudor domain loop region is positioned close to nucleosomal DNA and t

172 shing ligand residue approximation with this loop region is unique among family members and may help

173 s appear not only in cases where the Pro-Xaa loop-region is altered, but also when seemingly subtle a

174 structural similarity to ephrinB2 at the G-H loop region known to be involved in receptor binding.

175 dases including spinach glycolate oxidase, a loop region, known as loop 4, is completely visible when

176 Structural comparison highlighted two loop regions, L3 and L4, as potential sites of interacti

177 d three helix-bundled structure and a "bait" loop region linking helixes 1 and 2.

178 The loop region linking the beta-strands (loop 4) presents r

179 dition, the enzymatic digestion at the Lys28 loop region linking the two beta-sheets in Abeta fibrils

180 Each monomer has flexible loop regions linking the core alpha-beta-alpha sandwich

181 Both substitutions co-localize to a variable loop region located between the fourth beta-sheet and th

182 und in the sequence PNAIG) within a flexible loop region (loop 2) within the central core region.

183 l and mitochondrial dynamins, however, where loop regions manage membrane recruitment.

184 We also observe that the loop regions may exhibit unique flexibility, especially

185 a cluster of RP mutations in the intradiscal loop region, mediate dose-dependent rhodopsin destabiliz

186 Loop region mutations lead to a wide range of topologies

187 rmational behavior of the 5' half of the H69 loop region, observed as broadening of C1914 non-exchang

188 is region are removed, translocation of this loop region occurs largely by a YidC- and Sec-independen

189 e repair of a DNA base lesion located in the loop region of a CAG repeat hairpin can remove the hairp

190 substitution (Cys227Ser) in the predicted E-loop region of aquaporin 11, is responsible for the sjds

191 ely, synthetic peptides corresponding to the loop region of Bcl-2 were sufficient to potently inhibit

192 We found that an 8-oxoguanine located in the loop region of CAG hairpins of varying sizes was removed

193 gnificant changes in the dynamics of the F-G loop region of CBD2 that merit further characterization

194 These in silico studies showed that the B-C loop region of CYP2C9 moves away from the heme to a posi

195 rs, we found that a cysteine placed in the Q-loop region of DrrA traps DrrA in the dimeric state, thu

196 se antibodies to the highly conserved fusion loop region of E domain II.

197 The beta2-alpha2 loop region of endogenous prion protein, PrP(C), has bee

198 Env mutant containing a substitution in the loop region of gp41 (D589L) mediated transfer of lipids

199 The loop region of gp41 is also known as principal immunodom

200 For example, MAbs against the external loop region of gp41 made the most effective ITs against

201 roduction of truncated versions removing the loop region of gp41 or the utilization of nonphysiologic

202 The highly conserved stem loop region of hemagglutinin has been shown to undergo c

203 teristic fragment of the mitochondrial DNA D-loop region of horse onto the surface of magnetic microc

204 Here, we show that the terminal loop region of human primary microRNA transcripts is an

205 nd that Lin28 selectively binds the terminal loop region of let-7 precursors in vitro and that the lo

206 antibody that specifically recognizes the MT-LOOP region of MT1-MMP (LOOPAb) inhibited MT1-MMP functi

207 n enzyme, and the damage to the displacement loop region of mtDNA (D-loop) were analyzed in the retin

208 Mapping of Top1mt sites in the regulatory D-loop region of mtDNA in mitochondria revealed the presen

209 l 5-methylcytosine levels are found in the D-loop region of mtDNA in the entorhinal cortex in brain s

210 peptide constructs of the thrombin-sensitive loop region of murine anticoagulant protein S.

211 tive, including residues in the beta2-alpha2 loop region of PrP.

212 ious studies have implicated the beta6/beta7 loop region of SrtA in LPXTG recognition but have not sy

213 addition to the previously identified hinge-loop region of the 3D domain-swapped dimer, which reside

214 Replacing human PDE5 residues in the M-loop region of the binding site for the PDE5-selective i

215 ent DNAzyme, and a sequence identical to the loop region of the coadded hairpin structure.

216 the affinity on the sequence of bases in the loop region of the DNA.

217 Together, these results suggest that the loop region of the fingers domain may play a critical ro

218 d through insertion of TagRFP in a conserved loop region of the Galpha subunits.

219 idence of a capping structure within the top loop region of the i-motif.

220 hosphorylation of Thr(383)/Thr(387) in the T-loop region of the kinase domain an event that is a prer

221 E329 lies within the glycine-rich loop region of the kinase.

222 version and have found that the beta2-alpha2 loop region of the mouse prion protein (residues 165-175

223 GC-1alpha was specifically enriched at the D-loop region of the mtDNA, which contains the promoters f

224 conclude that 'rigidity' in the beta2-alpha2 loop region of the normal conformer of PrP has less effe

225 ptide from 1 protofilament connecting to the loop region of the peptide in the opposite protofilament

226 n 164 (mouse numbering), in the beta2-alpha2 loop region of the prion protein, to attempt to decipher

227 hT insert into the channel that forms in the loop region of the protofibril, sandwiched between two s

228 increase the susceptibility of the EF helix-loop region of the TTR B subunit to undergo conformation

229 y the direct association of an intracellular loop region of these proteins with Ca2+-CaM.

230 ing domain (aa 129-150) of the intracellular loop region of this connexin exhibited a high affinity,

231 previous work demonstrated that the 3' stem-loop region of U6atac snRNA contains a U12-dependent spl

232 es of chimeras in which putative DNA binding loop regions of APOBEC3G were replaced with the correspo

233 Deletion of the flexible loop regions of Bcl-2 and Bcl-X(L), which are located be

234 tions coincided with predicted extracellular loop regions of both P2 and P5.

235 sequences derived from various intracellular loop regions of G protein-coupled receptors (GPCRs) are

236 ify amino acid residues, predicted to lie in loop regions of GerVB on the exterior aspect of the memb

237 We also showed that substitutions in the loop regions of iMs give a distinctly different kinetic

238 between the amino acid sequences in flexible loop regions of native states and the corresponding expe

239 re small regulatory RNAs processed from stem-loop regions of primary transcripts (pri-miRNAs), with t

240 structural differences, particularly in the loop regions of the GI.7 P domain, altering its surface

241 old, despite substantial movement of several loop regions of the mutant, and, therefore, represents a

242 rmation including the functionally important loop regions of the protein structures.

243 hertz frequencies studied, the extracellular loop regions of the protein systems become vibrationally

244 e lowest frequencies probed, the cytoplasmic loop regions of the proteins are highly active; and at t

245 s of which corresponded to the more flexible loop regions of the proteins.

246 id substitutions lie in two highly conserved loop regions of uS12 with known roles in maintaining the

247 d by CAP-Gly varies, particularly around its loop regions, permitting its interaction with multiple b

248 ies provide strong evidence that the size of loop regions plays a critical role in determining the mo

249 ggest that the number of cysteines in the TM loop region readily distinguishes between covalent and n

250 n also bound recombinant EDA within the C-C' loop region recognized by the alpha(9)beta(1) integrin.

251 tended by a secondary motif formed by unique loop regions, recognizing 6-O-sulfated galactose dictate

252 erized by short runs of guanine separated by loop regions, regardless of the nature of the loop seque

253 at the primary structure of the beta2-alpha2 loop region (residues 165-175) in mammalian prion protei

254 A loop region (residues 243-266) near the purine base beco

255 pth analysis of phosphorylation within the T-loop region (residues 366-406).

256 Both stem and loop regions show high levels of sequence constraint whe

257 m wet-lab experiments in which the LEL delta-loop region showed a pronounced flexibility.

258 in distinct ways through diversification of loop region structure and composition in EC2 and EC3, wh

259 PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/g

260 gand-associated conformational change in the loop region surrounding the lectin site, one not previou

261 The gp41 disulfide loop region switches from a soluble state to a membrane-

262 Although the dynamic loop region targeted by these compounds presents challen

263 zinc finger and an approximately 40-residue loop region that appear to play roles in protein stabili

264 y site-directed mutagenesis, we identified a loop region that connects the A-box and B-box domains of

265 nvolved in maintaining the conformation of a loop region that covers the gamma-glutamyl binding site.

266 osylation of Srr2 and identified a conserved loop region that is crucial for acceptor substrate bindi

267 nds and multiple conformations of a flexible loop region that is thought to be involved in lipid bind

268 agonist segment with the third extracellular loop region that it has been shown to photolabel.

269 how that these mutations are in a loop-helix-loop region that positions the key residues of the catal

270 from those of other parvoviruses in surface loop regions that control receptor binding, tissue tropi

271 Loop regions that exhibit the most conformational flexib

272 flexibility within the hydrophobic core and loop regions that orient the DNA binding helices.

273 Several mobile loop regions that restrict access to the cofactor-bindin

274 slate to extensive structural changes in the loop regions that significantly alter the surface topogr

275 )N spin-relaxation NMR spectroscopy of three loop regions that surround the active site and contain f

276 geting porcine mitochondrial displacement (D-loop) region that yielded an unique amplicon of 712 base

277 sites can be found within Envelope variable loops, regions that play an essential role in HIV pathog

278 "off switch" into a catalytically essential loop region (the "WPD loop") of a protein tyrosine phosp

279 With deletions or mutations of the loop region, the lateral KT-MT attachment occurred norma

280 tamer engineering that involves removing one loop region, then systematically modifying the number of

281 The Ndc80 loop region, therefore, has an important role in the con

282 tructure of the Ad14P1 fiber knob in the F-G loop region, this did not significantly change the fiber

283 bility and/or altered structure in the hinge-loop region to accommodate the large conformational chan

284 190 act in concert with the flexible EF3/EF4 loop region to effectively form different peptide-bindin

285 tudies underscore the importance of the stem loop region to HA function and suggest potential sites f

286 conserved alpha-helix for COI1 docking and a loop region to trap the hormone in its binding pocket.

287 ositioning of the functionally important "BB-loop" region to a location more typical for TIR domains.

288 NMR structural ensembles are found in three loop regions, two of which undergo motions that are of f

289 licing regulators interacting with this stem-loop region using an RNA affinity pulldown-coupled mass

290 The Ndc80 loop region was required for Ndc80-Dam1 interaction and

291 d that RCC1 uses a conformationally flexible loop region we have termed the switchback loop in additi

292 rm the oxyanion hole and movement of the lid loop region when the active site is occupied.

293 tiary structure tend to be least accurate in loop regions, where non-canonical pairs are important fo

294 protein, and in parts of the E helix and CE loop regions, whereas in the equilibrium intermediate, a

295 dimer-dimer interaction involves a variable loop region, which differs in length and sequence from t

296 In contrast, the H69 UUU loop region, which lacks Psi modifications, is less orga

297 1I changed the flexibility of the 110-to-115 loop region, which may affect deoxynucleoside triphospha

298 The beta2-alpha2 loop region within PrPC varies substantially between spe

299 Two studies now demonstrate that a conserved loop region within the extended coiled-coil of Ndc80 pla

300 Furthermore, loop regions within junctions are high in adenine but lo