ライフサイエンスコーパス: lymphopenic

1 ers the rat diabetes resistant despite being lymphopenic.

2 n Jak3 plus p53 or in Jak3 plus Fas remained lymphopenic.

3 At baseline, patients were profoundly lymphopenic.

4 llele (f/f) between D4Rat253 and D4Rhw6 were lymphopenic (85 of 85, 100%) but did not develop diabete

5 icient form of the BAFF-R derived from the B lymphopenic A/WySnJ strain.

6 hat in times of need, such as in neonates or lymphopenic adults, RTEs perform well to fill the gaps i

7 gnificant expansion in AML patients rendered lymphopenic after chemotherapy, contributing to the repo

8 enic diabetes-resistant (DR) BB rats are not lymphopenic and are free of spontaneous autoimmune disea

9 DP-BB rats are consequently lymphopenic and circulate severely reduced numbers of T

10 Rapa inhibition is relative and results from lymphopenic and graft-versus-host disease models cannot

11 cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB)

12 is complicated because of the involvement of lymphopenic animals, as lymphopenia drastically alters n

13 aive, CD25-depleted, betagalTCR T cells into lymphopenic arrbetagal recipients, implicating regulator

14 (+) T cells could reconstitute mice rendered lymphopenic as a consequence of genetics, irradiation, o

15 Kdelr1 homozygous mutants were mildly lymphopenic, as were mice with a CRISPR/Cas9-engineered

16 Neonates were lymphopenic at birth (1118 +/- 128 lymphocytes per cubic

17 nly the patients receiving Cy/Flu/DLI became lymphopenic at the time of DLI.

18 Lymphopenic, autoimmune lupus erythematosus patients exh

19 PARgamma-deficient (T-PPAR) Teffs to mediate lymphopenic autoimmunity is associated with a significan

20 e carrying superantigen were severely B cell lymphopenic, but small numbers of B cells matured.

21 nt, which is only revealed in hosts rendered lymphopenic by neonatal thymic ablation.

22 In this study, we report that in lymphopenic CD24-deficient mice, T cells launch a massiv

23 T cells could not completely treat tumor in lymphopenic common gamma chain (gamma(c))-deficient host

24 homeostasis of the CD4 memory population in lymphopenic conditions and in the intact immune system.

25 ile that can be temporarily overridden under lymphopenic conditions but is inevitably reimposed, whic

26 21R, we discovered that under homeostatic or lymphopenic conditions IL-21 acts directly on CD8 T cell

27 D4(+) T cells accumulated in old mice, under lymphopenic conditions in a T cell transfer model of col

28 naive T cells is observed readily only under lymphopenic conditions in response to elevated levels of

29 ation of naive TRAF6DeltaT CD8 T cells under lymphopenic conditions is defective.

30 e proliferation of CD4+ T cells under severe lymphopenic conditions, and this division is associated

31 rom MHC II(-/-) mice hyperproliferated under lymphopenic conditions, differentiated into effector cel

32 Conversely, under lymphopenic conditions, enhanced proliferation by RTEs a

33 ells proliferate and become functional under lymphopenic conditions, even in a tolerogenic environmen

34 opoietic stem cell transplantation and other lymphopenic conditions, IL-7 plays an important role in

35 interleukin 7 (IL-7) levels are observed in lymphopenic conditions, including idiopathic CD4 lymphop

36 ls lacking both E2F1 and E2F2 in response to lymphopenic conditions, suggesting that E2F1 and E2F2 fu

37 In lymphopenic conditions, T cells expand to re-establish h

38 The findings suggest that under uniform lymphopenic conditions, the widely different rates of pr

39 aive T cells undergo robust proliferation in lymphopenic conditions, whereas they remain quiescent in

40 Production of HCs is induced in lymphopenic conditions, which have been shown to predisp

41 ulate homeostatic T cell proliferation under lymphopenic conditions.

42 ivo complexity of T-cell proliferation under lymphopenic conditions.

43 survival and homeostatic proliferation under lymphopenic conditions.

44 CD8(+) T cell homeostasis in both normal and lymphopenic conditions.

45 y T cells as a result of proliferation under lymphopenic conditions.

46 n during normal homeostasis as well as under lymphopenic conditions.

47 roliferation rates of NK cells in normal and lymphopenic conditions.

48 ete for homeostatic factors under normal and lymphopenic conditions.

49 c expansion capacity of memory T cells under lymphopenic conditions.

50 e process of homeostatic proliferation under lymphopenic conditions.

51 trolling lymphopoiesis under both normal and lymphopenic conditions.

52 ned the ability to proliferate in vivo under lymphopenic conditions.

53 quired for development of autoimmunity under lymphopenic conditions.

54 s from donor mice with or without cGvHD into lymphopenic congenic recipients showed that cGvHD impair

55 tion differentially in nonlymphopenic versus lymphopenic contexts.

56 In response to a lymphopenic cue, T lymphocytes undergo a slow-paced home

57 imap5-deficient cells lose weight and become lymphopenic, demonstrating a hematopoietic cell-intrinsi

58 IL-15Ralpha-/- mice are markedly lymphopenic despite grossly normal T and B lymphocyte de

59 CD4Cre/R-DTA mice remained lymphopenic despite the large available immunological "s

60 Congenitally lymphopenic diabetes-prone (DP) BioBreeding (BB) rats de

61 utes a larger percentage of the euthymic but lymphopenic diabetes-prone BB rat IEL population, and is

62 ing 1-deficient (SOCS1(-/-)) mice, which are lymphopenic, die <3 wk after birth of a T cell-mediated

63 s with SCID, as well as infants with other T-lymphopenic disorders detected by using NBS.

64 Mice lacking interleukin-7 receptor are lymphopenic, due to a defect in cell expansion at an ear

65 ule (PT) cells, independent of the canonical lymphopenic effects of S1P1 activation on B and T cells.

66 T cell proliferation occurs in response to a lymphopenic environment and is mediated by TCR and IL-7

67 evelopment or homeostatic proliferation in a lymphopenic environment are not required for this severe

68 ntial expansion of effector memory T-cell in lymphopenic environment could represent the major barrie

69 In this study, we show that the physiologic lymphopenic environment existing in neonatal mice also s

70 ive T cells have the capacity to expand in a lymphopenic environment in a process called homeostatic

71 Remarkably, this defect occurred despite the lymphopenic environment in LP hosts.

72 It has been shown that in a lymphopenic environment naive T cells undergo expansion

73 CD8+ T cells were introduced either into the lymphopenic environment of RAG2(-/-) mice or into P14/RA

74 creased proliferative renewal because of the lymphopenic environment of the mice.

75 te effective antitumor immunity in a defined lymphopenic environment through DC-based immunization.

76 Under the pressure of a T lymphopenic environment, mature naive T cells begin to p

77 In a lymphopenic environment, naive T cells undergoing homeos

78 meostasis is affected by an inflammatory and lymphopenic environment, we characterized the Treg compa

79 phoreplete mice and their proliferation in a lymphopenic environment, whereas survival and homeostati

80 pansion of T cells from young mice to fill a lymphopenic environment.

81 ) resembling the proliferation observed in a lymphopenic environment.

82 oietic and immune cells into an inflamed and lymphopenic environment.

83 ALT) after oral exposure to antigen and in a lymphopenic environment.

84 hocytes undergo homeostatic proliferation in lymphopenic environment.

85 ells, undergo homeostatic proliferation in a lymphopenic environment.

86 mphoid compartment, but was unnecessary in a lymphopenic environment.

87 different times after their transfer into a lymphopenic environment.

88 T cells undergo this type of expansion in a lymphopenic environment.

89 even agonist-driven autoimmune disease in a lymphopenic environment.

90 The host responds to lymphopenic environments by acute homeostatic proliferat

91 The host responds to lymphopenic environments by acute homeostatic proliferat

92 ate homeostatic CD8+ T cell proliferation in lymphopenic environments by competing for IL-15.

93 Lymphopenic environments lacking these key factors suppo

94 Introduction of naive cells into lymphopenic environments results in proliferation and di

95 T cells present in lymphopenic environments undergo spontaneous (homeostati

96 pendent on IL-21 for optimal accumulation in lymphopenic environments.

97 T cells during homeostatic reconstitution of lymphopenic environments.

98 igen stimulation when transferred into adult lymphopenic environments.

99 ry of CD25(+) regulatory T cells following a lymphopenic event can prevent exuberant Ag-stimulated CD

100 -line therapy for influenza in patients with lymphopenic hematological conditions and uptake of influ

101 lonal size instead of filling the space in a lymphopenic host appears to regulate homeostatic T-cell

102 g adoptive transfer of CD8(+) T cells into a lymphopenic host can augment the therapeutic antitumor r

103 lf-renew and maintain enhanced function in a lymphopenic host for at least a month.

104 Naive T cells dividing in a lymphopenic host upregulate CD44, CD122 (interleukin 2 r

105 ility to rapidly expand upon transfer into a lymphopenic host.

106 In addition, lymphopenic hosts accumulate increased levels of IL-7, a

107 BTLA agonism rebalances T cell expansion in lymphopenic hosts after aHSCT, thereby preventing GVHD w

108 expansion of naive CD8+ and CD4+ T cells in lymphopenic hosts and for CD8+ T cell survival in normal

109 strating how TCR transgenic cells repopulate lymphopenic hosts and target tumors in an antigen-specif

110 e to limit naive T cell proliferation within lymphopenic hosts by modulating stimulatory functions of

111 reased approximately 4-fold in reconstituted lymphopenic hosts compared with normal hosts.

112 Immune recovery in lymphopenic hosts depends largely on homeostatic periphe

113 ingly, the cells undergoing proliferation in lymphopenic hosts did not mature to cytotoxic effectors

114 Despite this, many lymphopenic hosts do not develop autoimmune disease, sug

115 Thus, T cells proliferating in lymphopenic hosts do not exhibit a unique gene-expressio

116 Lymphopenic hosts offer propitious microenvironments for

117 most quantitative studies were performed in lymphopenic hosts or in graft-versus-host disease models

118 that division of T cells in the periphery of lymphopenic hosts requires specific recognition of self-

119 Lymphopenic hosts supported increased proliferation of a

120 ts from a heightened sensitivity of infected lymphopenic hosts to the detrimental effects of Ag-drive

121 T cells transferred into severe lymphopenic hosts undergo rapid proliferation known as "

122 Expansion of CD8+ T cells in lymphopenic hosts was found to be peptide specific.

123 fect naive T cell proliferation in syngeneic lymphopenic hosts were investigated.

124 se to self MHC molecules after transfer into lymphopenic hosts, a process that has been termed homeos

125 lphaCD25-treated lymphoreplete hosts than in lymphopenic hosts, and adoptive immunotherapy was most e

126 EGFP(-) CD4(+) T cells when transferred into lymphopenic hosts, indicative of their common ontogeny w

127 suprahomeostatic concentrations achieved in lymphopenic hosts, is a potent and selective inducer of

128 Upon transfer into MHC-II-deficient lymphopenic hosts, mature CD4(+) T cells were found to a

129 Following transfer into lymphopenic hosts, naive CD8 T cells proliferate and acq

130 This regulation is particularly active in lymphopenic hosts, such as elderly and thymectomized pat

131 the absence of functional T(reg) cells into lymphopenic hosts, T(reg) cells with deletion of Foxp3 p

132 Moreover, upon transfer into lymphopenic hosts, Th17 cells rapidly lost their IL-17 e

133 When naive T cells reconstitute lymphopenic hosts, they transiently proliferate and diff

134 gatory for proliferation of naive T cells in lymphopenic hosts, whereas IL-15 did not influence their

135 transferred CD4 T cells failed to expand in lymphopenic hosts, whereas in the presence of CCL21 over

136 lls showed enhanced homeostatic expansion in lymphopenic hosts, which was abrogated by ectopic expres

137 In lymphopenic hosts, Zap70-deficient T cells survived far

138 of established tumors and depigmentation in lymphopenic hosts.

139 tantial in lymphoreplete hosts but absent in lymphopenic hosts.

140 wed cytokine responses when transferred into lymphopenic hosts.

141 immune response induced by Foxp3(-) cells in lymphopenic hosts.

142 sponse to the elevated levels of IL-7 in the lymphopenic hosts.

143 the efficacy of adoptive T-cell therapies in lymphopenic hosts.

144 ed by the transfer of CD4+CD25- T cells into lymphopenic hosts.

145 IKK2-deficient T cells to induce colitis in lymphopenic hosts.

146 n when adoptively transferred into syngeneic lymphopenic hosts.

147 ntly of cognate antigen when introduced into lymphopenic hosts.

148 stasis, and its availability is augmented in lymphopenic hosts.

149 ells when transferred together into the same lymphopenic hosts.

150 ed survival when adoptively transferred into lymphopenic hosts.

151 survival and IFN-gamma cytokine responses in lymphopenic hosts.

152 T cells that undergo "slow proliferation" in lymphopenic hosts.

153 antibiotics reduced the severity of GVHD in lymphopenic hosts.

154 s and promotes immunologic reconstitution in lymphopenic hosts.

155 he IL-7-driven immunologic reconstitution of lymphopenic hosts.

156 l-1 cells were inefficient at LIP in typical lymphopenic hosts.

157 radoxically, elevated systemic IL-7 found in lymphopenic humans is typically insufficient for CD4(+)

158 tically deficient in IL-7R(alpha) are highly lymphopenic in the peripheral lymphoid organs.

159 ripheral T cell repertoire that occurs after lymphopenic incidents, which frequently provoke either e

160 We performed a randomized phase 1/2 study in lymphopenic individuals after high-dose chemotherapy and

161 pansion during immune reconstitution, and in lymphopenic individuals receiving IL-2, the T(reg) cell

162 All T-cell lymphopenic infants avoided live vaccines and received a

163 Other T-cell lymphopenic infants had variant SCID or combined immunod

164 unclear, and whether effector sites are also lymphopenic is unknown.

165 nt mice have normal B cell numbers but are T lymphopenic, leading to defective homeostatic expansion

166 About 20% of patients were lymphopenic, mainly because of low CD4(+) and CD8(+) T-c

167 Naive CD8+ T cells transferred to lymphopenic mice acquire a memory-like phenotype, raisin

168 nt naive CD8(+) T cells proliferated even in lymphopenic mice deficient in major histocompatibility c

169 se cells provoke a lethal wasting disease in lymphopenic mice despite the presence of regulatory T ce

170 undergo homeostasis-driven proliferation in lymphopenic mice in the absence of overt antigenic stimu

171 ne disease, and depletion of T(reg) cells in lymphopenic mice induces autoimmunity.

172 Transfer of naive CD4 T cells into lymphopenic mice initiates a proliferative response of t

173 tory T cell-depleted polyclonal T cells into lymphopenic mice leads to rejection of B16 melanoma, whi

174 -N-nitrosourea-mutagenesis screen for T cell-lymphopenic mice prompted us to evaluate a T cell-defici

175 Adoptive transfer of mature NK cells into lymphopenic mice resulted in the generation of a long-li

176 f naive antigen-specific CD4(+) T cells into lymphopenic mice that express an endogenous antigen as a

177 , we demonstrate that sublethally irradiated lymphopenic mice transfused with autologous or syngeneic

178 Lymphopenic mice treated with anti-PD-L1 Ab demonstrated

179 Naive CD4 T cells transferred into lymphopenic mice undergo spontaneous proliferation and i

180 at the expansion of V alpha 14i NKT cells in lymphopenic mice was not dependent on CD1d expression an

181 Lymphopenic mice were selectively reconstituted with Tre

182 ired for peripheral CD8+ T cell expansion in lymphopenic mice without conventional antigenic stimulat

183 T cells undergo homeostatic proliferation in lymphopenic mice, a process that involves TCR recognitio

184 pansion of TNFR2-deficient Teff cells in the lymphopenic mice, as well as their reduced capacity to e

185 As in lymphopenic mice, where T cell proliferation depends upo

186 specific T cells in vaccinated reconstituted lymphopenic mice.

187 n of tumor-specific T cells in reconstituted lymphopenic mice.

188 he homeostatic expansion of naive T cells in lymphopenic mice.

189 , as well as in homeostatic proliferation in lymphopenic mice.

190 tly differentiate into Treg on transfer into lymphopenic mice.

191 fate (DSS) to mice or transfer of T cells to lymphopenic mice.

192 expression following adoptive transfer into lymphopenic mice.

193 thogenic than controls when transferred into lymphopenic mice.

194 However, the mechanism by which the lymphopenic microenvironment benefits Ag-specific CD8(+)

195 ansion and acquire an activated phenotype in lymphopenic microenvironments.

196 interest in the behavior of T and B cells in lymphopenic model systems has resurrected a certain cyni

197 Using experimental lymphopenic mouse models and IL-7-induced homeostatic pr

198 tness through homeostatic expansion into the lymphopenic neonatal environment.

199 ppropriate immune responses, particularly in lymphopenic neonates and adults.

200 generation of a diverse naive T cell pool in lymphopenic neonates that is mandatory for the maintenan

201 T cell clonal anergy induction in lymphopenic nu/nu mice was found to be ineffective.

202 S1P), but not to chemokines, were found in a lymphopenic patient with recurrent infections.

203 he basis for residual protective immunity in lymphopenic patients is not known.

204 or the maintenance of protective immunity in lymphopenic patients treated for ALL.

205 ration of DCs in bone marrow (BM) during the lymphopenic phase and in the blood and spleen during the

206 cious in controlling adenoviremia during the lymphopenic phase of HCT.

207 cells that proliferate when transferred into lymphopenic (Rag-1(-/-)) hosts.

208 of large established B16BL6-D5 melanomas in lymphopenic Rag1(-/-) recipients devoid of regulatory T

209 e rapid cycle entry was observed in vivo, in lymphopenic RAG2(-/-) hosts.

210 olated and adoptively transferred into naive lymphopenic Rag2(-/-) mice.

211 Genetically lymphopenic rats and congenic wild-type partners were co

212 enotype and were able to transfer disease to lymphopenic recipient mice.

213 DLI-induced GVHD was prevented in lymphopenic recipients by prior administration of a smal

214 Transfer of the same CD4(+) T cells into lymphopenic recipients expressing the self-antigen resul

215 of naive tumor-reactive CD4(+) T cells into lymphopenic recipients induces substantial T cell expans

216 When transferred into lymphopenic recipients of male skin grafts, Th17 lines e

217 optively transferred naive CD8(+) T cells in lymphopenic recipients or recipients containing a clonal

218 betagalTCR T cells before transfer into the lymphopenic recipients reduced EAU.

219 class Ib-restricted CD8+ T cells to congenic lymphopenic recipients revealed their ability to undergo

220 cells adoptively transferred into syngeneic lymphopenic recipients undergo proliferation.

221 transfer alloantigen-specific suppression to lymphopenic recipients was described.

222 d in vivo (expansion following transfer into lymphopenic recipients).

223 eriods upon adoptive transfer into intact or lymphopenic recipients, but not in IL-7- mice or in reci

224 ced by transfer of naive CD4(+) T cells into lymphopenic recipients, DRD3 deficiency not only affects

225 cell antigen receptor, when transferred into lymphopenic recipients, naive TGF-beta-unresponsive T ce

226 However, upon transfer into lymphopenic recipients, TCE fail to rapidly expand, but

227 TCR transgenic Rag1(-/-) CD8(+) T cells into lymphopenic recipients, who received vaccination, led to

228 he initial proliferation after transfer into lymphopenic recipients.

229 nificantly higher levels after transfer into lymphopenic recipients.

230 proliferative expansion after transfer into lymphopenic recipients.

231 roliferated and induced autoimmunity only in lymphopenic recipients.

232 8 T cell proliferation and accumulation in a lymphopenic setting, as revealed by truncated LIP in IL-

233 ses of autologous T cells occur in vivo in a lymphopenic setting.

234 T helper type 2 (Th2)-mediated disease in a lymphopenic setting.

235 ive (IL-7Ralpha(+)) dendritic cells (DCs) in lymphopenic settings paradoxically diminished the homeos

236 Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gammadelta

237 eir activity might be compromised in certain lymphopenic settings.

238 he T cell compartment during recovery from a lymphopenic state are incompletely understood.

239 The T-lymphopenic state associated with GIMAP5 deficiency rend

240 The lymphopenic state present in neonates was a factor in th

241 4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection.

242 Elevated serum IL-7 levels in lymphopenic states, including HIV infection, are thought

243 or inflammatory pathology that can emerge in lymphopenic states.

244 scent until they receive either antigenic or lymphopenic stimuli.

245 T of LTalpha-/- animals was disorganized and lymphopenic, suggesting that the organization and recrui

246 ne C57BL/6 splenocytes were transferred into lymphopenic T cell-deficient hosts and allowed to recons

247 lop autoimmunity after treatment are no more lymphopenic than their nonautoimmune counterparts, but t

248 atopoiesis, we observed that NHD13 mice were lymphopenic; the lymphopenia was due to a decrease in bo

249 ogical features as did fingolimod (maximally lymphopenic throughout), despite full reversal of lympho

250 Previous studies established that a lymphopenic transitional (TR) B cell compartment reduces

251 ional host Tregs initially occupy a niche in lymphopenic transplantation recipients, undergo signific

252 el-1 T cells were transferred to B16-bearing lymphopenic versus lymphoreplete mice receiving alphaCD2

253 srupted lymphoid organs from GvHD and remain lymphopenic with a restricted TCR-Vbeta repertoire and r

254 Three patients were lymphopenic with low natural killer cell counts, but a s

255 Neonatal mice are lymphopenic within the first week of life.