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1 m a non-ciliary localizing protein (Src) has low affinity.
2 at ASI could bind to GR in spite of relative low affinity.
3 ly (U) or d(T) while d(A) polymers bind with low affinity.
4 ab26 in its GTP-bound form, albeit only with low affinity.
5 the Cu-V103Z and L126Z variants demonstrated low affinity.
6 e to dioxin, and Xenopus AHRs bind TCDD with low affinity.
7 ve to the myristoylated glycine for high and low affinities.
8 ith a high degree of predisposition but with low affinities.
9 al ventricles of the neonatal mouse brain, a low-affinity AAV4 mutant (AAV4.18) displayed a striking
11 expanded to a greater extent in response to low-affinity Ags than did their mature T cell counterpar
13 es of engineered T cells expressing a native low affinity alphabeta-TCR chains or high affinity TCR-l
15 lls proliferated more readily in response to low-affinity and low-abundance ligands both in vitro and
16 bound IgE of the allergic effector cells via low-affinity anti-human IgE Abs with dissociation consta
17 strate that targeting surface-bound IgE with low-affinity anti-IgE Abs is capable of suppressing alle
19 llent safety profile, indicating that use of low-affinity anti-IgE mAbs holds promise as a novel ther
21 ability of allergic reaction blockade by the low-affinity anti-IgE mAbs was correlated with their cap
23 nity and stimulating capability of initially low-affinity antibacterial (e.g., Yersinia) Abs cross-re
26 ns lead us to propose that high-specificity, low-affinity attachment of MERS-CoV to sialoglycans duri
27 al. (2015) challenge this view, showing that low affinity B cells initiate Salmonella responses and a
28 cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expa
31 rom high affinity beta2-containing nAChRs to low affinity beta4-containing nAChRs, in addition to the
32 allows the determination of binding modes of low affinity binders in the protein-ligand interface and
34 with mixed-affinity binders (MABs), whereas low-affinity binders (LABs) are unsuitable for evaluatio
35 ABs), 3 mixed-affinity binders (MABs), and 3 low-affinity binders (LABs)-were studied with whole-body
36 tch regions of CDC42 or RAC1 and (ii) a very low affinity binding of GRD and a C terminus adjacent to
39 he overall enhancer architecture-clusters of low affinity binding sites-is maintained and required fo
40 (KD = 0.83 muM) compared to G7-B1 and shows low affinity binding to Grb2-, Grb10- and Grb14-SH2 doma
41 r between a QD and a molecular probe to even low-affinity binding events at the QD/solvent interface.
42 e substrate, whereas MDDMA and MDTMA adopt a low-affinity binding mode consistent with an inhibitor,
43 ional selection mechanism contrasts with the low-affinity binding mode of 53BP1, and it ensures 53BP1
45 is is achieved using multiple, minimalistic, low-affinity binding motifs that are in rapid exchange w
46 litate plasma membrane targeting through the low-affinity binding of NB to phosphorylated inositol po
47 bind approximately 1.6 thrombin molecules at low-affinity binding sites (Kd = 2.8 muM) and approximat
48 r the long-standing observation of high- and low-affinity binding sites for the prototypic inhibitor
49 cription factor Ultrabithorax (Ubx) utilizes low-affinity binding sites in the Drosophila melanogaste
50 ast, ADP occupies one high-affinity and five low-affinity binding sites in vitro, consistent with con
51 ochord enhancers, including those containing low-affinity binding sites that would be excluded by sta
52 r Irf4 abundance with its recruitment toward low-affinity binding sites within Teff cell cis-regulato
53 nd binding to GPCRs have revealed transient, low-affinity binding sites, termed metastable binding si
54 sion of DBP1 may have been selected to allow low-affinity binding to another receptor on Duffy-null e
58 ow enhancer contains binding sites with very low affinity, but optimal syntax, and therefore mediates
59 gh affinity and interacts with the CCTP with low affinity, but the reason for this difference is not
60 eloped novel genetically encoded ER-targeted low-affinity Ca(2+) indicators optimized for examining a
63 the ciliary transport regulator Arl3, while low-affinity cargo is released by Arl3 and its non-cilia
64 and low-affinity TDBs revealed that only the low-affinity CD3/CLL1 TDB was well tolerated and able to
66 n is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protection remains
67 ators IL-10, TIGIT, GITR, and CTLA4, whereas low-affinity cells displayed increased transcripts for A
70 sically disordered proteins may evolve via a low-affinity complex which is optimized by modulating di
71 cient route to binding site localization for low affinity complexes and is applicable to rapid screen
72 protein recognition domains frequently form low-affinity complexes with polysaccharides that are dif
76 ext-at low force or stiffness, they serve as low-affinity cross-links, but they can transition to for
77 llowed us to propose that D8 has a high- and low-affinity CS-binding region within its central crevic
79 in, Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal Cu exporter, or
80 differentially expressed genes had multiple, low-affinity CUX1 binding sites, features of analog gene
82 and TCR affinity for myelin, as the inherent low affinity does not allow the use of specific peptide:
83 ing defined recombinant soluble (rs) dimeric low-affinity ectodomains (rsFcgammaR) that have an absol
85 al avidity maturation and uncover a role for low-affinity effector T cells during early microbial con
95 be distinguished based on expression of the low-affinity FcgammaRIII: CD14(++)CD16 -: classical mono
102 take systems BicA and SbtA, where BicA has a low affinity for bicarbonate but high flux rate, and Sbt
104 gen-elicited memory T cells can have high or low affinity for cross-reactive allogeneic peptide-MHC,
108 olved in this process - Cyo has a relatively low affinity for O2 but is able to pump protons and henc
109 mice such that thymocytes bearing TCRs with low affinity for self-peptide are not efficiently select
110 alf of the EWS portion of the fusion) showed low affinity for smaller GGAA-microsatellites but instea
111 in these cases suggests that this ligand has low affinity for tau lesions primarily made of straight
117 ealed a significant population of relatively low-affinity gamma2 subunit-containing GABAA receptors i
119 particular in those tissues that express the low affinity glucose-phosphorylating enzyme glucokinase.
120 R and KLF15 physically interact and identify low affinity GR binding sites within glucocorticoid resp
121 ding restraints of this CC MBS.LZ PKG-Ialpha low-affinity heterotetrameric complex and allow reevalua
122 can engage the human FcgammaRII class of the low-affinity hFcgammaRs, demonstrating that N-linked gly
123 ession of the GS1 isogene Gln-1;2 encoding a low-affinity high-capacity GS1 protein in Arabidopsis (A
124 knowledge, on T4P flexibility and support a low-affinity, high-avidity adhesion mechanism that media
127 easurements, we find that SdrC is engaged in low-affinity homophilic bonds that promote cell-cell adh
128 mpaired generation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clear
129 mpaired generation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clear
130 FcepsilonRI) on mast cells and basophils and low-affinity IgE receptors (FcepsilonRII) on B cells.
131 tion of IgE interactions with both high- and low-affinity IgE receptors, and explains why omalizumab
135 oped a novel mouse strain in which the human low-affinity IgG receptor locus, comprising both activat
136 ic memory T cells or by cross-linking of the low-affinity IgG receptor, CD16, by Ag-Ab immune complex
138 to bind monovalently to immobilized mAb with low affinity in the absence of quinine and with fivefold
141 ic Fc-based scaffold that we here show binds low-affinity inhibitory receptors (FcRL5, FcgammaRIIb, a
144 e-guided mutation allows the generation of a low-affinity INPP5E mutant which loses exclusive ciliary
145 insufficient to induce deletion of high- or low-affinity InsB9-23-reactive CD4(+) T cells; however,
146 hat intracellular signaling activated by the low affinity interaction of mOSM with mLIFR is different
147 and PNKP together and thereby promoting the low-affinity interaction identified here, which then sti
149 ectin binding to a single glycan ligand is a low-affinity interaction, but the multivalency of galect
151 has the advantages that it is applicable to low-affinity interactions because the complexes are not
152 ocess may, in part, involve enabling crucial low-affinity interactions between Orai1 N-terminus and S
154 SCAR with a collagen fibril, with transient, low-affinity interactions initiated by the membrane-dist
155 ycan interactions have been considered to be low-affinity interactions that precede high-affinity pro
156 Profilin and cofilin display transient, low-affinity interactions with phosphoinositide-rich mem
157 hought to modulate neuronal function through low-affinity interactions with proteins, in particular w
158 +), HLA-Bw4-80Ile(-) genotype, predictive of low-affinity interactions, had a low incidence of relaps
161 es the expression of FET4, a gene encoding a low affinity iron transporter able to transport metals o
162 ) and HLA-Bw4-80Ile(+) patients, a predicted low-affinity KIR2DL2/3(+) and HLA-C1/C1 genotype was ass
165 othesized high affinity ligands compete with low affinity ligands for receptor binding and signaling.
166 olar side chain of T153 creates a barrier to low-affinity ligands that interact with E149 and A150.
170 e to peptide recognition, yet the pEF hand's low affinity limits Ca(2+) binding at normal physiologic
172 sed fluorescent ligands (presenting multiple low-affinity moieties) and ConA (presenting multiple bin
173 The identification of the binding sites for low affinity molecular encounters is essential for the d
174 y useful for the systematic investigation of low affinity molecules with residence times in the micro
175 o thousands of additional regions containing low-affinity multimerized IRF sites and composite IRF-AP
176 to be formed by phase separations caused by low-affinity, multivalent interactions involving protein
178 es derived from patients vaccinated with the low-affinity (native) peptide expressed slower koff rate
180 nistration in rats by the recruitment of the low-affinity neurotrophin receptor, p75NTR, whose activi
185 itination by WWP1 requires the presence of a low-affinity, noncovalent Ub-binding site within the HEC
187 rdings revealed that, despite the relatively low affinity of Cal-590 for Ca2+ (Kd=561 nM), single-act
189 s a decline in cellular [ATP]; the unusually low affinity of IP6Ks for ATP compels 5-InsP7 levels to
190 rder to overcome the inherent problem of the low affinity of the above pesticides, we have developed
193 ed by IL-2, thereby restricting responses to low-affinity or low-abundance self-antigens even in the
194 assemblies, including those with challenging low-affinity partners, and may facilitate the design of
200 at the +2 and +3 positions between high and low affinity peptides results in reversing their affinit
202 odimer may be responsible for generating the low-affinity pharmacology of the secondary beta1-adrenoc
203 from the soil, plants have evolved high- and low-affinity Pi transporters and the ability to induce r
204 of the enzyme and Cys303 providing a second, low affinity pigment binding site that is essential for
207 novel mechanism by which CD45 isoforms tune low affinity-primed memory CD8(+) T cells to become pote
208 CD45RB blockade prolonged graft survival in low affinity-primed mice, but not in high affinity-prime
209 n and timing of effector differentiation, as low affinity-primed T cells acquired cytotoxic activity
213 ng that despite a lower precursor frequency, low-affinity priming is sufficient to generate memory ce
215 agging approach that enables localization of low affinity protein-ligand binding clefts by detection
216 due specificity, GECX enables the capture of low-affinity protein binding (affibody with Z protein),
218 ursor cells expressing TCRs within a certain low-affinity range for complexes of self-peptide and maj
225 taining the beta2-subunit, beta2-nAChRs) and low-affinity receptors (containing the alpha7-subunit, a
228 that Mcm10 recruitment occurs via two modes: low affinity recruitment in the absence of CMG assembly
229 These results provide direct evidence for a low-affinity Rem2/Cavbeta4 interaction and show definiti
231 element ESS and indicated that proteins with low-affinity RNA-binding sites can be recruited in a fun
235 altered heavy chain usage and enrichment for low-affinity self-reactive specificities in murine margi
236 rrent consensus model has Q8H2 oxidized at a low affinity site (QL), passing electrons to a tightly b
239 (Exd) bound specifically to clusters of very low affinity sites in enhancers of the shavenbaby gene o
240 complexes, and that the presence of high and low affinity sites may influence the rate of isotopic ex
241 actor and cofactor concentrations could help low-affinity sites overcome their kinetic inefficiency.
242 ficant fraction of its hydrolysis cycle in a low affinity state but dissociates only slowly from this
243 85 pM) and excellent selectivity against the low-affinity state of D(2)R (D(2)RLow) (mean K(i) = 84 n
245 difference in affinity between the high- and low-affinity states is more compressed in alpha4beta1 (6
249 ic, state-dependent SLC13A5 inhibitors, with low-affinity substrate activity in the absence of citrat
250 ve inhibitor bisindolylmaleimide I displaces low affinity substrates more potently leading to substra
256 entire CD4+ T-cell repertoire, inclusive of low-affinity T cells missed by tetramers, using a T-cell
259 ons (CDRs) from the crystal structures of 34 low-affinity T-cell receptors and 40 high-affinity Fabs
260 on FcRn binding affinity that increased from low affinity (t1/2 29h), to wild type (t1/2 50h), to hig
261 a general mechanism to facilitate binding to low-affinity targets and that this may be a prevalent fe
262 onjunction with T1R1 or T1R3, can serve as a low-affinity taste receptor for l-glutamate in the prese
265 y and target cell depletion by the high- and low-affinity TDBs revealed that only the low-affinity CD
267 strates that thrombin initially binds to the low-affinity thrombin binding sites before preferentiall
269 f the natural antibody repertoire, bind with low affinity to a variety of structurally unrelated anti
275 ers and had a reduced Ab response, mostly of low affinity to T cell-dependent Ag, compared with wild-
276 0 = 60 muM), whereas it bound with only very low affinity to the ACh binding sites ([(3)H]ACh, IC50 =
277 mutant F273W revealed that Na(+) binds with low affinity to the apoprotein (Kd 120 mm), with a parti
278 that the PDZ domain of nNOS binds with very low affinity to the C termini of target proteins, and a
279 ion and EMSA, we found that STAT3 binds with low affinity to the caspase-3 promoter, suggesting that
280 ntagonists for CCR1 and CCR3, also bind with low affinity to the closely related receptors CCR2 and C
281 syl trichloroacetimidate activation revealed low affinity to the glycosyl donor but high affinity to
283 force accelerates transition from the bent (low affinity) to the extended (high affinity) state.
284 luated, and components with high, medium, or low affinity toward aprotinin could be successfully disc
286 Considering that Hsp104 is characterized by low affinity towards ATP and is strongly inhibited by ad
288 s under the regulation of the high-capacity, low-affinity transporter PMAT, not the low-capacity, hig
289 trode voltage clamp showed that TcPho91 is a low-affinity transporter with a Km for Pi in the millimo
293 enhancer, requiring a particular density of low affinity Ubx sites to confer both specific and robus
296 the 6-arylpicolinates (halauxifen), and very low affinity was found for picolinic acid-based auxins (
297 annel of voltage-dependent high capacity and low affinity, whereas DmHAK5 was identified as the first
298 Ig produced and recognizes multiple Ags with low affinity, whereas immune IgM is induced by Ag exposu
299 Ca(2+)-binding ratio ( approximately 15) and low affinity, whereas mobile buffers have high affinity.
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