ライフサイエンスコーパス: lymphoproliferation

1 is necessary for development of HCV-related lymphoproliferation.

2 t also causes massive double-negative T-cell lymphoproliferation.

3 m autoimmune diabetes without causing T-cell lymphoproliferation.

4 orm infection on host cytokine responses and lymphoproliferation.

5 negatively associated with rubella-specific lymphoproliferation.

6 who developed an Epstein-Barr virus-related lymphoproliferation.

7 itive patients who exhibit envelope-specific lymphoproliferation.

8 on in vitro does not preclude HIV-1-specific lymphoproliferation.

9 ormed to determine the cell type involved in lymphoproliferation.

10 cells are mainly responsible for preventing lymphoproliferation.

11 er monocytes to downregulate mitogen-induced lymphoproliferation.

12 bute to the costimulation of virally induced lymphoproliferation.

13 entify high-risk patients and diagnose early lymphoproliferation.

14 ion of PCD and in the inhibition of in vitro lymphoproliferation.

15 ciency strongly correlated with intensity of lymphoproliferation.

16 a long-term risk of AA amyloidosis and overt lymphoproliferation.

17 markers and were unable to induce allogeneic lymphoproliferation.

18 l dysfunction, perhaps related to EBV-driven lymphoproliferation.

19 isms, impaired production of antibodies, and lymphoproliferation.

20 st patients died of infection or progressive lymphoproliferation.

21 ify high-risk patients and to diagnose early lymphoproliferation.

22 ty, autoantibody production, and substantial lymphoproliferation.

23 confirmed the clonal B-cell nature of these lymphoproliferations.

24 tic target for treatment of some EBV-induced lymphoproliferations.

25 munodeficiency, we studied 39 EBV-associated lymphoproliferations (10 benign, 29 malignant) from four

26 ocyte responses at diagnosis, as measured by lymphoproliferation (7/7) or cytokine flow cytometry (3/

27 inhibition led to a reduction in spontaneous lymphoproliferation, a key ex vivo correlate of the immu

28 Spontaneous lymphoproliferation, a marker of T-cell activation in HA

29 ity locus Nba2 causes dramatic B cell and PC lymphoproliferation, accelerated autoantibody production

30 PS) is characterized by chronic nonmalignant lymphoproliferation, accumulation of double-negative T c

31 ng (a) H-TdR incorporation for inhibition of lymphoproliferation and (b) flow cytometry to analyze fo

32 ify the mTOR pathway as a major regulator of lymphoproliferation and aberrant differentiation in ALPS

33 At 4 mo of age, both groups showed extensive lymphoproliferation and aberrant T cell formation, altho

34 e Fas signaling, resulting in chronic benign lymphoproliferation and accumulation of TCRalphabeta(+)

35 WT Tregs also inhibited lymphoproliferation and acquisition of activation marker

36 had an impaired ability to induce allogeneic lymphoproliferation and activated autologous memory CD4+

37 erleukin-2 (IL-2) in T cells is critical for lymphoproliferation and an immune response.

38 es to interfere with gammaherpesvirus-driven lymphoproliferation and associated disease.

39 strategy to control gammaherpesvirus-driven lymphoproliferation and associated disease.

40 vo depletion of normal Thy-1+ cells restores lymphoproliferation and autoantibody production in such

41 induced a lupus-like chronic GVHD phenotype (lymphoproliferation and autoantibody production).

42 linking defects in Ca(2+)/NFAT signaling to lymphoproliferation and autoimmune disease.

43 er complications resulting from infiltrative lymphoproliferation and autoimmunity are presented.

44 We found that expression of MC159 led to lymphoproliferation and autoimmunity as exemplified by T

45 Its absence leads to devastating lymphoproliferation and autoimmunity in scurfy mutant mi

46 stigated whether Bim(-/-) DCs contributed to lymphoproliferation and autoimmunity in these mice.

47 to CTLA-4-/- animals, a complete rescue from lymphoproliferation and autoimmunity was observed.

48 ocyte apoptosis are associated with abnormal lymphoproliferation and autoimmunity.

49 le for infectious agents in the induction of lymphoproliferation and B cell autoimmunity in MRL-lpr m

50 pport an etiological role for HCV in causing lymphoproliferation and causing non-Hodgkin lymphoma.

51 IL-2 has been implicated in regulating lymphoproliferation and CD178 (FasL) expression.

52 Cell-mediated immune responses (lymphoproliferation and cytokine production) to HPV-16 L

53 monstrated suppression of adenovirus-induced lymphoproliferation and cytokine responses (interleukin-

54 higher than increases detectable by standard lymphoproliferation and cytotoxicity assays.

55 ne adults with a history of chickenpox, by T lymphoproliferation and cytotoxicity assays.

56 y role for dietary exposure in the extent of lymphoproliferation and development of nephritis in this

57 port on 13 individuals from 10 families with lymphoproliferation and early-onset solid-organ autoimmu

58 1(-/-) and the CTLA-4/B7-2(-/-) mice develop lymphoproliferation and enhanced T cell activation.

59 They showed massive lymphoproliferation and exacerbated inflammatory damage,

60 pr.H-2(d) mice, both types of mice developed lymphoproliferation and exhibited elevated levels of IgG

61 However, Sf.Il2-/- mice have increased lymphoproliferation and FasL expression.

62 TLA4Ig treatment of CTLA-4 -/- mice prevents lymphoproliferation and fatal multiorgan tissue damage i

63 ce of these drugs were also tested using the lymphoproliferation and flow cytometric assays.

64 ymph nodes (MLN), and spleen were assayed by lymphoproliferation and flow cytometry for the expressio

65 ogical activity of each subset, expressed as lymphoproliferation and gamma interferon (IFN-gamma) pro

66 atients without clinically detectable B-cell lymphoproliferation and generates many large B-cell clon

67 Adoptive transfer assays revealed lower lymphoproliferation and greater cell surface TGF-beta ex

68 ovide insight into mechanisms of EBV-induced lymphoproliferation and identify potential therapeutic i

69 The gammadelta T-cell lymphoproliferation and IFN-gamma production to stimulat

70 with this haplotype demonstrated higher mean lymphoproliferation and IFN-gamma secretion than did cel

71 SP-D NCRD no longer decreased lymphoproliferation and IL-2 cytokine production when CT

72 ess safety, pharmacokinetics, and effects on lymphoproliferation and immune dysregulation.

73 eviously shown to be important in preventing lymphoproliferation and immunodeficiency following infec

74 eficiency syndrome (MAIDS), characterized by lymphoproliferation and immunodeficiency in susceptible

75 Lymphoproliferation and immunodeficiency, the hallmarks

76 of virus-specific T cells and occurrence of lymphoproliferation and inflammatory autoimmune disease

77 ivity correlated with mycobacterial-specific lymphoproliferation and interferon-gamma responses.

78 tvaccination H3(Beijing/32) HA (H3)-specific lymphoproliferation and interleukin (IL)-2, IL-10, and i

79 on of autoreactive T and B cells, leading to lymphoproliferation and lupus-like autoantibody producti

80 infection of BALB beta2m-/- mice results in lymphoproliferation and lymphoma, providing a valuable t

81 immune surveillance resulted in rapid, fatal lymphoproliferation and lymphomagenesis.

82 exogenous sphingolipids cause inhibition of lymphoproliferation and PCD by two separate and distinct

83 All mice exhibited lymphoproliferation and plasmacytosis.

84 Mice homozygous for the lpr gene develop lymphoproliferation and produce autoantibodies closely r

85 polyclonal lymphocyte activation leading to lymphoproliferation and severe autoimmune nephritis with

86 )CD25(+) regulatory T cells, exhibit massive lymphoproliferation and severe inflammatory infiltration

87 ty similar to that shown in vitro, including lymphoproliferation and stimulation of interleukin-6 sec

88 This paradigm is based on the extensive lymphoproliferation and systemic autoimmunity in mice an

89 ses induced by NP DNA, which included robust lymphoproliferation and Th1-type cytokine secretion (hig

90 significantly down-regulated antigen-induced lymphoproliferation and the expression of interleukin-12

91 ontrols, BEL dose-dependently inhibited both lymphoproliferation and Treg generation in human leukocy

92 activation of T cells (LAT) show progressive lymphoproliferation and ultimately die at 4-6 mo age.

93 rhal fever, a fatal disease characterized by lymphoproliferation and vasculitis.

94 nsistent TRAF1 overexpression in EBV-induced lymphoproliferations and Hodgkin's disease.

95 s influences the phenotype of the developing lymphoproliferations and potentially the severity of dis

96 n bile duct-ligated (BDL) Fas-deficient lpr (lymphoproliferation) and wild-type mice.

97 logical changes in lymphoid organs, abnormal lymphoproliferation, and a greatly increased incidence o

98 on that leads to abnormalities of apoptosis, lymphoproliferation, and a lupus-like autoimmune disease

99 s and is often associated with leukocytosis, lymphoproliferation, and autoimmune phenomena.

100 s, antibody-dependent cellular cytotoxicity, lymphoproliferation, and cytotoxic CD8+ T cell activity

101 patients displayed multiorgan autoimmunity, lymphoproliferation, and delayed-onset mycobacterial dis

102 One patient had nonmalignant lymphoproliferation, and four had malignant PTLD, as ass

103 g from infection, in the absence of in vitro lymphoproliferation, and from vaccination.

104 r protein) cause a syndrome of autoimmunity, lymphoproliferation, and humoral immune deficiency.

105 ty to infection with encapsulated organisms, lymphoproliferation, and hypogammaglobulinemia.

106 Serial PPD induration, lymphoproliferation, and interferon-gamma responses.

107 fects of immunosuppression on EBV-associated lymphoproliferation, and may be an essential technique f

108 e dysregulation manifesting as autoimmunity, lymphoproliferation, and organ inflammation and thereby

109 Knocking out CTLA4 in mice causes lethal lymphoproliferation, and polymorphisms in human CTLA4 ar

110 ns of SNPs with measles-specific antibodies, lymphoproliferation, and secreted cytokines were determi

111 mmatory arthropathy, intermittent polyclonal lymphoproliferation, and significant chronic kidney dise

112 , which corresponded to antibody production, lymphoproliferation, and skin testing.

113 in delayed-type hypersensitivity responses, lymphoproliferation, and spontaneous apoptosis and with

114 tissue, in Epstein-Barr virus (EBV)-induced lymphoproliferations, and in malignant lymphomas with sp

115 Lytic gene expression in sites of lymphoproliferation appears to make a vital contribution

116 ar lymphocytic leukemias (T-LGLs) are clonal lymphoproliferations arising from either natural killer

117 indicative of lymphoaccumulation rather than lymphoproliferation as the cause of MZ expansion.

118 d the activation of autoreactive T cells and lymphoproliferation as well as production of autoantibod

119 repeat RT-PCR, nested DNA PCR, western blot, lymphoproliferation assay, cytotoxic T-cell lysis, CD8-d

120 Lymphoproliferation assays and cytokine enzyme-linked im

121 Lymphoproliferation assays measured functional responses

122 )-gamma enzyme-linked immunosorbent spot and lymphoproliferation assays.

123 chronic stimulation of the immune system and lymphoproliferation associated with storage of glucocere

124 Foxo3a deficiency leads to spontaneous lymphoproliferation, associated with inflammation of sev

125 s for one such subject revealed Env-specific lymphoproliferation at 11 DPI but no detectable Env-spec

126 family presenting with EBV-associated B-cell lymphoproliferation at an early age (12, 7(1/2), and 14

127 mmunosuppressive, inhibiting antigen-induced lymphoproliferation at micromolar concentrations.

128 iciency for the IFN-RI surprisingly worsened lymphoproliferation, autoantibody production, and end or

129 apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased

130 nt recipients are at high risk of EBV-driven lymphoproliferation because they lack EBV-specific memor

131 s to be required for uncontrolled aggressive lymphoproliferation, because none of the IL-15Ralpha(-/-

132 t antitumor effects in EBV-associated B-cell lymphoproliferations both in vitro and in vivo.

133 which was initially attributed to excessive lymphoproliferation but is now ascribed to the absence o

134 However, MPA alone inhibited lymphoproliferation but significantly enhanced Treg gene

135 e that overexpression of this locus leads to lymphoproliferation, but no experimental proof that dysr

136 e sensitivity of peripheral monitoring for B lymphoproliferation, but the dramatic reduction in PTLD

137 volved in the pathogenesis of several B cell lymphoproliferations, but the precise contribution it ma

138 induced tolerance and double-negative T-cell lymphoproliferation can be uncoupled from each other.

139 tic cows, demonstrating that the spontaneous lymphoproliferation characteristic of BLV-induced persis

140 gnificantly exacerbated the skin disease and lymphoproliferation characteristic of MRL/lpr mice.

141 factor pathway by EBV may contribute to the lymphoproliferation characteristic of type III latency.

142 s similarities and differences of the murine lymphoproliferations compared with human CLL.

143 biopsy revealed an Epstein-Barr virus-driven lymphoproliferation consistent with a polymorphic posttr

144 ystemic disease, in the form of unrestrained lymphoproliferation, continued unabated.

145 ayed type hypersensitivity (DTH) and in vivo lymphoproliferation correlated with MMc levels, suggesti

146 E7 and/or L1-specific WIL, as determined by lymphoproliferation, could be isolated from more than 75

147 DKO mice exhibit increased lymphoproliferation, decreased activation-induced cell d

148 Comparing HCDR3 regions of CD5(+) lymphoproliferations derived from this and published CLL

149 deleted region (CDR) changed the spectrum of lymphoproliferations developing in CDR- versus MDR-delet

150 e resulting FADD mutant mice did not develop lymphoproliferation diseases, unlike Fas-deficient mice.

151 munodeficiency associated with erythroderma, lymphoproliferation, elevated IgE, and hyperactive oligo

152 the Notch1 intracellular domain resulted in lymphoproliferation, exacerbated T(H)1 responses and aut

153 As shown by lymphoproliferation experiments, they contained allergen

154 man immunodeficiency virus-negative atypical lymphoproliferations expressing large amounts of the lat

155 and conventional MRL-lpr mice were noted in lymphoproliferation, flow cytometric analysis of lymph n

156 Several mice harbored abnormal lymphoproliferations following therapy--in these cases,

157 noculated intradermally into wild type (wt), lymphoproliferation gene (lpr) (Fas deficient), or gener

158 apoptotic pathway, and its role in mediating lymphoproliferation has been extensively examined.

159 Most studies of EBV infection and lymphoproliferation have focused on the pediatric age gr

160 dies, 77% of patients with envelope-specific lymphoproliferation have undetectable anti-CD4bd antibod

161 The simplest way of preventing EBV lymphoproliferation, however, may be to deplete B cells

162 mber of immunopathologic sequelae, including lymphoproliferation, hypergammaglobulinemia, and overt s

163 phomas, 4 systemic lymphomas, and 4 atypical lymphoproliferations, ie, in 60% of cases.

164 o 8 weeks after infection by the criteria of lymphoproliferation, impaired proliferative responses to

165 motes rather than inhibits Bcr-Abl-induced B lymphoproliferation in a murine model where BM cells fro

166 e of T-cell epitopes was determined based on lymphoproliferation in allergic patients.

167 important early event in the pathogenesis of lymphoproliferation in ALPS patients.

168 Pristane treatment also decreased lymphoproliferation in B6/lpr mice.

169 However, MP stimulated lymphoproliferation in CD4(+) T cells obtained from the

170 IgM(+) memory B cells as a general target of lymphoproliferation in HCV(+) patients, affecting appare

171 , our findings suggest that autoimmunity and lymphoproliferation in IL-2Ralpha-/- mice can result fro

172 ) effectively prevents and treats EBV-driven lymphoproliferation in immunocompromised hosts.

173 meostatic control may be responsible for CD4 lymphoproliferation in MAIDS.

174 with increased susceptibility to EBV-induced lymphoproliferation in patients associated with hypomorp

175 sensitivity responses and decreased in vitro lymphoproliferation in response to specific antigens hav

176 This approach accomplishes the control of lymphoproliferation in severe forms as well as the minim

177 4(+) T cells delays but does not prevent the lymphoproliferation in the CTLA-4(-/-) mice.

178 the marked decrease seen in mitogen-induced lymphoproliferation in the presence of infected monocyte

179 Concomitant envelope-specific lymphoproliferation in vitro was undetectable among 9 in

180 skin test to tuberculin, and antigen-induced lymphoproliferation in vitro were markedly suppressed in

181 The dramatic reversal of EBV-driven lymphoproliferations in bone marrow transplant patients

182 recapitulates the spectrum of CLL-associated lymphoproliferations in humans, including CLL, CD5(+) mo

183 enes faithfully recapitulate the spectrum of lymphoproliferations in humans?

184 Do the CLL-like lymphoproliferations in the mouse have the phenotypic, h

185 We investigated age-related EBV(+) B-cell lymphoproliferations in the Western population.

186 n at the single-cell level in EBV-associated lymphoproliferations in vivo.

187 differential diagnosis of extranodal T-cell lymphoproliferations, including those in immunosuppresse

188 by the production of anti-nucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1 and

189 by the production of antinucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1/IgE

190 constitutively active Raf transgene enhanced lymphoproliferation, indicating a role for the Ras-MAPK

191 ignificantly increased Ag85b-specific T cell lymphoproliferation, interferon (IFN)-gamma secretion, I

192 Nine of 21 animals developed a B-cell lymphoproliferation involving peripheral blood (9 of 9),

193 T3 mutations may distinguish truly malignant lymphoproliferations involving T and NK cells from react

194 Epstein-Barr virus (EBV)-associated B-cell lymphoproliferation is a life-threatening complication a

195 Lymphoproliferation is believed to be caused by impaired

196 Histologically, the lymphoproliferation is characterized by plasmablasts tha

197 Posttransplant lymphoproliferation is most often observed in pediatric

198 ninfected, nonpregnant mice, suggesting that lymphoproliferation is not a good indicator of the antim

199 CI promotes antibody production and inhibits lymphoproliferation is not understood.

200 cterized by progressive immunodeficiency and lymphoproliferation, known as murine AIDS (MAIDS).

201 was sufficient to trigger aggressive B-cell lymphoproliferation, leading to early postnatal lethalit

202 TLA-4 die at an age of 2-3 wk due to massive lymphoproliferation, leading to lymphocytic infiltration

203 homozygous gld mutations cause age-dependent lymphoproliferation, limiting the gld mutation to one al

204 We measured HCV-specific lymphoproliferation (LP), intrahepatic cytotoxic T lymph

205 Mice with spontaneous lymphoproliferation (lpr) and generalized lymphoprolifer

206 Wild-type and Fas-deficient lymphoproliferation (lpr) mice underwent bile duct ligat

207 ween this syndrome and that in mice with the lymphoproliferation (lpr) phenotype or the generalized-l

208 -nonbinding CTLA-4 mutant delayed the lethal lymphoproliferation observed in CTLA-4-deficient mice.

209 prevents all features characteristic of the lymphoproliferation observed in CTLA-4-deficient mice.

210 rlier occurrence of autoantibodies; a higher lymphoproliferation of B and T cells; and an earlier ons

211 ular lymphocyte (T-LGL) leukemia is a clonal lymphoproliferation of cytotoxic T cells (CTLs) associat

212 phocyte (T-LGL) leukemia is a chronic clonal lymphoproliferation of cytotoxic T cells often associate

213 ular lymphocyte leukemia is a chronic clonal lymphoproliferation of cytotoxic T cells often associate

214 eukemia (T-LGLL) is characterized by chronic lymphoproliferation of cytotoxic T lymphocytes (CTLs) an

215 a (T-LGL) is characterized by chronic clonal lymphoproliferation of cytotoxic T lymphocytes (CTLs).

216 In another patient with lymphoproliferation of donor lymphocyte origin, blood EB

217 ated by EBV contribute to the characteristic lymphoproliferation of IM.

218 on 2 patients demonstrated that spontaneous lymphoproliferation of PBLs was present but decreased re

219 Lymphoproliferation of selected CD4+ T cells was shared

220 erum antibodies to Chlamydia and significant lymphoproliferation of T-cells following stimulation wit

221 ion at 11 DPI but no detectable Env-specific lymphoproliferation or ex vivo gamma interferon (IFN-gam

222 ents the disease development without causing lymphoproliferation or immune suppression.

223 ey did not develop spontaneous autoimmunity, lymphoproliferation, or germinal center expansion althou

224 ss-switched memory B cells and propensity to lymphoproliferation (P = .002) in patients with CVID.

225 esponses that trended higher than Dryvax for lymphoproliferation (P = .06), but lower for IFN-gamma E

226 m infants had diminished poliovirus-specific lymphoproliferation (P<.001).

227 ls (P=.02) and higher rubella virus-specific lymphoproliferation (P=.002).

228 that, at least in NZB, the autoimmunity and lymphoproliferation phenotypes are not linked geneticall

229 ts also emphasize the importance of IL-6 for lymphoproliferation, possibly through induction of IL-2R

230 However, HIV-1-specific lymphoproliferation remained largely undetectable throug

231 ctivation was analyzed by flow cytometry and lymphoproliferation, respectively.

232 essing gp160/LAMP had greater gp160-specific lymphoproliferation responses and higher titers of anti-

233 Lymphoproliferation responses in vaccinia-nonnaive indiv

234 entity in which a bone marrow clonal B-cell lymphoproliferation results in autoimmune hemolytic anem

235 This spontaneous lymphoproliferation (SP) is one of the immunologic hallm

236 L13, SPP1), activated B-cell subtype (MUM1), lymphoproliferation (SPP1, TCL1A, CHI3L1), aggressive cl

237 d individuals can result in malignant B cell lymphoproliferations, such as PTLD.

238 that the increase in cell numbers was due to lymphoproliferation that occurred in situ.

239 In these lymphoproliferations, the KSHV-infected cells carry the

240 Unexpectedly, there was no progression of lymphoproliferation through 24 weeks, even though immune

241 Lymphoproliferation to HHV-7 lysate was demonstrated in

242 Marked increases in lymphoproliferation to HPV--11 L1 antigens were noted af

243 Significant lymphoproliferation to these peptides was observed in 12

244 autoimmune disease manifestations, including lymphoproliferation, vasculitis, glomerulonephritis, and

245 velop an autoimmune disease characterized by lymphoproliferation, vasculitis, glomerulonephritis, aut

246 In one patient, lymphoproliferation was associated with high titres whic

247 Lymphoproliferation was completely suppressed in B6CD4KO

248 d monitoring strategy detecting peripheral B lymphoproliferation was effective in the early diagnosis

249 ibodies, and their effect on mitogen-induced lymphoproliferation was examined.

250 utations in 8 families, up to 48 years after lymphoproliferation was first documented.

251 In addition, lymphoproliferation was induced after vaccination in per

252 (purified protein derivative [PPD])-induced lymphoproliferation was markedly impaired in vaccinated

253 treat ALPS, and found rapamycin's control of lymphoproliferation was superior.

254 Virus antigen-specific lymphoproliferation was vigorous in some LTNPs.

255 mice in that the number of CLL among B-cell lymphoproliferations was significantly elevated in the f

256 nd NF-kappaB activation, IL-2 secretion, and lymphoproliferation were inhibited by fish oil feeding.

257 ells and peripheral tissues played a role in lymphoproliferation, whereas the skin disease phenotype

258 early onset and aggressive polyclonal T cell lymphoproliferation with concomitant B cell expansion an

259 eatment, all patients showed amelioration of lymphoproliferation with lymph node sizes and spleen vol