ライフサイエンスコーパス: luminal cell

1 ed absorptive villus cells and the prostatic luminal cell.

2 lower levels, in oestrogen receptor-positive luminal cells.

3 egative stem/progenitor cells to ER-positive luminal cells.

4 egative stem/progenitor cells to ER-positive luminal cells.

5 maintaining ductal integrity and survival of luminal cells.

6 integrity and the proper differentiation of luminal cells.

7 XO, with XO concentrated on and in vascular luminal cells.

8 m cells and are the candidate progenitors of luminal cells.

9 erplasia, and atrophic glands denuded of the luminal cells.

10 n the cell cycle of primary myoepithelial or luminal cells.

11 c basal cells into transformation-preferable luminal cells.

12 tional progenitor, and CK8(+) differentiated luminal cells.

13 ynamic throughout pregnancy when compared to luminal cells.

14 basal conversion of the more differentiated luminal cells.

15 l cells (MECs) except the secretory alveolar luminal cells.

16 elia are composed predominantly of basal and luminal cells.

17 ntified 11 differentiation states for normal luminal cells.

18 nt basal cells into transformation-competent luminal cells.

19 of fully differentiated CK5+ basal and CK8+ luminal cells.

20 higher levels of ANTXR1 compared with mature luminal cells.

21 ficient basal cells was traced to neoplastic luminal cells.

22 ell receptors DP1 and CRTH2 was evaluated on luminal cells.

23 tin marker H3K27me3 than more differentiated luminal cells.

24 differentiate into transformation-competent luminal cells.

25 roid reductase 2, comparatively low-activity luminal cell 2B15 undergoes a complex pattern of regulat

26 se the proliferation of normal mouse mammary luminal cells adjacent to tumors.

27 imilar to the expression pattern of prostate luminal cells, also characterize a small series of Gleas

28 In contrast, AR deletion in luminal cells alters cell morphology and induces transie

29 uces the differentiation of basal cells into luminal cells, an alteration that rarely occurs under no

30 ary luminal cell lineage led to a paucity of luminal cells and an excessive expansion of basal cells,

31 of the lung contains ciliated and secretory luminal cells and basal stem/progenitor cells.

32 ) binding to the 11-kb region in both normal luminal cells and CARNs and discovered new androgen resp

33 n the apical plasma membrane of the prostate luminal cells and demonstrated its release into semen as

34 f the basal cell transcription factor p63 in luminal cells and excessive proliferation of basal cells

35 um containing both p63+ basal cells and p63- luminal cells and expressing a variety of prostate-speci

36 irculating XO can then bind avidly to vessel luminal cells and impair vascular function by creating a

37 al AR have increased apoptosis in epithelial luminal cells and increased proliferation in epithelial

38 ce new secretory acini composed of secretory luminal cells and myoepithelium.

39 tates acquisition of MaSC-like properties by luminal cells and predisposes them to development of mam

40 epithelium made up of ciliated and secretory luminal cells and undifferentiated basal progenitor cell

41 ytokeratin 14 (basal cells), cytokeratin 18 (luminal cells), and dorsolateral protein over time in th

42 rvival factor of prostatic cancer epithelial luminal cells, and as a suppressor for prostate cancer b

43 of cell proliferation, increased survival of luminal cells, and loss of cell polarity, resulting in t

44 s sandwiched between the basal cells and the luminal cells, and this layer was consistently p27Kip1 n

45 ntly decreased, and epithelial sloughing and luminal cell apoptosis increased from 6 to 32 weeks of a

46 autophagy in PI3K-H1047R structures triggers luminal cell apoptosis, resulting in lumen clearance.

47 Disrupting luminal cell AR signaling in mouse models promotes cytok

48 Luminal cells are believed to be the cells of origin for

49 -vivo lineage-tracing work demonstrates that luminal cells are capable of producing basal cells on ac

50 we show that adult rodent prostate basal and luminal cells are independently self-sustained in vivo.

51 Prostate luminal cells are more responsive to Pten null-induced m

52 Prevailing theories suggest that luminal cells are the origin of prostate cancer because

53 The CD57+ luminal cells are the terminally differentiated secretor

54 The prostate gland consists of basal and luminal cells arranged as pseudostratified epithelium.

55 opment and regulating ESR1/ERalpha and other luminal cell-associated genes in breast cancer.

56 on in vitro and in vivo, but does not affect luminal cell biology.

57 h a phenotype that resembles normal prostate luminal cells, but at their intermediate state of differ

58 -/-) UGS grafts contained neuroendocrine and luminal cells, but basal cells were absent.

59 mouse tracheal epithelium after ablation of luminal cells by inhaled SO2.

60 t loss of TRIM29 expression in normal breast luminal cells can contribute to malignant transformation

61 Here we demonstrate that luminal cells can develop independently of basal cells,

62 models have demonstrated that both basal and luminal cells can serve as cells of origin for prostate

63 G1P3 enhanced the survival of MCF10A acinar luminal cells causing hyperplasia by suppressing detachm

64 a failure in the apoptosis and clearance of luminal cells (cavitation).

65 nitor/differentiated cell balance within the luminal cell compartment towards the progenitors.

66 The prostate gland mainly contains basal and luminal cells constructed as a pseudostratified epitheli

67 basal type, a comparison of normal basal and luminal cells could yield insight into the tissue and ce

68 cently, a subpopulation of multipotent human luminal cells defined by CD26 expression that retains pr

69 and basal cells give rise to organoids, yet luminal-cell-derived organoids more closely resemble pro

70 Mutant luminal cells did not exhibit their distinctive transcri

71 tor that regulates genes involved in mammary luminal cell differentiation and tumor suppression.

72 In contrast, Smo expression altered luminal cell differentiation in a cell-autonomous manner

73 In summary, Foxc1 regulates sweat duct luminal cell differentiation, and mutant mice mimic mili

74 ster regulator of mammary alveologenesis and luminal cell differentiation, is markedly reduced in mam

75 at regulate luminal progenitor cell renewal, luminal cell differentiation, mammary tumorigenesis, tam

76 ogenitors, which express both basal cell and luminal cell-enriched genes.

77 these cultured cells, we show that basal and luminal cells exhibit distinct responses to ionizing rad

78 cer, because the disease is characterized by luminal cell expansion and the absence of basal cells.

79 loss, adult mice exhibited undifferentiated luminal cell expansion with basement-membrane detachment

80 lly defined by basal cell loss and malignant luminal cell expansion.

81 r, with loss of basal cells and expansion of luminal cells expressing prostate-specific antigen and a

82 gation in/on the gallbladder epithelium with luminal cell extrusion, for Salmonella maintenance in th

83 Even though luminal cells fail to respond, basal/stem cells demonstr

84 development during pregnancy by maintaining luminal cell fate and preventing uncontrolled basal cell

85 k consisting of GATA3, FOXA1, and PPAR drive luminal cell fate.

86 or synthesize testosterone for transport to luminal cells for reduction to DHT by 5alpha-steroid red

87 t the resistance is due to lower affinity of luminal cells for virus attachment, which can be overcom

88 and efficient method for isolating basal and luminal cells from normal human breast tissue.

89 murine lineage-tracing experiments show that luminal cells generate basal cells.

90 yoepithelial cell types, with the genomes of luminal cells harbouring more than twice the number of h

91 Luminal cells have long been considered the cellular ori

92 sults in a decrease in basal cell number and luminal cell hyperproliferation.

93 ntified populations of murine basal/stem and luminal cells in an in vivo prostate regeneration assay.

94 tubule structures containing both basal and luminal cells in vivo.

95 ch mouse basal cells self-renew and generate luminal cells, including differentiated ciliated cells,

96 creased nuclear cyclin D3 protein in D1(-/-) luminal cells, indicating one compensatory mechanism.

97 Downregulation of JARID1B in luminal cells induces basal genes expression and growth

98 whether attenuating AR activity in prostate luminal cells induces inflammation.

99 and Sox9 suffices to convert differentiated luminal cells into MaSCs with long-term mammary gland-re

100 ort that induced p53 loss in Krt8(+) mammary luminal cells leads to their clonal expansion without di

101 of PKCzeta directs the resistant CSCs to the luminal cell-like state and sensitization to tamoxifen,

102 rate that germline mutations in Brca1 impair luminal cell lineage and mammary development, with its d

103 Establishment of the mammary luminal cell lineage is controlled primarily by hormones

104 Deletion of Kdm6a in the mammary luminal cell lineage led to a paucity of luminal cells a

105 mammary epithelial cells in a differentiated luminal cell lineage.

106 tricted to the oestrogen receptor-expressing luminal cell lineage.

107 ting tubular structures containing basal and luminal cell lineages in a dissociated cell prostate reg

108 g is detected in both the prostate basal and luminal cell lineages.

109 this is a significant barrier to generating luminal cell lines and experimental tumours in vivo and

110 positive and ER-negative (MDA-MB-453, SKBR3) luminal cell lines in the presence or absence of transie

111 Luminal cell lines repressed a large number of cell cycl

112 Starting from ER(+)PR(+) luminal cell lines, we generated lines with varying lumi

113 more dependent on glycolysis for growth than luminal cell lines.

114 orally ablating Pten in keratin 8-expressing luminal cells, luminal-derived Pten-deficient prostate t

115 es from flow dependence of Na+ uptake across luminal cell membranes; however, the underlying physical

116 land explants, epithelial reorganization and luminal cell morphological changes were induced by the a

117 prostate duct combined with weakly directed luminal cell movement toward the proximal region of the

118 Nkx3.1 is ubiquitously expressed in luminal cells of hormonally intact prostate but, upon an

119 expression of the androgen receptor (AR) in luminal cells of human BPH specimens correlates with a h

120 GATA-3 was found in the luminal cells of mammary ducts and the body cells of ter

121 expressed heterogeneously in both basal and luminal cells of normal alveoli.

122 CK14 mRNA was absent in the luminal cells of the most of the PIN lesions but was see

123 ere persistently expressed in both basal and luminal cells of the tubular portion of normal glands as

124 ter and cellular proliferation, and detached luminal cells only in proximal tubules.

125 in the establishment and maintenance of the luminal cell phenotype during carcinogenesis and mammary

126 n human breast cancer and in influencing the luminal cell phenotype during normal mammary development

127 o- and functional differentiation, a role in luminal cell polarity and lumenization of the ducts was

128 ng to a reduction in the CD24(hi)/CD49f(mid) luminal cell population and concomitant gain of the CD24

129 tin signaling also led to amplification of a luminal cell population that was positive for stem cell

130 t claudin-low breast cancer can develop from luminal cells, possibly via a basal-like intermediate st

131 uring pregnancy leads to dramatic defects in luminal cell proliferation and differentiation, resultin

132 impaired Akt and MAPK signaling and reduced luminal cell proliferation and survival.

133 paB activity independent of Hes1, stimulates luminal cell proliferation by potentiating PI3K-AKT sign

134 ncy contributes to breast tumorigenesis from luminal cells remains elusive.

135 directs the final maturation of the adjacent luminal cell sheet during pregnancy.

136 rapid but labile cell cycle arrest, whereas luminal cells show a much more durable arrest, primarily

137 s such as p21(waf1), but the response in the luminal cells showed higher fold changes and included mo

138 partial secretory cell differentiation, the luminal cells showed weak to moderate staining for andro

139 anching, producing stunted ducts filled with luminal cells showing altered ovarian hormone receptor e

140 Thus, paracrine basal-to-luminal cell signaling, controlled by p63 via NRG1, orch

141 iles closely resembling mature human mammary luminal cell signatures.

142 ofiles suggest a key function for JARID1B in luminal cell-specific expression programs.

143 lls exhibit partial molecular resemblance to luminal cells, such as elevated Notch signaling and redu

144 impairs secretory function of mouse prostate luminal cells, suppresses anoikis of luminal epithelial

145 The luminal cell surface of the endothelium, which is direct

146 eration, without affecting androgen-mediated luminal cell survival or regeneration.

147 ed proportion of multiciliated and secretory luminal cells that are maintained and regenerated by a p

148 on of myoepithelial cells and an increase in luminal cells that express keratin 14 and integrin-alpha

149 netic lineage-marking demonstrates that rare luminal cells that express Nkx3-1 in the absence of test

150 tuating a population of surviving autophagic luminal cells that resist anoikis.

151 ermline mutation of Brca1 shifts the fate of luminal cells to cause luminal-to-basal mammary tumor tr

152 We also provide evidence that luminal cell translocation may drive clonal selection by

153 rmore, Tcfap2c influences development of the luminal cell type during mammary development.

154 er levels in the basal cell type than in the luminal cell type in mouse mammary tumors and human brea

155 e cells uniformly coexpressed both basal and luminal cell-type cytokeratins and the basal cell marker

156 erentiation of prostate cells to both NE and luminal cell types.

157 f the basal lineage disappeared, whereas the luminal cells underwent carcinogenesis.

158 cells, which appeared to differentiate from luminal cells via activation of Src.

159 A transient enrichment of K6-positive luminal cells was observed upon hormonal treatment sugge

160 Different movement behaviors for TA/ICs and luminal cells were assessed by their ability to recreate

161 in subclasses and isoforms characteristic of luminal cells were detected in this cell type.

162 amplifying/intermediate cells (TA/ICs), and luminal cells were individually modeled within a three-d

163 ion revealed that myosin IIC is expressed in luminal cells, whereas myosin IIB expression is up-regul

164 be bipotent and can generate either basal or luminal cells, whereas the luminal epithelium has not be

165 terminal differentiation markers in the duct luminal cells, which most likely contribute to keratotic

166 fferentiation of basal epithelial cells into luminal cells, while sustained ING4 expression induces a

167 transduced primary human prostate basal and luminal cells with lentiviruses expressing c-Myc and act