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1 CI: 0.43 to 0.99) compared with standard BP lowering.
2 ce due to the negative drain-induced barrier lowering.
3 Bimatoprost SR provided rapid, sustained IOP lowering.
4 similar low-density lipoprotein cholesterol lowering.
5 ay be on the rise in an era of intense lipid lowering.
6 the forbidden IR active mode due to symmetry lowering.
7 ansitions take place accompanied by symmetry lowering.
12 rmore, treating zebrafish with a cholesterol-lowering agent, ezetimibe, reduced susceptibility to S T
13 T: Atorvastatin calcium (ATV), a cholesterol-lowering agent, suffers from poor systemic availability
15 bidities, treatment (the use of oral glucose-lowering agents and insulin), control (hyperglycemia, dy
18 is one of the promising targets for glucose-lowering agents, and the development of GK activators ar
20 ffective ammonia-lowering therapies, whether lowering ammonia restores proteostasis and increases mus
23 that should be tolerated during intensive BP lowering and its association with risk of ESRD are uncle
26 fect the initiation of Abeta pathology while lowering apoE after Abeta seeding modulates plaque size
30 lines in kidney function in the intensive BP lowering arm of two trials in CKD associated with higher
31 lo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm] and JUPITER [Justification for the Use of
33 nknown whether intensive blood pressure (BP) lowering beyond that recommended would lead to more lowe
36 ned, and no mechanistic studies of the Lp(a) lowering by alirocumab in humans have been published to
38 d hepatic LDL receptors as the basis for LDL lowering by PCSK9 inhibitors, there have been no human s
39 tailed interrogation of the mechanism of TRL lowering by the APOC3 Ala43Thr (A43T) variant, the only
42 rating that, in ambient air, surface tension lowering can prevail over the reduction in the Raoult ef
45 a3beta4)2beta4-nAChR function principally by lowering cell-surface expression, whereas single-channel
48 5% to <20% eGFR decline during intensive BP lowering did not associate with a higher risk of ESRD in
51 mHg (aHR, 4.86) and prior/current use of IOP-lowering drops or surgery in the other eye (aHR, 4.17);
52 rome-related conditions, such as any glucose-lowering drug (PR = 0.28; 95% CI = 0.25-0.31) and lipid-
53 -induced LCH-like mouse with the cholesterol-lowering drug atorvastatin ameliorated the pathology, im
54 ouseholds able to afford four blood pressure-lowering drug classes were more likely to use at least o
55 nti-inflammatory and low-density lipoprotein-lowering drugs are currently being investigated in large
56 tients who filled a prescription for glucose-lowering drugs between 2012 and 2015 were included and f
58 ingle capsule containing four blood pressure-lowering drugs each at quarter-dose (irbesartan 37.5 mg,
59 of SGLT2 inhibitors and use of other glucose-lowering drugs for non-fatal myocardial infarction, non-
60 nitiated on any SGLT-2i versus other glucose-lowering drugs in 6 countries to determine if these bene
61 treatment with SGLT-2i versus other glucose-lowering drugs was associated with a lower risk of HHF a
62 ity of two or more classes of blood pressure-lowering drugs was lower in low-income and middle-income
63 study drug classes for detailed drugs (lipid-lowering drugs, gastroesophageal reflux disease drugs, a
64 d nondetailed drugs in 8 drug classes (lipid-lowering drugs, gastroesophageal reflux disease drugs, d
67 mortality compared with use of other glucose-lowering drugs-a finding consistent with the results of
72 ch thickens Lo domains and disperses them by lowering edge energy on domain boundaries, left integrin
73 lower day-to-day variability in the glucose-lowering effect and lower rates of hypoglycemia among pa
76 te the safety and intraocular pressure (IOP)-lowering effect of a biodegradable bimatoprost sustained
80 e to determine that the intraocular pressure-lowering effect of pregabalin is dependent on the Cacna2
81 n nonathletes, and in all subjects, the rate-lowering effect of the HCN selective blocker, ivabradine
82 tection, independent from its blood pressure lowering effect, have not yet been fully understood.
84 report that Gleevec also achieves its Abeta-lowering effects through an additional cellular mechanis
85 The pooled placebo-corrected blood pressure-lowering effects were 5/2 mm Hg and 7/5 mm Hg, respectiv
89 rize the 12-month intraocular pressure (IOP)-lowering efficacy of selective laser trabeculoplasty (SL
90 ary, this study demonstrates the cholesterol-lowering efficacy of short-term feeding of the Lab4 prob
91 mice and we reversed MA preference/taking by lowering endogenous glutamate and/or Homer2 expression w
94 pertensive medication, and more intensive BP lowering for many adults taking antihypertensive medicat
95 pertensive medication, and more intensive BP lowering for many adults taking antihypertensive medicat
96 These findings support more effective LDL-C lowering for primordial prevention, even in individuals
99 ute eGFR declines >/=20% during intensive BP lowering identified a subset of patients at higher risk
101 gent now exists to target further heart rate lowering in patients who have been stable on a "maximall
102 trials (RCTs) to assess whether intensive BP lowering in patients with acute ICH is safe and effectiv
103 rials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated sy
110 e system are then offered, with the goals of lowering insurance premiums, improving coverage rates, a
111 ria for causality, we conclude strongly that lowering intake of saturated fat and replacing it with u
113 analostomy/Phacoviscocanalostomy (VC/PVC) in lowering intraocular pressure (IOP) in Normal Tension Gl
115 is population and its CD40 expression, while lowering its CD134 expression, thereby confirming its ro
117 of dense lattice dislocations as a means of lowering kappaL , but also the importance of engineering
118 nce for the short- and long-term benefits of lowering LDL-C for the primary prevention of cardiovascu
119 CVD, and clinical trial data have shown that lowering LDL-C generally reduces cardiovascular risk.
122 ved assessment of the efficacy and safety of lowering low-density lipoprotein cholesterol levels with
126 secondarily, leads to a reduction in glucose-lowering medication in participants with type 2 diabetes
129 cket cost (copay), clinical diagnoses, lipid-lowering medication use, and low-density lipoprotein cho
130 patients who reported currently taking lipid-lowering medication, full implementation of the USPSTF r
133 d be treated sufficiently with primarily IOP lowering medications and without need for glaucoma surge
134 OAG were randomized to prompt washout of IOP-lowering medications followed by SLT, 3-month delay foll
135 ts that, for patients requiring multiple IOP-lowering medications, a fixed combination may provide im
136 nded by postrandomization use of cholesterol-lowering medications.CVD risk in postmenopausal women ap
137 re likely to use at least one blood pressure-lowering medicine (adjusted odds ratio [OR] 2.23, 95% CI
138 re likely to use at least one blood pressure-lowering medicine (adjusted OR 1.42, 95% CI 1.25-1.62; p
139 have access to more than one blood pressure-lowering medicine and, when available, they are often no
140 Ensuring access to affordable blood pressure-lowering medicines is essential for control of hypertens
141 useholds unable to afford two blood pressure-lowering medicines was 31% in low-income countries (1069
143 , costs, and affordability of blood pressure-lowering medicines with data recorded from 626 communiti
144 lability and affordability of blood pressure-lowering medicines, and the association with use of thes
146 cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing int
148 Rhizobiales bacteria possibly contributed to lowering O2 levels in leaf pockets but did not release d
149 nia-lowering therapy resulted in significant lowering of blood and skeletal muscle ammonia, increase
150 NTRODUCTION: It is unclear whether intensive lowering of blood pressure (BP) at the acute phase of in
155 iate management including ocular massage and lowering of intraocular pressure, the visual loss remain
156 clerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets
158 system's line tension energy, because of the lowering of line interface energy closer to mixing.
159 lisin-kexin type 9 (PCSK9), a target for the lowering of low-density lipoprotein (LDL) cholesterol.
160 anacetrapib seems to be largely explained by lowering of non-HDL-C (high-density lipoprotein choleste
162 Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic
163 Raoult effect, while maintaining substantial lowering of surface tension, even for partial surface co
164 ivity resulted from a chiral anion dependent lowering of the activation barrier for the desired pathw
165 R , leading to luminal RyR sensitization and lowering of the activation threshold for cytosolic CICR.
167 ly, leading to luminal RyR sensitization and lowering of the cytosolic Ca(2+) activation threshold.
170 yers, suggesting that BAM catalysis involves lowering of the kinetic barrier imposed by the hydrophob
173 g beyond that recommended would lead to more lowering of the risk of left ventricular hypertrophy (LV
174 at room temperature and therefore precludes lowering of the supply voltage and overall power consump
175 he above effect and a proportionally greater lowering of the vesicle lysis tension and hydration repu
176 to hexapeptide association, as manifested by lowering of transient interactions between the central a
177 We aimed to assess the benefits of LDL-C lowering on cardiovascular outcomes among individuals wi
178 hazard ratio of intensive versus standard BP lowering on CVD, 0.76 [95% confidence interval, 0.64-0.9
179 To examine the effects of intensive SBP lowering on kidney and cardiovascular outcomes and contr
180 Our aim was to determine the impact of PUA lowering on renal and vascular function in patients with
183 acute ICH randomised to either intensive BP-lowering or standard BP-lowering treatment protocols.
184 ms of reducing unscheduled physician visits, lowering patients' anxiety and increasing self-efficacy,
185 estigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related
186 To evaluate the intraocular pressure (IOP)-lowering performance and safety of an ab interno gelatin
187 SERS sensor involved drug release induced by lowering pH and increasing GSH levels, both occurring in
192 plements has an equally beneficial effect on lowering postprandial glucose.The aim of our study was t
193 has also been suggested that the cholesterol-lowering potential of KJM may be greater than that of ot
194 rmine whether aggressive blood pressure (BP) lowering prevents recurrent atrial fibrillation (AF) aft
196 e demonstrated a direct relationship between lowering remotely monitored PA pressures and heart failu
203 ssed the efficacy and safety of intensive BP-lowering strategies in older (age >/=65 years) hypertens
205 without glaucoma progression/additional IOP-lowering surgery), Snellen-equivalent visual acuity (VA)
208 ial): 4086 randomly assigned to intensive BP lowering (target SBP <120 mm Hg) and 4078 assigned to st
210 nsion but no diabetes mellitus, intensive BP lowering (target systolic BP <120 mm Hg) compared with s
211 lic BP <120 mm Hg) compared with standard BP lowering (target systolic BP <140 mm Hg) resulted in low
212 l cultures lithium attenuates iron efflux by lowering tau protein that traffics amyloid precursor pro
216 nd myriad risks and benefits associated with lowering the age of enrollment on oncology clinical tria
225 the Econamine process, without significantly lowering the CO2 absorption efficiency ( approximately 9
226 has been identified as a restriction factor, lowering the concentration of dNTP substrates to limit R
227 8 trial), treatment intensity was reduced by lowering the cumulative dose of etoposide (950 to 450 mg
230 te, clinicians often manage this disorder by lowering the dose of, or discontinuing, the causative dr
231 an exclusively thermodynamic manner, i.e. by lowering the free energy of the native state and with al
232 e presence of the amphiphilic replicator, by lowering the interfacial tension between droplets of the
233 involved preconcentration of analytes, thus lowering the limit of detection (LOD) to the nanograms p
234 oncentrated on the coating, and dramatically lowering the limits of detection attained by sole DART a
237 gs showed enhanced antibacterial activities, lowering the minimum inhibitory concentration (MIC) by m
241 1 (Gpa2CN/Rx1L) results in autoactivity, but lowering the protein levels restored its specific activa
244 The use of toppings masked the effect of lowering the sodium content, allowing to increase the re
246 iation and germinal center (GC) formation by lowering the threshold of antigen-driven activation.
247 the MTD are as efficacious, suggesting that lowering the total amount of drug administered could low
249 se findings suggest surgeons should consider lowering their threshold for using arterial grafts, and
250 or preclinical screening of personalized HTT lowering therapies in HD patients of East Asian descent.
251 espite the availability of effective ammonia-lowering therapies, whether lowering ammonia restores pr
252 derate-strength evidence suggests that urate-lowering therapy (allopurinol or febuxostat) reduces lon
253 foundly altered in HCV-positive men by lipid lowering therapy (change in HR with lipid-lowering thera
254 to high-intensity statin and nonstatin lipid-lowering therapy (LLT) were analyzed before (September 1
255 fed Sprague-Dawley rats treated with ammonia-lowering therapy by l-ornithine l-aspartate and rifaximi
257 erolaemia who were on stable LDL cholesterol-lowering therapy for at least 4 weeks; all patients rece
258 id lowering therapy (change in HR with lipid-lowering therapy for TC >240 mg/dL from 1.82 to 1.19 [HC
259 ning potential benefits of combination lipid-lowering therapy in individuals with CKD are needed.
263 and lay the foundation for prolonged ammonia-lowering therapy to reverse sarcopenia of cirrhosis.
264 L-c is reduced by more than 30% during lipid-lowering therapy, blood glucose monitoring is suggested
265 rences with patients before initiating urate-lowering therapy, including concomitant prophylaxis, in
266 uding enzyme replacement therapy, oral lipid-lowering therapy, stem-cell transplantation, and liver t
274 t per protein molecule could be minimized by lowering transcription levels, regulating translation sp
275 ensive BP-lowering treatment and standard BP-lowering treatment (OR: 0.99; 95% CI: 0.82 to 1.20, p=0.
277 between patients randomised to intensive BP-lowering treatment and standard BP-lowering treatment (O
278 isk associated with intensive blood pressure-lowering treatment can be established only via randomize
280 ifferences between intensive and standard BP lowering treatment groups in total mortality rates, unfa
281 surgery in many patients, and increased IOP-lowering treatment in the postoperative course was commo
282 t-effectiveness significantly increases when lowering treatment prices in early fibrosis stages.
284 o compare intraocular pressure (IOP) and IOP-lowering treatment requirements in patients with late in
287 operation group, respectively, required IOP-lowering treatment with glaucoma medications added, adju
290 conducted six parallel, multinational lipid-lowering trials enrolling 4300 patients with hyperlipide
296 resumably occur independent of blood glucose lowering, we also explore the potential use of SGLT2 inh
297 signed to the intensive (versus standard) BP lowering were 66% more likely to regress/improve their L
299 uman activities have resulted in water table lowering (WTL) and enhanced nitrogen (N) deposition in T
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