ライフサイエンスコーパス: low-affinity

1 m a non-ciliary localizing protein (Src) has low affinity.

2 at ASI could bind to GR in spite of relative low affinity.

3 ly (U) or d(T) while d(A) polymers bind with low affinity.

4 ab26 in its GTP-bound form, albeit only with low affinity.

5 the Cu-V103Z and L126Z variants demonstrated low affinity.

6 e to dioxin, and Xenopus AHRs bind TCDD with low affinity.

7 ve to the myristoylated glycine for high and low affinities.

8 ith a high degree of predisposition but with low affinities.

9 al ventricles of the neonatal mouse brain, a low-affinity AAV4 mutant (AAV4.18) displayed a striking

10 A third low affinity ACh binding site is formed when this access

11 expanded to a greater extent in response to low-affinity Ags than did their mature T cell counterpar

12 s in EBd-treated patients homozygous for the low-affinity allele.

13 es of engineered T cells expressing a native low affinity alphabeta-TCR chains or high affinity TCR-l

14 mGluR7 has low affinity and efficacy for activation by both L-gluta

15 lls proliferated more readily in response to low-affinity and low-abundance ligands both in vitro and

16 bound IgE of the allergic effector cells via low-affinity anti-human IgE Abs with dissociation consta

17 strate that targeting surface-bound IgE with low-affinity anti-IgE Abs is capable of suppressing alle

18 We demonstrated that these low-affinity anti-IgE mAbs bind to the cell surface-boun

19 llent safety profile, indicating that use of low-affinity anti-IgE mAbs holds promise as a novel ther

20 Instead, the low-affinity anti-IgE mAbs profoundly block human peanut

21 ability of allergic reaction blockade by the low-affinity anti-IgE mAbs was correlated with their cap

22 decreased brain exposure to a second dose of low-affinity anti-TfR bispecific.

23 nity and stimulating capability of initially low-affinity antibacterial (e.g., Yersinia) Abs cross-re

24 In contrast, low-affinity antigens induced a switch of migration mode

25 ic cells are soft and promote acquisition of low-affinity antigens through low forces.

26 ns lead us to propose that high-specificity, low-affinity attachment of MERS-CoV to sialoglycans duri

27 al. (2015) challenge this view, showing that low affinity B cells initiate Salmonella responses and a

28 cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expa

29 In aggregate, low-affinity/background sites also contribute to competi

30 Low-affinity BCR interactions with autoantigens generate

31 rom high affinity beta2-containing nAChRs to low affinity beta4-containing nAChRs, in addition to the

32 allows the determination of binding modes of low affinity binders in the protein-ligand interface and

33 ification of all subjects in high, mixed and low affinity binders.

34 with mixed-affinity binders (MABs), whereas low-affinity binders (LABs) are unsuitable for evaluatio

35 ABs), 3 mixed-affinity binders (MABs), and 3 low-affinity binders (LABs)-were studied with whole-body

36 tch regions of CDC42 or RAC1 and (ii) a very low affinity binding of GRD and a C terminus adjacent to

37 These results indicate a second low affinity binding site in the Robo-Slit complex as we

38 ve a value that allows interactions with the low affinity binding site.

39 he overall enhancer architecture-clusters of low affinity binding sites-is maintained and required fo

40 (KD = 0.83 muM) compared to G7-B1 and shows low affinity binding to Grb2-, Grb10- and Grb14-SH2 doma

41 r between a QD and a molecular probe to even low-affinity binding events at the QD/solvent interface.

42 e substrate, whereas MDDMA and MDTMA adopt a low-affinity binding mode consistent with an inhibitor,

43 ional selection mechanism contrasts with the low-affinity binding mode of 53BP1, and it ensures 53BP1

44 The number of low-affinity binding motifs is significantly depressed i

45 is is achieved using multiple, minimalistic, low-affinity binding motifs that are in rapid exchange w

46 litate plasma membrane targeting through the low-affinity binding of NB to phosphorylated inositol po

47 bind approximately 1.6 thrombin molecules at low-affinity binding sites (Kd = 2.8 muM) and approximat

48 r the long-standing observation of high- and low-affinity binding sites for the prototypic inhibitor

49 cription factor Ultrabithorax (Ubx) utilizes low-affinity binding sites in the Drosophila melanogaste

50 ast, ADP occupies one high-affinity and five low-affinity binding sites in vitro, consistent with con

51 ochord enhancers, including those containing low-affinity binding sites that would be excluded by sta

52 r Irf4 abundance with its recruitment toward low-affinity binding sites within Teff cell cis-regulato

53 nd binding to GPCRs have revealed transient, low-affinity binding sites, termed metastable binding si

54 sion of DBP1 may have been selected to allow low-affinity binding to another receptor on Duffy-null e

55 Domain 4 exhibited low-affinity binding to LRP6 in in vitro binding assays,

56 t the RNA-binding surface allow for high- or low-affinity binding with functional implications.

57 Low-affinity but highly specific protein-protein interac

58 ow enhancer contains binding sites with very low affinity, but optimal syntax, and therefore mediates

59 gh affinity and interacts with the CCTP with low affinity, but the reason for this difference is not

60 eloped novel genetically encoded ER-targeted low-affinity Ca(2+) indicators optimized for examining a

61 ty Ca(2+)/Mg(2+) mixed binding sites and two low-affinity Ca(2+)-specific sites.

62 C-terminal acidic region containing multiple low-affinity calcium binding sites.

63 the ciliary transport regulator Arl3, while low-affinity cargo is released by Arl3 and its non-cilia

64 and low-affinity TDBs revealed that only the low-affinity CD3/CLL1 TDB was well tolerated and able to

65 Although high- and low-affinity CD8(+) T cell clones are recruited into the

66 n is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protection remains

67 ators IL-10, TIGIT, GITR, and CTLA4, whereas low-affinity cells displayed increased transcripts for A

68 lective transporter, while NPF6.6 had only a low-affinity chloride transport activity.

69 Although the N-terminal low-affinity CNB domain (CNB-A) was dispensable for the

70 sically disordered proteins may evolve via a low-affinity complex which is optimized by modulating di

71 cient route to binding site localization for low affinity complexes and is applicable to rapid screen

72 protein recognition domains frequently form low-affinity complexes with polysaccharides that are dif

73 onist effects of its own through a secondary low-affinity conformation.

74 )4 of the beta1-adrenoceptor as key for this low-affinity conformation.

75 trates can suppress phosphorylation of their low affinity counterparts.

76 ext-at low force or stiffness, they serve as low-affinity cross-links, but they can transition to for

77 llowed us to propose that D8 has a high- and low-affinity CS-binding region within its central crevic

78 small tumor burdens was achieved by high- or low-affinity CTL.

79 in, Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal Cu exporter, or

80 differentially expressed genes had multiple, low-affinity CUX1 binding sites, features of analog gene

81 Transcription factors bind low-affinity DNA sequences for only short durations.

82 and TCR affinity for myelin, as the inherent low affinity does not allow the use of specific peptide:

83 ing defined recombinant soluble (rs) dimeric low-affinity ectodomains (rsFcgammaR) that have an absol

84 After activation, low-affinity effector CD8(+) T cells accumulated at effe

85 al avidity maturation and uncover a role for low-affinity effector T cells during early microbial con

86 The early release of low-affinity effector T cells led to rapid target cell e

87 AREG is a low affinity EGFR ligand, which is upregulated following

88 the channel sufficient for the activation of low-affinity endothelial KCa channels.

89 and revealed the importance of both high and low affinity epitopes for allergic responses.

90 y Fc receptors is based on the structures of low affinity Fc receptor in complex with Fc.

91 The low-affinity Fcgamma receptors, expressed on immune cell

92 The human-to-mouse low-affinity FcgammaR locus swap engendered hFcgammaRIIA

93 Low-affinity FcgammaR locus-switched mice represent an u

94 aRI binds to the Fc in a similar mode as the low-affinity FcgammaRII and FcgammaRIII receptors.

95 be distinguished based on expression of the low-affinity FcgammaRIII: CD14(++)CD16 -: classical mono

96 f these cells were reduced in PBMCs with the low-affinity FcgammaRIIIa-158F genotype.

97 6(+) macrophages in PMBCs that expressed the low-affinity FcgammaRIIIa.

98 n human PBMCs, especially PBMCs that express low-affinity FcgammaRIIIa.

99 However, polymorphisms in low affinity FcgammaRs have been associated with altered

100 Cells expressing the low-affinity FcgammaRs (FcgammaRII or CD32 and FcgammaRI

101 Its low affinities for cocaine and metabolites and its abili

102 take systems BicA and SbtA, where BicA has a low affinity for bicarbonate but high flux rate, and Sbt

103 the cytoplasm, NESs have evolved to display low affinity for Crm1.

104 gen-elicited memory T cells can have high or low affinity for cross-reactive allogeneic peptide-MHC,

105 ain after systemic drug injections and shows low affinity for DREADDs.

106 affinity for the neurotransmitter ACh and a low affinity for its metabolic product choline.

107 affinity for the neurotransmitter ACh and a low affinity for its metabolic product choline.

108 olved in this process - Cyo has a relatively low affinity for O2 but is able to pump protons and henc

109 mice such that thymocytes bearing TCRs with low affinity for self-peptide are not efficiently select

110 alf of the EWS portion of the fusion) showed low affinity for smaller GGAA-microsatellites but instea

111 in these cases suggests that this ligand has low affinity for tau lesions primarily made of straight

112 ynamically stable intermediate that exhibits low affinity for the assembly factors.

113 We also find that galectin-3 has low affinity for the surface layer of osteoarthritic car

114 ed under physiological conditions due to its low affinity for this substrate.

115 ts chicken c-CrkII from a high affinity to a low affinity form.

116 ne transport protein that has both high- and low-affinity functions.

117 ealed a significant population of relatively low-affinity gamma2 subunit-containing GABAA receptors i

118 HxtB was confirmed to be a low affinity glucose transporter, localizing to the plas

119 particular in those tissues that express the low affinity glucose-phosphorylating enzyme glucokinase.

120 R and KLF15 physically interact and identify low affinity GR binding sites within glucocorticoid resp

121 ding restraints of this CC MBS.LZ PKG-Ialpha low-affinity heterotetrameric complex and allow reevalua

122 can engage the human FcgammaRII class of the low-affinity hFcgammaRs, demonstrating that N-linked gly

123 ession of the GS1 isogene Gln-1;2 encoding a low-affinity high-capacity GS1 protein in Arabidopsis (A

124 knowledge, on T4P flexibility and support a low-affinity, high-avidity adhesion mechanism that media

125 Overexpression of either of two low-affinity, high-capacity glucose transporters, Hxt1 a

126 repeat contributes to MET activation through low affinity homodimerization.

127 easurements, we find that SdrC is engaged in low-affinity homophilic bonds that promote cell-cell adh

128 mpaired generation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clear

129 mpaired generation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clear

130 FcepsilonRI) on mast cells and basophils and low-affinity IgE receptors (FcepsilonRII) on B cells.

131 tion of IgE interactions with both high- and low-affinity IgE receptors, and explains why omalizumab

132 FcepsilonRII is a multifunctional low-affinity IgER that is involved in the pathogenesis o

133 ased production and activation of both CD32 (low affinity IgG receptor) and alphaMss2 integrin.

134 The inhibitory low-affinity IgG Fc-receptor FcgammaRIIB is co-expressed

135 oped a novel mouse strain in which the human low-affinity IgG receptor locus, comprising both activat

136 ic memory T cells or by cross-linking of the low-affinity IgG receptor, CD16, by Ag-Ab immune complex

137 Intestinal eosinophils expressed low-affinity IgG receptors, and the activating receptor

138 to bind monovalently to immobilized mAb with low affinity in the absence of quinine and with fivefold

139 rin in the binding trans configuration and a low affinity in their cis form.

140 the central acidic region to bind c-Jun with low affinity in vitro.

141 ic Fc-based scaffold that we here show binds low-affinity inhibitory receptors (FcRL5, FcgammaRIIb, a

142 1d, suggesting different roles for high- and low-affinity iNKT clones in immune regulation.

143 IL-13 cytokine secretion among Ag-stimulated low-affinity iNKT clones.

144 e-guided mutation allows the generation of a low-affinity INPP5E mutant which loses exclusive ciliary

145 insufficient to induce deletion of high- or low-affinity InsB9-23-reactive CD4(+) T cells; however,

146 hat intracellular signaling activated by the low affinity interaction of mOSM with mLIFR is different

147 and PNKP together and thereby promoting the low-affinity interaction identified here, which then sti

148 The low-affinity interaction site required the highly conser

149 ectin binding to a single glycan ligand is a low-affinity interaction, but the multivalency of galect

150 two antibodies, mAb12.3 and mAb36.3, showed low affinity interactions.

151 has the advantages that it is applicable to low-affinity interactions because the complexes are not

152 ocess may, in part, involve enabling crucial low-affinity interactions between Orai1 N-terminus and S

153 It is not clear how brief, low-affinity interactions can drive efficient transcript

154 SCAR with a collagen fibril, with transient, low-affinity interactions initiated by the membrane-dist

155 ycan interactions have been considered to be low-affinity interactions that precede high-affinity pro

156 Profilin and cofilin display transient, low-affinity interactions with phosphoinositide-rich mem

157 hought to modulate neuronal function through low-affinity interactions with proteins, in particular w

158 +), HLA-Bw4-80Ile(-) genotype, predictive of low-affinity interactions, had a low incidence of relaps

159 works tend to interact promiscuously through low-affinity interactions.

160 Low-affinity intercellular adhesion may play a role in f

161 es the expression of FET4, a gene encoding a low affinity iron transporter able to transport metals o

162 ) and HLA-Bw4-80Ile(+) patients, a predicted low-affinity KIR2DL2/3(+) and HLA-C1/C1 genotype was ass

163 4 also fully blocked D8 binding to CS-A, the low affinity ligand for D8.

164 ligands directly inhibited signaling by the low affinity ligands BMP-2, BMP-7, and BMP-9.

165 othesized high affinity ligands compete with low affinity ligands for receptor binding and signaling.

166 olar side chain of T153 creates a barrier to low-affinity ligands that interact with E149 and A150.

167 s of the thermostabilized receptors bound to low-affinity ligands.

168 of a high-affinity complex from a mixture of low-affinity ligands.

169 cell antigen receptor signaling response to low-affinity ligands.

170 e to peptide recognition, yet the pEF hand's low affinity limits Ca(2+) binding at normal physiologic

171 odes, whereas MDTMA exclusively binds to the low-affinity mode.

172 sed fluorescent ligands (presenting multiple low-affinity moieties) and ConA (presenting multiple bin

173 The identification of the binding sites for low affinity molecular encounters is essential for the d

174 y useful for the systematic investigation of low affinity molecules with residence times in the micro

175 o thousands of additional regions containing low-affinity multimerized IRF sites and composite IRF-AP

176 to be formed by phase separations caused by low-affinity, multivalent interactions involving protein

177 and leads to a partial mislocalization of a low affinity mutant of NPHP3.

178 es derived from patients vaccinated with the low-affinity (native) peptide expressed slower koff rate

179 of choline acetyltransferase (ChAT) and the low-affinity neurotrophin receptor, p75(NTR) .

180 nistration in rats by the recruitment of the low-affinity neurotrophin receptor, p75NTR, whose activi

181 T cells with low-affinity nimotuzumab-CAR selectively targeted cells

182 By contrast, maize NPF6.4 was a low-affinity nitrate transporter with efflux activity.

183 Here, we show that the bidirectional, low-affinity Nitrate Transporter1 (NRT1)/Peptide Transpo

184 ertoires of high affinity pathogenic IgE and low affinity non-pathogenic IgE.

185 itination by WWP1 requires the presence of a low-affinity, noncovalent Ub-binding site within the HEC

186 The low affinity observed for GCRho monomers is unusual for

187 rdings revealed that, despite the relatively low affinity of Cal-590 for Ca2+ (Kd=561 nM), single-act

188 Low affinity of IL-10Rbeta for cytokines has impeded eff

189 s a decline in cellular [ATP]; the unusually low affinity of IP6Ks for ATP compels 5-InsP7 levels to

190 rder to overcome the inherent problem of the low affinity of the above pesticides, we have developed

191 Despite the low affinity of the alternative site, the binding of the

192 The low affinity of the MCU complex, coupled to the activity

193 ed by IL-2, thereby restricting responses to low-affinity or low-abundance self-antigens even in the

194 assemblies, including those with challenging low-affinity partners, and may facilitate the design of

195 A low affinity peptide ligand behaved, regardless of ligan

196 Furthermore, we observed that the low-affinity peptide promoted the selective differentiat

197 groove of MHC I, resulting in the release of low-affinity peptide.

198 es by MHC I from amongst thousands of mostly low affinity peptides are not well understood.

199 We show that the low affinity peptides are released by both Arl2.GppNHp a

200 at the +2 and +3 positions between high and low affinity peptides results in reversing their affinit

201 that are either peptide-free or loaded with low-affinity peptides.

202 odimer may be responsible for generating the low-affinity pharmacology of the secondary beta1-adrenoc

203 from the soil, plants have evolved high- and low-affinity Pi transporters and the ability to induce r

204 of the enzyme and Cys303 providing a second, low affinity pigment binding site that is essential for

205 Following high-affinity rechallenge, low affinity-primed CD45RB(hi) cells became CD45RB(lo),

206 Mechanistically, low affinity-primed memory CD8(+) T cells produced more

207 novel mechanism by which CD45 isoforms tune low affinity-primed memory CD8(+) T cells to become pote

208 CD45RB blockade prolonged graft survival in low affinity-primed mice, but not in high affinity-prime

209 n and timing of effector differentiation, as low affinity-primed T cells acquired cytotoxic activity

210 We found that low-affinity-primed memory CD8(+) T cells produced high

211 Low-affinity-primed secondary effectors concurrently dow

212 In contrast to high-affinity priming, low-affinity priming elicited fully differentiated memor

213 ng that despite a lower precursor frequency, low-affinity priming is sufficient to generate memory ce

214 Little is known about the effect of low-affinity priming on memory cell generation and funct

215 agging approach that enables localization of low affinity protein-ligand binding clefts by detection

216 due specificity, GECX enables the capture of low-affinity protein binding (affibody with Z protein),

217 igh-affinity "canonical" EF (cEF) hand and a low-affinity "pseudo" EF (pEF) hand.

218 ursor cells expressing TCRs within a certain low-affinity range for complexes of self-peptide and maj

219 Whether or not CD4(+) T-cells express low affinity receptor FcgammaRIIIa (CD16a) in disease pa

220 These results reveal LYVE-1 as a low affinity receptor tuned to discriminate between diff

221 ied: the high-affinity receptor BLT1 and the low-affinity receptor BLT2.

222 n mice by targeting CD23 (FcepsilonRII), the low-affinity receptor for IgE on B cells.

223 Increasing evidence suggests that the low-affinity receptor for IgE, CD23, plays an important

224 The low-affinity receptor for IgE, FcepsilonRII (CD23), cont

225 taining the beta2-subunit, beta2-nAChRs) and low-affinity receptors (containing the alpha7-subunit, a

226 er [(11)C]raclopride measures both high- and low-affinity receptors.

227 nic tongue (e-tongue) is usually an array of low-affinity recognition units.

228 that Mcm10 recruitment occurs via two modes: low affinity recruitment in the absence of CMG assembly

229 These results provide direct evidence for a low-affinity Rem2/Cavbeta4 interaction and show definiti

230 the binding strength of high-, medium-, and low-affinity RGD-binders.

231 element ESS and indicated that proteins with low-affinity RNA-binding sites can be recruited in a fun

232 specific binding of a second RR dimer to the low-affinity secondary binding site.

233 Low-affinity secondary effectors significantly upregulat

234 tein, has evolved a changed preference for a low-affinity, secondary binding motif.

235 altered heavy chain usage and enrichment for low-affinity self-reactive specificities in murine margi

236 rrent consensus model has Q8H2 oxidized at a low affinity site (QL), passing electrons to a tightly b

237 The ligands bind to a low-affinity site, resulting in altered modulation of P-

238 These low affinity sites conferred specificity for Ubx binding

239 (Exd) bound specifically to clusters of very low affinity sites in enhancers of the shavenbaby gene o

240 complexes, and that the presence of high and low affinity sites may influence the rate of isotopic ex

241 actor and cofactor concentrations could help low-affinity sites overcome their kinetic inefficiency.

242 ficant fraction of its hydrolysis cycle in a low affinity state but dissociates only slowly from this

243 85 pM) and excellent selectivity against the low-affinity state of D(2)R (D(2)RLow) (mean K(i) = 84 n

244 The low-affinity state requires Lis1 to also bind to dynein

245 difference in affinity between the high- and low-affinity states is more compressed in alpha4beta1 (6

246 Low-affinity stimulation increased receptor association

247 Both high- and low-affinity stimuli elicited similar receptor phosphory

248 tes the response of mast cells to a high- or low-affinity stimulus.

249 ic, state-dependent SLC13A5 inhibitors, with low-affinity substrate activity in the absence of citrat

250 ve inhibitor bisindolylmaleimide I displaces low affinity substrates more potently leading to substra

251 iR395 in Nicotiana tobacum, which belongs to low affinity sulfate transporter group.

252 The p75(NTR) DD forms non-covalent, low-affinity symmetric dimers in solution.

253 an open, high affinity R state and a closed, low affinity T state.

254 In the thymus, low-affinity T cell antigen receptor (TCR) engagement fa

255 ones and/or cell-intrinsic processes exclude low-affinity T cells from the TM pool.

256 entire CD4+ T-cell repertoire, inclusive of low-affinity T cells missed by tetramers, using a T-cell

257 could enhance the expansion and function of low-affinity T cells.

258 Inherent intermediate- to low-affinity T-cell receptors (TCR) that develop during

259 ons (CDRs) from the crystal structures of 34 low-affinity T-cell receptors and 40 high-affinity Fabs

260 on FcRn binding affinity that increased from low affinity (t1/2 29h), to wild type (t1/2 50h), to hig

261 a general mechanism to facilitate binding to low-affinity targets and that this may be a prevalent fe

262 onjunction with T1R1 or T1R3, can serve as a low-affinity taste receptor for l-glutamate in the prese

263 CTL expressing low-affinity TCR may be effective against lymphoma, and

264 as these T cells tend to express relatively low-affinity TCRs.

265 y and target cell depletion by the high- and low-affinity TDBs revealed that only the low-affinity CD

266 The low-affinity, tetramer-negative, dodecamer-positive T ce

267 strates that thrombin initially binds to the low-affinity thrombin binding sites before preferentiall

268 Carbohydrates typically have low affinities to protein binding sites, and the develop

269 f the natural antibody repertoire, bind with low affinity to a variety of structurally unrelated anti

270 However, mechanisms that overcome low affinity to assemble Crm1-export complexes in the nu

271 ctions that were previously too transient or low affinity to be identified.

272 Modulators bind with low affinity to BvgS in the VFT2 cavity.

273 )-gp130 heterodimer and binds with only very low affinity to mLIFR.

274 GSB were resistant to oxygen and showed a low affinity to sulfide.

275 ers and had a reduced Ab response, mostly of low affinity to T cell-dependent Ag, compared with wild-

276 0 = 60 muM), whereas it bound with only very low affinity to the ACh binding sites ([(3)H]ACh, IC50 =

277 mutant F273W revealed that Na(+) binds with low affinity to the apoprotein (Kd 120 mm), with a parti

278 that the PDZ domain of nNOS binds with very low affinity to the C termini of target proteins, and a

279 ion and EMSA, we found that STAT3 binds with low affinity to the caspase-3 promoter, suggesting that

280 ntagonists for CCR1 and CCR3, also bind with low affinity to the closely related receptors CCR2 and C

281 syl trichloroacetimidate activation revealed low affinity to the glycosyl donor but high affinity to

282 , whereas hrp36 and hrp38 proteins bind with low affinity to the P-element silencer RNA.

283 force accelerates transition from the bent (low affinity) to the extended (high affinity) state.

284 luated, and components with high, medium, or low affinity toward aprotinin could be successfully disc

285 All investigated compounds had low affinity toward P-glycoprotein (P-gp, ABCB1).

286 Considering that Hsp104 is characterized by low affinity towards ATP and is strongly inhibited by ad

287 ptake by plant cells requires both high- and low-affinity transport activities.

288 s under the regulation of the high-capacity, low-affinity transporter PMAT, not the low-capacity, hig

289 trode voltage clamp showed that TcPho91 is a low-affinity transporter with a Km for Pi in the millimo

290 potentially nonredundant roles for high- and low-affinity Tregs in controlling autoimmunity.

291 We observed that high- and low-affinity Tregs were recruited to the pancreas and co

292 Participants with homozygous low-affinity TSPO binding were excluded.

293 enhancer, requiring a particular density of low affinity Ubx sites to confer both specific and robus

294 er than naive B cells that typically express low-affinity unmutated antibodies.

295 Unlike CDC42, an extremely low affinity was determined for the RAC1-GRD interaction

296 the 6-arylpicolinates (halauxifen), and very low affinity was found for picolinic acid-based auxins (

297 annel of voltage-dependent high capacity and low affinity, whereas DmHAK5 was identified as the first

298 Ig produced and recognizes multiple Ags with low affinity, whereas immune IgM is induced by Ag exposu

299 Ca(2+)-binding ratio ( approximately 15) and low affinity, whereas mobile buffers have high affinity.

300 ites from a state of high affinity to one of low affinity with no change in affinity per se).