ライフサイエンスコーパス: lunatic

1 While Lunatic and Manic Fringe inhibit Notch1 activation from

2 We found that Lunatic and Manic Fringe modified similar sites on Notch

3 ations at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation fro

4 used bone morphogenetic protein 4 (BMP4) and lunatic fringe (Fng) as molecular markers to identify th

5 th two other putative sensory organ markers, Lunatic Fringe (L-fng) and chicken Serrate1 (Ser1), both

6 We have shown here that Lunatic fringe (L-fng) expression is indicative of it be

7 helium, anteroposterior encroachment of alar lunatic fringe (L-fng) expression, and/or basal Shh sign

8 opus homologs of the Drosophila gene fringe, lunatic Fringe (lFng) and radical Fringe (rFng), were id

9 ntrally expressed otic genes such as NeuroD, Lunatic fringe (Lfng) and Six1 are shifted dorsally, whe

10 Lunatic fringe (Lfng) encodes a glycosyltransferase that

11 We have investigated the role of Lunatic fringe (Lfng) expression during neurogenesis in

12 Lunatic fringe (Lfng) expression in the presomitic mesod

13 In mice, lunatic fringe (Lfng) expression oscillates, and LFNG pr

14 aevis and Danio rerio, include an absence of lunatic fringe (lfng) expression within the presomitic m

15 mponents of the Notch pathway, including the Lunatic fringe (Lfng) gene, are also expressed during di

16 ce homozygous for a targeted mutation of the lunatic fringe (Lfng) gene, one of the mouse homologues

17 e we have analyzed the reaction catalyzed by Lunatic Fringe (Lfng) in detail.

18 The Notch pathway and the Notch modulator Lunatic fringe (Lfng) play multiple roles during segment

19 narily conserved 2.3 kb region in the murine Lunatic fringe (Lfng) promoter that drives periodic expr

20 Lunatic Fringe (Lfng), a glycosyltransferase that enhanc

21 Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch recep

22 d expression of the Notch target genes HEY1, lunatic fringe (LFNG), and ephrin-B2, reduced phosphoryl

23 ifferential regulation of Notch receptors by Lunatic Fringe (Lfng), which encodes an O-fucosylpeptide

24 es oscillatory expression of genes including Lunatic fringe (Lfng).

25 nistically linked by a process that requires lunatic fringe activity.

26 een a dorsal domain (dorsal roof) expressing lunatic fringe and Notch, and a ventral domain (posterio

27 We also identified pronephric expression of lunatic fringe and radical fringe that is temporally and

28 nge proteins in Chinese hamster ovary cells (Lunatic fringe and Radical fringe) as well as exogenous

29 ted that demonstrate that radical fringe and lunatic fringe are expressed in the granulosa cells of d

30 his study examines the distribution of chick lunatic fringe at sites of neural crest formation and ex

31 These results indicate that secreted lunatic Fringe can induce mesoderm and reveal that the F

32 further insight into the mechanism by which lunatic fringe controls somite development, we have cond

33 The gene lunatic fringe encodes a secreted factor with significan

34 tal plate prior to somite formation and that lunatic fringe expression cycles autonomously with a per

35 Recent observations of cyclic Lunatic fringe expression in chick and mouse embryos lin

36 nt, we have conducted a thorough analysis of lunatic fringe expression in the unsegmented paraxial me

37 new role for the Notch signaling pathway and lunatic fringe in mammalian folliculogenesis.

38 These findings point to a novel role for lunatic fringe in regulating cell division and/or produc

39 Expression of excess lunatic fringe in the cranial neural tube and neural cre

40 ols the periodic expression of genes such as lunatic fringe in the presomitic mesoderm.

41 Lunatic fringe is a vertebrate homologue of Drosophila f

42 Lunatic fringe is an important regulator of Notch signal

43 In addition, we show that lunatic fringe is expressed in a highly dynamic manner i

44 Shortly after neural tube closure, lunatic fringe is expressed in most of the neural tube,

45 Here we report that lunatic fringe is expressed predominantly in somite -II,

46 sruption in mouse embryos, we show here that lunatic fringe is likewise required for boundary formati

47 hough the beta 3GlcNAcT activity of manic or lunatic fringe is shown to be necessary for inhibition o

48 and heterodimerization of mutant Notch3 with Lunatic Fringe itself.

49 ic periodic expression pattern suggests that lunatic fringe may function to integrate notch signaling

50 ringe homologue and suggest a model in which lunatic fringe modulates Notch signalling in the segment

51 lunatic fringe mutants fail to form boundaries between i

52 axial skeleton, are severely disorganized in lunatic fringe mutants.

53 Lunatic fringe null female mice were found to be inferti

54 anscriptional level by clock elements in the lunatic fringe promoter.

55 The mature lunatic Fringe protein is secreted extracellularly, and

56 indirect reporter system, that the 3'UTR of Lunatic Fringe strongly destabilizes transcripts, while

57 Oscillations of lunatic fringe transcripts have now been shown to be con

58 Moreover, the murine ortholog of lunatic fringe undergoes a similar cycling expression pa

59 LFNG (Lunatic Fringe) and MFNG (Manic Fringe) transfer N-acety

60 Lrrn1 also regulates the glycosyltransferase Lunatic Fringe, a modulator of Notch signalling, maintai

61 mologues have been identified, Manic fringe, Lunatic fringe, and Radical fringe.

62 Finally, together with the modulator lunatic fringe, Dll3 altered N signaling levels that wer

63 ure expression delays for three transcripts [Lunatic fringe, Hes7/her1, and Notch-regulated-ankyrin-r

64 ption in somite 0 requires the expression of lunatic fringe, which modifies the activation of the Not

65 Histological analysis of the lunatic fringe-deficient ovary demonstrated aberrant fol

66 ntation, including the novel secreted factor lunatic fringe.

67 cloned and characterized: Manic, Radical and Lunatic Fringe.

68 g1 and one of three paralogous Fringe genes: Lunatic (Lfng), Radical (Rfng), and Manic (Mfng).

69 hat expression of mammalian fringe proteins (Lunatic [LFng], Manic [MFng], or Radical [RFng] Fringe)

70 Lunatic, Manic, and Radical Fringe (LFNG, MFNG, and RFNG

71 Mammals have three Fringes: Lunatic, Manic, and Radical.

72 have demonstrated that, similar to Manic and Lunatic, Radical fringe is also a fucose-specific beta1,