ライフサイエンスコーパス: loosely

1 number of fused thiophene rings packed more loosely.

2 chastic point process with a given rate, and loosely (2) the variance of the rates that would produce

3 MBP is loosely accommodated in the HLA-DR4-binding groove, acco

4 rface layer, a meshwork of surface-bound and loosely adherent glycosaminoglycans and proteoglycans, m

5 ly devoid of bacteria, followed by a second, loosely adherent layer that contains numerous bacteria.

6 d only when the two-dimensional material was loosely adhering to a substrate.

7 1b appeared as cytoplasmic diffuse granules, loosely aggregated filaments, or compact spheres in p75(

8 ested either strictly during each mitosis or loosely among several divisions.

9 ss synapses, whereas the remaining 44% had a loosely anchored ribbon.

10 This suggests that the remaining loosely anchored ribbons in Bsn(gt) IHCs were functional

11 e of unknown function, even when function is loosely and minimally defined as 'belonging to a superfa

12 y of fisheries and food security remain only loosely and superficially linked.

13 essed pellets of fluorescein and was sutured loosely (apposition group) or tightly to indent the scle

14 nd analysis of citational material that Livy loosely appropriated from earlier sources.

15 leus in parental KB-3-1 cells but it appears loosely arranged and widely dispersed throughout the cyt

16 a cellular proliferation of fibroblasts with loosely arranged collagen deposition and an occasional t

17 /=50%, >50%, or 100% of cells; identified as loosely arranged small myocytes positive to HCN4 immunos

18 ar portion, comprised of the LBD and NTD, is loosely arranged, mediating complex allosteric regulatio

19 ns, including bilaterally separate jaws that loosely articulate with the skull, hyper-expandable thro

20 mplexes extract predominantly in the form of loosely assembled tetramers from purified measles virus

21 -terminal distal three residues disrupts the loosely assembled trimer and favors the formation of a d

22 ross-linked by dynamin2 and cortactin became loosely associated after GTP addition when viewed by tra

23 Motor axons in frac LOF embryos are loosely associated and project ectopically, a phenotype

24 nd to structured RNAs and efficiently unwind loosely associated duplexes, which biases the proteins t

25 to high ionic strength that would strip more loosely associated integrase from internal regions of th

26 Electrostatic shielding from loosely associated metals is undoubtedly an important in

27 indicate that beta-sheet channels break into loosely associated mobile beta-sheet subunits.

28 aphic structures of hGITRL, which revealed a loosely associated open trimer with a deep cavity at the

29 mposed of 13 core subunits and either of two loosely associated regulatory subunits, Cdc20 and Cdh1.

30 ation with the bacterial surface, CA forms a loosely associated saccharide mesh that coats the bacter

31 ntexts cells migrate either individually, as loosely associated sheets or as clusters of cells.

32 tion factors eIF3, eIF1, eIF1A, and eIF3j, a loosely associated subunit of eIF3, can promote recyclin

33 H2A.Z in both yeast and human cells are more loosely associated with chromatin than the full-length p

34 rus/enterovirus FA targets revealed patterns loosely associated with EV-D68 that may be useful for co

35 Myosin II-B, however, is more loosely associated with PSD fractions than myosin Va, wh

36 SII supercomplex, whereas up to two more are loosely associated with PSII in state 1 in higher plants

37 e to abstract a proton from a water molecule loosely associated with the alpha-metal ion.

38 Fhl1 is loosely associated with the CURI complex; its absence pa

39 Mne1 is a mitochondrial matrix protein loosely associated with the inner membrane and is found

40 a conversion was incomplete, and Mo was only loosely associated with the NifEN-bound "FeMoco".

41 aused form of RNA polymerase II (Pol II) was loosely associated with the ORF45 promoter region during

42 Plant eIF4A is very loosely associated with the plant cap-binding complexes.

43 VioA forms a "loosely associated" homodimer as indicated by small-angl

44 g to their association status (unassociated, loosely associated, or tightly associated), improving ho

45 velope at their carboxyl termini, and E(rns) loosely associates with the viral envelope.

46 lly cleaved portion of XptC1 apparently only loosely associates with this binary complex.

47 water, in comparison to the more porous and loosely attached biofilms at low flow rates.

48 A loosely attached cell is more compliant under indenting.

49 ulations K3 also forms ion channels with 3-6 loosely attached mobile subunits.

50 ecific complement of functionally important, loosely attached peripheral proteins to that membrane.

51 ere rigidly attached as compared to the more loosely attached QDs.

52 Abeta(17-42) peptides form ion channels with loosely attached subunits and elicit single-channel cond

53 that PG-1 forms channel-like structures with loosely attached subunits when reconstituted in anionic

54 the barrels still break into heterogeneous, loosely attached subunits, in good agreement with AFM im

55 extract the correct Young's modulus of cells loosely attached to a substrate.

56 study mechanics of many other types of cells loosely attached to substrates, e.g., blood cells, some

57 ecies in solution and that two RAIDD-DDs are loosely attached to the 5:5 core.

58 c bones are suspended in a muscular sling or loosely attached to the pectoral girdle anteriorly.

59 do not develop sufficient adhesion, and are loosely attached to the substrate.

60 INF2-non-CAAX is loosely attached to this meshwork, being extracted by br

61 g the second phase (sampled at E38-E45), the loosely banded S-cell distributions were transformed int

62 l diffusion from water molecules that either loosely bind to or exchange protons with the DNA.

63 Our results show that, while the dominating loosely bond signature is attributed to a one-dimensiona

64 that tends to reorient water molecules more loosely bonded to the topmost water layer with oxygen to

65 resent in the natural aquatic environment as loosely bound aggregates or "flocs" and is responsible f

66 In contrast, an increase in loosely bound and a more pronounced increase in non-heme

67 brain and regional changes in the levels of loosely bound and non-heme iron that occur with developm

68 shaped ATPase motors, for example the use of loosely bound and tightly bound hydrolysis reactant and

69 lved in ion transport, because such ions are loosely bound and very difficult to detect experimentall

70 mponents that are present individually or in loosely bound assemblies.

71 sly the intimate interconnection between the loosely bound bimolecular intermediate identified concur

72 lecule enters into the binding pocket of the loosely bound binuclear center, originally occupied by t

73 r the AgNP surface, where nanoparticles with loosely bound capping agents are more effectively stabil

74 nd tightly bound cells than in epiphytic and loosely bound cells.

75 nically excited atom or molecule placed in a loosely bound chemical system (such as a hydrogen-bonded

76 This intermediate resembles a loosely bound complex between an electrophilic nitrosyl

77 fast rearrangement of the complex to form a loosely bound complex.

78 onspecific complexes, and a diffuse cloud of loosely bound complexes connecting the specific and nons

79 s and neural tissue maintain basal stores of loosely bound copper that can be attenuated by chelation

80 mal amount of MBCD to the RC sample captured loosely bound detergent from the protein-detergent compl

81 crystal contacts hypothesized for removal of loosely bound detergent.

82 enically cooling the ion and tagging it with loosely bound deuterium (D2) enabled detection of its vi

83 Because of their loosely bound electrons, electrides offer physical prope

84 ncrease in conductivity is attributed to the loosely bound Fe(2+) beta-spin electron.

85 We find that FtsZ forms bundles made of loosely bound filaments of variable length and curvature

86 abilization based on the results featuring a loosely bound first state, a tightly bound second state,

87 icals in soil, whereas air accesses only the loosely bound fraction, and these two pools are subject

88 ed that DCM removes both the sequestered and loosely bound fractions of chemicals in soil, whereas ai

89 In wildtype mice, levels of loosely bound iron decreased while non-heme iron increas

90 A new population of loosely bound LHCI was also found, contributing to an in

91 s an origin from spin-up and disruption of a loosely bound precursor within the past million years.

92 rature processing to strip away all free and loosely bound surfactant, leaving behind concentrated, k

93 excess target and stringent washing removes loosely bound targets.

94 l described by these analyses, but were more loosely bound than the bonds in events 2 and 3.

95 ealed experimentally, especially if they are loosely bound to macromolecular surface.

96 It is demonstrated that LHCIIs loosely bound to PSII in State I are the trimers mainly

97 We show that truncated SrtA mutants that are loosely bound to the cytoplasmic membrane form high-mole

98 f contact ion pairs with the glycosyl moiety loosely bound to the leaving group, and eventually solve

99 The substrate is loosely bound to the more exposed zinc ion (Znbeta2+) at

100 Such loosely bound triple systems will therefore appear to be

101 aments with heavy association of tightly and loosely bound water.

102 As in other classes of AC, the ribose is loosely bound, and as in class III, no base appears to i

103 ng data points to the presence of additional loosely bound, labile pools that can participate in dyna

104 n-Cooper-Schrieffer (BCS)-type superfluid of loosely bound, large Cooper pairs to Bose-Einstein conde

105 the active form is favored while a ligand is loosely bound.

106 A novel scaffold composed of loosely branched hollow silica microfibers that has been

107 opodia had abnormal morphology with wavy and loosely bundled actin organization.

108 e Z ring comprises short, discontinuous, and loosely bundled FtsZ polymers, some of which are tethere

109 ants and Mmp1 Mmp2 double mutant embryos are loosely bundled/fasciculated, with ectopic axonal projec

110 ally consisting of up to approximately eight loosely but irreversibly assembled monomeric subunits.

111 ection of a few peptide chains held together loosely by hydrophobic interactions into a spherical hyd

112 cells invested tightly by pericytes and more loosely by macrophages.

113 temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar a

114 oss environments, a phenomenon that has been loosely called 'demographic compensation', may allow spe

115 vaccine- or drug-based interventions can be loosely categorized by the degree to which the infectiou

116 Traditionally, viruses are loosely classed into two groups: slow-evolving DNA virus

117 pe I restriction endonucleases could only be loosely classified as enzymes since they functioned stoi

118 atic analysis shows that ALL populations are loosely clustered and close to the normal population tha

119 merous genomic positions generally serves to loosely coalign homologous chromosomes, while crossover-

120 g of the nucleoprotein to RNA can assemble a loosely coiled NC-like structure; the loose coil can be

121 substitution N(Y415A) or N(K417A) were more loosely coiled, as revealed by electron microscopy (EM).

122 on assay preferentially detects early-stage, loosely compacted lesions such as pale bodies in patient

123 We theorize that these levels are loosely connected by multiple constraints and that both

124 wever, we also observe that the subunits are loosely connected by partially disordered inner beta-she

125 ated by parsing single chain structures into loosely connected domains and are important features of

126 r the presence of brain lymphatics and found loosely connected endothelial cells with lymphatic molec

127 The observed loosely connected subunit organization suggests that amy

128 erhelical termini within each nucleosome are loosely connected to CENP-A, and we identify the key ami

129 ains form a tightly packed core that is only loosely connected to the a1 domain.

130 results suggest that the CH domain, which is loosely connected to the MO domain by a flexible linker

131 es have been limited to quantities which are loosely connected to the topological properties of these

132 Removal of a loosely conserved "putative" palindrome sequence in the

133 l of TP design is that they contain multiple loosely conserved motifs that are recognized at differen

134 ions rely on parameterizations that are only loosely constrained by present day changes.

135 ion to canonical SUMOs, land plants encode a loosely constrained noncanonical isoform and a variant c

136 : i) excessive CPU time requirements and ii) loosely constrained optimization problem due to lack of

137 The age of weathering, however, remains loosely constrained, which has an impact on existing geo

138 and their associated environmental variables loosely constrains the parameterization of process-based

139 and 8 microM free Ca(2+) contains a single, loosely coordinated metal ion.

140 rs by dialkylammonium cations coupled to the loosely coordinating superweak TFPB(-) anion has been ac

141 ts of individual mutations on ATP hydrolysis loosely correlated with RapA's nucleic acid remodeling a

142 mRNPs are organized into three major domains loosely corresponding to 5' untranslated regions (UTRs),

143 s for tail distributions, with the other two loosely corresponding to distributions with right-trunca

144 frican Khoisan fall into two genetic groups, loosely corresponding to the northwestern and southeaste

145 Na(+) conduction is shown to involve the loosely coupled "knock-on" movement of two solvated ions

146 A loosely coupled allosteric network, comprising three reg

147 This loosely coupled model can account for the observed physi

148 e propose that the decision is taken by many loosely coupled modules each of which represent a stocha

149 The loosely coupled motor is predicted to be especially adva

150 Under loads relevant to a swimming cell, the loosely coupled motor would perform about as well as a t

151 ce if implemented as a distributed system of loosely coupled parts that interact through clearly defi

152 anodine, consistent with cross-activation of loosely coupled ryanodine receptors.

153 on, and the translocation of kinesin becomes loosely coupled to ATP turnovers.

154 e neurons, we found that exocytosis was more loosely coupled to calcium entry than in fast synapses.

155 de array of hydrologic processes, and may be loosely coupled to climatic processes and therefore buff

156 and I identify many different elements only loosely coupled to each other.

157 he force-generating region of myosin is only loosely coupled to the ATPase reaction, with conformatio

158 ried waters whose exchange with bulk is only loosely coupled with the motion of loops in their vicini

159 SBML allows their distributed analysis using loosely coupled workflows, and with the advent of the In

160 L1 stalk closure and subunit ratcheting are loosely coupled, independent processes that must converg

161 rate that the mitochondria in EDL fibres are loosely coupled.

162 Using a network model of loosely-coupled Wilson-Cowan oscillators to simulate a p

163 The tools presented in this paper are loosely-coupled, and are intended to be incorporated int

164 rsible iron-catechol cross-links into a dry, loosely cross-linked epoxy network.

165 pread tendency to interpret data in terms of loosely defined 'age regulation', which does not usually

166 ry reconsolidation depends on a set of still loosely defined boundary conditions, limiting the transl

167 der to help further the field, we close with loosely defined design rules that are at the basis of th

168 asses of effectors in which the signal has a loosely defined motif and others in which secretion is d

169 We found a loosely defined pattern of softness peaks distributed bo

170 along surface pili, while RrgC is found in a loosely defined relationship with RrgA.

171 A loosely defined T cell area surrounded the B cell follic

172 of plasmid DNA within the periphery of this loosely defined, chromosome-containing region.

173 to a high affinity binding site that remains loosely defined.

174 onses to healthcare-associated exposures are loosely defined.

175 arative structural analysis identified three loosely-defined consensus structural motifs for kinase r

176 li exhibit rudimentary behaviors that can be loosely described in terms of cognitive phenomena such a

177 Spindle and round cells were loosely distributed with increased particles after TP tr

178 adherens junction protein P-cadherin appears loosely distributed within the albino RPE cells rather t

179 es from basal attine genera continue to farm loosely domesticated fungal cultivars capable of pursuin

180 ge cages and singly occupied small cages are loosely encaged and the vibrational modes are softened a

181 bilization of acetonitrile and release of a "loosely" encapsulated solvent molecule during 10a/b inte

182 chaperone must bind to and hold the protein loosely enough to allow the protein to change its confor

183 OS assembly has the dynamical structure of a loosely entangled polymer.

184 ts a beta-hairpin-like conformation with two loosely extended peptide chains, demonstrating the prefe

185 cation and inorganic (or organic) anion that loosely fit together, is extending the properties and cl

186 e incorporation of excess membrane to form a loosely fitting bilayer that can be used to study membra

187 A mask documented to be loosely fitting by a PortaCount fit tester, to simulate

188 ausative agent of anthrax, are enclosed by a loosely fitting exosporium composed of a basal layer and

189 fitted respirator performs no better than a loosely fitting mask.

190 the etiological agents of anthrax, possess a loosely fitting outer layer called the exosporium that i

191 n we found that the detached head occupies a loosely fixed position to one side of actin from which i

192 n the target region needs to be isolated but loosely focused when the target region is clearly segmen

193 Primary structure of dematin includes a loosely folded core domain and a compact headpiece domai

194 gh a step that requires ATP hydrolysis and a loosely folded domain on the protein, but appears indepe

195 teasomes, but only if the proteins contain a loosely folded domain.

196 f CapG-sev crystal structure suggests a more loosely folded inactive conformation than gelsolin, with

197 further characterized in the context of the loosely folded isomerized native-like state {N(iso)} pre

198 Unfolded or loosely folded polypeptides can inhibit this tighter bin

199 Thus, ubiquitinated loosely folded proteins, after becoming bound to the 26

200 they bind a ubiquitinated protein, which is loosely folded.

201 Our data reveal that the loosely formed capsid structure is reinforced post-assem

202 me-substrate intermolecular interactions are loosely formed when the substrate is in the reactant and

203 These problems are loosely grouped into challenges concerning nosology and

204 or virus manipulation of RNA granules can be loosely grouped into three nonexclusive categories: (a)

205 nate thalamically and downstates cortically, loosely grouping spindle occurrence.

206 Energetic analysis of tightly and loosely held computed hydration sites indicates protein

207 tween the N- and C-terminal domains that are loosely held together by hydrophobic and hydrogen bond i

208 elative to its N-substituted (and therefore "loosely held") analogue 9, provided compelling experimen

209 ereas weak binding low affinity ligands bind loosely in the active site, resulting in a distribution

210 we introduce an active matter system that is loosely inspired by biology and which we term an active

211 Tightness-looseness is part of a complex, loosely integrated multilevel system that comprises dist

212 rmed by beta-sheets spontaneously break into loosely interacting dynamic units that associate and dis

213 ructures that are highly intraconnected, but loosely interconnected.

214 Mechanistic analyses reveal that loosely ion-paired halide ions in DMA-LiCl are critical

215 proach was used to examine water soluble and loosely ionically bound CWPs.

216 thods, we determine that the NBD and SBD are loosely linked and can move in cones of +/-35 degrees wi

217 ient of collateral innervation might help to loosely maintain functional synaptic circuits if functio

218 provide the main driving force for binding, loosely mimicking the binding mode found in the recognit

219 of mineral elements in the planktonic cells loosely mirrors the media composition; however the uniqu

220 ich has been several years in the making, is loosely modeled after a key pinacol shift in the propose

221 two separate phases (cyclase and oxidase) as loosely modeled after terpene biosynthesis.

222 m, insect-scale, flapping-wing robot modeled loosely on the morphology of flies.

223 e a model animal, with a neural system based loosely on the rodent hippocampus, which performs mental

224 Based loosely on this sequence, we identified five potential N

225 anges in the C-terminal arm result in a more loosely organized active site and flexible binding modes

226 a basal lamina significantly denser than the loosely organized CNS matrix.

227 remains flexible and adaptive by maintaining loosely organized domains, while its heterodimerization

228 We suggest that the transition state is a loosely organized ensemble of conformations.

229 on, but large marrow spaces infiltrated with loosely organized fibrous connective tissue and/or lipid

230 l- and tissue-based assays usually reside in loosely organized files of poorly documented provenance.

231 in colonic epithelium, often accompanied by loosely organized lamina propria infiltrates.

232 ortical and spinal motor command centers are loosely organized with respect to the musculotopic spati

233 lections that contained fewer bacteria, were loosely organized, and lacked the normal transition to a

234 sting databases of plasmids and features are loosely organized.

235 good healing, whereas group 2 aneurysms were loosely packed (volumetric packing density, <20%), which

236 in aquatic environments are associated with loosely packed aggregates of particulate material called

237 Electron microscopy revealed the presence of loosely packed and disorganized mitochondrial cristae in

238 izable podosomes, their podosome arrays were loosely packed and improperly localized within the cell.

239 ism in GFP folding forming an incorrectly or loosely packed barrel under intermediate (hysteretic) fo

240 llel, four-helix bundle; and HAMP(B), a more loosely packed bundle with an altered AS2/AS2' packing a

241 After irradiation, there is an increase in loosely packed collagen fibrils, which is significantly

242 nel in a membrane environment suggest a more loosely packed conformation with water-accessible intras

243 Here we report a loosely packed crystal of dendrimeric rotor 2 and the fa

244 the near-surface electric field generated by loosely packed dipoles on mixed F/H-terminated surfaces

245 und reduction of EndoIII on both closely and loosely packed DNA films.

246 For loosely packed DNA monolayers, the conjugation of the po

247 Overall, multimeric VWF appears to be a loosely packed ellipsoidal protein with non-covalent int

248 helices at the intracellular end but is more loosely packed from 10' to the extracellular end than th

249 rmational extremes of a tightly packed and a loosely packed HAMP four-helix bundle support only low l

250 o individual GFC beta-sheets and a large but loosely packed hydrophobic cluster.

251 t ligand-binding pocket, which ranges from a loosely packed hydrophobic core to a small tunnel, is to

252 ms to be poised toward downhill folding by a loosely packed hydrophobic core with low aromatic conten

253 h burial of these probes in a collapsed, but loosely packed intermediate, followed by the rate-limiti

254 that K-Ras4B can be distributed in rigid and loosely packed membrane domains.

255 Output helices that are too tightly or too loosely packed most likely produce kinase-off output sta

256 between ellipsoids lead to the formation of loosely packed or arrested structures on the air-water i

257 ets is covered by a shell of less-activated, loosely packed platelets.

258 elets overlaid by a shell of less-activated, loosely packed platelets.

259 ets is covered by a shell of less-activated, loosely packed platelets.

260 particle extends previous findings that the loosely packed precursor RNP undergoes a dramatic confor

261 t stimuli, consistent with facile changes in loosely packed receptors.

262 of the molecular diodes, and junctions with loosely packed SAMs result in poorly performing molecula

263 dilute fluids of colloidal hard spheres form loosely packed sediments, where the volume fraction of t

264 higher flexibility of the AHR PAS-A and its loosely packed structural elements, suggest a dynamic st

265 mpse of the intron RNP precursor as a large, loosely packed structure.

266 he protein assumed a roughly spherical, very loosely packed structure.

267 entropy-based resistance to ordering of the loosely packed surfactant layers was initially considere

268 ith significant secondary structure but only loosely packed tertiary structure, has been suggested to

269 MA and DNA indicate that these complexes are loosely packed with excess charge due to DNA in their ou

270 usters are lined with residues that are more loosely packed, a structural feature that facilitates mo

271 that, within 3-d colonies, E. coli cells are loosely packed, and colonies produce about 2.5 times as

272 structures in which the adjacent arenes are loosely pi-stacked.

273 , fast-diffusing proteins corresponding to a loosely, probably electrostatically bound state; 2), slo

274 ative green/sodium dodecyl sulfate gels, the loosely PSII-bound LHCb was separated from the LHCb that

275 urines in various mammalian tissues has been loosely quantified, the concentration of purines present

276 ese future-oriented thoughts may be based on loosely related past experiences or unrealistic optimism

277 that they detect sensitization which is only loosely related to clinical allergy.

278 tion factors bind to sites that are long and loosely related to each other.

279 ed on past experiences, including those only loosely related; perceived familiarity with treatment op

280 is possible to engineer charge clusters that loosely resemble catalytic sites in a scaffold protein w

281 ific for either Sp1 or TATA elements but was loosely selective for the initiator and flanking sequenc

282 ensive overlap in Gr-ligand interactions and loosely separates sweet receptors into two groups matchi

283 The results indicated that Cr(VI) was loosely sorbed as an outer-sphere complex on Mn(IV)O(2),

284 and DegB, a hydrophobic sequence within the loosely structured C-terminal tail of Ndc10.

285 riptional repression by Alu RNA involves two loosely structured domains that are modular, a property

286 idues were in conformational exchange with a loosely structured intermediate with a population of 1-2

287 The p66 monomer exists as a loosely structured molecule in which the fingers/palm/co

288 rrence of relatively short (10-70 residues), loosely structured protein regions within longer, largel

289 ed in a unique phenotype: precursor vesicles loosely tethered to the MOP but did not contact its surf

290 s all substrates and products, although more loosely than P450 17A1.

291 on at the stem-loop interface is packed more loosely than with Mg(2+), to allow for a lower charge de

292 These separate clusterings adhere loosely to an overall consensus clustering, and hence th

293 chromatin proteins are hyperdynamic and bind loosely to chromatin in ES cells.

294 12-HSL, and because 3OC6-HSL bound much more loosely to QscR than other acyl-HSLs tested, we were abl

295 nt gene pools (Q1, Q2 and Q3), corresponding loosely to the west, central and eastern MB, respectivel

296 ng sintered samples, which ranged from being loosely to very well consolidated.

297 peculate that temperature drives Aqy1 from a loosely- to a tightly-blocked state.

298 d personal linkages bind these organisations loosely together as components of an international nutri

299 uclei lack direct sensory input and are only loosely topographically organized, forming interlocking

300 d thus appear to have progressed beyond the "loosely zippered" state of docked synaptic vesicles.