ライフサイエンスコーパス: lymphotoxin-alpha

1 of two test antibodies, humAb4D5-8 and anti-lymphotoxin alpha.

2 affinity of poxvirus TNFRs for TNFalpha over lymphotoxin-alpha.

3 40+) and produce IL-6, IL-10, TNF-alpha, and lymphotoxin-alpha.

4 activation on macrophages by T cell-derived lymphotoxin alpha(1)beta(2) controls proinflammatory res

5 different cytotoxic TNF family ligands: TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related

6 tic deletion of lymphotoxin beta receptor or lymphotoxin alpha abrogated development of lymphatic ves

7 t al report that Reed-Sternberg cell-derived lymphotoxin-alpha activates endothelial cells to enhance

8 because TNFR knockout (KO), TNF KO, and TNF/lymphotoxin alpha and beta triple KO mice showed 2- to 3

9 ceptor expressed by T lymphocytes (LIGHT) or lymphotoxin alpha and BTLA.

10 model decreased the muscle protein levels of lymphotoxin alpha and Il17a by 32% and 42%, respectively

11 ember, BALM, unique to fish; 3) orthologs of lymphotoxins alpha and beta were not clearly identified

12 ontribute to splenic organization, including lymphotoxins alpha and beta.

13 rdiaI infarction with the LTA gene (encoding lymphotoxin-alpha), and a follow-up study found that an

14 ts and effector molecules (interferon gamma, lymphotoxin alpha, and myxovirus resistance 1) were redu

15 238] and TNFA [-308]), the gene that encodes lymphotoxin-alpha, and alleles of the TNF-alpha microsat

16 ion of BM B cells is dependent on TNF-alpha, lymphotoxin-alpha, and both TNF receptors, TNFR1-p55 and

17 files with differential production of CD40L, lymphotoxin-alpha, and interferon-gamma.

18 e canonical TNF-related cytokines, LIGHT and Lymphotoxin-alpha, and the Ig-related membrane proteins,

19 al kinase activation and secretion of IL-10, lymphotoxin-alpha, and TNF-alpha were partially blocked.

20 uired for development of the MZ, i.e., muMT, lymphotoxin-alpha, and TNFR1.

21 Thus, TNF-alpha and lymphotoxin-alpha are required for loss of BM B lineage

22 onses, the conventional TNF ligand LIGHT and lymphotoxin alpha, as well as herpes simplex virus glyco

23 ear if soluble LT alpha 3, and/or cell-bound lymphotoxin-alpha beta (LT alpha beta) mediate these dev

24 The lymphotoxin-alpha beta complex (LT alpha beta) is found

25 he woodchuck tumor necrosis factor (TNF) and lymphotoxin-alpha, -beta (LT-alpha, -beta) cDNAs, genes

26 s the lymphorganogenic cytokines/chemokines, lymphotoxin-alpha/-beta, CCL19, CCL20, CCL21, and CXCL13

27 nct from regions where the ligands LIGHT and lymphotoxin-alpha bound HVEM.

28 recruitment was independent of L-selectin or lymphotoxin-alpha but required CCR7 expression.

29 king either lymphotoxin beta receptor or the lymphotoxin alpha-chain, and there was minimal overlap b

30 s in infection by and immunity to rotavirus, lymphotoxin alpha-deficient (LTalpha(-/-)) mice that lac

31 Lymphotoxin alpha-deficient (LTalpha-/-) mice show drama

32 Lymphotoxin alpha-deficient (LTalpha-/-) mice, which lac

33 ne the role of lymph node in CNV, we lasered lymphotoxin alpha-deficient mice (LTalpha-/-) and measur

34 We demonstrate in this report that lymphotoxin alpha-deficient mice develop CD8(+) T cells

35 es of transitional B cells in splenectomized lymphotoxin alpha-deficient mice that lack all secondary

36 Lymphotoxin- alpha-deficient (LTalpha(-/-)) mice have no

37 Lymphotoxin-alpha-deficient (LT-alpha-/-) mice manifest

38 Neutralization of IL-17 in CCR7(-/-) or in lymphotoxin-alpha-deficient animals specifically inhibit

39 Lymphotoxin-alpha-deficient mice infected with RSV were

40 CD8(+) RTEs efficiently populated the gut of lymphotoxin-alpha-deficient mice, which lack lymphoid or

41 egins, ftILCPs accumulate at PP anlagen in a lymphotoxin-alpha-dependent manner.

42 gene (TNF-308) and the +250 site within the lymphotoxin-alpha gene (LT alpha+250) on the risk of pro

43 The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attenti

44 TNF-beta that is encoded by lymphotoxin-alpha gene (LTA) regulates adhesion molecule

45 Polymorphisms in the TNF-alpha and lymphotoxin alpha genes influence TNF-alpha production.

46 on and by polymorphisms in the TNF-alpha and lymphotoxin alpha genes.

47 xpression, as infected mice deficient of TNF/lymphotoxin-alpha genes did not demonstrate attenuated c

48 40 to induce expression of CD23, ICAM-1, and lymphotoxin-alpha genes in B cells.

49 onsiveness to fish oil appeared unrelated to lymphotoxin alpha genotype.

50 ype was 6 times more frequent than the other lymphotoxin alpha genotypes among responsive individuals

51 examined the relation between TNF-alpha and lymphotoxin alpha genotypes and the ability of dietary f

52 Anti-lymphotoxin alpha has fast nonspecific clearance in cyno

53 IL-17 acted by promoting lymphotoxin-alpha-independent expression of the chemokin

54 c variation at the human LTA locus, encoding lymphotoxin-alpha, is associated with susceptibility to

55 ng wild-type control mice and splenectomized lymphotoxin alpha knockout (LT) mice deficient in SLOs a

56 Lymphotoxin alpha knockout mice lacking Peyer's patches

57 Lymphotoxin alpha (LT alpha)-deficient mice revealed cri

58 ntenance in germinal centers is dependent on lymphotoxin alpha (LT-alpha) and LT-beta signaling compo

59 In mice deficient in either lymphotoxin alpha (LT-alpha) or type I tumor necrosis fa

60 Although lymphotoxin-alpha (LT alpha) has been shown to be requir

61 Lymphotoxin-alpha (LT alpha) has recently been demonstra

62 Human lymphotoxin-alpha (LT alpha) is found in a secreted form

63 ols were genotyped for six biallelic TNF and lymphotoxin-alpha (LT alpha) polymorphisms and eight cla

64 Mice deficient in lymphotoxin-alpha (LT alpha-/- mice) have no lymph nodes

65 We identify surface lymphotoxin-alpha (LT-alpha) as common to T(H)0, T(H)1 a

66 In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosi

67 is factor receptor-associated factor family, lymphotoxin-alpha (LT-alpha), and a membrane-associated

68 Using lymphotoxin-alpha-(LT-alpha)-, TNF-alpha-, or TNFRp55-de

69 e polymorphism (SNP) haplotype involving the lymphotoxin alpha (LTA) and tumor necrosis factor (TNF)

70 se hypersensitive sites corresponding to the lymphotoxin alpha (LTA) and tumour necrosis factor (TNF)

71 modified by a functional polymorphism in the lymphotoxin alpha (LTA) gene (LTA C+80A, where the CC ge

72 We now demonstrate a critical role for lymphotoxin alpha (LTA) in the pathogenesis of Sjogren's

73 were determined for polymorphisms in the TNF/lymphotoxin alpha (LTA) region.

74 in B cells (lkappaBL), inhibitor-like 1 and lymphotoxin alpha (LTA), in relation to nutritional iron

75 within a 4.5-kb region encompassing TNF and lymphotoxin alpha (LTA).

76 olymorphisms in the TNF -308G>A (rs1800629), lymphotoxin-alpha (LTA) 252A>G (rs909253), IL10 -3575T>A

77 The TNF-alpha (TNF) and lymphotoxin-alpha (LTA) genes belong to the TNF gene sup

78 The proinflammatory cytokine lymphotoxin-alpha (LTA) is thought to contribute to the

79 n separated by sex, a variant in intron 1 of lymphotoxin-alpha (LTA), a gene adjacent to TNF, was ass

80 ndertaken, and the pro-inflammatory cytokine lymphotoxin-alpha (LTA), and its key ligand galectin-2 (

81 at HVEM binds two cellular ligands, secreted lymphotoxin alpha (LTalpha) and LIGHT, a new member of t

82 Lymphotoxin alpha (LTalpha) can exist in soluble form an

83 We show that targeted mutation of the lymphotoxin alpha (LTalpha) gene efficiently rescued tum

84 contrast, the role of the related cyto-kine lymphotoxin alpha (LTalpha) in CM has been overlooked.

85 The importance of lymphotoxin alpha (LTalpha) in lymphoid organogenesis is

86 sized the role of type 1 IFN (IFN-alpha) and lymphotoxin alpha (LTalpha) in the pathogenesis of the d

87 Lymphotoxin alpha (LTalpha) signals via tumor necrosis f

88 Tumor necrosis factor alpha (TNFalpha) and lymphotoxin alpha (LTalpha, originally TNFbeta) are pote

89 ECT CrmD cysteine-rich region bound TNF and lymphotoxin-alpha (LTalpha) and blocked their in vitro c

90 d membrane extracts detected the presence of Lymphotoxin-alpha (LTalpha) but not tumor necrosis facto

91 association between genetic variants in the lymphotoxin-alpha (LTalpha) gene and leprosy.

92 udy, we show in vitro that HRS cells secrete lymphotoxin-alpha (LTalpha) which acts on endothelial ce

93 Lymphotoxin-alpha (LTalpha)(-/-) and LTbetaR(-/-) mice s

94 Lymphotoxin-alpha (LTalpha), a cytokine crucial for deve

95 Lymphotoxin-alpha (LTalpha), lymphotoxin-beta (LTbeta),

96 enes, including interferon-gamma (IFNgamma), lymphotoxin-alpha (LTalpha), tumor necrosis factor-alpha

97 phoid organs, NALT develops independently of lymphotoxin-alpha (LTalpha).

98 Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought t

99 TNF/LTalpha/LTbeta (tumor necrosis factor/lymphotoxin-alpha/lymphotoxin-beta) triple knockout (KO)

100 nhanced C5aR expression in the brains of TNF/lymphotoxin-alpha -/- mice and in normal animals even in

101 the genes for TNF and lymphotoxin-alpha (TNF/lymphotoxin-alpha -/- mice) showed significantly attenua

102 mmune response by reversing the LN defect in lymphotoxin-alpha(-/)- mice, thereby restoring the capac

103 Similar results were obtained in lymphotoxin alpha-/- mice, which lacked peripheral lymph

104 receptors that share the HVEM ligands LIGHT, Lymphotoxin-alpha, or BTLA.

105 induced by CD4(+) thymocytes via CD80/86 and lymphotoxin-alpha signals.

106 on, since mice lacking the genes for TNF and lymphotoxin-alpha (TNF/lymphotoxin-alpha -/- mice) showe

107 ocument a novel link between IL-12Rbeta2 and lymphotoxin-alpha, TNF-alpha, and IFN-gamma expression,

108 vated T cells and impaired overexpression of lymphotoxin-alpha, TNF-alpha, and IFN-gamma in the brain

109 hisms in the TNF-alpha (TNF*1 and TNF*2) and lymphotoxin alpha (TNFB*1 and TNFB*2) genes were determi

110 selectively binds and inhibits TNF/TNFR1 and lymphotoxin-alpha/TNFR1 signaling with good affinity and