ライフサイエンスコーパス: loss of imprinting

1 id incompatibility has indeed been linked to loss of imprinting.

2 methyltransferase DNMT1 causes a widespread loss of imprinting.

3 In vitro culture of mouse embryos results in loss of imprinting.

4 is biallelic in G9a -/- ES cells, indicating loss of imprinting.

5 Removal of a gene's DMD leads to a loss of imprinting.

6 ence of methylation of SNRPN consistent with loss of imprinting.

7 of 27 tumors informative for IGF2 manifested loss of imprinting.

8 tion in both wild-type and mutant mice, with loss of imprinting.

9 3 promoter in primary human gliomas led to a loss of imprinting and decreased PEG3 mRNA expression th

10 Choriocarcinomas are embryonal tumours with loss of imprinting and hypermethylation at the insulin-l

11 The overexpression of Dnmt3b1 caused loss of imprinting and increased expression of Igf2 as w

12 elapse with loss of heterozygosity, 25% with loss of imprinting, and 3.3% relapse with retention of t

13 vents, such as promoter hypermethylation and loss of imprinting, are also involved in carcinogenesis.

14 Loss of imprinting at 11p15 was identified in one of 42

15 tations in WT1 and loss of heterozygosity or loss of imprinting at 11p15, which results in biallelic

16 the constitutional imprinting and six showed loss of imprinting at either H19 or IGF2.

17 Loss of imprinting at IGF2, generally through an H19-ind

18 We propose a model in which loss of imprinting at the 14q32 domain leads to overexpr

19 These data suggest that loss of imprinting at the IGF2 and H19 loci play a role

20 In humans, loss of imprinting at this locus is associated with tumo

21 hese data indicating environmentally induced loss of imprinting at VTRNA2-1 constitute a plausible ca

22 and the vulnerability of imprinted genes to loss of imprinting changes, there has been extensive spe

23 hat misregulation of non-imprinted genes and loss-of-imprinting characterize the ART-induced overgrow

24 this dynamic period and to determine whether loss of imprinting continues at later stages of developm

25 As a result of loss of imprinting, DLX5 was upregulated in 69% of preec

26 To determine whether loss of imprinting in cancer might be reversed by alteri

27 The maternally expressed gene DLX5 showed a loss of imprinting in lymphoblastoid cells from individu

28 The discrepancy between IGF2 and IGF2-AS loss of imprinting in some tumors demonstrates the contr

29 ted head and neck squamous carcinoma for the loss of imprinting in the IGF2 and H19 genes to determin

30 ncreased maternal allele expression of Igf2 (loss of imprinting) in adenoma which form, despite pater

31 occurs through a loss of heterozygosity- or loss of imprinting-independent process.

32 by in vitro reprogramming, and suggest that loss of imprinting is associated with the loss of activi

33 f 5-aza-2'-deoxycytidine on tumor cells with loss of imprinting is not random but specific to one all

34 arental inheritance of chromosome 11p15, and loss of imprinting is observed in several cancers includ

35 Loss of imprinting is the silencing of active imprinted

36 olved in maintenance of imprinting (MOI) and loss of imprinting (LOI) are unresolved.

37 Loss of imprinting (LOI) associated with hypomethylation

38 Although loss of imprinting (LOI) at fetal promoters contributes

39 Loss of imprinting (LOI) at the IGF2/H19 locus on the ma

40 We also found a loss of imprinting (LOI) for Igf2 in a limited number of

41 Loss of imprinting (LOI) has been observed in many types

42 Alterations of genomic imprinting or loss of imprinting (LOI) have been observed in a number

43 s, and some developmental disorders, exhibit loss of imprinting (LOI) in key genes such as insulin-li

44 Loss of imprinting (LOI) is a common epigenetic event in

45 Loss of imprinting (LOI) is an epigenetic alteration inv

46 Loss of imprinting (LOI) is an epigenetic alteration of

47 Loss of imprinting (LOI) is an epigenetic event that rel

48 IGF2 loss of imprinting (LOI) is fairly prevalent and implica

49 Loss of imprinting (LOI) is the most common molecular ab

50 Loss of imprinting (LOI) is the reactivation of the sile

51 tion patterns at imprinted loci resulting in loss of imprinting (LOI) may lead to serious imprinting

52 Loss of imprinting (LOI) of H19 is observed in human mal

53 ic acid supplementation during pregnancy and loss of imprinting (LOI) of IGF2 and H19 genes in placen

54 Constitutive loss of imprinting (LOI) of IGF2 has been associated wit

55 expression, and suggest a new mechanism for loss of imprinting (LOI) of Igf2, which may be important

56 nts (50%) showed biallelic expression, i.e., loss of imprinting (LOI) of LIT1.

57 Loss of imprinting (LOI) of the insulin-like growth fact

58 Loss of imprinting (LOI) of the insulin-like growth fact

59 a recent study showing that a mouse model of loss of imprinting (LOI) of the insulin-like growth fact

60 thylation and promoter hypermethylation, and loss of imprinting (LOI) of the insulin-like growth fact

61 We applied the assay to analysis of loss of imprinting (LOI) of the insulin-like growth fact

62 We hypothesize that loss of imprinting (LOI) of the insulin-like growth fact

63 Recently, we and others have described loss of imprinting (LOI) of the insulin-like growth fact

64 Loss of heterozygosity and loss of imprinting (LOI) of this region are frequently o

65 Loss of imprinting (LOI), an epigenetic alteration affec

66 ics recapitulate those observed in the human loss-of-imprinting (LOI) overgrowth syndrome Beckwith-Wi

67 locus in LOI cancer cells suggests that the loss of imprinting may lead to a variety of changes in g

68 Thus, loss of heterozygosity or loss of imprinting might simultaneously affect several g

69 egulated in testicular germ cell tumors, and loss of imprinting occurs frequently in testicular semin

70 ly inherited chromosome causes bidirectional loss of imprinting of all genes in the cluster.

71 A deletion within this region results in loss of imprinting of both H19 and Igf2.

72 t synthesize gamma-aminobutyric acid (GABA), loss of imprinting of Dlx5 may alter GABAergic neuron ac

73 ncluding infrequent mutation of p57(KIP2) or loss of imprinting of either of two imprinted gene domai

74 Paternal inheritance of Ex1A-T leads to loss of imprinting of Gsalpha and loss of expression of

75 Paternal inheritance of Ex1A-T-CON leads to loss of imprinting of Gsalpha, resulting in preweaning g

76 t a similar mechanism may be responsible for loss of imprinting of IGF-II in normal brain and Wilms'

77 that show loss of heterozygosity of 11p15 or loss of imprinting of IGF2 also silence HOTS (7/7 and 10

78 Loss of imprinting of IGF2 is the most common molecular

79 informative for the ApaI IGF2 polymorphism, loss of imprinting of IGF2 was observed in both normal a

80 Some patients display loss of imprinting of IGF2, a fetal-specific growth fact

81 e LOI of IGF2, only two of six tumors showed loss of imprinting of IGF2-AS, whereas four of six tumor

82 a disease that has also been associated with loss of imprinting of IGF2.

83 Loss of imprinting of insulin-like growth factor-II gene

84 Loss of imprinting of the IGF2 gene is frequently observ

85 with a luciferase reporter gene resulted in loss of imprinting of the transgene.

86 These findings strongly suggest that loss of imprinting or switching of allelic expression of

87 Different from a loss of imprinting pattern, loss of IR and IGF1R causes

88 overed a novel genetic alteration in cancer, loss of imprinting, which affects several of these genes