ライフサイエンスコーパス: low-frequency

1 trimer that has been shown to be sampled at low frequency.

2 European populations where they are found at low frequency.

3 alysis detected Ag-specific human T cells of low frequency.

4 ones acquiring the ALT pathway but at a very low frequency.

5 lt intestine, crypt fission is observed at a low frequency.

6 ted prostatic intraepithelial neoplasia at a low frequency.

7 titis categories at high frequencies than at low frequencies.

8 ates was found in the optomagnetic signal at low frequencies.

9 data are correlated with the EIS signals at low frequencies.

10 any functional residual acoustic hearing at low frequencies.

11 stems, including the mammalian cortex, where low-frequency (0.01 Hz) calcium oscillations refine topo

12 ents matured over several hours into regular low-frequency (0.03 Hz) oscillations.

13 vals, high-frequency (HF) (0.15 to 0.40 Hz), low-frequency (0.04 to 0.15 Hz), and the low-frequency/H

14 During blockade of either D1R or MOR, low-frequency (0.2 or 3 Hz) stimulation (LFS) to the sci

15 at high frequencies than at low frequencies (low frequency: 0.08, 0.24, and 0.20 for steatosis, infla

16 sis, inflammation grade, and fibrosis stage (low frequency: -0.475, 0.157, and 0.209, respectively; h

17 In contrast, low frequency (1 Hz, 180 repetitions) electrical stimula

18 Using high frequency (300-700 THz) and low frequency (1-8 MHz) dielectric spectroscopy combined

19 he speech rate and lagged the time course of low-frequency (1-5 Hz) sensory synchronization.

20 stimulation of the network at desired nodes; low frequency (10 Hz) sinusoidal (0.5 V peak-to-peak) vo

21 -AF thresholds and audiometric thresholds at low frequencies (125-1000 Hz) but not at high frequencie

22 In low-frequency AC fields, long DNA molecules form macro-i

23 is fundamental for the future application of low-frequency AC iDEP for technological applications of

24 We develop an analytical theory of the low-frequency ac quantum spin Hall (QSH) effect based up

25 emor that was recorded by seismic and remote low-frequency acoustic (infrasound) stations, including

26 ws", and possible changes that occurred when low-frequency acoustic cues were restored.

27 he corresponding predictions are signaled in low-frequency activity (<30 Hz).SIGNIFICANCE STATEMENT O

28 ence were associated with local decreases in low-frequency activity in posterior cortical regions.

29 Accumulating low-frequency activity was predictive of eye movement dy

30 REM (NREM) sleep, characterized by prominent low-frequency activity.

31 h frequencies (adjusted R(2) = 0.57) than at low frequencies (adjusted R(2) = 0.21).

32 specific to Finns (frequency 1.1%), with the low-frequency allele associated with an increase in fast

33 and show that it achieves higher accuracy in low-frequency allele discovery and substantially lower c

34 We did not identify any coding low-frequency alleles (1-5%) with moderate effect.

35 orphs of a prey species may be maintained at low frequencies alongside cryptic morphs.

36 We demonstrate SWNT trapping at low-frequency alternating current (AC) electric fields w

37 These antibodies arose at low frequencies among naive B cells and were selected in

38 The best results were observed at low frequencies and voltage OH processes on whey acerola

39 rola-flavoured drinks should be performed at low frequencies and voltages (</=100Hz and 45V), an alte

40 ) in vivo remains challenging because of the low frequency and often poor durability of transduced T

41 s (MAF > 0.01) and rare variant analysis for low frequency and rare variants (MAF < 0.05).

42 en extensive analyses to identify regions of low frequency and rare variants that are associated with

43 However, all these mutations are found at low frequency and their role in pyrethroid resistance co

44 s of mutations that arise synchronously from low frequency and track tightly with one another.

45 ranking of treatments suggested that priming low-frequency and bilateral rTMS might be the most effic

46 overed protein-coding variants, particularly low-frequency and rare ones, showed involvement of skin

47 d a whole-genome sequencing study of common, low-frequency and rare variants to associate genetic var

48 focused explorations on the contribution of low-frequency and rare variants to human traits.

49 tudies, this GWAS also probed association in low-frequency and rare variants.

50 els and neutrophil count, aggregate tests of low-frequency and rare variation were significantly asso

51 ni, an endangered species which vocalizes at low frequencies, and bigeye Pempheris adspersa, a noctur

52 netoreception and the possibility that weak, low-frequency anthropogenic electromagnetic fields may h

53 kpropagating APs gated STDP induction during low-frequency AP-EPSP pairing, with both LTP and LTD abs

54 tivity in the time domain and an increase in low-frequency ( approximately 5-7 Hz) power followed by

55 adio burst fine structures observed with the Low Frequency Array, an instrument with high-time resolu

56 to why these preferentially occur on top of low frequency as well as low-intensity sinusoidal backgr

57 probe neglected in previous models based on low-frequency assumptions.

58 e TO phonon modes of B1 and B2 symmetries at low frequencies at different temperatures.

59 ged 60 years or more with normal or elevated low-frequency audiometric thresholds.

60 or Foxo3 in preserving hearing is likely, as low frequency auditory function is absent in noise expos

61 f the Anterior Cingulate Cortex (ACC) in the low frequency band suggesting the presence of a cortical

62 of SOM cell spiking reduces the spontaneous low-frequency band (<30-Hz) oscillations and selectively

63 res) that supports the formation of wide and low-frequency band gaps, while simultaneously reducing t

64 metric elastic wave transmission in multiple low frequency bands.

65 ar as transient bursts in distinct high- and low-frequency bands, and it is not yet clear how these b

66 r sensory streams also phase entrain ongoing low frequency brain oscillations but how and why this ha

67 d the derived predictions are represented in low-frequency brain activity.

68 eased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss

69 persisted after hearing onset in a subset of low-frequency bushy cells (characteristic frequency< 10

70 n large, even late-onset effects are kept at low frequency by purifying selection.

71 ophila neuromuscular junctions (NMJs), where low-frequency Ca(2+) oscillations are required for synap

72 specificities in a single sample, and detect low-frequency CD8 T cells specific for virus- or cancer-

73 ime, to assess the contributions of multiple low frequency cell lineages to the regenerating limb at

74 ore susceptible to sound-induced damage than low-frequency cells; high-frequency inner hair cells mus

75 312 individuals with a comprehensive set of low frequency coding variants (ExomeChip), combined with

76 followed by genotyping, we have identified a low-frequency coding variant rs2076349 (V527M) in the la

77 Both common variants and low-frequency coding variants in CPN1 were associated wi

78 ring steps, we retained 439 obesity-enriched low-frequency coding variants.

79 away from the location of indentation and at low frequencies compels endolymph displacement along the

80 0.4 Hz), an indicator of vagal activity, the low-frequency component (0.04-0.15 Hz), a mixture of bot

81 The low-frequency component (mean [SEM], 52.7 [4.0] nu vs 39

82 demonstrated that individuals can reduce the low frequency components of elbow impedance by 35%.

83 Conversely, the low frequency components of the stress signal, with limi

84 Both slow neural fluctuations (low-frequency connectivity) and transient, stimulus-evok

85 displays a 1/f frequency dependence (above a low-frequency corner frequency).

86 pulvinar deactivation caused an increase in low-frequency cortical oscillations, often associated wi

87 a neural mechanism that resets the phase of low-frequency cortical oscillations.

88 g inhibitory neurons that reset the phase of low-frequency cortical rhythms.

89 ared with neutral landscape stimuli enhances low-frequency coupling between the amygdala and the hipp

90 In conclusion, we describe a low-frequency CYP2R1 coding variant that exerts the larg

91 high-frequency (inter-annual variation) from low-frequency (decadal trends) components of climate osc

92 entate granule cells in mice does not affect low-frequency dentate to CA3 glutamatergic synaptic tran

93 es are leaky-wave antennas which utilize the low frequency dependence.

94 t recovery of neurotransmitter release after low-frequency depression.

95 Under low-frequency droughts, plants fixed carbon (C) and nitr

96 eratures due to contribution from Tl-induced low-frequency Einstein modes as also evidenced from THz

97 Upon low-frequency electro-stimulation, endocytotic FM1-43 (S

98 PE studies in audition have capitalized on low-frequency event-related potentials (LF-ERPs), such a

99 spontaneous quantal synaptic transmission or low frequency evoked synaptic transmission at the endbul

100 ent processing was also disrupted, dampening low-frequency excitatory input and potentiating high-fre

101 based morphometry (VBM) and the amplitude of low-frequency fluctuation (ALFF) in first-episode drug-n

102 hronic smokers using fractional amplitude of low-frequency fluctuation (fALFF).

103 p=1.33 x 10(-3)) in the resting amplitude of low frequency fluctuations analysis; and reduced activat

104 e-adjusted voxelwise fractional amplitude of low-frequency fluctuations (fALFF; 0.01-0.08 Hz) of the

105 lity that a significant part of the observed low-frequency flux noise measured in these devices is ul

106 isolates, leading to enrichment of rare and low-frequency functional variants, using novel statistic

107 ignaling and survival pathways, and multiple low-frequency genetic alterations.

108 We sought to identify low-frequency genetic variants that strongly increase th

109 rrently the only technique capable of taking low-frequency (GHz to THz) vibrational spectra in soluti

110 hb, Fshb gene induction has a preference for low-frequency GnRH pulses.

111 ose-dependently decreased the firing rate of low-frequency GPe neurons, but did not alter the firing

112 confidence interval: 1.06 to 1.17), and for low frequency/HF was 1.08 (95% confidence interval: 1.03

113 z), low-frequency (0.04 to 0.15 Hz), and the low-frequency/HF ratio (denoting a greater sympathetic t

114 were available for interventions other than low-frequency, high-frequency, and bilateral rTMS.

115 not required to drive spatially informative low-frequency hippocampal oscillations during navigation

116 risk sexual activity (26; 95% CrI, 6-66) and low-frequency IDU (22; 95% CrI, 4-68).

117 ntification of mutations that are present at low frequencies in clinical samples is an essential comp

118 mtDNA variants that are initially present at low frequencies in normal cells preferentially expand in

119 dendritic cells (DCs), which are present at low frequencies in the nondiseased CNS, are completely r

120 The results demonstrate no superiority of low frequencies in timing judgments but reveal a robust

121 resistance in Southeast Asia are present at low frequency in Africa.

122 be deleterious although it was found with a low frequency in control individuals.

123 ported by co-segregation with the phenotype, low frequency in control populations and the application

124 HV-6B integrated into a telomere occurs at a low frequency in most populations studied to date, but i

125 Ruminococcus gnavus, which tended to have a low frequency in nonallergic subjects (P = .0004).

126 re either not detected or detected with very low frequency in the blood, suggesting the existence of

127 for their potential deleterious nature and a low frequency in the general population.

128 ndicated that PPHGI-1 would be maintained at low frequency in the population long term, if it confers

129 available, allowing the investigation of the low-frequency ion modes in dense matter.

130 ctrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common (ZMIZ2,

131 oon rainfall and a weakening variance of its low-frequency ISO (LF-ISO) cycle.

132 ally subdivided into high frequency (HF) and low frequency (LF) events, whereas intermediate "Hybrid"

133 of hsl7 and kel1, which arose together in a low-frequency lineage.

134 ures were higher at high frequencies than at low frequencies (low frequency: 0.08, 0.24, and 0.20 for

135 Optical stimulation of 5-HT terminals at low frequencies (</=1 Hz) evoked a short-latency excitat

136 power, but the strength of phase locking at low frequencies (</=10 Hz) increased with increasing LFP

137 ns of the guinea pig cochlea that respond to low frequencies (<2 kHz) and found that mechanical tunin

138 tactile sensation also operates in the same low frequencies (<500 Hz) as the acoustic hearing in EAS

139 This effort yielded hundreds of low frequency (<5%) and rare (<1%) variants with a stron

140 ons exhibit attention-dependent decreases in low-frequency (<10 Hz) coherence, but deep layer neurons

141 receptor currents, thus suggesting a high-to-low frequency maturation pattern.

142 AMPA receptor currents, suggesting a high-to-low frequency maturation pattern.

143 With our technique, even low-frequency mechanical oscillators can in principle be

144 gion's gamma power, suggesting a predominant low-frequency mechanism for inter-regional communication

145 Low-frequency membrane potential (Vm) oscillations were

146 rom 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding

147 ics from 19 cohorts identified in CYP2R1 the low-frequency (minor allele frequency = 2.5%) synonymous

148 We found low-frequency missense variants in MAP1A (rs55707100, mi

149 additional genotyping steps, we selected 28 low-frequency missense, nonsense and splice site variant

150 ea level and understanding the potential for low-frequency modulation of future TWS impacts including

151 The low-frequency mosaic pattern of transfection-based CRISP

152 Specifically, low-frequency motions involving concerted motions of the

153 t low-grade mechanical energies from various low-frequency motions, such as everyday human activities

154 prone, which precludes the identification of low frequency mutations for early cancer detection.

155 uccessfully apply o2n-seq to screen de novo, low-frequency mutations in human tumours.

156 Detection of de novo, low-frequency mutations is essential for characterizing

157 preparation method for discovering de novo, low-frequency mutations.

158 These findings show that low-frequency neuronal activity in the subthalamic nucle

159 Phase locking (entrainment) of ongoing low-frequency neuronal oscillations to rhythmic stimuli

160 EGFP and Npas1-tdTm mice strains to identify low-frequency neurons.

161 ol decreased the firing of a large subset of low-frequency neurons.

162 vel heart rate loci, and one new independent low-frequency non-synonymous variant in an established h

163 Low-frequency nuclear noise, responsible for fast (10 ns

164 to-parietal component of the AR (ARC1) and a low-frequency occipito-temporal component (ARC2), charac

165 natural grassland, a set of populations with low frequencies of antibiotic resistance genes.

166 uncovered a significant correlation between low frequencies of macroH2A1 staining and advanced, aggr

167 nts with only low level BK viremia expressed low frequencies of polyfunctional T cells.

168 Both operation methods seemed safe, with low frequencies of serious perioperative and postoperati

169 visible postviremia but was associated with low frequencies of ZIKV-specific Ab-secreting cells in l

170 Sheath shortening is associated with a low frequency of [Ca(2+)]i transients but with longer du

171 niazid monoresistance were associated with a low frequency of ADR.

172 The low frequency of autoreactive mature naive B cells in UN

173 spite high viral loads, natural hosts have a low frequency of CD4(+) cells expressing the SIV corecep

174 al hernia repair in men is associated with a low frequency of chronic pain and recurrent operations,

175 The low frequency of HIV-1 recombinants within entire viral

176 condary contact region is characterized by a low frequency of hybridization, where mitochondrial DNA

177 ency of self-compatible hermaphrodites and a low frequency of males.

178 ation differed, with absence of swelling and low frequency of perilesional oedema (10%) at diagnosis,

179 sseau-Kropotkin position correctly notes the low frequency of reactive aggression.

180 The low frequency of these events, however, has hindered the

181 cal fluctuations have a strong effect on the low-frequency optical conductivity, resulting in behavio

182 Our data demonstrate that most of the low-frequency or rare coding variants associated with li

183 trate that abnormal coupling of the phase of low frequency oscillations to the amplitude of gamma osc

184 Low-Frequency Oscillations (LFO) in the range of 7-9 Hz,

185 quency TMS to left parietal cortex increases low-frequency oscillations and improves behavior.

186 our results provide compelling evidence that low-frequency oscillations in the theta and alpha range

187 in the targeted area, tDCS does induce large low-frequency oscillations in the underlying tissue.

188 f oscillations that is neither restricted to low-frequency oscillations nor to periods outside of sti

189 We speculated that low-frequency oscillations observed in the granular laye

190 support the proposition that entrainment of low-frequency oscillations serves a mechanistic role in

191 uring a perceptual decision-making task; STN low-frequency oscillatory (LFO) activity (2-8 Hz), coupl

192 Together, our results demonstrate that STN low-frequency oscillatory activity and corresponding mPF

193 By spontaneously generating low-frequency oscillatory behaviors, the EGN model is ab

194 Low-frequency oscillatory entrainment may reflect a gene

195 s reveals that some function is preserved in low frequency outer hair cells, despite concomitant prof

196 ted far-IR spectra showed a red shift of the low-frequency peaks upon peptide binding.

197 how strikingly similar hierarchically nested low-frequency phase and high-gamma amplitude coupling, e

198 We show that the combination of long-range, low-frequency phase synchronization and local cross-freq

199 In this study, low-frequency phase synchronization between prefrontal a

200 nected to the prefrontal cortex by increased low-frequency phase synchronization within the theta/alp

201 interact with prefrontal cortex via enhanced low-frequency phase synchronization.

202 ategies typically focus on the scattering of low-frequency phonons by interfaces and high-frequency p

203 encing of excreted viruses revealed numerous low-frequency polymorphisms and 20 consensus-level subst

204 d for all phenotypes and are indicative that low-frequency polymorphisms contribute to phenotypic var

205 n of the refractory period affected only the low-frequency portion of the monaural AM-tuning curve.

206 We found that low frequency power spectral density and wavelet transfo

207 ated PM2.5 effect on HR by 150% (P = 0.003), low-frequency power by 90% (P = 0.01), total WBC count b

208 Although occurring at a low frequency, PrfA(-)/LLO(-) mutational events in L. mo

209 We validate previous reports of protective low-frequency protein-altering variants within IFIH1 (en

210 t analyses long-distance subionospheric very low frequency radiowave observations of the NAA 24.0 kHz

211 ion of atomic force microscopy and high- and low-frequency Raman spectroscopy of many dislocated WSe2

212 rations that are more directly probed by the low-frequency range of IR and Raman spectra and the appl

213 gions might coordinate their activity in the low-frequency range to engage local stimulus-related pro

214 regions through synchronized activity in the low-frequency range.

215 ariations of dependence in the low and ultra-low-frequency range.

216 5Hz (X5), frequency of resonance (Fres), and low-frequency reactance area (ALX), by using a MostGraph

217 Furthermore, low-frequency regulatory variants were grouped by gene,

218 ed to the onset of nonergodicity and loss of low-frequency relaxations caused by crowding, and the ja

219 Low frequency responses are related to larger organ and

220 hat the hippocampus can actually produce two low-frequency rhythms at nearby frequencies: one that in

221 this activity correlates significantly with low-frequency rhythms from electrocorticographic recordi

222 cal power, we did not identify any other new low-frequency risk variants and found that such variants

223 ng to some extent bilateral rTMS and priming low-frequency rTMS.

224 sequencing (WGS) can comprehensively capture low-frequency sequence variation for the cost of a dense

225 and wood composition traits, and common and low-frequency single-nucleotide polymorphisms detected b

226 or p70S6k phosphorylation site, along with a low frequency site at Thr(40), using an in vitro phospho

227 The near constant high levels of low frequency sound and consequential reduction in the c

228 tectors with a high-sensitivity reception of low-frequency sound from greater distances and zero refl

229 eismic surveys map the seabed using intense, low-frequency sound signals that penetrate kilometers in

230 lity to compare the relative arrival time of low-frequency sounds at both ears.

231 stitute an important cue for localization of low-frequency sounds in the horizontal plane.

232 Thus, the neural encoding of low-frequency sounds, which includes most of the informa

233 the hypothesis that odontocetes evolved from low-frequency specialists [4], we find evidence that ste

234 n ABP was associated with an increase in the low frequency spectra of systolic BP (13.9 +/- 4.3% tota

235 -mediated pressor response and the increased low frequency spectra of systolic BP response were fully

236 unexplored variation across the common- and low-frequency spectra.

237 y HIV-1 splicing at a depth that allows even low-frequency splice variants to be monitored.

238 tablished the efficacy of cell type-specific low-frequency stimulation (LFS) in controlling ictogenes

239 Low-frequency stimulation (LFS) is an alternative tool f

240 np54p, long-term depression (LTD) induced by low-frequency stimulation was blocked in the mouse hippo

241 e and high levels of PE persistently reduced low-frequency stimulation-induced eCB-LTD.

242 c core, TLR4.KO animals exhibit a deficit in low-frequency stimulation-induced NMDAR-dependent long-t

243 We show that at low-frequency stimulations, a first sub-pool is graduall

244 sponses in mutant fish can follow faithfully low-frequency stimuli despite the reduced amplitude.

245 ivated by high-contrast stimuli dominated by low frequencies such as natural stimuli.

246 lective constraints, these variants occur at low frequencies, such that there is often insufficient s

247 educed the sensitivity of the cone signal to low frequencies, suggesting that local horizontal cell f

248 olysis or oxidative phosphorylation can fuel low-frequency synaptic function and inhibiting both unde

249 Both Na(+) and K(+) conductances suppress low-frequency synaptic inputs, so cells with larger volt

250 eta activity intracranially in humans during low-frequency tACS and find no stable entrainment of spi

251 We conclude that low-frequency tACS at common stimulation intensities nei

252 This contrasts with the TFS-LF (low-frequency) test, which measures the smallest detecta

253 The low frequency theta rhythm is thought to promote the for

254 Low-frequency TMS to left parietal cortex increases low-

255 80 degrees from approximately 135 degrees at low frequencies to approximately -45 degrees at the best

256 [4.0] nu vs 39.9 [3.8] nu; P = .03) and the low frequency to high frequency ratio (mean [SEM], 1.37

257 d sympathetic activity, and the ratio of the low frequency to high frequency, reflecting the cardiac

258 ring applications, from seismic shielding at low frequency to ultrasonic cloaking at higher frequency

259 es when the high-frequency tone followed the low-frequency tone than vice versa.

260 lous Hall effect has been investigated using low-frequency transport measurements.

261 observe that, upon temperature increases, a low-frequency transverse phononic gap emerges while high

262 of insufficient length to accurately assess low frequency trends and forcing mechanisms.

263 significant decrease in MAE duration whereas low-frequency tRNS caused a significant corresponding in

264 roups were administered with either high- or low-frequency tRNS.

265 ux and exocytosis changes from nanodomain in low-frequency tuned hair cells ( approximately <2 kHz) t

266 frequency response of light-adapted flies to low frequencies typical of dark-adapted flies.

267 Localized, low-frequency ultrasound has recently been shown to enab

268 The use of low-frequency ultrasound in the GI tract represents a no

269 ered in the Pacific Ocean is closely tied to low frequency variability of TWS in key areas across the

270 forcings, this system simulates the observed low-frequency variability of precipitation, soil water,

271 No low-frequency variant associations were identified at ge

272 we showed that heterozygote carriers of this low-frequency variant have an increased risk of vitamin

273 ting evidence for association at eight novel low-frequency variant signals.

274 A low-frequency variant, rs28929474, (beta = 0.04, P = 2 x

275 h optimization of the genetic composition of low frequency variants, which together cooperate to circ

276 nome-wide association study (GWAS) including low-frequency variants (minor allele frequency >/=0.005)

277 We grouped low-frequency variants (minor allele frequency </= 5%) b

278 Rare and low-frequency variants (minor allele frequency </=5%) we

279 mic diversity reveals that: (i) both new and low-frequency variants are significantly more deleteriou

280 e-genome sequence data, we examined rare and low-frequency variants for association with non-HDL chol

281 add empirical support to the contribution of low-frequency variants in complex traits, demonstrate th

282 Several of the protective rare and low-frequency variants in IFIH1 and TYK2 disrupt conserv

283 Our results suggest that both common and low-frequency variants need to be considered for a compr

284 ntly large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect assoc

285 not been previously identified, including 9 low-frequency variants pointing to functional candidates

286 lthough the study was well-powered to detect low-frequency variants with large effect sizes, suggesti

287 population, and show enrichment of rare and low-frequency variants with predicted functional consequ

288 o increase power to detect associations with low-frequency variants, multiple-marker association test

289 ed sample size and more complete coverage of low-frequency variation, all novel associations were dri

290 ture of glassy frustration-anharmonicity and low-frequency vibrational modes.

291 ee text] density of states of quasilocalized low-frequency vibrational modes.

292 eration sequencing is decreased so that even low-frequency viral variants can be accurately detected.

293 hese findings show, for the first time, that low-frequency Vm oscillations can significantly modulate

294 Recently, low-frequency Vm oscillations have been described in ina

295 Yet, very little is known about how low-frequency Vm oscillations influence sensory processi

296 Therefore, low-frequency Vm oscillations play a role in shaping sen

297 igh frequency) and local-field oscillations (low frequency) was characterized in vitro using an artif

298 re detected in ASYMP individuals, while only low frequencies were detected in SYMP individuals.

299 ion limit of oscillating light at relatively low frequencies, which was shifted to higher frequencies

300 th high-frequency summer and spring NAO, and low-frequency winter NAO components are highly correlate