ライフサイエンスコーパス: lutropin

1 MP) in MLT cells, in response to the hormone lutropin.

2 igand binding sites enable them to recognize lutropins.

3 , and 56 of alpha-subunit loop 2 had similar lutropin activities to those of hCG; that in which it wa

4 t residues 45-51, 86, 88, 90, and 91 reduced lutropin activity substantially.

5 ntributed also to its ability to distinguish lutropin and follitropin receptors.

6 rations indicated the short SSDs in marmoset lutropin and salmon follitropin receptors have KH domain

7 the anterior pituitary hormones follitropin, lutropin, and thyrotropin.

8 The complex mechanism for lutropin assembly may be required to provide an addition

9 a-subunit facilitates formation of the human lutropin beta-subunit by two mechanisms.

10 Here, we show that the human lutropin beta-subunit is not folded completely prior to

11 A critical element of lutropin bioactivity in vivo is its rapid removal from t

12 Bovine lutropin (bLH) and human chorionic gonadotropin (hCG) ar

13 clonal antibodies), the variants bind to the lutropin/CG receptor and activated adenylate cyclase in

14 ic monoclonal antibodies and did not bind to lutropin/CG receptor.

15 The lutropin/choriogonadotropin receptor (LH/CG-R) contains

16 ted that the same active conformation of the lutropin/choriogonadotropin receptor (LHR) is involved i

17 Using the C-terminal tail of the rat lutropin/choriogonadotropin receptor (rLHR) as "bait" in

18 xes while 293 cells transfected with the rat lutropin/choriogonadotropin receptor (rLHR) internalize

19 The rat lutropin/choriogonadotropin receptor (rLHR) is a G prote

20 The rat lutropin/choriogonadotropin receptor (rLHR) is a member

21 e agonist-induced phosphorylation of the rat lutropin/choriogonadotropin receptor (rLHR) to a locus o

22 The lutropin/choriogonadotropin receptor is a seven-helix tr

23 The lutropin/choriogonadotropin receptor is a seven-transmem

24 examine the roles of the five TM Pros of the lutropin/choriogonadotropin receptor, these residues wer

25 acid sequences of the human (h) and rat (r) lutropin/choriogonadotropin receptors (LHR) are 87% iden

26 e polypeptide and two subunits), whereas the lutropin/chorionic gonadotropin receptor (LH/CGR) is a s

27 The lutropin/chroriogonadotropin receptor (LH/CG-R) is a mem

28 rge cell-to-cell variations for all supplied lutropin concentrations, ranging from 36 to 536 attomol

29 We assembled models of lutropin, follitropin, and thyrotropin receptors by alig

30 ges in its sequence during the divergence of lutropins, follitropins, and thyrotropins and the specia

31 tary gonadotropes, the secretion profiles of lutropin (LH) and follitropin (FSH) differ.

32 Lutropin (LH) and follitropin (FSH) receptors belong to

33 Lutropin (LH) and other glycoproteins bearing oligosacch

34 Lutropin (LH) directs ovulation and implantation by regu

35 latory half-life of the glycoprotein hormone lutropin (LH) is precisely regulated by the mannose (Man

36 nd activated the TSH receptor but not the CG/lutropin (LH) receptor.

37 rionic gonadotropin (CG), thyrotropin (TSH), lutropin (LH), and follitropin (FSH) are heterodimers, c

38 coproteins, such as the glycoprotein hormone lutropin (LH), bear oligosaccharides terminating with th

39 CG together with the pituitary hormones lutropin (LH), follitropin, and thyrotropin constitute t

40 nalpha are present on the pituitary hormones lutropin (LH), thyrotropin, and pro-opiomelanocortin.

41 ified multiple noncontiguous residues of the lutropin (LHR) and follitropin (FSHR) receptors that dic

42 odimer and enable the hormone to distinguish lutropin (LHR), follitropin, and thyrotropin receptors.

43 nds either human choriogonadotropin (hCG) or lutropin (luteinizing hormone, LH) and, therefore, plays

44 TSHRs, but not the closely related lutropin or follitropin receptors, exhibit persistent cA

45 in with a type I PDZ domain as a novel human lutropin receptor (hLHR) binding partner.

46 pitation techniques suggested that the human lutropin receptor (hLHR) constitutively self-associates

47 agonist-induced internalization of the human lutropin receptor (hLHR) has been documented previously

48 The human lutropin receptor (hLHR) is a G protein-coupled receptor

49 The human lutropin receptor (hLHR) plays a pivotal role in reprodu

50 f the second extracellular loop of the human lutropin receptor (hLHR) showed that mutation of most of

51 In contrast to the human lutropin receptor (hLHR), very few naturally occurring a

52 f human reproductive cells that utilizes the lutropin receptor (LHr) as both the induction signal for

53 titutive activation of the G protein-coupled lutropin receptor (LHR), some of which also result in re

54 We present evidence that GC recognize the lutropin receptor (LHr), which recognizes both luteinizi

55 ation of the two functional domains sets the lutropin receptor and its subfamily of receptors apart f

56 erence in affinity could be used to identify lutropin receptor contacts.

57 f its role in posttranscriptional control of lutropin receptor expression.

58 unit carboxyl terminus do not participate in lutropin receptor interactions.

59 We found that the region that links the lutropin receptor leucine-rich repeat domain (LRD) to it

60 In previous studies, a lutropin receptor mRNA binding protein implicated in the

61 ent studies have examined the specificity of lutropin receptor mRNA recognition by LRBP-1 and mapped

62 ein implicated in the hormonal regulation of lutropin receptor mRNA stability was identified.

63 e sequence within nucleotides 203 and 220 of lutropin receptor mRNA with a high degree of specificity

64 ty shift assay to specifically interact with lutropin receptor RNA sequences.

65 hich human choriogonadotropin (hCG) contacts lutropin receptors (LHR) have been stymied by the comple

66 an significantly influence the activities of lutropins, thereby confounding efforts to identify ligan

67 lf maximal effective concentration (EC50) of lutropin to have an average value of 2.51 +/- 0.44 ng/mL