ライフサイエンスコーパス: low-abundance

1 bleaching (either due to absence or extreme low abundance).

2 led structural analysis of TPPII despite its low abundance.

3 persisted in the brain, albeit sometimes in low abundance.

4 ack of gamma2 subunit capture was not due to low abundance.

5 gical samples is cumbersome because of their low abundance.

6 acromolecular assemblies, which are often of low abundance.

7 nked PG precursors, which are of notoriously low abundance.

8 her nonspecific for malignant disease or had low abundance.

9 yst for this is platinum-a precious metal of low abundance.

10 short anti-sense RNA species expressed with low abundance.

11 Both complexes are of very low abundance.

12 ons from retina explants, and because of its low abundance.

13 protein allergen, Ara h 9, were detected in low abundance.

14 educing producers' ability to invade when at low abundance.

15 soil, but key decomposers are ubiquitous in low abundance.

16 lotypes, but all were found to be present at low abundances.

17 discrimination of overlapped ion peaks with low abundances.

18 SPalphabeta ultracentrifuge studies reveal a low abundance 2:2 complex with approximately 10-fold low

19 found in few flies; in contrast, despite its low abundance (2.9%), DNA from the Fabaceae family was d

20 cleotide small interfering RNAs (siRNAs) and low-abundance 22-nucleotide siRNAs produced from double-

21 The sensitive method enables detection of low-abundance 5hmC sites, providing a more complete 5hmC

22 Dematin is a relatively low abundance actin binding and bundling protein associa

23 s abundant fatty acid carboxylate anions and low-abundance acyl neutral losses as free acids and kete

24 on and possesses great potential in studying low-abundance ADC analytes such as those from animal or

25 a Treg cell repertoire that is biased toward low abundance agonist self-peptides.

26 To analyze low-abundance amino-terminally truncated Abeta peptides

27 threshold (false positives), while peaks of low abundance analytes may occasionally fall below the f

28 isualizing and spatially characterizing very low abundance analytes separated only by 20 mDa.

29 g proteomics tool capable of profiling >1000 low-abundance analytes with high sensitivity and high pr

30 duct ion scoring, which enables detection of low-abundance analytes with poor precursor ion signal.

31 Furthermore, we identified untargeted and low-abundance analytes, including neuropeptides deriving

32 re normally limited only by random errors of low-abundance analytes, the method maximizes the range o

33 process of H2 export, as was the relatively low abundance and activity of methanogens and sulfate re

34 ing and regulatory proteins are expressed at low abundance and are difficult to measure in single cel

35 Measurements of low abundance and heterogeneously distributed d-AAs in c

36 f challenges related to materials, including low abundance and high costs of redox-active metals, exp

37 enhanced proteome coverage, particularly for low abundance and high MW proteoforms.

38 Their typically low abundance and highly heterogeneous nature, however,

39 ared expression and shared structure despite low abundance and low sequence identity.

40 their intrinsic properties of short length, low abundance and sequence homology among family members

41 is challenging in part due to the relatively low abundance and short length of the miRNAs.

42 muscle SP cells has been challenged by their low abundance and the absence of specific SP cell marker

43 ld explain general lncRNA properties such as low abundance and tissue specificity.

44 s are unknown at the molecular level, as the low abundance and transient nature of assembly intermedi

45 Retaining low-abundance and dynamic subcellular structures or macr

46 Notably, TRPML channels are activated by the low-abundance and LEL-enriched signalling lipid phosphat

47 d elusive because they exist transiently, in low abundance, and involve subtle movements of protons t

48 The essential nature of this subcomplex, its low abundance, and its multiple interactions with key di

49 d with mitochondrial disease, R-loops are of low abundance, and there is mitochondrial DNA aggregatio

50 We use the technique to isolate low abundance antibodies specific to different HIV antig

51 ventional diffusometry can be compromised at low-abundance antigens because proteins are much smaller

52 Certain low-abundance bacterial species, such as the periodontit

53 localization, and structural confirmation of low abundance bioactive ceramides and other sphingolipid

54 for the detection and the quantification of low abundance biomarkers.

55 is a viable alternative to NS tears for many low-abundance biomarkers and is able to replicate major

56 /MRM-MS) has been frequently used to measure low-abundance biomarkers in tissues and biofluids, owing

57 clude insufficient sensitivity for detecting low-abundance biomarkers, poor measurement reproducibili

58 washout (WO) method as an NS alternative for low-abundance biomarkers.

59 ant proteins, but is relatively untested for low-abundance biomarkers.

60 ur assay on microRNAs, an important class of low-abundance biomarkers.

61 of ICR biosensing measurements for detecting low-abundance biomolecules by lowering the limit of dete

62 CRTs)--those taxa that are typically in very low abundance but occasionally achieve prevalence--were

63 As with other low abundance but persistent members of the microbiota,

64 eaked whale sightings is the result of their low abundance, but this is in contrast to our estimates

65 vers or alpha-bugs) exert their influence at low abundance by modulating both the composition and lev

66 lity network specifying whether a species at low abundance can increase in frequency in an environmen

67 rotocol should be widely applicable to other low abundance cell types and factors.

68 We demonstrate that the DBS method counts low abundance cell types such as immature reticulocytes

69 s a major obstacle for epigenomic studies of low-abundance cells.

70 ) binds to RG4s in the KRAS transcript under low-abundance cellular conditions.

71 s detection and mapping of G4s in important, low-abundance cellular RNAs.

72 manner, which tends to preclude detection of low abundance chemicals and chemicals found in small sub

73 mer (i.e., phosphatidylglycerol, PG, another low-abundance class of phospholipids).

74 cylglycero)phosphate (BMP), an important but low-abundance class of phospholipids, has been hindered

75 amine (PE)) and enhance the signals from the low-abundance CLs and gangliosides to allow their GCIB-S

76 izing the receiving ecosystem, but mostly as low abundance community members.

77 he inherent challenges of hydrophobicity and low abundance, complete membrane proteome coverage of cl

78 lure to address batch-specific truncation of low abundance compounds.

79 ughput, this method allows the annotation of low-abundance compounds that are otherwise not amenable

80 al samples with limited starting material or low-abundance cytosine modifications.

81 n provide new insights into diagnosing other low-abundance diseases in the future.

82 rasensitivity in monitoring trace amounts of low-abundance early biomarkers or environmental toxins,

83 many present high-ZT materials are based on low-abundance elements that pose challenges for scale-up

84 ng yields an analysis workflow for essential low-abundance endogenous metabolites that has enhanced s

85 htly controlled recruitment of telomerase, a low-abundance enzyme, to telomeres is essential for regu

86 tructing the investigations of important but low abundance epimers in isomeric mixtures.

87 xist in dynamic equilibrium with short-lived low-abundance 'excited states' that form by reshuffling

88 urification and mass spectrometry identified low-abundance exosome-associated proteins and protein co

89 LC-MS/MS detected isomers and low abundance fluorinated chain lengths.

90 he model reliably captures areas of high and low abundance for the large majority of functional group

91 oteome-wide identification of weak affinity, low abundance Fucalpha(1-2)Gal glycan-binding proteins (

92 larly well suited for the rapid detection of low-abundance fungal pathogens and identification of the

93 Furthermore low-abundance GATA1 mutant clones were detected by targe

94 pimastigote form of the organism expresses a low abundance glycoprotein associated with the flagellum

95 ditions to achieve labeling and detection of low-abundance GPCRs in live cells.

96 ss spectrometry (MS)-based methods to detect low-abundance HCP impurities.

97 e improvement of fragmentation efficiency of low-abundance HCP peptides by correlating the collision

98 For both samples, low-abundance HCPs (down to 1 ppm) were confidently iden

99 m high-abundance homodimers and Pi-regulated low-abundance heterodimers.

100 m complexes, in facilitating presentation of low abundance high affinity antigens, or in preventing d

101 rehensive profiling of scarcely investigated low-abundance histone marks, revealing that concentratio

102 f next-generation sequencing (NGS) to detect low-abundance HIV-1 variants.

103 Owing to their low abundance, however, health risks were primarily asso

104 ammalian gastrointestinal tract and includes low-abundance human oral bacteria that appear to prolife

105 served greater than threefold improvement in low-abundance human-protein identification and quantitat

106 More importantly, low abundance hybrid oligosaccharides can only be detect

107 d selectivity of MRM enable the detection of low abundance IgG glycopeptides, even when IgG was diges

108 microfluidic method to identify and quantify low-abundance IgG N-glycans and show some of these IgGs

109 f the Abeta fibril, but they are actually of low abundance in an Abeta fibril several micrometers lon

110 ify preexisting drug resistance mutations at low abundance in an HIV-infected subject.

111 stic biomarkers (i.e. proteins) are often in low abundance in bodily fluids presenting many challenge

112 in heterogeneity and study microorganisms at low abundance in complex microbial communities from terr

113 a novel splice variant that was expressed at low abundance in normal human tissues but was significan

114 ly expressed in many human cancers but is of low abundance in normal tissues, [corrected] the Wnt/bet

115 Since they are in low abundance in samples like oxidized low-density lipop

116 occurs only for library members that are of low abundance in the absence of a replication pathway.

117 The sensitivity of pH to soluble elements in low abundance in the host rocks, such as carbon, alkali

118 he advanced lesions, they were in relatively low abundance in the newly described early lesions that

119 e "enriched" sequences that are absent or of low abundance in the other tissue.

120 undant bacteria that were undetectable or at low abundance in their diet.

121 single radial glia cells but is detected at low abundance in tissues.

122 cing also facilitated detection of clades at low abundance in unexpected places.

123 igh volatility and incompatibility, but have low abundances in most geological and planetary material

124 990s, and many populations have persisted at low abundances in recent years.

125 To exclude low-abundance infections, we subjected 514 of these samp

126 d and demonstrated for the enrichment of the low abundance ions.

127 able to identify and image both abundant and low-abundance isobaric and isomeric species within each

128 chnique allowed us to generate ion images of low-abundance isobaric lipids.

129 in which fractionation was used to identify low-abundance kinases.

130 more readily in response to low-affinity and low-abundance ligands both in vitro and in vivo due to a

131 brittleness, low infrared transmittance and low abundance limit suitability for certain industrial a

132 ternative mechanism might better explain how low-abundance lncRNAs transcribed from noncoding DNA fun

133 As (lncRNAs), with increased sensitivity for low-abundance lncRNAs.

134 halophilus and Methanolobus were detected at low abundance (<2%) in produced waters several months af

135 9 (9%) untreated CLL that, due to their very low abundance (median allele frequency: 2.1%), were miss

136 D2-HG is a low-abundance metabolite, but we show that it can meanin

137 Detection of low abundance metabolites is important for de novo mappi

138 yses, and are poorly suited for detection of low abundance metabolites present in urine samples.

139 quantitative information recovery of various low abundance metabolites.

140 l the major metabolites of APAP and multiple low-abundance metabolites (e.g., acetaminophen hydroxy-

141 ization of statistically relevant changes in low-abundance metabolites in body fluid.

142 f the raw mass spectrometry data, especially low-abundance metabolites.

143 ed the idea of the "keystone-pathogen" where low-abundance microbial pathogens (Porphyromonas gingiva

144 Here, we discovered that the low abundance minor spliceosome's catalytic snRNP, U6ata

145 re-based detection systems, where 88% of the low abundance miRNA targets could not be detected under

146 for miRNAs derived from blood cells, and for low abundance miRNAs (non-detectable in over 10% of samp

147 ed 100 times (to 1 pM) allowing us to detect low-abundance miRNAs in an RNA extract.

148 MmiR is not sufficiently sensitive to detect low-abundance miRNAs.

149 Nowadays, it is still a challenge to detect low-abundance miRNAs.

150 a powerful method for the identification of low-abundance modified peptides within the same sample.

151 lso contribute to faster detection times for low abundance molecules in small sample volumes.

152 ecessary for spatially resolved detection of low-abundance molecules in complex matrices.

153 ated with increased metabolite diversity and low-abundance molecules, suggesting they include cumulat

154 he absolute quantification of both high- and low-abundance mRNA transcripts, as well as micro-RNAs th

155 e, we present a fluorescence-based assay for low-abundance mutation detection based on toehold-mediat

156 ew assay accurately detected DRMs, including low-abundance mutations that were often missed by Sanger

157 l for detecting nucleic acids with extremely low abundance not only for food safety control but also

158 The low abundance of bacterial proteins in human serum durin

159 the gut microbiome are warranted because the low abundance of bifidobacteria and butyrate-producing s

160 ired for maintenance of DNA methylation, and low abundance of histone transcripts involved in heteroc

161 rincipal component analysis indicated that a low abundance of lactate-producing and butyrate-producin

162 Bacterial vaginosis (BV) is characterized by low abundance of Lactobacillus species, high pH, and imm

163 We also find that the low abundance of lncRNAs observed from cell population m

164 However, this is challenging due the low abundance of microbial DNA relative to the host.

165 n remains a significant challenge due to the low abundance of phosphoproteins and the low stoichiomet

166 absence of suitable gamma emissions and its low abundance of positron emissions.

167 Low abundance of potential pathogens was detected by 16S

168 AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentat

169 ha5, alpha7, beta2, and beta4 subunits and a low abundance of RNAs for alpha2, alpha4, alpha6, and al

170 gainst higher organisms, the high price, and low abundance of silver.

171 The minute sample volumes and low abundance of some constituents in cells hinder our u

172 The low abundance of TAG is also valid with respect to expre

173 hate is thought to be limited in part by the low abundance of the critical micro-nutrient iron.

174 sient nature of these contacts and the often low abundance of the participants present significant ex

175 higher levels of uncoupling protein 1 and a low abundance of the proinflammatory interleukin-6, a co

176 Due to the low abundance of the protein and some difficulty with th

177 Despite the low abundance of this last category of isoforms, their p

178 ows are developed to allow detection of very low abundance of transcripts, accurate quantitative dyna

179 The low abundance of VZV nucleic acids in human neurons has

180 The low abundances of Ir and Ru in the earth's crust and, he

181 ore branched alkyl side chains (>/=80%) with low abundances of n-alkanes and aromatics (<5%), similar

182 Consequently, relatively low abundances of small particles are predicted at the o

183 he CI deficiency concomitantly occurred with low abundances of the mtDNA transcription factors TFAM a

184 challenging to detect and quantify, certain low abundance oligosaccharides are highly relevant to th

185 Detection and quantitation of low abundance oligosaccharides can also be achieved usin

186 less acidic and neutral species that are in low abundance or absent with NH4OH reagent.

187 Partial IGP food webs that had either a low abundance or high abundance of total prey were also

188 s potential for enhancing the sensitivity of low abundance or targeted species.

189 ticularly attractive for reactions involving low-abundance or expensive reagents.

190 In contrast, responses from low abundance organisms of the NOR5/OM60 gammaproteobact

191 between naturally driven periods of high and low abundance over time scales of decades to centuries a

192 Most of the missing values are found to be low abundance peak pairs.

193 f the selected precursor can be removed, and low abundance peaks that are believed to have limited co

194 23%, and 34% for high, medium, low, and very low abundance peaks, respectively.

195 rogeneity and thus increase detectability of low abundance peaks.

196 e effective sampling and characterization of low abundance peptides derived from the antigen-binding

197 alyzed by SPE-GEMS allowing the detection of low abundance peptides usually not observed by direct ma

198 n for the direct quantitative MS analysis of low abundance peptides was observed.

199 on step and improved the signal intensity of low abundance peptides.

200 ted reaction monitoring (LC-SRM) analyses of low-abundance peptides spiked into a highly complex mixt

201 ylinositol 3,5-bisphosphate [PI(3,5)P2] is a low-abundance phosphoinositide presumed to be localized

202 Low-abundance populations with high intra-population div

203 re achieves improved MS/MS scan coverage for low-abundance precursor ions not captured by auto-MS(2)

204 reactivity of the cofactor coupled with its low abundance pressured development of an efficient syst

205 Melanoma antigen-A11 (MAGE-A11) is a low-abundance, primate-specific steroid receptor coregul

206 We now show that low-abundance Primer IDs (offspring Primer IDs) are gene

207 al-to-noise ratio in MALDI-MS analysis for a low abundance protein, hemopexin.

208 used as a label-free system for detection of low-abundance protein biomarkers.

209 Quantitation of low-abundance protein modifications involves significant

210 Here we show that Ypt11 is normally a low-abundance protein whose ER localization is only dete

211 However, precise quantification of extremely low abundance proteins (e.g., </= 100 pg/mL in blood pla

212 sibly trapped proteins remain captured while low abundance proteins are released and recovered in the

213 ting their high abundance proteins, as their low abundance proteins are upregulated.

214 be applied for the multiplexed detection of low abundance proteins from complex biological samples s

215 col enables the discovery of interactors for low abundance proteins in rice and opens the possibility

216 at promise for precisely measuring extremely low abundance proteins or protein modifications, especia

217 Isolation of low abundance proteins or rare cells from complex mixtur

218 coral isolate, showed that a large number of low abundance proteins were exclusively detected in OMVs

219 Translational readthrough gives rise to low abundance proteins with C-terminal extensions beyond

220 eomics has limited success at detecting many low abundance proteins, such as transcription factors fr

221 abundant proteins at higher efficiency than low abundance proteins, which are enriched in the supern

222 eting efficiency and to purify and visualize low abundance proteins.

223 ities for mapping a large number of high and low abundance proteins.

224 al individuals were randomized, enriched for low-abundance proteins by MAF, digested endoproteolytica

225 orm that enables single-molecule counting of low-abundance proteins by mechanically slowing-down thei

226 on limit and a 30% increase in the number of low-abundance proteins detected.

227 tudy conformation and interaction changes of low-abundance proteins directly in their endogenous cell

228 rminal sulfonation confirmed the identity of low-abundance proteins in 2-D gel spots that contained m

229 icating proof of concept for detecting these low-abundance proteins in crude extracts.

230 ced and identification of newly synthesized, low-abundance proteins is challenging.

231 all 10 influenza A virus proteins, including low-abundance proteins like the matrix protein 2 and non

232 nt when applied to the isolation of multiple low-abundance proteins or cell types.

233 improvements make possible the detection of low-abundance proteins present at sub-attomolar levels,

234 orescent proteins (FPs) in E. coli, allowing low-abundance proteins to be counted using standard tota

235 ethods for proteins, the immune-detection of low-abundance proteins using antibodies is fundamentally

236 ProteoMiner technology for the enrichment of low-abundance proteins with stable isotope-coded protein

237 Analyzing the spatial distribution of low-abundance proteins within cells is highly challengin

238 suggest that degradation is limited to a few low-abundance proteins.

239 ultrasensitive detection systems to measure low-abundance proteins.

240 abundance require tailoring to penetrate to low-abundance proteins.

241 FP repeats, critically enabling the study of low-abundance proteins.

242 MW proteins up to 223 kDa and also revealed low abundance proteoforms that are post-translationally

243 k, we first developed a new method to detect low-abundance PSVs with improved sensitivity.

244 t is the limited sensitivity for quantifying low-abundance PTMs, requiring the use of affinity reagen

245 Importantly, mRNAs encoding low-abundance regulatory proteins tend to be enriched in

246 the signal transduction pathway owing to its low abundance relative to its binding partners.

247 composed of highly heterogeneous, relatively low-abundance repeat-derived DNA, supporting a scenario

248 chococcus and Cyanobium) with a long tail of low abundance representatives, and local peaks of bloom-

249 visualize native RNAs, particularly, short, low-abundance RNAs in live cells, can dramatically impac

250 e-function relationships of the multitude of low-abundance RNAs that prevail in living cells.

251 ondary-structure models, enables analysis of low-abundance RNAs, disentangles sequence polymorphisms

252 s and focused in vivo investigations of even low-abundance RNAs.

253 ease until they equal the influx rate of the low abundance sample species.

254 Early-occurring, low-abundance "scout" DSBs lack homolog bias.

255 eby restricting responses to low-affinity or low-abundance self-antigens even in the context of an in

256 horylates phytic acid (InsP6) to produce the low abundance signaling molecules InsP7 and InsP8.

257 horylated phosphoinositide lipids (PPIs) are low-abundance signaling molecules that control signal tr

258 suggests that lower female recruitment into low abundance sites is contributing to these skews.

259 The detection and quantification of low-abundance somatic DNA mutations by high-throughput s

260 t the use of stressed conditions to generate low abundance species for detailed characterization of r

261 functions of antibody-based drugs; however, low-abundance species are difficult to detect.

262 ate that these exceptionally short-lived and low-abundance species form Watson-Crick-like base pairs,

263 s universally applicable to the detection of low-abundance species, since no Raman signal enhancement

264 tified, the functional significance of these low-abundance sphingolipids is unknown.

265 Surprisingly, a low-abundance subset of SECs containing ELL2 and AFF1 wa

266 cific miRNAs, some with few target genes and low abundances, suggests their recent evolutionary origi

267 quantification of rare-event cells carrying low-abundance surface biomarkers.

268 ngle cells, including the ability to amplify low-abundance tags to make them detectable with sequenci

269 ingent limit-of-detection specifications for low-abundance target molecules.

270 quivalent proficiency, revealing hundreds of low-abundance targets missed by previous approaches.

271 ore increase the proportion of NGS reads for low-abundance targets.

272 ften had low relative abundances, suggesting low-abundance taxa may significantly contribute to rhizo

273 ere both non-linear and flow-dependent, with low abundance thresholds needed to suppress plant commun

274 ye fluorescence and permits visualization of low-abundance tissue markers such as Bcl-6 or MSH-6.

275 ecisely quantify these previously undetected low-abundance, trace and even ultra-trace N-glycans.

276 rectly assay the O-GlcNAcylation status of a low-abundance transcription factor from cell lysates wit

277 that microarray profiling fails to identify low abundance transcripts directly activated by p53.

278 efficient rRNA removal enhanced detection of low abundance transcripts via qPCR.

279 sensitivity is demonstrated by detection of low-abundance transcripts and rare cells.

280 gain mainly due to its improved accuracy for low-abundance transcripts.

281 APE-LMPCR to query the in vivo structures of low-abundance transcripts.

282 otein-coding transcripts were categorized as low-abundance transcripts.

283 y other amino acid-increases selectivity for low-abundance transition metal transport in the presence

284 ose members selectively and tightly bind the low-abundance transition metals, Ni(2+) and Co(2+).

285 ich enabled direct analysis of intrinsically low-abundance transmembrane proteins.

286 This sSNP introduces a codon pairing to a low-abundance tRNA that is particularly rare in human br

287 Low-abundance tRNAs decode rare codons slowly, but it is

288 itivity and specificity for the detection of low-abundance tumor cells was designed.

289 Low-abundance tyrosine phosphorylation is crucial to not

290 f >1,000 phosphorylation sites including 366 low-abundance tyrosine phosphorylation sites, with high

291 We probe the structure of low-abundance U12 small nuclear RNA (snRNA) in Arabidops

292 How this low-abundance ubiquitin ligase targets rare stall-genera

293 tistical algorithm for identifying authentic low-abundance variants.

294 Real-time measurements of many low-abundance volatile organic compounds (VOCs) in breat

295 Our data illustrate that taxa driven to low abundance when dietary MACs are scarce are inefficie

296 e-biased sites are more frequent in areas of low abundance, which are now widespread across much of s

297 unity richness resulted from taxa present in low abundance with similar patterns of phyla distributio

298 ing a 2-OH-Trp72 group (oxTrp72-apoA1) is in low abundance within the circulation but accounts for 20

299 were exploited to improve the enrichment of low-abundance yeast cells in an iDEP channel.

300 have the potential to aid the enrichment of low-abundance yeast cells when filler volume fractions a