ライフサイエンスコーパス: lymphatic endothelial cell

1 ular endothelial growth factor-A, and D2-40 (lymphatic endothelial cells).

2 paracrine activation of the mTOR pathway in lymphatic endothelial cells.

3 the expression of JAM-B on murine and human lymphatic endothelial cells.

4 proliferation in primary human blood versus lymphatic endothelial cells.

5 has proliferative and chemotactic effects on lymphatic endothelial cells.

6 oted by glucocorticoid receptor signaling in lymphatic endothelial cells.

7 g glucocorticoid receptor phosphorylation in lymphatic endothelial cells.

8 EGFR3), the major growth factor receptor for lymphatic endothelial cells.

9 olymphangiogenic VEGF-D and proliferation of lymphatic endothelial cells.

10 ion, invasion, and survival of proliferating lymphatic endothelial cells.

11 cells; on further cultivation, they generate lymphatic endothelial cells.

12 dentified expression of several connexins in lymphatic endothelial cells.

13 and tube formation in cocultured vascular or lymphatic endothelial cells.

14 leading to increased receptor expression in lymphatic endothelial cells.

15 imulation that resulted from cross talk with lymphatic endothelial cells.

16 ed Notch receptors in contrast to uninfected lymphatic endothelial cells.

17 with KSHV and has markers of both blood and lymphatic endothelial cells.

18 hages, because IL-10 did not directly affect lymphatic endothelial cells.

19 verexpressing tumors contained proliferating lymphatic endothelial cells.

20 ylation, and induced mitogenesis in vitro of lymphatic endothelial cells.

21 transmembrane ligand podoplanin expressed by lymphatic endothelial cells.

22 te chemotactic migration of EMT cells toward lymphatic endothelial cells.

23 s pathological changes in gene expression in lymphatic endothelial cells.

24 hand, TGF-beta1 promoted CCL21 expression in lymphatic endothelial cells.

25 d changes in the gene expression patterns of lymphatic endothelial cells.

26 1-mediated crosstalk between tumor cells and lymphatic endothelial cells.

27 tone for the differentiation and function of lymphatic endothelial cells.

28 atic vessels in mice and in human intestinal lymphatic endothelial cells.

29 ell identity, in Tie2 lineage venous-derived lymphatic endothelial cells.

30 In human dermal lymphatic endothelial cells, activation of Notch1 or Not

31 odel of lymphatic uptake, we have shown that lymphatic endothelial cells actively enhanced lymphatic

32 TNFR1 signalling pathway directly stimulates lymphatic endothelial cell activity through a VEGFR3-ind

33 n of T1alpha/podoplanin expression decreased lymphatic endothelial cell adhesion.

34 difying protein 2/3, are highly expressed in lymphatic endothelial cells and are required for embryon

35 subcapsular sinus or medulla, near or within lymphatic endothelial cells and CD169(+) macrophages.

36 TSC2 correction, AML cells mature into adult lymphatic endothelial cells and have functional attribut

37 gers phosphorylation of cell surface TLR3 on lymphatic endothelial cells and induces apoptosis.

38 ferentiation of blood endothelial cells into lymphatic endothelial cells and may be relevant to the d

39 the expression pattern of the Prox1 gene in lymphatic endothelial cells and other Prox1-expressing o

40 platelet-derived growth factor B (PDGF-B) in lymphatic endothelial cells and signaling through platel

41 VEGF receptor-3 stimulation activate eNOS in lymphatic endothelial cells and that NO donors induce pr

42 nd Notch4 were expressed in normal and tumor lymphatic endothelial cells and that Notch1 was activate

43 ed, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms

44 rtially remodeled blood vessels incorporated lymphatic endothelial cells and were permeable to blood.

45 galectin-1 is also highly expressed by human lymphatic endothelial cells, and deposition of galectin-

46 le to promote increased COX-2 mRNA levels in lymphatic endothelial cells, and had enhanced capacity t

47 These results establish lymphatic endothelial cells, and potentially other LN-re

48 al microvascular endothelial cells, isolated lymphatic endothelial cells, and purified vascular endot

49 Our data provide evidence that lymphatic endothelial cells are an in vivo source of S1P

50 SC subsets, fibroblastic reticular cells and lymphatic endothelial cells are known to directly induce

51 Most studies have suggested that lymphatic endothelial cells are the main vehicles for D6

52 es express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both flui

53 lopmental or pathological differentiation of lymphatic endothelial cells as well as to KSHV pathogene

54 promotes platelet adhesion to primary mouse lymphatic endothelial cells at low shear.

55 of the disease, with active proliferation of lymphatic endothelial cells at the early stages of lymph

56 Platelets are activated by interaction with lymphatic endothelial cells at the lymphovenous junction

57 om E9.75 to E13.5, resulting in misspecified lymphatic endothelial cells based upon reduced expressio

58 at platelet CLEC-2 and Syk directly modulate lymphatic endothelial cell behavior in vitro.

59 These brain lymphatic endothelial cells (BLECs) derive from venous e

60 on is strongly downregulated in normal adult lymphatic endothelial cells, but is activated in patholo

61 through the extracellular matrix and across lymphatic endothelial cells, but it has no effect on mig

62 n, migration, and tube formation of cultured lymphatic endothelial cells by activating fibroblast gro

63 Similarly, blood and lymphatic endothelial cells contribute to tissue homeost

64 Additionally, a human lymphatic endothelial cell culture system was used to ex

65 lates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non

66 Lymphatic endothelial cell-derived S1P was not required.

67 During development, lymphatic endothelial cells differentiate from preexisti

68 infection of blood endothelial cells induces lymphatic endothelial cell differentiation.

69 receptors, Unc5B and neogenin, expressed by lymphatic endothelial cells, do not suppress netrin-4-in

70 orphogenesis was studied using a conditional lymphatic endothelial cell driver either to delete Notch

71 nic cytokines and increased proliferation of lymphatic endothelial cells during coculture, suggesting

72 calization in the luminal plasma membrane of lymphatic endothelial cells during later development.

73 w did not alter vessel identity in vivo, but lymphatic endothelial cells exposed to similar levels of

74 Lymphatic endothelial cells express key components of th

75 We demonstrate that LN-resident lymphatic endothelial cells express multiple peripheral

76 inantly keratinocytes and a subset of dermal lymphatic endothelial cells, express ACKR4 and are capab

77 We also propose that lymphatic endothelial cell-expressed D6 might have a dis

78 SEMA3F were chemorepulsive for vascular and lymphatic endothelial cells expressing neuropilin-2 (NRP

79 d lymphangiogenesis, lymphatic function, and lymphatic endothelial cell expression of chemokine (C-C

80 known regulator of lymphatic development and lymphatic endothelial cell fate, as a direct interacting

81 Arteriovenous-lymphatic endothelial cell fates are specified by the ma

82 Lymphatic endothelial cells, for example, directly prese

83 In cultured lymphatic endothelial cells, FOXC2 inactivation conferre

84 d Foxc mutants show a defect in sprouting of lymphatic endothelial cells from veins in early lymphati

85 xamine the effect of VLA-1 gene depletion on lymphatic endothelial cell functions in vitro using smal

86 dition, our study shows that obesity-induced lymphatic endothelial cell gene expression changes are r

87 In addition, exercise normalized isolated lymphatic endothelial cell gene expression of lymphatic

88 l zone and that the S1P transporter SPNS2 on lymphatic endothelial cells generated this gradient.

89 Whether lymphatic endothelial cells have a single or dual, venou

90 and few molecules that are truly specific to lymphatic endothelial cells have been identified to date

91 Alternative nonvenous sources of lymphatic endothelial cells have been suggested in chick

92 we studied PD-L1 expression in human dermal lymphatic endothelial cells (HDLECs), which play key rol

93 of this interaction in primary human dermal lymphatic endothelial cells (HDLECs).

94 doplanin(+) cells highly express markers for lymphatic endothelial cells, hematopoietic lineages, and

95 transcription factor, a master regulator of lymphatic endothelial cell identity, in Tie2 lineage ven

96 Soluble LYVE-1 and knockdown of LYVE-1 in lymphatic endothelial cells impaired FGF2 signaling and

97 P-2 is involved in the outgrowth of cultured lymphatic endothelial cells in a collagen matrix in vitr

98 ce proliferation and/or survival of cultured lymphatic endothelial cells in a dose-dependent manner.

99 This first report on brain lymphatic endothelial cells in a vertebrate embryo ident

100 d, CXCL12, is expressed by cells adjacent to lymphatic endothelial cells in a zone that abuts but min

101 significantly decreased the proliferation of lymphatic endothelial cells in culture and the number of

102 , and one of the most widely used markers of lymphatic endothelial cells in normal and tumor tissues.

103 we investigated the development of blood and lymphatic endothelial cells in prenatal human skin in si

104 inhibited KSHV infection of blood vessel and lymphatic endothelial cells in the micromolar concentrat

105 a nor progesterone receptor were detected in lymphatic endothelial cells in the mouse mammary gland,

106 Lymphatic endothelial cells in turn responded to Reelin

107 hesion, tube formation and survival of human lymphatic endothelial cells in vitro comparable to well-

108 atelet aggregate formation on the surface of lymphatic endothelial cells in vivo and ex vivo.

109 IP-Tag2 mice upregulates c-Met expression in lymphatic endothelial cells, increases the number of int

110 Incubation with supernatant from lymphatic endothelial cells induced an endothelium-like

111 r 2 (CLEC-2) on platelets with Podoplanin on lymphatic endothelial cells initiates platelet signaling

112 ar level, we showed that FGFR-1 expressed in lymphatic endothelial cells is a crucial receptor that m

113 endothelial nitric oxide synthase (eNOS) in lymphatic endothelial cells is required for robust lymph

114 heptahelical membrane protein, expressed by lymphatic endothelial cells, is able to bind with high a

115 membrane protein expressed on the surface of lymphatic endothelial cells, is required in nonhematopoi

116 Lymphatic endothelial cells lack the Ca(2+) -activated K

117 Non-mutually-exclusive mechanisms are lymphatic endothelial cell (LEC) chemotaxis and prolifer

118 Previous studies show that lymphatic endothelial cell (LEC) fate is highly plastic

119 blood endothelial cells (BECs) to acquire a lymphatic endothelial cell (LEC) fate.

120 opment of the lymphatic system by specifying lymphatic endothelial cell (LEC) fate.

121 Lymphatic endothelial cell (LEC) junctions in initial ly

122 Our data show that lymphatic endothelial cell (LEC) migration through colla

123 at excess VEGF-C did not enhance the rate of lymphatic endothelial cell (LEC) migration, the density

124 Ang-4 decreased human dermal lymphatic endothelial cell (LEC) monolayer permeability

125 f lymphangiogenesis in Prox1-positive venous lymphatic endothelial cell (LEC) progenitors.

126 potent lymphangiogenic factor that promotes lymphatic endothelial cell (LEC) proliferation through a

127 Thus, Kaposi sarcoma tumors express numerous lymphatic endothelial cell (LEC) signature genes.

128 VEGFR-3 does not affect galectin-8-mediated lymphatic endothelial cell (LEC) sprouting.

129 KS spindle cells are believed to be of the lymphatic endothelial cell (LEC) type.

130 CCL21, a lymphatic endothelial cell (LEC)-derived chemokine, and

131 okine-scavenging receptor D6 is expressed on lymphatic endothelial cells (LEC) and contributes to sel

132 We previously identified lymphatic endothelial cells (LEC) as the repository for

133 h neuropilin-2 (NRP2) is highly expressed in lymphatic endothelial cells (LEC) but not in oral epithe

134 induces the collapse of the cytoskeleton of lymphatic endothelial cells (LEC) in a neuropilin-2-, pl

135 Though lymphatic endothelial cells (LEC) lining the LV express

136 us cell types across primary mouse and human lymphatic endothelial cells (LEC), and validated the mod

137 ane glycoprotein expressed on the surface of lymphatic endothelial cells (LEC).

138 We isolated lymphatic endothelial cells (LECs) and blood vascular en

139 nregulate essential transcription factors of lymphatic endothelial cells (LECs) and inhibit tube form

140 hyaluronan receptor 1 (LYVE1), which include lymphatic endothelial cells (LECs) and liver sinusoidal

141 nstrated generation of purified hPSC-derived lymphatic endothelial cells (LECs) and tested their ther

142 lls of Kaposi sarcoma are closely related to lymphatic endothelial cells (LECs) and that Kaposi sarco

143 a consequence of increased proliferation of lymphatic endothelial cells (LECs) and was also observed

144 We show here that lymphatic endothelial cells (LECs) are a prominent sourc

145 ystem, and there is growing recognition that lymphatic endothelial cells (LECs) are involved in immun

146 Lymphatic endothelial cells (LECs) are known to produce

147 Fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) are nonhematopoietic

148 In the absence of Prox1, lymphatic endothelial cells (LECs) are not specified.

149 Lymphatic endothelial cells (LECs) are the building bloc

150 Recent studies have identified lymphatic endothelial cells (LECs) as a major source of

151 We show that abnormal flow sensing in lymphatic endothelial cells (LECs) caused by Sdc4 or Pec

152 In this five-stage protocol, human lymphatic endothelial cells (LECs) cocultured with derma

153 Lymphatic endothelial cells (LECs) directly express peri

154 Dermal lymphatic endothelial cells (LECs) emerge from the dorso

155 We tested the hypothesis that lymphatic endothelial cells (LECs) exhibit Ca(2+) and el

156 In vitro cultured mouse lymphatic endothelial cells (LECs) expressed VitD Recept

157 othelial cells (BECs) with the properties of lymphatic endothelial cells (LECs) has been identified i

158 ranscriptional profiling of ex vivo isolated lymphatic endothelial cells (LECs) identified 160 genes

159 Until recently, the known roles of lymphatic endothelial cells (LECs) in immune modulation

160 Tumor cell migration to lymphatic endothelial cells (LECs) in vitro is inhibited

161 Lymphatic endothelial cells (LECs) induce peripheral tol

162 Transendothelial transport across lymphatic endothelial cells (LECs) is commonly considere

163 In this study, we demonstrate that lymphatic endothelial cells (LECs) modulate the maturati

164 However, whether LPA exerts an effect on lymphatic endothelial cells (LECs) or on lymphangiogenes

165 In vitro evaluation of lymphatic endothelial cells (LECs) revealed that low, re

166 In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation

167 Antigen is captured by lymphatic endothelial cells (LECs) under conditions that

168 These Prox1-expressing lymphatic endothelial cells (LECs) will exit the CV to f

169 that they are formed by the intercalation of lymphatic endothelial cells (LECs) with a subpopulation

170 Here we show that lymphatic endothelial cells (LECs), a component of LVs w

171 sarcoma-associated herpesvirus infection of lymphatic endothelial cells (LECs), but not blood endoth

172 upregulates mTOR signaling in primary human lymphatic endothelial cells (LECs), but not blood endoth

173 on, and morphologic differentiation of human lymphatic endothelial cells (LECs), consistent with an i

174 atory cytokines trigger activation of dermal lymphatic endothelial cells (LECs), leading to expressio

175 ess responses in blood endothelial cells and lymphatic endothelial cells (LECs), only LECs display re

176 which induced migration and proliferation of lymphatic endothelial cells (LECs), processes required f

177 o CPX inhibitory effect on tube formation in lymphatic endothelial cells (LECs), whereas downregulati

178 immune responses has included a new focus on lymphatic endothelial cells (LECs).

179 receptor that is expressed on both blood and lymphatic endothelial cells (LECs).

180 cognate receptor VEGF receptor-3 (VEGFR3) in lymphatic endothelial cells (LECs).

181 2 expression) and human dermal microvascular lymphatic endothelial cells (LECs).

182 lymphatic vasculature: the specification of lymphatic endothelial cells (LECs).

183 r Prox1 functions to reprogram venous ECs to lymphatic endothelial cells (LECs).

184 si sarcoma (KS), a tumor genetically akin to lymphatic endothelial cells (LECs).

185 smorphogenesis of vascular channels lined by lymphatic endothelial cells (LECs).

186 activity results in the complete absence of lymphatic endothelial cells (LECs).

187 essels (blood vascular endothelial cells and lymphatic endothelial cells [LECs]) were exposed to low-

188 Moreover, genetic inactivation of Dll4 in lymphatic endothelial cells led to lacteal regression an

189 Under these conditions, lymphatic endothelial cells, like tumor cells, had stron

190 he trans-differentiation of macrophages into lymphatic endothelial cell-like structures in culture.

191 Lymphatic endothelial cells lining the ceiling of the su

192 ACKR4-mediated CCL21 scavenging by lymphatic endothelial cells lining the subcapsular sinus

193 ls, but did not affect MT1-MMP expression in lymphatic endothelial cells, LVI, or lymph node metastas

194 These cells also express another lymphatic endothelial cell marker, Flt4/VEGFR3, but not

195 Here, we demonstrated the expression of lymphatic endothelial cell markers by the SC in murine a

196 We found that AML cells express lymphatic endothelial cell markers consistent with lymph

197 lacked luminal valves and expression of the lymphatic endothelial cell markers podoplanin and lympha

198 lial growth factor resulted in expression of lymphatic endothelial cell markers.

199 DV infects human pulmonary microvascular and lymphatic endothelial cells (MECs and LECs, respectively

200 sponse, while in vitro, the cells stimulated lymphatic endothelial cell migration via the actions of

201 uely correlating interstitial fluid flow and lymphatic endothelial cell migration with lymphatic func

202 ated receptor kinase signaling and blood and lymphatic endothelial cells migration and proliferation.

203 cteristic of this cell lineage, suggesting a lymphatic endothelial cell of origin for AML.

204 Further, inactivation of Ephb4 in lymphatic endothelial cells of developing mouse embryos

205 Our results show lymphatic endothelial cells of the thoracic duct arise f

206 ome enriched and differentially expressed by lymphatic endothelial cells on the upstream and downstre

207 (1) interstitial fluid channels form before lymphatic endothelial cell organization and (2) lymphati

208 In development, lymphatic endothelial cells originate within veins and d

209 blood endothelial cells reprograms them to a lymphatic endothelial cell phenotype.

210 ed into the lymphatic vasculature, displayed lymphatic endothelial cell phenotypes, and increased lym

211 phenotype that is a blend of both blood and lymphatic endothelial cell phenotypes.

212 tic endothelial cell markers consistent with lymphatic endothelial cell precursors in vivo and in vit

213 gene depletion led to a marked inhibition of lymphatic endothelial cell processes of adhesion, prolif

214 Demonstration of a previously unknown lymphatic endothelial cell progenitor population will no

215 Infiltrating lymphatic endothelial cells proliferated, aggregated, an

216 GFR-2 during infection led to a reduction in lymphatic endothelial cell proliferation and simultaneou

217 etion of CLEC-2 induced a profound defect in lymphatic endothelial cell proliferation, resulting in l

218 ugular lymphatic vessels due to reduction in lymphatic endothelial cell proliferation.

219 bitor inhibited the proliferation of primary lymphatic endothelial cells promoted by mammary gland co

220 FOXC2 and oscillatory shear stress maintain lymphatic endothelial cell quiescence through intercellu

221 change in vessel identity was the result of lymphatic endothelial cell reprogramming rather than rep

222 transcripts and protein in keratinocytes and lymphatic endothelial cells, respectively.

223 ptor that activates platelets in response to lymphatic endothelial cells, resulted in backfilling of

224 ted Prox1 and VEGFR-3 expression in cultured lymphatic endothelial cells, resulting in increased prol

225 Normally, VEGFR-3 activates Akt signaling in lymphatic endothelial cells, resulting in lymphangiogene

226 Studies in cultured lymphatic endothelial cells revealed that VEGF-A induced

227 KSHV-infected lymphatic endothelial cells showed induction of receptor

228 In mice, lymphatic endothelial cell-specific (LEC-specific) delet

229 The induction of the lymphatic endothelial cell-specific transcription factor

230 red for KSHV-induced expression of VEGFR3, a lymphatic endothelial-cell-specific receptor important f

231 ermined that from venous-derived lymph sacs, lymphatic endothelial cells sprouted, proliferated, and

232 transgenic mouse models, we demonstrate that lymphatic endothelial cells support the survival of T ce

233 s Unc5B and neogenin, are expressed by human lymphatic endothelial cells, suppression of either or bo

234 el role for Notch1 in limiting the number of lymphatic endothelial cells that differentiate from the

235 ically, we demonstrate that in primary human lymphatic endothelial cells, the integrin-alpha9-EIIIA i

236 the recent isolation of pure populations of lymphatic endothelial cells, the investigation of lympha

237 the migration and intercellular adhesion of lymphatic endothelial cells through a pathway that depen

238 lar development by directly interacting with lymphatic endothelial cells through C-type lectin-like r

239 Thus, the VEGFR-3-induced lymphatic endothelial cell tip cell formation is a prere

240 However, VEGFR3-induced lymphatic endothelial cell tips are a prerequisite for l

241 We used human lymphatic endothelial cells to establish a reliable thre

242 gene expression profiles of ex vivo isolated lymphatic endothelial cells to identify novel lymphatic

243 1 signaling regulates the differentiation of lymphatic endothelial cells to influence the lymphatic v

244 the production of the main growth factor for lymphatic endothelial cells, VEGFC.

245 The peptide inhibits blood and lymphatic endothelial cell viability, migration, adhesio

246 because critical specific characteristics of lymphatic endothelial cells were discovered only recentl

247 vascular smooth muscle cells, and VEGFR3 in lymphatic endothelial cells were essential for their dev

248 primary arterial, venous, microvascular, and lymphatic endothelial cells were performed using PBS.

249 Gp38) is highly expressed on the surface of lymphatic endothelial cells, where it regulates developm

250 y, Prox1 expression is high in valve-forming lymphatic endothelial cells, whereas cells of the lympha

251 Lymphatic endothelial cells, which experience much lower