ライフサイエンスコーパス: lysin

1 N)SGGG, removing their C-terminal structural lysin.

2 , VERL, complexed with cognate sperm protein lysin.

3 ic peptide derived from staphylococcal delta-lysin.

4 ys-C yields a diGly motif attached to target lysines.

5 the dichlorotriazine favored reactivity with lysines.

6 ng the solvent inaccessibility of the target lysines.

7 ed stable crosslink formation at telopeptide lysines.

8 ii) reductive methylation to dimethylate all lysines.

9 additionally requires contributions of other lysines.

10 ation enzymes are autoneddylated at multiple lysines.

11 es malonyl and succinyl moieties from target lysines.

12 indicating accommodation of the neighboring lysines.

13 nd Lys-322 were identified as SIRT3-targeted lysines.

14 s containing two or more adjacent acetylated lysines.

15 tions with enhanced reactivity for substrate lysines.

16 h demethylating mono-, di-, or trimethylated lysines.

17 ith ubiquitin attachment sites mapped to six lysines.

18 by a mechanism dependent upon cytosolic GDU1 lysines.

19 ne domain, and 3) close to the ubiquitinated lysines.

20 by acetylation (neutralization) of multiple lysines.

21 hat control the ubiquitination state of ENaC lysines.

22 ely; P < .01) with preferential glycation of lysines 107 and 557, sites involved in fibrin binding an

23 glutamine concentration, GS is acetylated at lysines 11 and 14, yielding a degron that is necessary a

24 ay crystallography, we found that acetylated lysines 115 and 122 in histone H3 are solvent accessible

25 Instead, we found that acetylation of lysines 115 and 122 increases the predisposition of nucl

26 volving arginines 102, 104, 106, and 107 and lysines 117 and 119.

27 uring neutrophil development, acetylation of lysines 121 and 198 were found to be crucial for termina

28 Lysines 16 and 20 seem to play a greater role in reactin

29 e simultaneous pseudo-acetylation of hTau at lysines 163, 280, 281 and 369 drastically decreased hTau

30 generation of Lin(Ub)n-Bcl10 requires Bcl10 lysines 17, 31, and 63, CARD11, MALT1, and the HOIP subu

31 ed and used to determine that acetylation of lysines 19 and 26 of MPC2 is enhanced in Akita heart mit

32 TRalpha was sumoylated at lysines 283 and 389, and TRbeta at lysines 50, 146, and

33 further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these

34 mined by mass spectrometry, were found to be lysines 340, 383, and 410, which are all located on the

35 tic stem and progenitor cells and a novel NK-lysin 4(+) cell type, representing a putative cytotoxic

36 ed T cells with a subsequent expansion of NK-lysin 4(+) cells and myeloid cells.

37 dy-state levels of methylation at histone H3 lysines 4 (H3K4me) and 36 (H3K36me) were sensitive to mu

38 Cotranscriptional methylation of histone H3 lysines 4 and 36 by Set1 and Set2, respectively, stimula

39 ng RA exposure, and we found that histone H3 lysines 4 and 9 are demethylated by the lysine-specific

40 hyltransferase with highest activity towards lysines 4 and 9.

41 Histone H3 trimethylated at lysines 4 or 27 is present during transcription but, sur

42 IM5alpha internal lysines with Ub especially lysines 45 and 50, rather than modifying the N-terminal

43 We demonstrate that mutations in histone H4 lysines 5 and 12 in yeast confer hypersensitivity to rep

44 etylation of newly synthesized histone H4 at lysines 5 and 12 that accompanies replication-coupled ch

45 elated with the acetylation of histone H4 on lysines 5 and 12, but not with acetylation of histone H3

46 olein reacts with lysine residues, including lysines 5 and 12, sites important for chromatin assembly

47 he diacetylation of the NH2-terminal tail on lysines 5 and 12.

48 l location 1.5, but other amino acids (e.g., lysines 5, 8, and 12) compensate in their absence.

49 ylated at lysines 283 and 389, and TRbeta at lysines 50, 146, and 443.

50 ythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and

51 found that alpha-synuclein is acetylated on lysines 6 and 10 and that these residues are deacetylate

52 equired Lys(48)-linked polyubiquitination of lysines 767/771 in the C-terminal domain of the GABAB2 s

53 histones H3 and H4 undergo trimethylation at lysines 9 (H3K9), 27 (H3K27), 79 (H3K79), and 20 (H4K20)

54 rized by increased methylation of histone H3 lysines 9 and 27 (H3K9 and H3K27).

55 s are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26.

56 he Pcsk9 gene and deacetylates histone H3 at lysines 9 and 56, thereby suppressing the gene expressio

57 ethodology of studying E. coli cell lysis by Lysin A and its truncations after expressing these prote

58 nly one of these domains and the full-length Lysin A caused M. smegmatis cell lysis.

59 Our experiments establish that Lysin A harbors two catalytically active domains, both o

60 so demonstrate that the C-terminal domain of Lysin A selectively binds to M. tuberculosis and M. smeg

61 Several truncated versions of Lysin A were constructed, and their activities were anal

62 tion and regulation of mycobacteriophage D29 Lysin A.

63 ys(1107), and the combined mutation of these lysines almost completely eliminated both the ubiquitina

64 We previously demonstrated that cNK-lysin and cNK-2, a synthetic peptide incorporating the c

65 These rapidly adduct to protein lysines and are presented by dendritic cells as neoantig

66 We address this issue for lysines and arginines in designed transmembrane helices.

67 ositions due to the insertion of "anchoring" lysines and arginines into the DNA minor grooves.

68 The specific arrangement and number of the lysines and arginines of the PBD vary among the lipins.

69 pB), which differ in their selectivity after lysines and arginines, respectively, collectively accoun

70 mologs indicated conservation of a series of lysines and arginines, which could represent a nuclear l

71 element (IN2GHRE) histone methylation of key lysines and DNA methylation.

72 Here, we combined chemical modification of lysines and multiple-reaction monitoring mass spectromet

73 he bromodomain (BD), which recognizes acetyl-lysines and recruits proteins to sites of acetylation ac

74 o-glutamine (KQ) mutants to mimic acetylated lysines and screened 15 KQ mutants.

75 s are, with time, polyubiquitinated on other lysines and targeted to degradation.

76 lts illustrate how a protein exploits unique lysines and the metal distribution to accomplish lysine

77 d for rapid screening of engineered chimeric lysins and report a unique "chimeolysin", ClyR, with rob

78 ed that LOG2 ubiquitinates GDU1 at cytosolic lysines, and GDU1 protein levels decreased upon co-expre

79 These results demonstrate that coumarin lysines are a new and valuable class of optical probes t

80 Lysines are acetylated in histone tails and the core dom

81 w that in the bound structure, the conserved lysines are important for membrane binding, whereas the

82 Although lysines are known to be critical for ligand binding to L

83 rated two SMN mutants, SMN(K0), in which all lysines are mutated to arginines and thereby abolishing

84 By comparison, these lysines are not conserved in Xenopus laevis Ku, and Ku f

85 ns indicate that the roles of the individual lysines are not equivalent and that helical lysines play

86 In eukaryotic proteins, lysines are often mono-, di-, or trimethylated, which ma

87 onjugating enzyme Ubc9, however the acceptor lysines are perfectly accessible in Ran/NTF2 complexes.

88 Our data indicate that internal lysines are the dominant Ub acceptor sites in both A3F a

89 Lysins are bacteriophage-derived enzymes that degrade ba

90 Autolysins and phage lysins are peptidoglycan hydrolases, enzymes that have e

91 Bacteriophage lysins are promising alternatives to antibiotics; howeve

92 ntrolled trials will determine if phages and lysins are safe and effective adjuncts or alternatives t

93 iotic resistance, phages and their products (lysins) are rediscovered as antibacterial bioagents.

94 The conservative changes of lysines at positions 111 and 112 to arginine were of par

95 dence is provided that the membrane-proximal lysines at positions 144 and 237, located in the Cx43 in

96 oA dehydrogenase 9, two related enzymes with lysines at positions equivalent to Lys-318/Lys-322, were

97 rationalized by hydrophobic interactions of lysines at the bilayer interface.

98 sheet model of PrP(Sc), not only would these lysines be clustered within the 101-110 region of the pr

99 I) chains as a result of their C-telopeptide lysines being more completely oxidized to aldehydes.

100 For lysines (but not arginines) at two locations within diol

101 The acetylation of as few as three lysines by aspirin in A4V apo-SOD1-a variant that causes

102 ate that binding domains from autolysins and lysins can be fused to the Fc region of human IgG, creat

103 For substrates without Ltn1p-accessible lysines, CAT-tailing enabled degradation by exposing lys

104 A lack of APP C-terminal lysines caused APP redistribution from endosomal intralu

105 xymethyl)lysine (CML), N(euro)-(carboxyethyl)lysin (CEL), and methylglyoxal-derived hydroimadazolidin

106 Lysin CF-301 is being developed to treat Staphylococcus

107 Chicken NK-lysin (cNK-lysin), the chicken homologue of human granul

108 to posttranslational modifications of these lysines contributed to gB/gH-gL cell-cell fusion.

109 ons of gly-262 and thr-269 in Hsp90beta with lysines convert Hsp90beta to a Hsp90alpha-like protein.

110 nto cells, a mutant version of Cx43 with all lysines converted to arginines behaved similarly to wild

111 e prepared constructs of Cx43 with different lysines converted to arginines.

112 Intriguingly, acetylation of several histone lysines correlated with the acetyl-CoA: (iso)butyryl-CoA

113 Escherichia coli, acetylation of proteins at lysines depends largely on a non-enzymatic acetyl phosph

114 surprising to find that acetylation of some lysines depends on binding of ORC to the origin, suggest

115 , in this study, we investigated whether cNK-lysin derived peptides modulate the immune response in t

116 search on the in vivo behavior of phages and lysins, dialogues between researchers and regulatory age

117 to 4 or 10, which could alter the charge of lysines, did not measurably impair DNA translocation or

118 Condensation with other allysines or lysines drives the formation of inter- and intramolecula

119 f ligand binding in which a proximal pair of lysines engages the negatively charged pocket of a CR do

120 hat RasG ubiquitination occurs at C-terminal lysines equivalent to lysines found in human K-Ras but n

121 electron microcopy indicated that bovine NK-lysins exhibited their antimicrobial activities by lytic

122 The ability to lyse bacterial cells make lysins extremely significant.

123 tion results from pausing on consecutive AAA-lysines followed by ribosome sliding on homopolymeric A

124 n act as a signal at five cytodomain-located lysines for endosomal sorting of APP.

125 DAIP contains 5 potential glutamines and 10 lysines for MTG-mediated cross-linking.

126 ubstrate-binding domain to prioritize target lysines for ubiquitination.

127 Additionally, those lysines for which the SETA reactivity increased under de

128 f the heavy and light chains and susceptible lysines), forming either hemiaminal (+148 Da) or Schiff

129 n occurs at C-terminal lysines equivalent to lysines found in human K-Ras but not in H-Ras and N-Ras

130 n clots by removing C-terminal arginines and lysines from partially degraded fibrin.

131 increased with considerable variation among lysines from the same protein.

132 site core, whereas the two other active site lysines from the two other domains are not able to move.

133 In summary, the single NK-lysin gene in other mammals has expanded to a four-membe

134 rovide evidence for the existence of four NK-lysin genes in a repetitive region on cattle chromosome

135 nine substitutions at other known methylated lysines (H3K9 and H3K36) are sufficient to cause specifi

136 ctions in affinity have been found when such lysines have been mutated.

137 ter the binding of FH19-20 to proteins where lysines have reacted with malondialdehyde (MDA).

138 e therapy reagents containing purified viral lysins have been developed against gram-positive organis

139 orating the core alpha-helical region of cNK-lysin, have antimicrobial activity against apicomplexan

140 The most potent lysin identified to date is PlyC, an enzyme assembled fr

141 tn1p efficiently accessed only nascent-chain lysines immediately proximal to the ribosome exit tunnel

142 ctrometry analysis, identifying 4 acetylated lysines in 3 distinct functional domains.

143 ly studies showed that sirtuins deacetylated lysines in a reaction that consumes NAD(+), more recent

144 We identify over a thousand sumoylated lysines in a total of 468 proteins and quantify changes

145 lization, as previously shown for acetylated lysines in H3 histone tails.

146 While acetylated lysines in histone tails are frequently recognized by ot

147 acyl groups from the epsilon-amino group of lysines in histones and other substrate proteins.

148 Ubiquitination of lysines in Hrd1's RING-finger domain is required for sub

149 e have quantified, in total, more than 9,000 lysines in human cell proteomes and have identified seve

150 San1 prevents this by containing no lysines in its disordered regions; thus the canonical re

151 ity, and robust activity was also reliant on lysines in Ku70 analogous to K31 and K160.

152 ent sorting is essential for modification of lysines in multiple collagen types.

153 t NeuCode SILAC partners enables counting of lysines in product ions, and when the information is use

154 re reversibly installed at the side chain of lysines in proteins.

155 terminus and two conserved phosphate-binding lysines in the beta-arrestin2 N-domain.

156 Mutational analysis of the lysines in the calmodulin-binding site revealed that Lys

157 Thus, Pro-102 and Pro-105, as well as the lysines in the central lysine cluster, impede amyloid fo

158 mediated acetylation on two conserved tandem lysines in the cohesin Smc3 subunit.

159 revealed that a highly conserved cluster of lysines in the gamma-ENaC N terminus regulates accessibi

160 /SNF and RSC, acetylation of lateral surface lysines in the histone octamer serves as a crucial regul

161 lustered in the N-terminal region but not at lysines in the oligomerization, intramembrane, or C-term

162 iquitin-like modifier) by mutating conserved lysines in the polyQ AR that are sites of SUMOylation.

163 Individual mutation of three solvent-exposed lysines in the villin headpiece subdomain significantly

164 rporation and conservation of arginines over lysines in these motifs.

165 Mutating a cluster of five lysines in this region largely eliminates Yku70 sumoylat

166 Attachment of SUMO moieties to internal lysines in Ubc9 itself can further lead to the formation

167 aradoxically, acetylation of p53 at the same lysines in various cancer cell lines leads to the induct

168 relates with acetylation of specific histone lysines in WAT but not in the liver.

169 Lysines in wild-type- and ALS-variant apo-SOD1 could als

170 (LLP) motifs and are scarcely substituted by lysines, in contrast to gp120 and the ectodomain of gp41

171 dules, condense the search radius for target lysines, increase the chance of active-site collision wi

172 We designed polyglutamines with a few lysines inserted to overcome the hindrance of extreme in

173 arlier finding that individual arginines and lysines inside human PCNA are essential for polymerase d

174 NK-lysin is an antimicrobial peptide and effector protein i

175 and that an interaction(s) mediated by these lysines is essential for B. burgdorferi murine infection

176 Post-translational acetylation of lysines is most extensively studied in histones, but thi

177 The reversible acetylation of lysines is one of the best characterized epigenetic modi

178 rated two OAT1 mutants, each having multiple lysines (K) simultaneously mutated to arginine (R).

179 , these two arginines (R83 and R153) and two lysines (K215 and K217) mitigate the negative charge on

180 acetylating newly synthesized histone H4 on lysines K5 and K12.

181 an Dvl2 DIX domain mono-ubiquitinated at two lysines (K54 and K58) by genetically encoded orthogonal

182 Lysines K82, K163, and K170 of DbpA are known to be impo

183 Taken together, these data showed that lysines K82, K163, and K170 potentiate the binding of Db

184 sure of Arabidopsis increases acetylation of lysines K9 and/or K14 of histone H3 at UVR8-regulated ge

185 labels [1-(13)C]glycine and L-[epsilon-(15)N]lysin, L-[1-(13)C]lysine and D-[(15)N]alanine, or D-[1-(

186 different generations of dendrigraft poly-L-lysines leading to quantitative information (i.e., stoic

187 These lysines lie within previously predicted actin-binding si

188 mia, is a homotetramer with multiple surface lysines, limiting conventional approaches for albuminati

189 Sec61p to glycines, serines, aspartates, or lysines lowered the hydrophobicity required for integrat

190 e substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resis

191 The positive charge on two of these lysines, Lys(49) and Lys(120), is critical for coordinat

192 d the specific binding contributions of four lysines, Lys-253, Lys-256, Lys-270, and Lys-289, in the

193 mediate Gap1 ubiquitylation of two possible lysines, Lys-9 and Lys-16, the Aly proteins promote ubiq

194 When this site is unavailable, three nearby lysines may become ubiquitinated.

195 P accumulation, ubiquitination of cytodomain lysines may represent a key signal controlling APP endos

196 The lysines modified by DOB are often post-translationally m

197 contains an N-terminal carbohydrate-binding lysin motif (LysM) domain and a C-terminal domain of unk

198 characterized by the presence of one or more lysin motif (LysM) domains in the extracytoplasmic porti

199 OXR1 contains the Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic (TLDc) domain, a mo

200 We show that LYSIN MOTIF DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSIT

201 s nodulation receptor-like kinase (NORK) and lysin motif domain-containing receptor-like kinase 3 (LY

202 cular pattern recognized in Arabidopsis by a lysin motif receptor kinase (LYK), AtCERK1.

203 ular patterns (MAMPs) that are recognized by LYSIN MOTIF RECEPTOR KINASE5 (LYK5), inducing the format

204 The lysin motif receptor-like kinase, NFP (Nod factor percep

205 or receptors NOD FACTOR PERCEPTION (NFP) and LYSIN MOTIF RECEPTOR-LIKE KINASE3 (LYK3) in establishing

206 RLKs with lysin-motif (LysM) ectodomains confer recognitional spec

207 necrosis-inducing-Phytophthora-protein- and Lysin-motif- containing proteins believed to have direct

208 nhibited catalytic activity and labeled four lysines; mutagenesis demonstrated that two of these, Lys

209 inant virus encoding an M protein with seven lysines mutated was generated, and this virus exhibited

210 f geometrical motifs featuring histidines or lysines near tyrosines, facilitating histidine and lysin

211 Mutation of six C-terminal lysines of DCP1a suppresses decapping activity and impai

212 eubiquitination, mutation of the cytoplasmic lysines of ENaC reduced the effect of USP8 on ENaC cell

213 Replacement of several arginines and lysines of exosite 2 with alanine did not affect thrombi

214 Acetylation on previously identified lysines of Htz1 plays little role in NER or cell surviva

215 fer of this fluorophore from IgG to specific lysines of its binding partner SpA but not to bovine ser

216 Mutating several lysines of the gamma2IL into arginines makes the gamma2

217 These ligases transfer ubiquitin to lysines of the ligands' intracellular domains (ICDs), wh

218 sin is promoted by acetylation of N-terminal lysines of the Smc3 subunit by the acetyltransferases Ec

219 unmethylated, mono-, di-, and trimethylated lysines on a single histone tail sequence, identificatio

220 the specificity and selectivity of multiple lysines on a single substrate (H3) by Gcn5.

221 own by increased acetylation at SIRT6 target lysines on histone 3, reduced TNF-alpha secretion, GLUT-

222 Methylated lysines on histones and nonhistone proteins promote the

223 omain family of proteins binds to acetylated lysines on histones and regulates gene transcription.

224 etics of acetylation turnover at 19 distinct lysines on histones H3, H4 and H2A.

225 antibacterial activity of dendrigraft poly-L-lysines on Micrococcus luteus and Erwinia carotovora.

226 bly transferred ubiquitin to surface exposed lysines on target proteins and even catalyzed the format

227 modomains that mediate binding to acetylated lysines on target proteins to regulate gene expression.

228 ivates UHRF1 ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 histone-bin

229 dependent deacetylation of N(epsilon)-acetyl lysines on various protein substrates.

230 on to block the methylation of corresponding lysines on wild type histones.

231 ected functionalization at introduced unique lysines or cysteines facilitate many applications.

232 Mutation of lysines or p300 inhibitor treatment causes the loss of e

233 he arginines with alanines or more conserved lysines or replacement of isoleucine with alanine or val

234 lysines are not equivalent and that helical lysines play a more prominent role in determining bindin

235 be required for the attachment of the phage lysin PlyG with the bacterial envelope and for bacterial

236 of the isotope peaks indicates the number of lysines present in the protein, information that aids in

237 Of interest, mutating any one of the three lysines prevented the ubiquitin conjugation to the other

238 Chemical derivatization of lysines prior to enzymatic digestion circumvents these p

239 ge-neutralizing substitutions of four nearby lysines promoted spontaneous prion formation.

240 blocks the functional readout of acetylated lysines, reduced heroin self-administration and cue-indu

241 poly-A tail, encoding for positively charged lysines regardless of the reading frame, would act as a

242 analyses show that yku70 mutants with these lysines replaced by arginines exhibit reduced Ku-DNA ass

243 ically label the side chains of cysteines or lysines, respectively, in native proteins.

244 CAT-tailing enabled degradation by exposing lysines sequestered in the ribosome exit tunnel.

245 selectively recognize mono- and dimethylated lysines, SFMBT1 binds di- and trimethyl H3K4, both of wh

246 cross-linking, N-homocysteinylation of these lysines should impair cross-linking.

247 istone 4 residues neighboring the acetylated lysines significantly influenced binding.

248 es, we found that AtPRORP1 exploits specific lysines strategically positioned at the tips of it's V-s

249 d the ubiquitin conjugation to the other two lysines, suggesting that Lys297, Lys303, and Lys315 may

250 or sites, and variable combinations of these lysines support both full transcriptional activity and v

251 onserved tail fiber called a tail-associated lysin, suspended from their tail tips that projects a pe

252 Interestingly, lysines targeted for acetylation were among the residues

253 Substrate lysines targeted for ubiquitination are also often locat

254 hat an increase in the number of substituted lysines tends to increase APP metabolism.

255 ClyR is the first lysin that demonstrates activity against the dominant de

256 caries-causing pathogen as well as the first lysin that kills all four of the bovine mastitis-causing

257 lation assay, we identified highly conserved lysines that are targeted by p300 for acetylation.

258 ults in the formation of spatially clustered lysines that could serve as recognition patches for bind

259 ectively transferred between amino groups of lysines that reside within ~10 A at the protein-protein

260 s of ubiquitinated RelA, we identified seven lysines that were attached to degradative and non-degrad

261 Upon infection, mycobacteriophages produce lysins that catalyze cell wall peptidoglycan hydrolysis

262 Bacteriophages deploy lysins that degrade the bacterial cell wall and facilita

263 DJ-1 deglycates cysteines, arginines, and lysines (the three major glycated amino acids) of serum

264 Chicken NK-lysin (cNK-lysin), the chicken homologue of human granulysin, is a

265 ompared to traditional NHS ester-labeling of lysines, the cysteine-maleimide strategy resulted in far

266 h the RRS1 WRKY domain, and PopP2 acetylates lysines to block DNA binding.

267 Mutagenesis of these lysines to leucines abolished protein disulfide isomeras

268 hindrance of extreme insolubility and two D-lysines to limit the lengths of beta-strands.

269 DNA-sensing lysines trigger ATP hydrolysis to open the SMC head inte

270 epressor Tup1 is sumoylated, at two specific lysines, under various stress conditions.

271 An APP mutant lacking all C-terminal lysines underwent the most pronounced increase in proces

272 Three N-terminal lysines unique for the pancreatic isoform (Lys-12/Lys-13

273 transcripts of male-specific vitelline coat lysin (VCL) and female-specific vitelline envelope recep

274 ale-specific vitelline envelope receptor for lysin (VERL) could identify sex over a complete year.

275 Dimethylation of lysines was achieved quantitatively and specifically wit

276 The effect on cross-linking lysines was quantitatively very similar to that previous

277 nal amino group followed by dimethylation of lysines was used with different stable isotopes of forma

278 When positive charges of lysines were eliminated by acetic anhydride instead of M

279 The genetically encoded coumarin lysines were successfully applied as fluorescent cellula

280 Remarkably, both lysins were able to lyse only Gram-positive bacterial st

281 riaminepentaacetic acid (p-SCN-DTPA) via the lysines, whereas JVZ-007-cys was conjugated to maleimide

282 domain is ubiquitinated in vivo at multiple lysines, which can be antagonized by various deubiquitin

283 ly 168 polypeptides contained early glycated lysines, which did not resemble the sites of advanced gl

284 the screening method resulting in a powerful lysin with potential for treating most streptococcal ass

285 lecule, they are directly labeled on surface lysines with a biotinylated derivative of the small ubiq

286 we show that substitution of APP C-terminal lysines with arginine disrupts APP ubiquitination and th

287 -labeled acetyl groups onto specific histone lysines with quantitative mass spectrometry.

288 Ube2W targets multiple TRIM5alpha internal lysines with Ub especially lysines 45 and 50, rather tha

289 pulsion between four closely spaced cationic lysines within a central lysine cluster of residues 101-

290 catalytic module to drive ubiquitination of lysines within an accessible zone.

291 ditional mutation of Ku70 K160 and six other lysines within Ku80 were required to eliminate all activ

292 As there are three lysines within Nt(17), we evaluated the impact of lysine

293 We show here that lysines within the 14-3-3zeta binding pocket and protein

294 Acetylation occurs at eight lysines within the C-terminal domain (CTD) of the larges

295 Lysines within the lyase domain are required for process

296 Acetylation of selected lysines within the NID activates DNA binding.

297 structures dependent upon the TREX1 CTR and lysines within the TREX1 catalytic core.

298 monstrate that Gcn5p acetylation of separate lysines within the zinc cluster domain negatively impact

299 Ubiquitylation of lysines within this site leads to rapid proteasomal degr

300 critical for their interaction and multiple lysines within TPP1 that are oligo-ubiquitinated and deu