ライフサイエンスコーパス: low yield

1 proach is that it is both time-consuming and low yield.

2 culture was less sensitive and had extremely low yield.

3 4)(O(t)Bu)(12)Cl][U(CH(2)SiMe(3))(5)] (1) in low yield.

4 e conditions, protracted differentiation and low yield.

5 binding using a Ni column with a relatively low yield.

6 using potassium t-butoxide gave isoprene in low yield.

7 eld, whereas the CB[5] analogue is formed in low yield.

8 H(2)O to give the copper porphyrin albeit in low yield.

9 ines containing -CH(2)OR groups proceeded in low yield.

10 l testing for these specific mutations is of low yield.

11 versial in this population given the overall low yield.

12 e-induced cleavage was observed, although at low yield.

13 al other monomeric products were obtained in low yield.

14 oes not perform well in this setting and has low yield.

15 grape-based compost, but this coincided with low yield.

16 activated alkenes have typically occurred in low yield.

17 24 followed by lactone formation gave 26 in low yield.

18 2) followed by lactonization gave 26 also in low yield.

19 omer with the desired stereochemistry but in low yield.

20 lls are technically demanding and relatively low-yield.

21 ide poor and random cell contact, leading to low yields.

22 carbamoyl allenes, while the acetates afford low yields.

23 nificantly larger 45-nm particles, albeit in low yields.

24 sslinked to TnC, TnT and actin, but all with low yields.

25 recovery of terpenes from plants because of low yields.

26 favorable amino acids or with prohibitively low yields.

27 ligand are cumbersome and typically lead to low yields.

28 d the desired products are often produced in low yields.

29 es to provide ortho-(alkyltelluro)phenols in low yields.

30 sulfur that have previously been reported in low yields.

31 irconium methodology is effective, albeit in low yields.

32 rted, the procedures are relatively long and low yielding.

33 on is challenging since direct reactions are low yielding.

34 relatively slow, inefficient, and frequently low-yielding.

35 use their synthesis is challenging and often low-yielding.

36 -confined dipole variation associated with a low-yield (13-14%) trans-cis isomerization of the azoben

37 ar conditions afford the carbocycles in very low yields (2% and 6%, respectively).

38 31-73%); cyclic aliphatic substrates provide low yields (24-38%).

39 anded clusters were detected, albeit at very low yields (37 Fpg-OxyPurine clusters Gbp(-1) kJ(-1) m(2

40 e protected cyclotetrasyringyl derivative in low yield (7%), which was fully characterized by (1)H NM

41 anediamine with dimethyldioxirane, albeit in low yield (7%).

42 It provides the adducts in low yields accompanied by complex mixtures of secondary

43 edure is simple, it provides 3 in relatively low yield, accompanied by a smaller amount of the isomer

44 is of Boc- or Cbz-D-Hyv lactone proceeded in low yield; additionally, the lactones are too unreactive

45 disturbance, however, could be resilient to low-yield agriculture and thus fare better under land sh

46 where, more than any other tropical country, low-yielding agriculture has been replaced by intensive

47 tuent at the 5-position typically results in low yield and a mixture of porphyrin products derived fr

48 xplosive mixtures, but they suffer from very low yield and are intrinsically limited to small volumes

49 Enterobacter cloacae SLD1a-1 is purified in low yield and has relatively low activity in the pure fo

50 The low yield and high cost of endoscopic screening of patie

51 vailable from a yeast system with relatively low yield and high cost, which has made it difficult to

52 ss II I-A molecules have been limited by the low yield and instability of soluble, recombinant hetero

53 e (3-Cl-Tyr), although 3-Cl-Tyr is formed at low yield and is subject to metabolism.

54 d size with an increased length/width ratio, low yield and less starch content in the early storage r

55 mplex analytic approaches that generate very low yield and purity.

56 mouse HSC isolation is commonly hampered by low yield and purity.

57 is frequently complicated by the problems of low yield and specificity, especially when the GC conten

58 nthesis lengths, high synthesis error rates, low yield and the challenges of assembling long construc

59 holangiography is discouraged in view of its low yield and the significant rate of false positive cho

60 ely damaging to the environment, making them low yield and very expensive.

61 DIs are generally lengthy, nonselective, and low yielding and their polymeric analogues have yet to b

62 of pteroyl-gamma-glutamate-cysteine provide low yields and are not easily reproducible.

63 proteins in plants is limited by relatively low yields and difficulties in extraction and purificati

64 approaches rely on multi-step ligations with low yields and incomplete products.

65 To address low yields and low income both, the soil fertility, the

66 ous catalysts at high temperatures, but with low yields and low selectivity.

67 fforded the desired cyclopropane products in low yields and poor enantioselectivity.

68 use of undercooled metals, primarily due to low yields and poor stability.

69 phthalene and dihydronaphthalene substrates, low yields and product mixtures have reduced the impact

70 With conventional ligation procedures low yields and random orientation of oligomers makes clo

71 nts in vitro as reflected by their extremely low yields and shortened lengths upon isolation.

72 multistep syntheses, which also suffer from low yields and/or poor precursor scopes.

73 op-down method is time-consuming, costly and low-yield and it produces fragmented nanosheets with sub

74 Low-yielding and moderately alpha- and diastereoselectiv

75 hemical method addresses this challenge in a low-yielding and not fully understood fashion: Schonecke

76 development are limited by poor solubility, low yield, and protein misfolding.

77 Synthesis, however, proceeds with low yields, and derivatives are difficult to prepare.

78 e specialized substrates, bulky fusion tags, low yields, and extra purification steps to achieve the

79 such as the poor availability of precursors, low yields, and use and production of undesirable substa

80 mary amine side chain of lysine demonstrated low yields ( approximately 0.2%) of chloropicrin, but hi

81 stereomeric mixtures ( approximately 2:1) in low yields ( approximately 40%).

82 led several largely converted yet relatively low-yielding areas (such as central, eastern, and northe

83 -deficient substrates afford product in very low yields at room temperature, but moderate to good yie

84 We find that forest recovery is superior to low-yielding biofuel production scenarios such as oil pa

85 ion, a laborious process that often leads to low yield both in the amount of DNA and the fraction of

86 of tetraphenylbenzyne, has been prepared in low yield by diazotization of 3,4,5,6-tetraphenylanthran

87 d by enzymatic reduction of 5-FU and in very low yield by hydrogenation of 5-FU; however, a practical

88 iopharmaceuticals that can be made only with low yields by currently available equipment.

89 enium ion 1c, but they are generated in very low yields (ca. 10%) so it is not possible to definitive

90 erally problematic and frequently results in low yield, cell toxicity, protein aggregation and misfol

91 ed pluripotent stem cells (hiPSCs) result in low yields, cellular heterogeneity, and limited scalabil

92 -nitrosamines in inhaled smoke from filtered low-yield cigarettes.

93 Co-transfections of high- and low-yielding constructs demonstrated that under conditio

94 Compared to a low-yielding cultivar, a high-yielding cultivar signific

95 ystem was implemented: Examinations that had low-yield decision support scores could not be scheduled

96 The fraction of low-yield (decision support score, 1-3) examinations req

97 Low-yielding, deep bedrock wells may require large contr

98 ethods, but such approaches typically have a low yield due to inhomogeneous oxidation.

99 toward one another could only be obtained in low yields due to a combination of stability and steric

100 lution coupling in aqueous medium results in low yields due to the solvent incompatibility of DNA and

101 the relative yield reductions are larger in low-yielding environments (e.g., high reference temperat

102 are now well-defined criteria for rejecting low-yield ETAs from adults, but it is uncertain whether

103 RNAs, including aptamers, ribozymes, and, in low yield, even tRNA.

104 ll women in the HMO aged 50-64 years) and of low-yield examinations (ie, sinus, rib, and skull radiog

105 port crop production (i.e. reconstruction of low yield farmland, and agricultural subsidies), combine

106 y clinical exome sequencing, with relatively low yield for cardiovascular abnormalities.

107 ficult to purify, and this caused an overall low yield for the synthesis.

108 d pyrrolidine than a 2-lithiated piperidine; low yields for the lithiation-substitution of N-Boc-2-ph

109 The low-yield formation of nC(60) from organic solvent solut

110 This complex is formed in low yield from [Ir(COD)(OMe)](2), dtbpy, COE, and B(2)pi

111 A second species can be isolated in low yield from the reaction mixtures of 1, namely [Li(OE

112 ligate chaperone of PDE6 and that it enables low yield functional folding of cone PDE6C in cultured c

113 ported in vivo assembly techniques have been low yielding, generating only tens to hundreds of constr

114 in hypoxic tumor regions are constrained by low-yielding glycolysis, and any means of reducing the c

115 tions from high-yield/low-price fisheries to low-yield/high-price fisheries, generating severe strain

116 tively selecting parents to produce high- or low-yield hybrids.

117 Because standard imaging has a low yield identifying potential recurrence, blind (131)I

118 esulted in a substantially decreased rate of low-yield imaging examinations and a markedly increased

119 mia before emergency department discharge is low yield in patients with negative troponins and TIMI s

120 erihepatic lymph nodes will therefore have a low yield in patients without some evidence of disease o

121 e pre-employment TB screening program was of low yield in the detection of active TB or increased LTB

122 ower S states, which are probably present in low yield in these samples.

123 Because of its low yield in unselected specimens, stool culture is ofte

124 Their synthesis has been complicated by low yields in solid-phase syntheses.

125 entified oxidation products were observed in low yields in the oxidations.

126 The less reactive diazoacetamides give very low yields in their reactions with benzhydryl imines but

127 ene cycloadduct could be detected, albeit in low yield, in the photolysate.

128 fficult coupling partners that often deliver low yields, in particular in reactions with aryl amines.

129 nd 2-acylated furans are obtained, albeit in low yield, instead of nitroalkanols.

130 ction, originally occurring spontaneously in low yields, into a practical methodology.

131 the Z-delta isomer is initially produced in low yield, it is continually reformed via decomposition

132 he art suffers from limited substrate scope, low yields, long reaction times, and anomeric mixtures.

133 art methods include limited substrate scope, low yields, long reaction times, and anomeric mixtures.

134 a few (four) instances and has proceeded in low yield (</=6%).

135 of these hybrid materials have relied on the low-yield manual exfoliation and stacking of individual

136 oxorubicin derivatives were isolated in very low yield, most likely because of the inherent base labi

137 tion, which is responsible for the extremely low yields observed for the incorporation of the North p

138 through dismutation reaction, resulting in a low yield of (1)O(2) detected.

139 azolone (20) at 600 degrees C affords only a low yield of azabutadiene (18) due to chemically activat

140 yl radical with O(2) in benzene results in a low yield of benzene oxide, which is shown by isotopic l

141 The low yield of cross-sectional imaging performed for evalu

142 because of lack of comprehensive studies and low yield of diagnostic approach.

143 clones, but an important disadvantage is the low yield of DNA, both for vectors alone and when carryi

144 nificantly contributing to the high cost and low yield of drug discovery.

145 ly deleted in this region resulted in a very low yield of H37-expressing clones.

146 However, this assay results in a low yield of high-quality data, defined as the complete

147 bility occurring after assignment, and (c) a low yield of information for explaining why certain effe

148 The low yield of isoprenoids in plants makes them difficult

149 0(-7) mbar) source, good chemical stability, low yield of matrix-related ions, low matrix consumption

150 hypothesized that a potential reason for the low yield of mouse BMSCs is the flushing of the marrow u

151 ins derived from other ketones resulted in a low yield of phlorin from acetophenone (5%) and no detec

152 to coat protein, there is a correspondingly low yield of proper procapsids.

153 Unfortunately, the low yield of Rdh54 from the yeast expression system has

154 The low yield of screening colonoscopy in this age group is

155 nderwent silylation in good yield, whereas a low yield of siloxane was obtained from 2-bromofuran, an

156 Because of the low yield of the baculovirus system, the E. coli-express

157 The reasons for the relatively low yield of the H5N1 strains are not fully understood,

158 DM2/p53 inhibitor AM-8553 was impeded by the low yield of the initial synthesis.

159 A low yield of the platinum(II) complex could also be isol

160 Despite the low yield of the ROS, jack bean urease was shown to be i

161 gain gave mainly triazole together with very low yields of 1-(1,2,4-triazol-1-yl)-2,4,6-trimethylbenz

162 The trisubstituted epoxide gave low yields of adducts with all (2-pyridyl)methyllithium

163 Bu(3)SnH reduces DMF, but along with the low yields of Bu(3)SnOSnBu(3) (but no Bu(3)SnOCH(2)NMe(2

164 neurons is hindered by the long duration and low yields of existing protocols for in vitro differenti

165 ell differentiation protocols are limited by low yields of hematopoietic progeny.

166 This paradox could explain the low yields of hemochromatosis screening reported by some

167 g hydroxy fatty acids (HFA) have resulted in low yields of HFA compared with the native castor (Ricin

168 Low yields of photoproducts, namely pyrimidine dimers, a

169 aterial, and labor resources while providing low yields of products.

170 nation of rAAV with the Ad helper virus, (2) low yields of rAAV and (3) production of replication-com

171 simulated vent structures appear to generate low yields of simple organics.

172 roduced mainly difluoro products (8h-k) with low yields of tertrafluoro derivatives (9h-k).

173 ntiation result in mixed cell populations or low yields of the cells of interest.

174 Such transitions happen rarely, resulting in low yields of the photocatalytic water splitting observe

175 ols such as screening tracers with initially low yield or labeling efficiency, imaging low receptor d

176 yl halides, but these organisms produce very low yields or are not amenable to industrial production.

177 ; however, these procedures either result in low yields or require numerous sequential reactions and

178 r pumping, e.g., in groundwater wells with a low yield, or in long-term time series, in which short-t

179 entration) characterized by rapid growth and low yield, our highly concentrated NP system supplies re

180 Copying is low-yielding, particularly for long RNA.

181 Low yields, poor stability, and inefficient binding to c

182 l of prebiotic synthesis, in contrast to the low yields previously obtained under more dilute conditi

183 o predefined features, which are necessarily low-yield processes and which can introduce undesirable

184 This low yield prompted us to perform a more quantitative ass

185 etrating peptides for instance) provide very low yields: QDs stay at the plasma membrane or are trapp

186 so afford carbaporphyrin products, albeit in low yields ranging from 5 to 8%.

187 hindered by syntheses that are traditionally low-yielding, requiring long reaction times, laborious p

188 technical advances in sample preparation for low-yield sample inputs and a computational pipeline for

189 In conclusion, rejecting specimens of proven low yield saves reagent costs and, more importantly, sav

190 -yielding season but less rapidly during the low-yielding season if observed temperature and radiatio

191 A fermentation method that bypasses the low-yielding semisynthesis of epirubicin (4'-epidoxorubi

192 with fewer gaps, concerns about error rates, low yields, stringent DNA requirements and uncertainty a

193 yclic architectures that require lengthy and low-yielding syntheses; for example, one glucose-selecti

194 ods typically afford ill-defined products in low yields (that is, less than 10-20wt%).

195 In spite of its low yield, the UDP-Galf is readily purified from startin

196 a water extraction step) or is too slow and low-yielding to be practical.

197 ides and dialkylalkynes normally afford only low yields under our standard reaction conditions.

198 ulty associated with crystallization such as low yield, unsuitability for large-scale synthesis, etc.

199 ed bases, abasic sites, and strand breaks at low yields, we tested whether it also produces clusters

200 products 42 and 43 were obtained, albeit in low yield, when bulky ethyl and isopropyl groups were em

201 d that myocardial perfusion imaging would be low yield with limited short-term value and that early r

202 eactions that gave either no product or very low yields with the corresponding less electrophilic N-t

203 ined when clinicians suspect sepsis, yet are low-yield with a false-positive rate up to 50%.