ライフサイエンスコーパス: loss

1 isk) or aversion to negative outcomes (e.g., loss).

2 ce substantially reduced progressive hearing loss.

3 n the context of concurrent tumor suppressor loss.

4 were associated with higher risks of hearing loss.

5 ng behavioral changes to promote a 5% weight loss.

6 oss alternating with phases of no detectable loss.

7 the mechanism of complex 1-deficient vision loss.

8 Prevalence and main causes of vision loss.

9 who smoke, suffer from a high rate of tooth loss.

10 s, arrested tooth-root development and tooth loss.

11 uction of myelin and progressive neuroaxonal loss.

12 s of enamel resulting in irreversible enamel loss.

13 MJ) dysfunction and spinal motor neuron (MN) loss.

14 year (OR, 1.61) were risk factors for vision loss.

15 al symmetry breaking upon varying the cavity loss.

16 d DGF and 2553 (33.9%) experienced allograft loss.

17 nclusions associated with extensive neuronal loss.

18 or of colorectal tumorigenesis following APC loss.

19 inct functions that are perturbed upon BAF47 loss.

20 to iatrogenic glaucoma and permanent vision loss.

21 ) is the leading cause of conductive hearing loss.

22 cause large RAV reduced above-ground biomass loss.

23 or in skin pathologies with comorbid hearing loss.

24 was developed to quantify methane leaks and losses.

25 maintained biomass, only suffering diversity losses.

26 levels liver fluke burdens cause production losses.

27 al acuity 0.008, P = 0.890; and visual field loss, -0.019, P = 0.819).

28 sion accounted for 67.4 to 84.8% of sediment loss across all high wind events.

29 These recommendations can include weight loss, adequate hydration, avoidance of excessive fluids,

30 Child weight loss after 6 months was -0.25 BMI z scores in both PBT a

31 However, in contrast to Tet2 loss, Aid loss does not contribute to enhanced HSC self-

32 ow distinct GJB2 mutations result in hearing loss alone or in skin pathologies with comorbid hearing

33 OFD1 loss also adversely impacted upon the DSB-induced G2-M c

34 here, with phases of substantial soil carbon loss alternating with phases of no detectable loss.

35 ith higher risks for patient death and graft loss, although SRL + MPA was associated with a lower ris

36 Mid-frequency to high-frequency hearing loss, an expected adverse event, was documented in all p

37 ure is sustained hepatitis B surface antigen loss and anti-HBs gain, with normalization of serum amin

38 3) were scored for the presence of bile duct loss and assessed for clinical and laboratory features,

39 ectomy is associated with significant weight loss and catabolism, and negatively impacts quality of l

40 To describe factors that predict visual loss and complications in intermediate uveitis.

41 th faster aggregation promoting pluripotency loss and ectoderm, and slower aggregation favoring mesod

42 associated with CRS cases who reported smell loss and facial pain and/or pressure and had the weakest

43 gher biological activity (smooth muscle cell loss and fibrin deposition) in the FP-PES compared with

44 While forest loss and fire continued after RSPO certification, certif

45 Loss and gain of IL-10RA expression directly correlates

46 e was no association between risk of hearing loss and hair color (for black hair vs. red or blonde ha

47 s remodels circuitry through dendritic spine loss and hyper-excitability, thus influencing recovery.

48 challenges (ovarian development after queen loss and immune activation after pathogen exposure).

49 y colon cancer, augmented DSS-induced weight loss and increased tumor multiplicity, size, and invasiv

50 s studies on ammonia-induced skeletal muscle loss and lay the foundation for prolonged ammonia-loweri

51 ed/promoted papillomas in the context of p53 loss and novel NF-kappaB expression, whereas increased t

52 Here, we analyze effects of this loss and other cochlear loads on TM traveling waves.

53 However, Arf loss and p53 loss produce differing outcomes-loss of p53

54 Degree of hard tissue loss and type of final prosthetic restoration should be

55 reconnecting fragments could prevent species losses and allow locally extinct species to recolonize f

56 swine species and provoking severe economic losses and health threats.

57 genes whose expression was affected by CNOT3 loss, and also at sites modulated in certain types of co

58 ere no associations between induction, graft loss, and incident cancer.

59 e input pump power, the linear and nonlinear losses, and the coupling factors.

60 The pairing of both loss- and gain-of-function datasets reveals complex gene

61 and obesity are strongly linked, and weight loss appears to improve psoriasis symptoms and severity.

62 d mechanisms in (involuntary) adipose tissue loss as well as its systemic metabolic consequences are

63 ossibilities exist for prevention of hearing loss, as do unprecedented opportunities to reduce the ge

64 nic stress and were protected against weight loss associated with chronic stress.

65 ximal lung endoderm with complete epithelial loss at later stages of development.

66 Enumerating the losses at each step in the care cascade enables appropri

67 romodulators, cortisol and noradrenaline, on loss aversion during financial decision making.

68 s B cell-deficient mice showed CD4(+) T cell loss but recovered from infection without lethality.

69 More severe clinical attachment loss (CAL) was observed in the 3D RSA measurement than i

70 ed in the collection were examined for tooth loss, cavity occurrence, average and maximum lingual and

71 resulted in rapid lethality marked by weight loss, changes in nutritional as well as blood parameters

72 Weight loss combined with sarcopenia presented the greatest ris

73 ction (systole) in aged animals, where their loss culminates in fibrillatory cardiac arrest.

74 ment strategy prevented tubular brush border loss, diminished tubular iron deposition, blocked the de

75 However, in contrast to Tet2 loss, Aid loss does not contribute to enhanced HSC self-renewal or

76 ilms which suffer from significant plasmonic losses due to grain boundaries and rough silver surface.

77 ction status areas experienced higher forest losses (e.g. 0.39% yr(-1) in IUCN cat III), yet even hig

78 we also present a possible strategy based on loss engineering to achieve more control over the mode s

79 nd that our patients with psychogenic memory loss fell into four distinct groups, which we categorize

80 first randomized trial of behavioral weight loss for HIV-infected patients (n = 40).

81 110 K and larger contributions from clamping losses for T < 110 K.

82 Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encount

83 The unavoidable energy loss from plasmon decay, initially seen as a detriment,

84 Africa thought to reside in Gabon [1], their loss from the park is a considerable setback for the pre

85 Ecosystem carbon losses from soil microbial respiration are a key compone

86 nd may have significant implications for CO2 losses from tropical forest soils under future rainfall

87 Thus, analyses of gene gain and losses, gene architectures, synteny and other genomic fe

88 Accuracy for categorization by Genant height loss grade was 0.68 (77 of 113; 95% CI: 0.59, 0.76), wit

89 Mice with fibroblast-specific Smad3 loss had accentuated adverse remodeling after reperfused

90 (HR, 1.38; 95% CI, 1.12-1.71; overall graft loss [HR, 1.08; 95% CI, 0.91-1.28]; mortality [HR, 0.84;

91 maining teeth, percentage of teeth with bone loss, implant function time, implant surface, and presen

92 ks of miscarriage, stillbirth, and pregnancy loss in a sensitivity analysis restricted to artemisinin

93 tons but highly expressed due to methylation loss in all domesticated cottons tested.

94 oach was able to produce a targeted autosome loss in aneuploid mouse embryonic stem cells with an ext

95 l feature of reversible gels, arising from a loss in entropy as chains transition to a conformational

96 hancing osteoclastogenesis, which drive bone loss in health.

97 rmally avascular photoreceptors cause vision loss in many eye diseases, such as age-related macular d

98 opamine neurons while exhibiting milder cell loss in PD, we aimed to define the electrophysiological

99 xamine the association between DGF and graft loss in pediatric and adolescent deceased donor kidney t

100 emporary and permanent noise-induced hearing loss in preclinical studies.

101 m likely to contribute to PN dysfunction and loss in SCA2.

102 benign peripheral nerve tumors driven by NF1 loss in Schwann cells (SCs).

103 survival, and is the leading cause of vision loss in the elderly.

104 omplained of sudden painless profound visual loss in the left eye (LE) two hours after embolization.

105 Preceding RGC loss in the Ndufs4 KO is the loss of starburst amacrine

106 r solubility of fatty acid and a substantial loss in the therapeutic activity.

107 sts in black grama grassland suffered severe losses in cyanobacterial biomass and diversity, but comp

108 ient ion collection at low pressure minimize losses in the FAIMS step.

109 vated CO2 can only weakly reduce these yield losses, in contrast to irrigation.

110 nositol and glycine levels, suggesting sleep loss-induced modifications downstream of mGluR5 signalin

111 ines the effects of Moving Forward, a weight loss intervention for African American breast cancer sur

112 ed the effects of a diet and exercise weight-loss intervention on skeletal muscle (SM) mass and selec

113 Hippocampal volume loss is a hallmark of clinical depression.

114 Arctic sea-ice loss is a leading indicator of climate change and can be

115 Halting global biodiversity loss is central to the Convention on Biological Diversit

116 t for the alternative hypothesis that forest loss is most detrimental in already fragmented landscape

117 ere defined as the average image area with a loss less than first-percentile confidence interval of t

118 drome phenotype, characterized by renal salt loss, marked hypokalemia, and metabolic alkalosis.

119 Noise induced hearing loss (NIHL) is a disease that affects millions of Americ

120 ow-up with a mean difference in child weight loss of 0.001 (95% CI, -0.06 to 0.06).

121 Thermogravimetric analysis showed a weight loss of 85.81+/-0.52% and a decomposition temperature of

122 ults in a male-to-female conversion, whereas loss of a single suppressor of female development drives

123 key role in regulating myofiber length, as a loss of Abl2 leads to excessively long myofibers in the

124 Although there was loss of abundance relative to uncrowded myoglobin analyz

125 dified ASOs in the liver as evidenced by the loss of activity of GalNAc conjugated and unconjugated A

126 latively stable at 77 degrees C, with 59.93% loss of activity.

127 Furthermore, loss of AIBP increased vascular density and facilitated

128 Tln2 in preserving heart function, but that loss of all Tln forms from the heart-muscle cell leads t

129 teroids, like prednisone, are known to delay loss of ambulation in patients with Duchenne muscular dy

130 , the absence of alphaXbeta2 resulted in the loss of antifungal activity by tissue Mvarphi and inhibi

131 This resulted in a selective loss of approximately 60% of layer VI A1-MGBv neurons.

132 motes both tumor initiation and progression; loss of Arf promotes tumor progression but not initiatio

133 a, is induced upon obesity, and silencing or loss of ARG2 markedly suppresses PDA.

134 glutamate and potassium buffering capacity, loss of astrocyte coupling, and changes in cell morpholo

135 of DC autophagy slowed disease, the combined loss of autophagy in both cell types resulted in a letha

136 inantly protective or deleterious effects on loss of B cell self-tolerance in vivo, we depleted neutr

137 : 0=no impaired permeability to 100=complete loss of barrier function).

138 SK3beta), followed by phosphorylation of and loss of beta-catenin from the nucleus, thereby reducing

139 uses its time-dependent dissociation and the loss of both DHO and ATC activities.

140 Loss of both RECQL5 and WRN severely compromises DNA rep

141 Loss of Cadm1 protected mice from obesity, and tract-tra

142 rogates binding to DNA and leads to complete loss of canonical TH action.

143 ing support to a causal relationship between loss of CB1 in adipocytes and systemic metabolic changes

144 Loss of cell-cycle control is a hallmark of human cancer

145 lowing infarction, which was associated with loss of chromatin accessibility around cell cycle genes

146 Loss of circular fibres led to a bifurcated anterior-pos

147 Loss of ClpC repression in MD mutants causes constitutiv

148 ed microbiota destruction and the consequent loss of colonization resistance can result in intestinal

149 mination of cardiac activity associated with loss of consciousness, of spontaneous breathing, and of

150 Loss of CXCR7 expression by CRISPR-Cas9 gene editing res

151 To better understand how loss of D2-family dopamine receptors can ameliorate tau

152 Although a loss of DC autophagy slowed disease, the combined loss o

153 Taken together, these data indicate that loss of DDRGK1 decreases SOX9 expression and causes a hu

154 of PERK-K618A in primary neurons rescues the loss of dendritic outgrowth and number of synapses after

155 vation of PERK using GSK2656157 prevents the loss of dendritic spines and rescues memory deficits aft

156 cued parkin mutant phenotypes, in particular loss of dopaminergic neurons, mitochondrial network stru

157 hat result in lack of glycosylation and thus loss of effector function, we demonstrate that the N297G

158 ex of 8-oxoG:dA extension results in further loss of efficiency when compared to 8-oxoG:dC extension.

159 ies, exactly as predicted by the alternative loss of either of the internal introns at the DNA level

160 tric amount (0.25 equiv) without significant loss of enantioselectivity.

161 Conditional loss of endothelin receptor A in granulosa cells also de

162 embryonic lethality) or results in profound loss of fitness.

163 ve chloride secretion, with the accompanying loss of fluid, is not normally stimulated by intestinal

164 tment use among patients with 0, 1, or 2 FLG loss of function (LOF) alleles was compared as well as t

165 ing GPI anchor protein pathway genes induced loss of function mutations in human and mouse cell lines

166 mutations included five de novo heterozygous loss of function mutations/deletions in the PBX homeobox

167 The loss of function of MKK4/MKK5 also results in the same p

168 Pathogenic mutations cause a loss of function of the encoded protein Parkin.

169 Fragile X syndrome (FXS), caused by the loss of functional FMRP, is a leading cause of autism.

170 Genetic loss of Gcn2 intensified hepatic PERK activation to aspa

171 As a result, loss of GIRK function can enhance neuron excitability, w

172 istic target of rapamycin (mTOR) activation, loss of glutamate and potassium buffering capacity, loss

173 d to the extent that net oxidation occurs by loss of H2.

174 Despite a major loss of H3K27me3, PRC2 activity is still detected in DIP

175 These data support a role for loss of HBEGF in the neuroblastoma tumor microenvironmen

176 A mutation or high percentage of genome-wide loss of heterozygosity.

177 n of CD4 Th cells most likely contributes to loss of immune control of LTBI in HIV-infected individua

178 ry, people with dementia may also experience loss of interest in sexuality and intimacy.

179 mpairment of mitochondrial morphology with a loss of internal cristae.

180 ne with this, Foxp2-null mutants also show a loss of ITCs at postnatal time points, suggesting that F

181 A gene can be defined as essential when loss of its function compromises viability of the indivi

182 Loss of KRIT1 leads to decreased microvessel barrier fun

183 Western blot analyses showed that the loss of LKB1 and phosphatase and tensin homolog deleted

184 of the Rasa1 gene in adult mice resulted in loss of LV endothelial cells (LECs) specifically from th

185 To better understand how loss of maternal UBE3A function derails brain developmen

186 right to others that proposed that with the loss of memory, people with dementia may also experience

187 the mitochondrial unfolded protein response, loss of mitochondrial membrane potential and sensitivity

188 In contrast, loss of Mll3/4 proteins leads to strong depletion of enh

189 apitulate the human disease-with progressive loss of motor neurons in heterozygous animals.

190 inal muscular atrophy (SMA) is caused by the loss of motor neurons, but astrocyte dysfunction also co

191 s in centrosome integrity do not result from loss of mRNA export.

192 pathogenic SIV infection is characterized by loss of naive B cells, loss of resting memory B cells du

193 r Ca(2+) transport, could be affected by the loss of nBMP2.

194 n undefined, but postulated pathways include loss of neuronal progenitor cells, damage to the develop

195 The neuropathological hallmark of HD is the loss of neurons in the striatum and, to a lesser extent,

196 Parkinson's disease (PD) patients experience loss of normal motor function (hypokinesia), but can dev

197 In humans, tolerance of the loss of one or both functional copies of a gene is relat

198 o) from stromal cells is associated with the loss of osteoblastoid markers.

199 attributed to attenuation of the reflection loss of p-polarized light and multiple reflections withi

200 In this study, we investigate the effect of loss of P2X7 receptor function on retinal structure and

201 loss and p53 loss produce differing outcomes-loss of p53 promotes both tumor initiation and progressi

202 We demonstrate that partial loss of p85alpha increases the amount of p110alpha-p85 h

203 Importantly, we have found here that loss of PDHK4, a key regulator of the pyruvate dehydroge

204 ) with night blindness, and 56% (14/25) with loss of peripheral vision.

205 rtex identified either reduced expression or loss of phosphorylation at critical residues of differen

206 s (EAE), to evaluate the hypothesis that the loss of plasminogen would exacerbate neuroinflammatory d

207 , which led to a less-diverse microbiome and loss of protective gut commensal strains (of the family

208 istribution of ceramic result in much slower loss of protective oxide layers formed during ablation t

209 lineages, lower reconstitution potential and loss of protein polarity.

210 es manipulating small sample volumes without loss of rare disease-causing cells.

211 e largest effect on pseudogene formation and loss of regulatory regions.

212 Furthermore, loss of release did not disrupt the morphogenesis of pre

213 We show that loss of RER in B. subtilis causes strand- and sequence-c

214 n is characterized by loss of naive B cells, loss of resting memory B cells due to their redistributi

215 Loss of rfaH affected LPS synthesis in both species, res

216 Interestingly, loss of RP-MDM2 binding significantly accelerated colore

217 We now show that the loss of S100A4 produces two mechanistically distinct phe

218 Moreover, loss of SEP4 severely impaired mutant conidiation, melan

219 Loss of Sin3a in mouse early foregut endoderm led to a s

220 ntagonism after experimental stroke prevents loss of splenic MZ B cells, preserves IgM levels, and re

221 Preceding RGC loss in the Ndufs4 KO is the loss of starburst amacrine cells, which may be an import

222 We demonstrate that loss of STIM2 results in decreased SOCE, particularly at

223 sultines was kinetically preferred over the loss of sulfur dioxide leading to o-quinodimethane, whic

224 aptic function and inhibiting both underlies loss of synaptic transmission via massive vesicle releas

225 abstraction is likely to further exacerbate loss of taxa and ecosystem alteration, especially in dry

226 Werner syndrome protein (WRN) suppresses the loss of telomeres replicated by lagging-strand synthesis

227 Loss of THAP1 function disrupts a core set of OL maturat

228 The WhiB1 structure suggests that loss of the iron-sulfur cluster (by nitrosylation) permi

229 y of platelet mRNAs is slowed by the natural loss of the mRNA surveillance and ribosome rescue factor

230 nd palate and tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mes

231 Surprisingly, the ubiquitous loss of the protein uniquely affects the formation of th

232 differentiation defects that are mimicked by loss of the transcription factor KLF4.

233 Loss of the tumor suppressor p53 (encoded by TP53) provi

234 distribution of MENPs inside the cell and no loss of their elemental and crystalline characteristics.

235 Loss of this organization underlies disturbed insulin se

236 high sequence and structural similarity, and loss of Tim10 is accelerated by the disruption of conser

237 the role of regulatory T (Treg) cells in the loss of tolerance to gluten remains poorly understood.

238 Mechanistically, loss of UNC-45A results in increased levels of NMII acti

239 c1, suggesting that this deletion caused the loss of vernalization response.

240 s, MEK inhibitors did not cause irreversible loss of vision or serious eye damage.

241 rs characterized by slow growth, progressive loss of vision, and limited therapeutic options.

242 We demonstrate that loss of Wnt5a results in cerebellar hypoplasia and deple

243 and 95th percentiles for the time until the loss of ZIKV RNA detection were 14 days (95% confidence

244 Recent high annual losses of honey bee colonies are associated with many fa

245 es into account the radiation and scattering losses of the nano-sized probe neglected in previous mod

246 i) needed for chamber SOA mass yields due to losses of vapors to walls as a function of species volat

247 Severe loss-of-function cases were incompatible with life, wher

248 acellular domain resulted in either gain- or loss-of-function changes, part of which was attributable

249 In the tissue model, loss-of-function mutations facilitated breakdown of exci

250 Significantly, both RhoA GTPase gain- and loss-of-function mutations have been discovered in prima

251 In contrast, loss-of-function mutations in GLI1 have remained elusive

252 fection by Salmonella Typhimurium because of loss-of-function mutations in Nramp1 (SLC11A1), a phagos

253 Loss-of-function mutations in ORGANELLE RNA RECOGNITION

254 This finding is in contrast to the loss-of-function mutations in SMCHD1 that have been asso

255 Specifically, loss-of-function mutations in the gene encoding LegC4 re

256 Loss-of-function mutations in the MCOLN1 gene, which enc

257 rcent of patients have compound heterozygous loss-of-function mutations in the Shwachman-Bodian-Diamo

258 Loss-of-function of FRS7 and FRS12 results in early flow

259 ominant diseases that feature both gain- and loss-of-function pathologies or have a heterogeneous gen

260 Loss-of-function point mutations in a component of this

261 Loss-of-function studies showed that autophagy in NP cel

262 Many cancers are initiated by loss-of-heterozygosity (LOH) events that lead to the rep

263 This impact of p53 loss on 5-methylcytosine (5mC) heterogeneity was also ev

264 espite disparate impacts of Setd2 and Arid1a loss on tumor development, each resulted in a gene expre

265 th de novo DSA experienced accelerated graft loss once DSA was detected, reaching a 28% failure rate

266 ntial for neural circuit function, and their loss or dysfunction is implicated in human neuropsychiat

267 endosymbiosis is operationally defined when loss or removal of the endosymbiont from the host result

268 However, Arf loss and p53 loss produce differing outcomes-loss of p53 promotes bot

269 Adding exercise to a short-term weight-loss program should be considered as a useful strategy f

270 ed (n = 125) or self-guided (n = 121) weight loss program supporting behavioral changes to promote a

271 r malondialdehyde (MDA) content, lower water loss rates, lower relative Na(+) content, and higher chl

272 which central serotonin action leads to fat loss remain unknown.

273 y adjusted models, only death-censored graft loss remained significant (HR, 1.38; 95% CI, 1.12-1.71;

274 0.01) and significantly lower proportions of loss responsive neurons (p<0.05) in the STN, but not in

275 This loss results in the accumulation of toxic transcripts of

276 t the development of single analyzer neutral loss scans in a linear quadrupole ion trap using orthogo

277 ondary end points included short-term weight loss, serum obesity-related hormone levels, hunger and s

278 First and foremost, treating hearing loss should be investigated as a means of improving cogn

279 ents, the degree of rod and cone sensitivity losses showed a relationship, thereby providing an oppor

280 rther shown to be unaffected by more salient loss signals and resistant to response cost increases.

281 This deposition is accompanied by neuronal loss, spongiform change, astrogliosis, and conspicuous m

282 perimental periodontal inflammation and bone loss, suggesting a promising platform for the developmen

283 The waveguide features lower propagation loss than its conventional hybrid waveguiding counterpar

284 onal water inputs because of increased water loss through the stomata.

285 suggest a large treatment gap (pre-treatment loss to follow-up) between the numbers of patients with

286 cent research has linked age-related hearing loss to impaired performance across cognitive domains an

287 nts observed in Ackr4-deficient LNs to ACKR4 loss upstream.

288 r mesic conditions, are most vulnerable to N loss via NO as interactions between pH, SOM, and drought

289 The prevalence of vision loss was 11.2% (95% CI, 9.5-13.1) in Indigenous Australi

290 (3, 4, and 6 kHz) were computed, and hearing loss was defined as a PTA>25 dB in adults and PTA>15 dB

291 n months 24 and 48, the rate of lung density loss was reduced in delayed-start patients (from -2.26 g

292 A Dean scale score of 0 to 2 (</=50% hair loss) was defined as treatment success.

293 Fire-driven carbon and nitrogen losses were substantial in savanna grasslands and broadl

294 vity during fast flight, but limiting acuity loss when the fly is still.

295 es a reduction in yield, or seasonal warming losses, where raised temperature is thought to increase

296 scNOMe-seq therefore controlled for fragment loss, which enabled direct estimation of the fraction of

297 Chronic oligodendrocyte loss, which occurs in the demyelinating disorder multipl

298 mmunity composition and function after tooth loss, with smaller alterations in current tobacco smoker

299 a reduced BCAA diet promotes rapid fat mass loss without calorie restriction in obese mice.

300 conjugation inhibition and promoting plasmid loss would be an effective strategy to limit conjugation