ライフサイエンスコーパス: loose

1 Her stools were variably loose.

2 crossover trial of tight (80-110 mg/dL) vs. loose (120-150 mg/dL) glycemic control in patients with

3 ediates 11b-d on treatment with zinc bromide loose a molecule of benzotriazole followed by intramolec

4 Images of in situ and loose accumulations of abundant, haematite-rich spherica

5 recision of blastx-based annotations without loosing accuracy.

6 the result of a conformationally flexible or loose active site that adapts with small energetic cost

7 natural dNTPs, due to their low fidelity and loose active site, but are limited by poor processivity

8 which suggests that the surface deposits are loose aggregates.

9 Sociality based on loose aggregation is followed by a second shift to stabl

10 Loose aggregations of fishes, or shoals, are a basal soc

11 These studies demonstrate a loose allosteric coupling of the agonist-binding site an

12 rn in the middle of the exon 9 peptide and a loose alpha-helical conformation for the rest of the pep

13 the window training approach, which includes loose alternating interlimb coordination, is more effect

14 to the RASopathy, Noonan-like syndrome with loose anagen hair (NS/LAH).

15 -a-string structures that combine regions of loose and compact fiber independently of the characteris

16 tain different types of aggregates including loose and dense aggregates, as well as hydrodynamically

17 m1 causes failure of the cytoplasm to become loose and detach from the head and the neck region of th

18 d localized) in the swollen phase but large (loose and spread out) in the dense phases.

19 w some limits were circumvented, and compare loose and tight limits.

20 s revealed spontaneous transitions between a loose and tightly zippered state at the SNARE complex C

21 These results suggested that the loose and transient interaction between T20 and T1144 ma

22 en mixed in solution, T20 and T1144 showed a loose and transient interaction, with a moderate 10% alp

23 properties, such as higher shear strength in loose and wet forms.

24 actions of phosphate and sulfate esters are "loose" and indistinguishable from that in solution, sugg

25 es, together with simulations, emphasise the loose architecture of the AMPAR extracellular region (EC

26 unit length that is consistent with a rather loose arrangement of nucleosomes.

27 are deformable, which is consistent with the loose arrangement of pentamers and latticework of holes

28 ansfer quenching is mediated by a relatively loose arrangement.

29 The relatively loose (as seen in solution) tetramer interface is assemb

30 neurotransmission is thought to occur via a loose association between nerve varicosities and smooth

31 In both reactions, loose association of the NADP(H) was followed by two con

32 ed upon Brefeldin A exposition, indicating a loose association with Golgi membranes.

33 ts indicate that human pol delta maintains a loose association with PCNA while replicating DNA.

34 lls with low pH or denaturants, suggesting a loose association with the cell wall or cell surface.

35 rack contact points of alternating tight and loose attachment convert domain rotations to unidirectio

36 h, which allows robust distinction between a loose attachment with low tension and a strong attachmen

37 oximately 7 degrees , resulting in tight and loose axial subunit packing in the rod and hook, respect

38 delayed, and numerous axon-SC profiles show loose basal lamina, suggesting altered interactions of t

39 aining different surface functionalities and loose beads such as titania and zirconia for phosphopept

40 e Aalpha406-483 fragment identified a second loose beta-hairpin formed by residues 459-476, yielding

41 n beta-PGM is consistent with the relatively loose binding indicated by the large K(m) for Mg(2+) act

42 Loose binding may enable small cageless chaperones to he

43 their low surface energy suggests relatively loose binding of H2O on the internal and external surfac

44 We propose that upon initial loose binding of MgATP at two nucleotide-binding domains

45 pre-exponential factor, probably due to the loose binding of X inside the cage.

46 through subtle conformational changes into a loose binding site in which hydrolysis occurs faster.

47 b-Angstrom gradual changes between tight and loose binding site structures dramatically alter the hyd

48 restoration role of resveratrol toward some "loose-binding" substrates of SIRT1, and has significant

49 The resulting loose, black powders are convenient materials for chemic

50 emoral acetabular impingement, labral tears, loose bodies and chondral lesions.

51 ear similarities, including effusions, large loose bodies, and bubbling and delamination of the carti

52 Transmission initially involved a "loose" bottleneck, which became strongly selective after

53 nd application of steroid ointments improved loose bowels and skin lesions as well as laboratory data

54 olute size and introduces what seems to be a loose but clade-wide mammalian constraint on head shape.

55 , showing that transmission is governed by a loose, but highly variable, transmission bottleneck whos

56 and CD8, whereas CD2(+) subsets can gain or loose CD8.

57 ntricate interplay may enhance the spread of loose cell ensembles in pathophysiological conditions su

58 most common ALCB management practice is the loose cell system, in which cocooned bees are removed fr

59 Proliferation was modestly reduced in the loose cells of the sclerotome.

60 DVL prevents NEK2-controlled dissolution of loose centrosomal linker and subsequent centrosomal sepa

61 dense clustering of hydrogen bonds within a loose chemical network.

62 This loose chemomechanical coupling is represented by the loo

63 greater transcriptional variation with only loose clustering of strains with different phenotypes.

64 experiments, we observed CART expression in loose clusters of spinocerebellar mossy fibers in the mo

65 acting on the transmembrane segment produce loose clusters, while cytoplasmic protein interactions m

66 n chlorine additions, and behave as soft (or loose) clusters in solution.

67 mble a loosely coiled NC-like structure; the loose coil can be condensed by binding of the viral matr

68 that cells move on planar surfaces and in a loose collagen matrix using prominent, curved planar pro

69 yosin II signaling on a 2D substrate or in a loose collagen type I matrix.

70 In the second phase, the loose collection of bacteria in the IBC matured into a s

71 ervations have shown that some asteroids are loose collections of rubble rather than solid bodies.

72 h as the beta(2)AR, previously shown to form loose complexes with beta-arrestin ("class A") promote a

73 th muscle cell-rich fibrous tissue (12%) and loose connective tissue (9%).

74 5-4.0 mm) contained valve tissue composed of loose connective tissue (collagen and elastic fibers) wi

75 haly, digital abnormalities, hypospadias and loose connective tissue) and resemble one another facial

76 found sparsely in the stroma of subcutaneous loose connective tissues.

77 ith that from LHCI to the PSI core, suggests loose connectivity between LHCII and PSI-LHCI.

78 Comparison of these loops revealed a loose consensus sequence.

79 noderms and vertebrates, possibly reflecting loose constraints on the primary structures of the prote

80 contact with the neural tube, and they never loose contact with the neural ectoderm.

81 ose was under tight control as compared with loose control (3.2 +/- 0.6 vs. 2.4 + 0.4, p = .02 [whole

82 ction in pi overlap (as these two p-orbitals loose coplanar state) resulting in a very weak -M effect

83 Scattered genes with relatively loose correlations should be excluded from the clusters.

84 line with the previously observed unusually loose coupling between nucleotide and actin binding to n

85 l energy of ATP hydrolysis is used through a loose coupling between the chemical reaction and the tra

86 hrough integration of local activity inputs, loose couplings with neighboring cortical columns, and g

87 att1 has a loose cuticle membrane ultrastructure and shows increase

88 nd 11.7 kcps/MBq at the center for tight and loose cuts, respectively, increased to 8.8 and 13.9 kcps

89 ing rate of 19.5 and 22.7 kcps for tight and loose cuts, respectively, was achieved for an activity c

90 rgy and timing cuts-400-650 keV and 7 ns-and loose cuts-350-700 keV and 10 ns.

91 se skin for salt rejection and (ii) a fairly loose dense skin for emulsified oil particle rejection.

92 The bacteria associated with loose deposits and pipe wall biofilm that accumulated in

93 cteria, and the contributions of bacteria in loose deposits and pipe wall biofilm were comparable.

94 The accumulation of loose deposits and the aging process create variable mic

95 ose deposits were dependent on the amount of loose deposits locally.

96 Moreover, loose deposits protect the associated bacteria from disi

97 ess create variable microenvironments inside loose deposits structures for bacteria to grow.

98 system; however, the communities present in loose deposits were dependent on the amount of loose dep

99 sociated bacteria (from suspended solids and loose deposits) have long been neglected.

100 teria within the phases of suspended solids, loose deposits, and pipe wall biofilm were similar in ph

101 Depending on the amount of loose deposits, its contribution can be 7-fold higher th

102 er, pipe wall biofilm, suspended solids, and loose deposits, were quantified and identified by adenos

103 phases, especially the bacteria harbored by loose deposits.

104 ree enzyme to NO induces dissociation of the loose dimer into monomers in a reaction that follows sin

105 synthase dimer arrays, which differ from the loose dimer rows in all other organisms observed so far.

106 aphic structure of the Bacillus subtilis NOS loose dimer shows an altered association state with seve

107 The loose dimer structure indicates that non-native interact

108 nverts nitric oxide synthases (NOSs) from a "loose dimer", with an exposed active center and higher s

109 H4B, the enzyme is a mixture of monomer and loose dimer.

110 Ligand binding or heme reduction converts loose dimers to tight dimers in solution and crystals.

111 ukaryotic NOSs affect the propensity to form loose dimers.

112 hydrolysis of phosphate monoesters through a loose, dissociative transition state, similar to that in

113 d macrophages were present in the linear and loose ECM of inflamed colons and polarized to the M1 phe

114 , we find that both types of apparatuses can loose elements of their cytoplasmic region, which may th

115 n the absence of BBG, these junctions become loose, enabling the intestinal flora to trigger a consti

116 re less discriminating than those toward the loose end.

117 ns alpha0-beta6 whereas intermediate I2 is a loose ensemble of states with N-terminal structure varyi

118 d patient presented with lymphedema, protein loosing enteropathy, and sclerosing cholangitis and was

119 e findings of microcysts, fingerprint lines, loose epithelium, and/or faint scars.

120 subunit in these cells converts them from a "loose" epithelium, characterized by low expression of E-

121 l fluoride with azide ion proceeds through a loose (exploded) transition-state (TS) structure.

122 on beta1 or beta2 integrins, was observed in loose fibronectin and collagen regions, whereas T cells

123 because of a more open NBP but because of a loose fit of substrates bound in the catalytic centers.

124 The spore is surrounded by an exosporium, a loose-fitting membrane composed of proteins and carbohyd

125 of B. anthracis are enclosed by a prominent loose-fitting structure called the exosporium.

126 ause of anthrax, are enclosed by a prominent loose-fitting structure called the exosporium.

127 of WOX3 function in M. truncatula leads to a loose-flower (lfl) phenotype, where defects are observed

128 ution structure of PDEgamma, which reveals a loose fold with transient structural features resembling

129 the dense form of the light stripes and the loose form of the dark stripes.

130 dense iridophores but down-regulated in the loose form.

131 spirasome)-a major 'tight' form and a minor 'loose' form (resolved at the resolution of 5.8 A and 6.7

132 w modality for physicians to address chronic loose, frequent stools with FI in patients with CMI in t

133 hronic mesenteric ischemia (CMI) for chronic loose, frequent, and urgent stools.

134 complex, but did not affect formation of the loose FXa-TFPI complex.

135 However, the loose GAC particles and slow kinetics of this primitive

136 It reveals a predominant contribution of loose H bonds even for fully hydrated states, irrespecti

137 nd acceptor, and results show the need of a "loose" H-bond acceptor for improved adduct stability.

138 a low tolerance of deviant behavior) versus loose (have weak social norms and a high tolerance of de

139 ure, the long PEVK peptide retains residual, loose helical configurations.

140 he simulations show chromonic columns with a loose hexagonal packing and an intercolumn distance of 2

141 rising two helices packed together through a loose hydrophobic core and connected by an unstructured

142 mational dynamic profile, making hinges more loose (i.e., softening the hinges), thus impairing the a

143 as CXCL12-expressing stromal cells, and only loose infiltrates of T cells are present.

144 ve design was used for glycemic control with loose insulin (n=33) for the initial 2 yrs or intensive

145 15% reduction in 33 patients treated with a loose insulin protocol.

146 Mortality was similar in the intensive and loose insulin treatment groups (14% vs. 15%, p=.9), as w

147 y establish "head-to-shoulder" contacts with loose interactions between each other.

148 ross tight subunit interfaces but not at the loose interfaces, indicating that DNA-binding is governe

149 inhibits GluA2Q(flip) by forming an initial, loose intermediate that is partially conducting; however

150 rom intrauterine arrest of compaction of the loose interwoven meshwork of the fetal myocardial primor

151 ng the initial state of quenching, viz., the loose ion pair and the exciplex, based on the time-resol

152 ere interpreted in terms of the tight versus loose ion pairing in RTILs.

153 Furthermore, we observed that Numb looses its characteristic membrane localization in fibro

154 proaches the cloaca but the tip subsequently looses its integrity.

155 In the absence of Mg+2, pol X looses its selectivity for short ssDNA gaps.

156 e selectivity filter together as a unit in a loose "knock-on" mechanism of permeation in both inward

157 rough three conformational stages designated loose (L), tight (T), and open (O) in a concerted fashio

158 The network constructed from these loose leader-follower relations is hierarchical, and the

159 k earlier; (3) mSNA (modified SNA), SNA plus loose ligation of the adjacent L4 spinal nerve with infl

160 Such loose linkage between the alphaI and betaI is attributed

161 "traditional" diarrhea case definition (>/=3 loose/liquid stools within 24 hours).

162 t diarrhea or 1-2 vomiting episodes plus 1-2 loose/liquid stools within 24 hours).

163 nds is from the intrinsic fluctuation of the loose loops flanking the cofactor at the function site.

164 taRD1 predominantly produces nonnecrotizing, loose macrophage aggregates.

165 ely redundant for motility and chemotaxis in loose matrices.

166 es also had larger hemorrhage (P = .003) and loose matrix (P = .014) areas and a smaller lumen area (

167 4), neovasculature (r = 0.68, P < .001), and loose matrix (r = 0.42, P = .03) content.

168 1), neovasculature (r = 0.71, P < .001), and loose matrix (r = 0.50, P = .01) content.

169 eovasculature, necrotic core, calcification, loose matrix, and dense fibrous tissue.

170 contexts, including locomotion in fluids and loose media, impact and penetration problems, and geospa

171 one floccular biofilm, consisting of small, loose, microbial aggregates, and one granular biofilm, f

172 ting of mmu-let-7a duplex-bulges stabilizes "loose" miRNA:mRNA target associations and functions to e

173 minority member of communities in the outer (loose) mucus layer, in the cecum and colon, starting at

174 y, suggesting that these two pathways form a loose network involved in polarized cell migratory movem

175 We find a loose network of filaments, growing over time, which int

176 He reported having loose, nonbloody stools.

177 The results show a loose nucleosome array on the Nanog gene promoter in und

178 The results revealed two loose nucleosomes, N1 at -44 (3' boundary) from the tran

179 exhibiting secondary structure elements with loose or absent tertiary contacts, represent important i

180 Pressureless sintering of loose or compacted granular bodies at elevated temperatu

181 lectivities are proposed to be the result of loose or tight cation-dienolate ion pairs.

182 Patients with diarrhea, defined as loose or watery stool, and two or more Clostridium diffi

183 ent risk factors in women are advancing age, loose or watery stools, more than 21 stools per week, mu

184 Independent risk factors in men are age, loose or watery stools, poor self-rated health, and urin

185 IBS symptoms, bloating, abdominal pain, and loose or watery stools.

186 forms large networks that in colon build the loose outer mucous layer that provides the habitat for t

187 ucture of randomly close-packed and randomly loose-packed sediments is determined by the well-known s

188 luminates various data, including the random-loose-packed state.

189 ellular domain beta-sandwich cores, and that loose packing contributes to their ability to rapidly sw

190 approaches in frictional systems the random loose packing limit, varphiRLP = 0.55.

191 Loose packing of hydrophobic cores is not infrequent in

192 We propose that loose packing of the hydrophobic beta-core developed as

193 These results are consistent with the loose packing of the M2 segments inferred from the struc

194 gand-gated ion channels are characterized by loose packing of their extracellular domain beta-sandwic

195 structure of the mature fibrils demonstrate loose packing with ~1 peptide per 4.75 Abeta-sheet repea

196 that the loosest way to pack spheres (random loose packing) gives a density of approximately 55 per c

197 of indistinct tight junctions, and areas of loose paracellular spaces.

198 to the receptor involves the formation of a loose, partially conducting channel intermediate, which

199 s, did not form self-supporting gels and had loose particle arrangements.

200 the association of pyrethroid residues with loose particles in runoff water from concrete surfaces a

201 ponge-wipe method to collect and analyze the loose particles on concrete.

202 The importance of loose particles should be considered when developing pra

203 packing fraction is increased sufficiently, loose particulates jam to form a rigid solid in which th

204 Here, we use dual perforated/whole-cell and loose patch clamp on isolated OHCs to sequentially recor

205 Loose patch photolysis allows the measurement of transme

206 In addition, loose patch photolysis revealed that the influx of Ca(2+

207 The novel loose patch photolysis technique allowed the dissection

208 The developed loose patch photolysis technique can provide striking ne

209 from excitation at apical, middle, and basal loose patch sites before and after perforated patch rupt

210 equency tuning and ITD tuning during in vivo loose-patch (juxtacellular) recordings from principal ne

211 intracellular recordings and a custom-built loose-patch amplifier, we have recorded unitary granule

212 Here, by combining in vivo loose-patch and whole-cell recordings, we found that com

213 Using loose-patch current-clamp recordings in brainstem slices

214 Loose-patch electrophysiological recordings of SCN neuro

215 differentiation during cochlear maturation, loose-patch extracellular recordings were made from ANF

216 signals were recorded extracellularly with a loose-patch pipette.

217 The spiking response, measured with loose-patch recording, adapted despite essentially no ga

218 orescent protein (RFP), followed by targeted loose-patch recordings and two-photon imaging of calcium

219 In vitro, loose-patch recordings from RTN neurons show that P2 rec

220 Loose-patch recordings in the hindbrain and spinal cord

221 Simultaneous cell-attached loose-patch recordings of Na(+) currents on each membran

222 Patch-clamp and loose-patch recordings revealed severely affected inhibi

223 Finally, whole-cell and loose-patch recordings were also performed on slices fro

224 Loose-patch recordings were used to demonstrate for all

225 Using a combination of in vivo loose-patch recordings, iontophoretic drug application,

226 Using in vivo loose-patch recordings, we found in excitatory neurons i

227 Using paired somatic whole-cell and axonal loose-patch recordings, we show that action potentials r

228 ways be an ideal transition state analog for loose phosphoryl transfer transition states.

229 the polymer chain and (ii) the formation of loose polymer aggregates.

230 tail loop enables the nucleoprotein to form loose polymers as well as rigid helices, both of which a

231 Spirorbid tubes are comprised of a loose prismatic fabric of calcite crystals.

232 Microcompartments are loose protein cages that encapsulate enzymes for particu

233 e unbound form of the SAM-II riboswitch is a loose pseudoknot structure that periodically visits conf

234 tosensitive if the reaction pathway involves loose radical ion pair states.

235 Subsequent pilot-level trials using 1kD, loose reverse osmosis (LRO) and reverse osmosis (RO) spi

236 ic assemblies - a flexuous, helical rod or a loose ribonucleoprotein.

237 n of both alpha- and beta-mannosides involve loose S(N)2-like transition-state structures with signif

238 d to guide tight-seal whole-cell somatic and loose-seal cell-attached axonal/dendritic patch-clamp re

239 ripts due in part to direct recognition of a loose sequence motif.

240 temporal input patterns tend to fire in some loose, sequential manner that is reminiscent of experime

241 ix to improve the mechanical strength of the loose soil and simultaneously mitigate potential contami

242 We describe a novel protein, sisters on the loose (SOLO), which is essential for meiotic cohesion in

243 Compared with loose states, tight states have higher levels of social

244 creativity, and lower happiness relative to loose states.

245 f three or more loose stools in 24 h, or one loose stool with visible blood) were identified through

246 l pain and bloating scores of 3 or more, and loose stool, located at 270 centers in the United States

247 (0.5 days vs 2.1 days, p=0.0006) with fewer loose stools (3.7 vs 10.5, p<0.0001) than placebo.

248 oup reductions in abdominal pain (p < 0.01), loose stools (p < 0.01), bloating (p < 0.05), flatulence

249 rrheal illness <7 d duration comprising >/=3 loose stools in 24 h and >/=1 of the following: sunken e

250 (defined as maternal report of three or more loose stools in 24 h, or one loose stool with visible bl

251 Diarrhoea was graded by the number of loose stools in 24 h: mild (three), moderate (four or fi

252 years old, hospitalized with diarrhea (>/=3 loose stools in 24 hours) at two district hospitals in N

253 from baseline and a decrease in frequency of loose stools of >/=50% from baseline, for 2 or more week

254 e diarrhoea (defined by WHO as three or more loose stools per day for less than 14 days).

255 ossibility when the patient has fewer than 3 loose stools per day; the glutamate dehydrogenase test f

256 Secondary hyperparathyroidism and loose stools were more frequent after distal gastric byp

257 s return, he developed diarrhea, cramps, and loose stools without blood or mucus in the absence of fe

258 lated gastrointestinal side effects (nausea, loose stools, vomiting) were common but did not limit th

259 oswitch aptamers without their ligands and a loose structure for the recently discovered human HoxA9D

260 arrestin-3 we show that the presence of this loose structure is correlated with reduced arrestin sele

261 ilock braking system (ABS) for vehicles on a loose surface.

262 tion rate (Descemet's folds, epitheliopathy, loose sutures) was 18%.

263 eval of connectivity, the synchrony evolves: Loose synchrony appears already at weak connectivity, wi

264 the inner plexiform layer (IPL) and formed a loose, tangential plexus in the middle of this layer.

265 A 46-year-old male patient presented with loose teeth for assessment of implants.

266 ng "bone loss/deep pockets" (P < 0.001) and "loose teeth" (P < 0.001).

267 self-reported "bone loss/deep pockets" and "loose teeth" was assessed; associations of self-report w

268 Scaling and root planing treatments, loose teeth, and the use of mouthwash, combined with dem

269 orating self-report measures on gum disease, loose teeth, and tooth appearance alone were most useful

270 f-reported gum health and treatment history, loose teeth, bone loss around teeth, tooth not looking r

271 Among patients with RA, "loose teeth," but not other self-report items, was assoc

272 For many years, menstrual migraine was a loose term used to describe an undefined association bet

273 The other is a loose tetramer with all four subunits accessible to solv

274 only induce a stoichiometric shift but also loose the coupling between available N and P.

275 ysiological levels [K+]o (5 mM) for 14 days, loose the majority of granule cells in the anterior lobe

276 Cells loose their apical-basal polarity, mislocalize DE-cadher

277 A2/A5 mutant mice, the spinal cord neurites loose their preference for the membranes of correspondin

278 and because the best long-range bound is too loose to accurately describe the relevant dynamical time

279 ures into an infectious form, morulae become loose to allow bacteria to exit from host cells to infec

280 The peptide prevented transition from the loose to the tight FXa-TFPI complex, but did not affect

281 a inhibition, i.e. for the transition of the loose to the tight FXa-TFPI complex.

282 ng the developmental homeostatic switch from loose to tightly coupled synaptic release at a single cl

283 Self-rated "gum" health and presence of a loose tooth were the only periodontal measures that were

284 hosphate (GTP) hydrolysis proceeds through a loose transition state as suggested in our previous stud

285 ctroscopic data, suggest that Ras promotes a loose transition state by stabilizing negative charge in

286 dge oxygens and the leaving group indicate a loose transition state that approaches a metaphosphate.

287 d GTP hydrolysis reaction proceeds through a loose transition state that is similar in nature to the

288 phosphate monoesters undergo hydrolysis by a loose transition state with extensive bond fission to th

289 xed p-nitrophenyl phosphate occurs by a very loose transition state with little bond formation to the

290 eneral acid catalysis, are consistent with a loose transition state with partial neutralization of th

291 zes phosphate monoester hydrolysis through a loose transition state, similar to that in solution.

292 gen and the pro-S beta nonbridge oxygen of a loose transition state, whereas Lys-16 of Ras and Mg(2+)

293 The computed loose transition states are clearly different from the m

294 The calculations suggest that similar loose transition states are involved in both enzymes, de

295 bservations are best explained by calculated loose transition structures with extensive scissile bond

296 the rate-limiting hydrolysis step and a very loose TS.

297 n where the interhelical contacts are rather loose, while the motif's center with best established co

298 h is unable to trigger target cell lysis, is loose, with multiple protrusions in the effector cell me

299 ure, and modulates terminal DNA to match the loose wrap that is found on native CENP-A nucleosomes at

300 lin-forming glia were present and had formed loose wraps around axons but did not form compact myelin