ライフサイエンスコーパス: lumenal

1 nant negative towards transcytosis, inhibits lumenal accumulation.

2 tential means for misfolded extracellular or lumenal alpha-syn to access cytosolic alpha-syn.

3 somes are specialized platforms for both the lumenal and cytosolic sensing of pathogens.

4 establishes a functional connection between lumenal and membrane events driving this process.

5 macaques by 16S sequencing feces and paired lumenal and mucosal samples from ten sites distal to the

6 -length A34 or a construct consisting of the lumenal and transmembrane domains restored normal traffi

7 smic reticulum (ER) transmembrane protein is lumenal and which one is facing the cytosol.

8 septate junction formation, deposition of a lumenal/apical extracellular matrix, and lumenal secreti

9 is also frequently assayed by the mixing of lumenal aqueous compartments, using probes of low molecu

10 (LPS), (2) cluster on the surface of native lumenal bacteria, (3) prevent the adherence of enteropat

11 d are associated with increased levels of ER Lumenal Binding Protein (BiP).

12 Depletion of either one of the ER lumenal BiP co-chaperones, ERj3 and ERj6, but not the ER

13 Lumenal bovine serum albumin (BSA) lowered the lumenal i

14 NPC, potentially through the formation of a lumenal bridge with Pom152p.

15 4899Q, E4900N) eliminated the block from the lumenal but not the cytosolic side.

16 R gating through calsequestrin (CSQ), the SR lumenal Ca(2+) buffer.

17 steady-state P(o) effectively increase as SR lumenal Ca(2+) increases.

18 However, recent experiments suggest that SR lumenal Ca(2+) may also participate in regulating RyR ga

19 simulation under controlled cytosolic and SR lumenal Ca(2+).

20 expand (or reseal), slowing the dispersal of lumenal cargo proteins and granule membrane proteins.

21 rom fusion sites and promotes the release of lumenal cargo proteins.

22 le cells are trafficked to generate a common lumenal cavity.

23 In human lumenal cells, activation of TP53 by inhibiting MDM2 or

24 ired for specification of the basal, but not lumenal cells.

25 served membrane-intrinsic helix hairpin, the lumenal channel protonates an acidic glutamate in the c-

26 on, a ratcheting mechanism is used by the ER-lumenal chaperone BiP in eukaryotes, and a pushing mecha

27 lly we show that a conserved cysteine in the lumenal chaperone BiP is susceptible to oxidation by per

28 ERp44 is an ER lumenal chaperone protein that favors the maturation of

29 78/BiP, a typical endoplasmic reticulum (ER) lumenal chaperone, can be expressed on the cell surface,

30 ion has been described, massive reduction of lumenal chloride is observed that is 10(3) fold greater

31 This mucosal and lumenal community variability corresponded to functional

32 ittle fusion with the more rigorous assay of lumenal compartment mixing.

33 g proteoliposomes was required for efficient lumenal compartment mixing.

34 pressed proteins into either the membrane or lumenal compartment of OMVs.

35 The entry of the analogue into the lumenal compartment was confirmed by demonstrating that

36 remained inaccessible to both cytosolic and lumenal compartments until translation was terminated.

37 ssment of lipid mixing, the mixing of intact lumenal compartments, any lysis that occurs, and the mem

38 water channel are delivered to cytosolic and lumenal compartments.

39 permeability may facilitate the movement of lumenal contents across the mucosa, thus helping to expl

40 y granule membrane with the plasma membrane, lumenal contents are rapidly discharged and dispersed in

41 -limiting completion of fusion and mixing of lumenal contents.

42 ther Crumbs or phosphomimetic Moesin induced lumenal cysts and decreased terminal branching.

43 selectivity filter motif GGGIG, a conserved lumenal DE motif that has a critical role in RyR ion per

44 ESCRT-independent pathway of ILV sorting by lumenal determinants and a requirement for ILV sorting i

45 o ILVs by a mechanism that is dependent upon lumenal determinants and conserved in non-pigment cells.

46 T cell receptor (TCR) as a model to analyze lumenal determinants of ER quality control with a partic

47 ed in tracheal fusion cell morphogenesis and lumenal development.

48 CystC-deficiency increased lumenal diameter and lesion size compared with control m

49 The lumenal diameters of PMN blebs and vesicles are signific

50 Lumenal diameters of the remaining capillaries in wet AM

51 ERdj3 was identified as a soluble, lumenal DnaJ family member that binds to unassembled imm

52 We found that the core ER-lumenal domain (cLD) of yeast Ire1 binds to unfolded pro

53 that similar to yeast, human IRE1alpha's ER-lumenal domain (hIRE1alpha LD) binds peptides with a cha

54 ression system for the endoplasmic reticulum lumenal domain (residues 1 to 100) of Ad type 2 E3-19K t

55 Interaction of NPC2 with NPC1 lumenal domain 2 is only detected at acidic pH, conditio

56 For these experiments, a soluble NPC1 lumenal domain 2 was engineered by replacing adjacent tr

57 cific physical interaction between the Heh1p lumenal domain and the massive cadherin-like lumenal dom

58 ted mutant of bZIP28 eliminating most of the lumenal domain does not bind BiP and is not retained in

59 Unfolded ER proteins cause IRE1alpha lumenal domain homo-oligomerization, inducing trans auto

60 IRAP without the lumenal domain is faithfully targeted to the donor membr

61 we report that oligomeric assembly of the ER-lumenal domain is sufficient to drive Ire1 clustering.

62 , we identify a novel transmembrane protein, lumenal domain like LAP1 (LULL1), which also appears to

63 h lamina-associated polypeptide 1 (LAP1) and lumenal domain like LAP1 (LULL1).

64 he companion to this paper, we show that the lumenal domain of A33 is sufficient for interaction with

65 In contrast, the lumenal domain of A33 is sufficient for interaction with

66 Furthermore, the lumenal domain of A33 is sufficient to restore the prope

67 panel of charge-to-alanine mutations in the lumenal domain of A33 to map the B5 interaction site.

68 Thbs bind the ER lumenal domain of activating transcription factor 6alpha

69 ot necessarily its own, is requisite for the lumenal domain of B5 to interact with A33.

70 d system and chemical cross-linking that the lumenal domain of IRAP can interact with the lumenal loo

71 inA substrate, as expression of the isolated lumenal domain of LAP1 inhibits the NE localization of "

72 The ER lumenal domain of MKS3 interacted with a complex that in

73 chromatography, we show here that the second lumenal domain of NPC1 binds directly to NPC2 protein.

74 l prop to position other determinants in the lumenal domain of p75 for oligomerization.

75 However, truncations of the N-glycosylated, lumenal domain of Pom152p and pom152 mutants lacking N-l

76 Here we show that the lumenal domain of recombinant Cosmc directly interacts s

77 lumenal domain and the massive cadherin-like lumenal domain of the membrane nucleoporin Pom152p.

78 ity by direct binding to cysteine 148 in the lumenal domain of the sensor, which is oxidized when IRE

79 n model, one specific region within the ATF6 lumenal domain was identified as a specific ER stress-re

80 ytosolic Hsc70-binding J domain, but not the lumenal domain, is essential for its targeting to the fo

81 or Sel1L directly through Sel1L's N-terminal lumenal domain, thereby linking ERdj5 to the Hrd1 comple

82 d occurred even in the absence of its native lumenal domain.

83 ion involves a coiled-coil domain within the lumenal domain.

84 its transmembrane domain and has a prominent lumenal domain.

85 nsmembrane segments (TMs) and three distinct lumenal domains A (also designated NTD), C, and I.

86 that the two proteins interact through their lumenal domains and that the coiled-coil domain of B5 is

87 Thus, folded lumenal domains can impede protein retrotranslocation.

88 Binding of torsinA to their C-terminal lumenal domains is stabilized when residues in any one o

89 n together, our results demonstrate that the lumenal domains of A33 and B5 interact and that the inte

90 erved between NBD1 and other cytoplasmic and lumenal domains of ABCA4.

91 t of GSVs, and we show it interacts with the lumenal domains of GLUT4 and other GSV constituents.

92 roteins, and membrane proteins with adhesive lumenal domains that may have contributed to the evoluti

93 in has 13 transmembrane domains, three large lumenal domains, and a cytoplasmic tail.

94 ent on the synergy of both nucleoplasmic and lumenal domains.

95 The lumenal EF-hand and SAM domains of STIM1 are believed to

96 till be monitored conventionally in the FAVE lumenal effluent.

97 g that Val49 fits into a constriction at the lumenal end of the M2 helix of SERCA, possibly controlli

98 lar sinus endothelium as opposed to the vein lumenal endothelium, and the opposite pattern with VWF (

99 nd helical segments close to the stromal and lumenal ends.

100 uberant immune system and a highly antigenic lumenal environment, the intestinal epithelium must rema

101 ntify other proteins including the monotopic lumenal enzyme cyclooxygenase 1 (prostaglandin H synthas

102 obasally polarized cysts, reminiscent of the lumenal epiblast stage, providing a model to explore key

103 of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis of human pluripotent

104 at allows them to self-organize and form the lumenal epiblast-like stage.

105 orphogenesis and defects in the clearance of lumenal epithelial cells.

106 ial cells, and Gli3 is also found within the lumenal epithelium.

107 reductase by determining susceptibility of a lumenal epitope in the enzyme to in vitro protease diges

108 Susceptibility of the lumenal epitope to protease digestion and thus membrane

109 Lumenal ER calcium depletion caused rapid oligomerizatio

110 ontrol of membrane proteins and connects the lumenal ER chaperone machinery to membrane protein bioge

111 merous misfolded proteins including soluble, lumenal ERAD-L and membrane-anchored ERAD-M substrates.

112 R)-associated degradation (ERAD) of numerous lumenal (ERAD-L) and membrane-anchored (ERAD-M) substrat

113 ER membrane translocation and connect these lumenal events with events on the ER membrane.

114 he Ca2+-binding site is located close to the lumenal exit of a putative proton channel leading from t

115 toxin treatment of HIEs caused physiological lumenal expansion detected by time-lapse microscopy, rec

116 Arteriogenesis, or the lumenal expansion of pre-existing arterioles in the pres

117 The other lumenal extrinsic proteins (PsbO, PsbU, PsbV, and PsbQ)

118 ed in the context of recruitment of the PSII lumenal extrinsic proteins and Mn4CaO5 cluster assembly.

119 taPsbU cells, the amounts of the other three lumenal extrinsic proteins and the electron donation rat

120 has been proposed that the Psb27 protein, a lumenal extrinsic subunit, serves as a PSII assembly fac

121 nds must extend for at least 20 A across the lumenal face of the Mn(4)Ca cluster.

122 Prior to ER membrane penetration, ER lumenal factors impart structural rearrangements to the

123 RAD substrate was encapsulated with selected lumenal factors inside mammalian microsomes.

124 Our study thus pinpoints two ER lumenal factors that coordinately prime SV40 for ER memb

125 In this report, we identify two ER lumenal factors that prepare the virus for ER membrane t

126 of GAB2 with antiapoptotic oncogenes causes lumenal filling, whereas coexpression with Neu (also kno

127 f the jacket and permeates in, rendering the lumenal flow strongly acidic (pH </= 2) that suppresses

128 led reversed net water secretion and reduced lumenal flux of different molecular probes (bovine serum

129 Thus, in addition to its well-established ER lumenal functions, calreticulin has an independent role

130 terminal domain, the intramembrane hole, the lumenal gate, the lumen of LptD channel, and the extrace

131 -pHluorin (SpH), a synaptic vesicle-targeted lumenal GFP (green fluorescent protein), whose fluoresce

132 kar2 mutant was defective for transfer of NE lumenal GFP, but not diffusion within the lumen, suggest

133 phate linkage with recovery of its lipid and lumenal glycan components.

134 mbination of intracellular and extracellular/lumenal glycoproteins.

135 s to the degradation of a mutant lacking the lumenal glycosylation domain (DeltaGly).

136 We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for S

137 ression of an ER-adapted catalase to degrade lumenal H2O2 attenuated PRDX4-mediated disulfide bond fo

138 the cytoplasmic half of TM7 and TM8 and the lumenal half of TM3, TM4, and TM7.

139 unit a and the proteolipid ring, whereas the lumenal hemichannel is located within subunit a at the i

140 tent with this hypothesis, yeast lacking the lumenal Hsp40s, Jem1 and Scj1, exhibited defects in ENaC

141 e forms an aqueous pore that is gated by the lumenal Hsp70 chaperone BiP.

142 We discovered that the ER lumenal Hsp70, BiP, an associated Hsp40, Scj1, and a nuc

143 ic reticulum (ER), it interacted with the ER-lumenal Hsp70, BiP, and bound to BiP substrates.

144 uestion, we introduced mutations into the ER-lumenal Hsp70, BiP/Kar2p, and found that an R217A substi

145 with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP encourages disassembly.

146 C5(-/-) mice displayed significantly reduced lumenal inflammatory infiltration and cytokine productio

147 Previous work has suggested that the lumenal interaction between Glut4 and sortilin and the c

148 We suggest that lumenal interactions between Glut4 and IRAP play an impo

149 menal bovine serum albumin (BSA) lowered the lumenal ionic strength at which ProP became active.

150 The attainable range of lumenal ionic strength was expanded by lowering the phos

151 d proteins, several thylakoid proteases, and lumenal isomerases did not change, while PsbS increased

152 Conversely, when a mammalian ER-lumenal JDP, ERdj3, was directed to the yeast cytosol, i

153 For each power stroke, a lumenal lever from a single subunit is electrostatically

154 Thus physical properties of the lumenal ligand-receptor complex appear to act as key det

155 ological reporters in bacteria, we deduced a lumenal location for the redox active domains of the pro

156 te opening, mutations were introduced into a lumenal loop (L7) that connects TM7 and TM8.

157 inear sequences of the endoplasmic reticulum-lumenal loop (Ser52-Phe55) and the first (Leu22-Lys30) a

158 P activity involves binding of BiP to the ER lumenal loop 7 of Sec61alpha in the vicinity of tyrosine

159 assembly into the STT3A complex, whereas the lumenal loop and the N-terminal cytoplasmic segment are

160 ter two functions are thought to involve the lumenal loop and the N-terminal domain.

161 CP43, possibly in the vicinity of the large lumenal loop connecting transmembrane helices 5 and 6 of

162 the psaD-->C-->A-->B organization contains a lumenal loop conserved in PsaA proteins from Synechococc

163 TM3 and the adjoining lumenal loop contribute residues important for Dnf1 PC p

164 The conformation of the lumenal loop domain is surprisingly different between LH

165 However, distances comprising the lumenal loop domain show broader distance distributions,

166 olved in current crystal structures, and the lumenal loop domain.

167 The lumenal loop linking the two most C-terminal transmembra

168 lumenal domain of IRAP can interact with the lumenal loop of Glut4.

169 By comparison, charge neutralization of lumenal loop residues (D4899Q, E4900N) eliminated the bl

170 We showed that lumenal lysosomal chloride, which is implicated in vario

171 ed that ProP is an ionic strength sensor and lumenal macromolecules activate ProP by altering ion act

172 , and overexpression of ERdj3 and ERdj4, two lumenal mammalian Hsp40s, increased the proteasome-media

173 and, in contrast to them, do not contain ER-lumenal markers possessing a C-terminal HDEL sequence.

174 or the dynamic organization of the transient lumenal matrix and normal structure of the cuticle that

175 Clearance of lumenal matrix and subcellular localization of clathrin

176 -1 adaptor in apical polarity during de novo lumenal membrane biogenesis in the C. elegans intestine.

177 lular leaflet of the plasma membrane and the lumenal membrane leaflet of the ER by a mechanism that d

178 The localization of His-379 on the lumenal membrane surface is consistent with a role for t

179 on transfer protein plastocyanin (Pc) to the lumenal membrane surface of the cytb6f complex using a P

180 On the lumenal membrane surface, subunit f establishes direct c

181 fts and is selectively incorporated into the lumenal membranes of the endosomes to escape the endosom

182 t loses its capacity to prevent adherence of lumenal microbes.

183 onstrates that increased recombination among lumenal microbial populations is a phenotype associated

184 mposition of mucosa-associated compared with lumenal microbiota in pig caecum.

185 e.g., Helicobacter and Treponema), while the lumenal microbiota showed inter-individual variation and

186 s these populations a higher potential, than lumenal microbiota, in exerting effects on the host.

187 Using real-time analyses of lumenal microenvironmental parameters, in conjunction wi

188 here-designated UPR-L, is induced by the ER lumenal misfolded protein, CPY*.

189 leak channel in HeLa cells and identified ER lumenal molecular chaperone immunoglobulin heavy-chain-b

190 pyrophosphate (Dol-P-P) is discharged in the lumenal monolayer of the endoplasmic reticulum (ER).

191 ylatable peptide, to generate Dol-P-P in the lumenal monolayer produced corresponding increases in th

192 traverse the membrane, defining torsinA as a lumenal monotopic membrane protein and requiring a new p

193 hes in ER sheets, as might be expected for a lumenal monotopic membrane protein.

194 -) tracheas exhibited significant, neonatal, lumenal mucus accumulation.

195 apsulated mutants remain agglutinated within lumenal mucus and, thus, are less likely to transit to t

196 psonophagocytosis--escape from entrapment in lumenal mucus.

197 cargo proteins and lead to the formation of lumenal MVB vesicles that are predominantly small compar

198 epends on terminal processing of a subset of lumenal N-glycans.

199 Morphometric measurement demonstrated lumenal narrowing from inwards collapse of hyalinized ar

200 plex plexiform-like lesions characterized by lumenal obliteration, intimal disruption, medial hypertr

201 Lumenal obstruction has typically been regarded as the c

202 acetylcholine to the airway constrictive and lumenal obstructive response after inhalation injury and

203 nascent chain exposure between cytosolic and lumenal occur without compromising the permeability barr

204 The mutations clustered around the lumenal opening of the transporter and mapped to either

205 PEG-mal in the absence of SDS, suggesting a lumenal orientation.

206 ER lumenal p58(IPK) could be coimmunoprecipitated with a ne

207 PsbU is a lumenal peripheral protein in the photosystem II (PS II)

208 Owing to its lumenal pH (approximately 5) and fusion with endolysosom

209 tively by ratio fluorometry to determine the lumenal pH of the phagosomes and a FRET-based technique

210 nus subdomain, which acts as a sensor of the lumenal pH, able to tune the quenching level of the comp

211 -free suspension medium caused a decrease of lumenal pH, eliminated by protonophore.

212 on flux was out of the LUV lumen, increasing lumenal pH.

213 al activity (Pi(1/2)/RT), decreased with the lumenal phosphate concentration.

214 overed multiple mutations clustered near the lumenal plug of Sec61alpha, thus revealing cotransin's l

215 hich localizes its interaction site near the lumenal plug of Sec61alpha.

216 wed that both a 20-amino acid stretch of the lumenal portion and a 10-amino acid stretch of the cytop

217 factor essential for proper assembly of the lumenal portion of the complex.

218 ted from the loss of a high concentration of lumenal potassium, which enabled the influx of potassium

219 ed, cannulated, and pressurized to 55 cm H2O lumenal pressure without flow.

220 aired each cancer sample with matched benign lumenal prostate epithelial cells and profiled transcrip

221 ere we report that the chloroplast thylakoid lumenal protein MAINTENANCE OF PHOTOSYSTEM II UNDER HIGH

222 The ER lumenal protein Yos9p is required for both release of DH

223 ontaining protein disulfide isomerase, an ER lumenal protein, near immature viral membranes.

224 by examining the localization of non-mature lumenal proteins in the Arabidopsis plsp1-null mutant an

225 he observation of marked alterations in many lumenal proteins in the cs26 mutant compared with the wi

226 e multiple mechanisms to control unprocessed lumenal proteins in thylakoids.

227 plastids suggest that complete maturation of lumenal proteins is a critical step for proper thylakoid

228 h levels in pre-complexes lacking any of the lumenal proteins PsbP, PsbQ, or PsbV.

229 e not significantly altered by replacing all lumenal proteins with only protein disulfide isomerase o

230 In contrast, two other lumenal proteins, PsbU and PsbV, were absent in both of

231 degradation of both membrane-associated and lumenal proteins.

232 In contrast, the thylakoid lumenal proteome showed a wide diversity of N-terminal r

233 upling stoichiometrically to glutamate flux, lumenal protons and chloride allosterically activate ves

234 rize a chloride conductance that is gated by lumenal protons and chloride and supports glutamate upta

235 re was a significant amount of the extrinsic lumenal PsbO protein in the His27PSII, but not in the Hi

236 n-like domain of LTO1 interacts with PsbO, a lumenal PSII subunit known to be disulfide bonded, and a

237 s support a model in which MKS3 links the ER lumenal quality control machinery with the cytosolic deg

238 m homeostasis and suggest that modifying the lumenal redox environment may affect the progression of

239 ysteine cathepsins through modulation of the lumenal redox potential.

240 The US2 endoplasmic reticulum (ER)-lumenal region is the class I binding domain, whereas th

241 resent evidence for a potential role of this lumenal region of ATP7A in copper transfer to cuproenzym

242 weaning piglets modulates the composition of lumenal-residing gut microbiota and reduces weaning-rela

243 ns, and the absence of endoplasmic reticulum lumenal retention sequences.

244 for the expression of epithelial CRBPII and lumenal retinoids to imprint local gut DCs with an intes

245 a barrier-independent function that promotes lumenal secretion of Vermiform and Serpentine, extracell

246 f a lumenal/apical extracellular matrix, and lumenal secretion of Vermiform and Serpentine, two putat

247 IC-3 mutants lacking the signal peptide, the lumenal segment or the coiled-coil domain, but not in mu

248 mammalian cells and discovered that (1) two lumenal sensors of misfolded ER proteins, the kinase/nuc

249 ctions of its B subunit, PltB, with specific lumenal sialylated glycan packaging receptors.

250 aries and scavenge microparticles from their lumenal side in a steady state.

251 e-stabilizing extrinsic protein binds to the lumenal side of photosystem II (PS II) close to the Mn(4

252 ed by the Mn(4)CaO(5) cluster located at the lumenal side of PS II.

253 by binding to the extrinsic proteins on the lumenal side of PSII, which differ significantly between

254 hat retrotranslocation is coordinated on the lumenal side of the ER membrane.

255 idine and methionine residues located on the lumenal side of the membrane.

256 he water splitting complex is located on the lumenal side of the PSII reaction center and contains ma

257 en-evolving complex, which is located on the lumenal side of the PSII reaction center and which conta

258 oplasmic side of the ER and completed on the lumenal side, requiring flipping of the intermediate Man

259 dition to negatively charged residues on the lumenal side, rings of four negative charges formed by D

260 to a greater extent from the cytosolic than lumenal side.

261 ch connect pairs of grana membranes at their lumenal sides.

262 Rather, it is a lumenal signal that sorts protein into clefts, which the

263 (2+) activation and inactivation, and one SR lumenal site for CSQ binding.

264 t to exploitation of a hitherto unrecognized lumenal source of H2O2 by PRDX4 and a parallel slow H2O2

265 isplays microvilli and a primary cilium; its lumenal space is rich in Ca(2+) Time-lapse imaging of is

266 splitting of membranes and encloses a single lumenal space.

267 aling epidermal, myoepithelial-specific, and lumenal-specific injuries.

268 ing mapped to a seven-residue stretch in its lumenal stem domain next to the transmembrane domain.

269 rting receptor sortilin interacting with the lumenal stem domain of GPP130.

270 nsable for its ability to respond to Mn, its lumenal stem domain was required and it had to be target

271 ealed an extensive network of human-specific lumenal structures containing erythrocytes, indicating f

272 maturation in melanocytes, requires a third lumenal subdomain and proteolytic processing that itself

273 letion analyses indicate that two N-terminal lumenal subdomains are necessary and sufficient for ILV

274 ER-associated degradation of a lumenal substrate, CPY*, is blocked in the absence of Pb

275 We conclude that this lumenal subunit is present in the vicinity of the CP43 p

276 Thus, we propose an exchange of lumenal subunits and cofactors during PSII assembly, in

277 (alphabetaTCR), we show that unassembled ER-lumenal subunits are rapidly degraded, whereas specific

278 tPA added extracellularly bound to the lumenal surface of fused granules.

279 e mammalian cilium protrudes from the apical/lumenal surface of polarized cells and acts as a sensor

280 by binding and presenting chemokines at the lumenal surface of the endothelium.

281 d alphaN-catenin is enriched in rings at the lumenal surface, reflecting localization at adherens jun

282 ameter when vesicles fuse with the expanding lumenal surface.

283 tion of stereociliary bundles located on the lumenal surfaces of mechanosensory hair cells located wi

284 ary epithelial cells (mMECs) progressed from lumenal to basal-like phenotypes based on expression of

285 This uncoupling of MVB cargo sorting and lumenal vesicle formation suggests that the Vps4-mediate

286 Here, we show that lumenal vesicle fusion depends on the small GTPase RAL-1

287 plays a unique role in the regulation of MVB lumenal vesicle size, whereas Vtal and Vps60 promote eff

288 hich target ubiquitylated receptors to intra-lumenal vesicles (ILVs) of multivesicular bodies, are th

289 PIN1 was detected in MVB lumenal vesicles of control cells but remained in the li

290 s integral membrane proteins sorted into the lumenal vesicles of late-endosomal multivesicular bodies

291 and targeted for degradation are sorted into lumenal vesicles of multivesicular bodies (MVBs) by the

292 ing of transmembrane cargo proteins into the lumenal vesicles of multivesicular bodies (MVBs) depends

293 of most integral membrane proteins into the lumenal vesicles of multivesicular bodies (MVBs) is depe

294 inclusion of transmembrane proteins into the lumenal vesicles of multivesicular bodies (MVBs).

295 the vacuole/lysosome by directing them into lumenal vesicles of multivesicular bodies (MVBs).

296 ting of ubiquitinated membrane proteins into lumenal vesicles of multivesicular bodies is mediated by

297 ts ubiquitinated transmembrane proteins into lumenal vesicles of the compartment.

298 chmp1b mutant forms significantly fewer MVB lumenal vesicles than the wild type.

299 Here, we show that these native "lumenal vesicles" (LVs) (1) contain catalytically active

300 efficient sorting of MVB cargo proteins into lumenal vesicles.