ライフサイエンスコーパス: lymphotoxin-beta

1 the hTNFR2 blocks the biological activity of lymphotoxin beta.

2 t CrmB and CrmD also inhibit the activity of lymphotoxin beta.

3 eron-gamma, tumor necrosis factor-alpha, and lymphotoxin-beta.

4 ive CD4 and CD8 T-cell subsets and decreased lymphotoxin-beta, a key factor for maintenance of FRC ne

5 s, which, in turn, removed a major source of lymphotoxin-beta, a survival factor for FRCs during SIV

6 (tumor necrosis factor alpha, IL-1beta, and lymphotoxin-beta), and leukocyte genes (S100A9, Aif1/Iba

7 on of lymphoid chemokines CXCL13, CCL19, and lymphotoxin-beta, and is associated with development of

8 anistically, we show that CD8(+) T cells and lymphotoxin beta are central mediators of HCC formation.

9 Lymphotoxin beta-deficient mice also showed substantial

10 We report that lymphotoxin beta-deficient mice form GC cell clusters in

11 resembling that observed in B-cell-specific lymphotoxin-beta-deficient mice, including disruption of

12 find that grb2(-/-) B cells are defective in lymphotoxin-beta expression.

13 AT5 regulates expression of the TNFalpha and lymphotoxin-beta genes in osmotically stressed T cells.

14 DCs were the main producers of lymphotoxin beta in freshly resected HEV(high) breast tu

15 TNF family that also includes TNF-alpha and lymphotoxin-beta (LT beta).

16 complex with a second related protein called lymphotoxin-beta (LT beta).

17 through the TNF receptor family member, the lymphotoxin-beta (LT-beta) receptor (LT-betaR), also reg

18 promoter regions, a CpG island in exon 4 of lymphotoxin beta (LTB), the 3' end of nuclear factor of

19 phage colony-stimulating factor (GM-CSF) but lymphotoxin beta (LTbeta) does not.

20 Lymphotoxin beta (LTbeta) expression in DCs maintained A

21 Endothelial cell (EC)-specific lymphotoxin beta (LTbeta) receptor signaling is critical

22 Lymphotoxin beta (LTbeta), a cytokine produced by T cell

23 Lymphotoxin-beta (LTbeta) is a key regulator of immune s

24 A lymphotoxin-beta (LTbeta) receptor-Ig fusion protein (LT

25 Lymphotoxin-alpha (LTalpha), lymphotoxin-beta (LTbeta), and tumor necrosis factor-alp

26 osis factor (TNF), interleukin-1 (IL-1), and lymphotoxin-beta (LTbeta).

27 variant NF-kappaB-signaling cascade based on lymphotoxin-beta (LTbeta)/RelB.

28 s and that this loss was caused by decreased lymphotoxin-beta mainly produced by the CD4 T cells.

29 dendritic cells (FDC) may act, we challenged lymphotoxin beta null and wild-type (wt) controls with a

30 tumor necrosis factor (TNF)-alpha, TNF-beta, lymphotoxin-beta, or TNFR1, TNFR2, Fas, or death recepto

31 eatment with interferon-gamma, which induced lymphotoxin beta receptor (LT beta R) expression, was re

32 implex virus entry mediator (HVEM) and LIGHT/lymphotoxin beta receptor (LT beta R) interactions decre

33 The lymphotoxin beta receptor (LT beta R) was originally des

34 is study demonstrates enhanced expression of lymphotoxin beta receptor (Lt betaR) during the demyelin

35 Recent studies revealed that the lymphotoxin/lymphotoxin beta receptor (LT)/LTbetaR system activates

36 We found that a soluble decoy lymphotoxin beta receptor (LT-betaR)-Fc, which can block

37 Our previous studies indicated that lymphotoxin beta receptor (LTbetaR) activation controls

38 ediated by at least two receptors, including lymphotoxin beta receptor (LTbetaR) and herpes simplex v

39 cells including HT29 cells that express both lymphotoxin beta receptor (LTbetaR) and HVEM/TR2 recepto

40 tosis of various tumor cells expressing both lymphotoxin beta receptor (LTbetaR) and TR2/HVEM recepto

41 or receptors (TNFRs) as a homotrimer and via lymphotoxin beta receptor (LTbetaR) as a heterotrimeric

42 Lymphotoxin beta receptor (LTbetaR) blockade reduces hom

43 eady-state and after bone marrow transplant, lymphotoxin beta receptor (LTbetaR) controls entry of T

44 Lymphotoxin beta receptor (LTbetaR) deficiency is associ

45 onditional gene-deficient mice, we find that lymphotoxin beta receptor (LTbetaR) directly controls th

46 DC-derived lymphotoxin beta receptor (LTbetaR) ligands were critica

47 Lymphotoxin beta receptor (LTbetaR) ligation-induced Air

48 (LT)alpha(1)beta(2) on inducer cells and the lymphotoxin beta receptor (LTbetaR) on stromal cells ini

49 fusion protein between the IgG Fc domain and lymphotoxin beta receptor (LTbetaR) reduces lung fibrosi

50 bind the cytoplasmic domains of CD40 and the lymphotoxin beta receptor (LTbetaR), both of which are k

51 inflammation mediated by LIGHT, a ligand for lymphotoxin beta receptor (LTbetaR), not only stimulates

52 fic deletion of the thymus medulla regulator lymphotoxin beta receptor (LTbetaR), we show that thymic

53 a substantial reduction in the expression of lymphotoxin beta receptor (LTbetaR)-controlled migration

54 Lymphotoxin beta receptor (LTbetaR)-driven induction of

55 Administration of lymphotoxin beta receptor (LTbetaR)-Ig to wild-type mice

56 Lymphotoxin beta receptor (LTbetaR)-induced activation o

57 to that of homozygosity for deletion of the lymphotoxin beta receptor (LTbetaR).

58 these genes in response to engagement of the lymphotoxin beta receptor (LTbetaR).

59 nt region of IgG and extracellular domain of lymphotoxin beta receptor (LTbetaRIg) interrupted clonal

60 Components of lymphotoxin beta receptor (LTBR)-associated signaling co

61 Induction of PNAd in mutant PPs requires lymphotoxin beta receptor activity, and its upregulation

62 f lymphotoxin was confirmed, as the use of a lymphotoxin beta receptor agonist results in partial res

63 both of its identified signaling receptors, lymphotoxin beta receptor and herpes virus entry mediato

64 rmation was dependent on lymphotoxin and the lymphotoxin beta receptor and independent of lymphocytes

65 LIGHT protected mice from colitis via the lymphotoxin beta receptor and was expressed mainly by my

66 ion of LT and LIGHT signaling with a soluble lymphotoxin beta receptor decoy protein attenuated the d

67 LIGHT signals through the lymphotoxin beta receptor in the colon to regulate the i

68 xin axis, and pharmacological stimulation of lymphotoxin beta receptor might represent a novel therap

69 s, herpesvirus entry mediator on T cells and lymphotoxin beta receptor on stromal cells, are implicat

70 Genetic deletion of lymphotoxin beta receptor or lymphotoxin alpha abrogated

71 lary epithelial cells of mice lacking either lymphotoxin beta receptor or the lymphotoxin alpha-chain

72 ory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.

73 mphangiogenesis in the thyroid and implicate lymphotoxin beta receptor signaling in this process.

74 Notch-dependent Esam(hi) DC subset required lymphotoxin beta receptor signaling, proliferated in sit

75 found that an agonistic antibody against the lymphotoxin beta receptor was able to facilitate liver r

76 ts receptors, herpesvirus entry mediator and lymphotoxin beta receptor, are found in T cells and stro

77 e protein binds to the cytoplasmic domain of lymphotoxin beta receptor, which is a member of tumor ne

78 tinal inflammation when transferred into the lymphotoxin beta receptor-deficient mice, and herpes vir

79 belonging to the TNF superfamily, by soluble lymphotoxin beta receptor-Ig (LTbetaR-Ig) inhibits the c

80 Blockade of LIGHT by its soluble receptors, lymphotoxin beta receptor-Ig or HVEM-Ig, inhibits the in

81 d state, blockade of this stimulation with a lymphotoxin beta receptor-immunoglobulin fusion protein

82 ands, including those that bind CD30 and the lymphotoxin beta receptor.

83 that CD30 signals predated those through the lymphotoxin beta receptor.

84 IGHT receptors herpesvirus entry mediator or lymphotoxin beta receptor.

85 4 interacts with the cytosolic domain of the lymphotoxin-beta receptor (LT beta R) and weakly with th

86 Here we report that blocking LT alpha beta/lymphotoxin-beta receptor (LT beta R) interaction in viv

87 Lymphotoxin-beta receptor (LT beta R) is a member of tum

88 hese clones encode the cytoplasmic domain of lymphotoxin-beta receptor (LT betaR), which is a member

89 osis factor-alpha (TNF-alpha), whereas decoy lymphotoxin-beta receptor (LT-betaR) fusion protein had

90 nsduction of the TNF receptor 2 (TNFR2), the lymphotoxin-beta receptor (LT-betaR), CD40, CD30, and LM

91 ult mice was reduced by systemic blockade of lymphotoxin-beta receptor (LTbeta R) signaling with a so

92 re NIK for activation of NF-kappaB, only the lymphotoxin-beta receptor (LTbeta-R) is expressed in mel

93 The lymphotoxin-beta receptor (LTbetaR) activates the NF-kap

94 Lymphotoxin-beta receptor (LTbetaR) and CD40 are members

95 K) and TNF receptor family members including lymphotoxin-beta receptor (LTbetaR) and CD40.

96 ammatory mechanism, including membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine re

97 LIGHT engages the lymphotoxin-beta receptor (LTbetaR) and HVEM (TNFRSF14),

98 r, which binds two known cellular receptors, lymphotoxin-beta receptor (LTbetaR) and the herpesvirus

99 this effect through the interaction with the lymphotoxin-beta receptor (LTbetaR) but not herpes virus

100 Ligation of the lymphotoxin-beta receptor (LTbetaR) by LIGHT (lymphotoxi

101 Moreover, we show that signals through the lymphotoxin-beta receptor (LTbetaR) in DC are also requi

102 R4-activated canonical NF-kappaB pathway and lymphotoxin-beta receptor (LTbetaR) induced non-canonica

103 The lymphotoxin-beta receptor (LTbetaR) plays critical roles

104 Ligation of the lymphotoxin-beta receptor (LTbetaR) recruits tumor necro

105 romal cell microenvironments is dependent on lymphotoxin-beta receptor (LTbetaR) signaling.

106 Lymphotoxin-beta receptor (LTbetaR), a member of the tum

107 equires innate lymphoid cells, which promote lymphotoxin-beta receptor (LTbetaR)-dependent maintenanc

108 ors, herpes virus entry mediator (HVEM), and lymphotoxin-beta receptor (LTbetaR).

109 high), is dependent on signaling through the lymphotoxin-beta receptor (LTbetaR).

110 SF-14) is a ligand of stromal cell-expressed lymphotoxin-beta receptor and T cell-expressed herpes vi

111 of six single chain-Fv fragments of the anti-lymphotoxin-beta receptor antibody, statistically signif

112 Conversely, stimulation of lymphotoxin-beta receptor by agonistic antibody leads to

113 Signaling through the lymphotoxin-beta receptor controlled the fate of adipocy

114 de development during embryogenesis involves lymphotoxin-beta receptor engagement and subsequent diff

115 al-associated lymphoid tissue by LTbetaR-Ig (lymphotoxin-beta receptor human Ig fusion protein) treat

116 nobese diabetic (NOD) mice were treated with lymphotoxin-beta receptor immunoglobulin fusion protein

117 CICD was strongly activated by both TNF and lymphotoxin-beta receptor ligation in IKKbeta-/- MEFs an

118 as well as pharmacological inhibition of the lymphotoxin-beta receptor markedly delays tumor developm

119 LIGHT, a ligand for the lymphotoxin-beta receptor, establishes lymphoid-like tis

120 nd on activated lymphocytes and binds to the lymphotoxin-beta receptor, which is generally present on

121 on in the thymi of lymphotoxin-deficient and lymphotoxin-beta receptor-deficient mice contributes to

122 In lymphotoxin-beta receptor-Ig-treated mice, which lack LN

123 ions including BO, and that treatment with a lymphotoxin-beta receptor-immunoglobulin fusion protein

124 75 neurotrophin receptor and weakly with the lymphotoxin-beta receptor.

125 tion, BALB/c mice were treated in utero with lymphotoxin beta-receptor Ig fusion protein to generate

126 is factor superfamily member LIGHT activates lymphotoxin beta-receptor signaling, leading to the prod

127 activated, LTalphabeta(+), lymphocytes with lymphotoxin beta-receptor-expressing fibrosarcoma tumor

128 Coexpression of a soluble lymphotoxin beta-receptor:Ig fusion protein, an inhibito

129 ated by intragraft TLOs and whether blocking lymphotoxin-beta-receptor (LTbetaR) signaling, a pathway

130 Meanwhile, vascular smooth muscle cell lymphotoxin beta receptors (VSMC-LTbetaRs) protected aga

131 estingly, both the tumor necrosis factor and lymphotoxin beta receptors were down-regulated by NS5A.

132 analyzed death after ligation of the TNF and lymphotoxin-beta receptors, respectively.

133 to the cytosolic domains of CD30, CD40, and lymphotoxin-beta receptors.

134 tory cytokines, such as IL-1alpha, IL-1beta, lymphotoxin beta, TNFalpha, and IL-6, also increased.

135 colony-stimulating factor, stem cell factor, lymphotoxin beta, transforming growth factor beta1, and

136 eta (tumor necrosis factor/lymphotoxin-alpha/lymphotoxin-beta) triple knockout (KO) mice show a signi

137 We found that lymphotoxin beta was overexpressed in tumors containing

138 kin (IL)-2, interferon-gamma (IFN-gamma) and lymphotoxin-beta, which mediate pro-inflammatory functio