ライフサイエンスコーパス: lysine

1 ine, Nepsilon-(carboxyethyl)-l-lysine, total lysine).

2 inding of STIM1 to SUR1 was enhanced by poly-lysine.

3 e amino acid at position 431 from Proline-to-Lysine.

4 ation enzymes are autoneddylated at multiple lysines.

5 ic damage via its RQC domain, interacting at Lysine 1016 and Phenylalanine1037 with the N-terminal ac

6 Lysine 104 in KRAS can be modified by ubiquitylation and

7 We find that lysine 104 is important for GEF recognition, because mut

8 nction reported in yeast, we determined that lysine(114) in the deduced Endocarpon pusillum MBF1 prot

9 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of othe

10 Histone H2B lysine 120 mono-ubiquitination (H2Bub1) catalyzed by Rnf

11 ciation to histone H3 peptides acetylated at lysine 14 (H3K14Ac), validating the importance of this s

12 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacet

13 F) mediates the acetylation of histone H4 at lysine 16 (H4K16ac) and is crucial for murine embryogene

14 in histone H3 (H3K36me3) and acetylation of lysine 16 in histone H4 (H4K16ac) have important roles i

15 by acetylating histone H4 preferentially at lysine 16.

16 e simultaneous pseudo-acetylation of hTau at lysines 163, 280, 281 and 369 drastically decreased hTau

17 Protein lysine 2-hydroxyisobutyrylation (Khib) is a newly identi

18 Lysine 2-hydroxyisobutyrylation is a recently identified

19 However, non-histone protein lysine 2-hydroxyisobutyrylation remains largely unexplor

20 ogical processes were preferably targeted by lysine 2-hydroxyisobutyrylation, including glycolysis/gl

21 catalyzes the dimethylation of histone H4 at lysine 20 (H4K20me2).

22 of the tandem Tudor domain with dimethylated lysine 20 of histone H4 (H4K20me2).

23 stone acetylation; in particular, histone H3 lysine 23 acetylation was lower in HFD-fed mice.

24 domain of PIPKIgamma via its C2 domain while Lysine 255 in PIPKIgamma acts as the major ubiquitin acc

25 The evolutionarily conserved lysine-265 (K265) of the myosin-2 motor from Dictyosteli

26 and enhancer activity measured by histone 3 lysine 27 (H3K27) acetylation.

27 tter induces the expression of the histone 3 lysine 27 (H3K27) demethylase Jumonji d3 (Jmjd3), which

28 is responsible for methylation of histone H3 lysine 27 (H3K27), and trimethylated H3K27 (H3K27me3) is

29 he formation of facultative heterochromatin, lysine 27 (H3K27).

30 arked by histone 3 containing the acetylated lysine 27 (H3K27ac).

31 ression correlated with decreased histone H3 lysine 27 acetylation (H3K27Ac) in the FBP1 enhancer.

32 H3 lysine 4 monomethylation, and histone H3 lysine 27 acetylation (H3K4me3, H3K4me1, and H3K27ac) an

33 atin modifier responsible for methylation of lysine 27 in histone H3.

34 e latter leading to deposition of histone H3 lysine 27 methylation chromosome-wide.

35 igenetic disturbances to hyperacetylation of lysine 27 of histone H3, showing dynamic correlations wi

36 nt upregulation of Skp2, Ezh2 and histone H3 lysine 27 trimethylation (H3K27me3) in both Pten null mo

37 derepression of genes marked with histone H3 lysine 27 trimethylation (H3K27me3), and inhibition of g

38 We identified elevated histone H3 lysine (27) trimethylation (H3K27me3), decreased E-cadhe

39 appaB subunit is activated by acetylation of lysine 310.

40 Additionally, mutation at lysine 311 affects cellular transcriptome altering the e

41 ated with active transcription, lysine 4 and lysine 36 (H3K4, H3K36); a site associated with the form

42 Among these modifications, trimethylation of lysine 36 in histone H3 (H3K36me3) and acetylation of ly

43 Histone H3 lysine 36 methylation (H3K36me) is critical for epigenet

44 Histone H3 lysine 36 methylation (H3K36me) is thought to participat

45 Mutations in SETD2, encoding the histone 3 lysine 36 trimethyltransferase, are enriched in relapsed

46 balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1).

47 ficient macrophages had increased histone 3, lysine 4 (H3K4) monomethylation, and H3K9 acetylation, a

48 y marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type-specific manner.

49 sites associated with active transcription, lysine 4 and lysine 36 (H3K4, H3K36); a site associated

50 d with EPO signaling, we compared histone H3 lysine 4 dimethylation (H3K4me2) in EPO treated and cont

51 stone H3 lysine 4 trimethylation, histone H3 lysine 4 monomethylation, and histone H3 lysine 27 acety

52 domain (PHD) finger of Set3 binds methylated lysine 4 of histone H3 in vitro and in vivo; however, pr

53 MPASS chromatin complex, which trimethylates lysine 4 on histone H3 (H3K4me3), regulates lifespan in

54 Two histone marks on histone H3, lysine 4 trimethylation (H3K4me3) and lysine 9 acetylati

55 on-PCR detected increased ETS1 and histone 3 lysine 4 trimethylation (H3K4Me3) at the CDKN2A promoter

56 genetic alterations in histone H3 N-terminal lysine 4 trimethylation (H3K4me3) over the Crhr1 promote

57 ns enriched for the histone marks histone H3 lysine 4 trimethylation, histone H3 lysine 4 monomethyla

58 Methylation of lysine-4 of histone H3 (H3K4men) is an important regulat

59 A point mutation converting lysine 44 of Dyn2 to alanine (Dyn2K44A) disrupts its GTP

60 R2DP1 We demonstrate how K44-KIR2DP1(F) with lysine 44 recognized C1(+)HLA-C, whereas T44-KIR2DP1(F)

61 We further identify lysine 477 (K477) of HIF-1alpha as a major ubiquitinatio

62 of synaptic proteins, presumably mediated by lysine 48 (K48) of ubiquitin, is a key mechanism in syna

63 SIRT2 bound to LKB1 and deacetylated it at lysine 48, which promoted the phosphorylation of LKB1 an

64 f the SEC, as does acetylation of histone H4 lysine 5 to a lesser extent.

65 Intriguingly, the accumulation of lysine 5-acetylated H2B was cell age-dependent and was a

66 ults in accumulation of the epigenetic mark, lysine 5-acetylated H2B.

67 etylation of newly synthesized histone H4 at lysines 5 and 12 that accompanies replication-coupled ch

68 ythroid-derived 2-related factor 2 (NRF2) on lysines 506 and 508, leading to a reduction in total and

69 n was modified; instead, we demonstrate that lysine-56 is the key nucleophilic residue.

70 P78, whereas homeostatic, METTL21A-dependent lysine 585-trimethylated GRP78 is reduced.

71 dopaminergic neurons, whereas mutagenesis of lysine 68 to arginine (K68R), mimicking deacetylation, i

72 Site directed mutagenesis of lysine 68 to glutamine (K68Q), mimicking acetylation, de

73 study, we show that WHSC1L1 mono-methylates lysine 721 in the tyrosine kinase domain of EGFR, and th

74 an RBM25 species that is mono-methylated at lysine 77 (RBM25K77me1), and here we used quantitative m

75 Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements

76 Lysine-84 of Stv1NT is essential for interaction with PI

77 e formation of constitutive heterochromatin, lysine 9 (H3K9); and a site associated with the formatio

78 ps for chromatin accessibility and histone 3 lysine 9 acetylation (H3K9ac) enrichment in young seedli

79 d1b haploinsufficiency suppressed histone H3 lysine 9 acetylation (H3K9ac) overall and particularly r

80 ne H3, lysine 4 trimethylation (H3K4me3) and lysine 9 acetylation (H3K9ac), co-localize on active gen

81 (CIP1) and p53, as well as trimethylation of lysine 9 at histone H3 (H3K9me3), also operate as critic

82 ementary nascent RNAs to initiate histone H3 lysine 9 di- and trimethylation (H3K9me2 and H3K9me3, re

83 DNA methylation, histone marking (acetylated lysine 9 in histone H3 and trimethylated lysine 9 in his

84 ted lysine 9 in histone H3 and trimethylated lysine 9 in histone), and gene-expression profiles in na

85 These proteins recognize histone H3 lysine 9 methylated tails via their chromodomain and rec

86 asive genes by erasing repressive histone H3 lysine 9 methylation, KDM3A promotes chemoresistance by

87 1 (also known as Kmt1e; encodes a histone H3 lysine 9 methyltransferase), including a large topologic

88 Furthermore, lysine 9 on histone H3 is necessary for maximal pol II p

89 sferase that monomethylates histone 3 at the lysine 9 residue (H3K9me1), in the rat dorsomedial prefr

90 omatic regions are associated with histone 3 lysine 9 trimethylation (H3K9me3) or H3K27me3, but these

91 Histone H3 lysine-9 (H3K9) methylation is essential for retinoblast

92 Mutation of the active-site lysine abolished PtaA activity and affected folding as w

93 ing this approach, we demonstrated that both lysine acetylation and lysine succinylation can be insta

94 vestigate, for the first time, the effect of lysine acetylation and phosphorylation, as well as the c

95 ersely proportional to the degree of in vivo lysine acetylation during growth transition and growth a

96 Strikingly, a ketogenic diet increased lysine acetylation in Cpt2M(-/-) hearts 2.3-fold compare

97 hc, and demonstrate the importance of p66Shc lysine acetylation in vascular oxidative stress and diab

98 Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins as

99 Lysine acetylation of histone proteins is a fundamental

100 activity or expression results in decreased lysine acetylation of Nav1.5, which promotes the traffic

101 High glucose-stimulated lysine acetylation of p66Shc facilitates its phosphoryla

102 itro non-enzymatic acetyl phosphate mediated lysine acetylation, and the presence of purified CobB pr

103 t of Sirt1, uncover a unique Sirt1-regulated lysine acetylation-dependent mechanism that governs the

104 pigenetic modifications targeting histone H4 lysine acetylation.

105 ils the impact of perifosine on proteome and lysine acetylome in SK-N-AS cells and expands our unders

106 Here, we explore an emerging concept that lysine acetyltransferase (KAT) enzymes drive cellular pl

107 The Mtb Rv2170 protein shows lysine acetyltransferase activity, which is capable of p

108 ntrast the role of missense mutations in the lysine acetyltransferase domain that are more frequently

109 K (lysine) acetyltransferase 8 (KAT8), an important compone

110 K(lysine) acetyltransferase 8 (KAT8, also known as MOF) me

111 The effect of the lysine acylation on the prion-like seeding of SOD1 was a

112 hanging the phosphinothioester identity, any lysine acylation type could be introduced.

113 ively correlated (r=0.9101) with chlorogenic-lysine adduct content.

114 nate distinctive catalytic mechanisms of the lysine adenylylation reaction.

115 methionines are sulfoxides (aS4ox); a fully lysine-alkylated aS (acetyl-aS); and aS fibrils, testing

116 gainst pentosidine and Nepsilon-carboxyethyl-lysine, although the amount of HT in the biscuit was 100

117 palladium(II)-aryl complex and a weak base, lysine amino groups underwent C-N bond formation at room

118 d with glycine, H2O2, malondialdehyde, and a lysine analog in PBS at a physiological temperature, whi

119 esis of a panel of 2-aryl-5-carboxytetrazole-lysine analogs (ACTKs) and their site-specific incorpora

120 yond simple electrostatics; within this code lysine and arginine residues are non-equivalent and pren

121 e metabolite that forms adducts on cysteine, lysine and arginine residues of proteins, thereby affect

122 enzymatically cleave proteins C-terminal to lysine and arginine residues prior to LCMS/MS analysis o

123 predicted, and proline, glycine, glutamate, lysine and arginine, which were all consumed significant

124 Lysine and cadaverine contents discriminated PRs from GR

125 ytophilum (ApOmpA), an adhesin that uses key lysine and glycine residues to interact with alpha2,3-si

126 o-glutamine (KQ) mutants to mimic acetylated lysines and screened 15 KQ mutants.

127 Biofilm cadaverine, lysine, and other amino acid (AA) contents were determin

128 ditions, for each charge state, for both the lysine- and cysteine-biotin conjugates.

129 atty Acid Receptor 2 suggested that a single lysine - arginine variation at the extracellular face of

130 agonist function indicated that although the lysine - arginine variation between human and mouse orth

131 Mutations that replaced the lysine at codon 110 and the arginine at codon 111 with a

132 Current methods for studying lysine-based polyubiquitination are not suitable for the

133 tly identified the YEATS domain as an acetyl-lysine-binding module, but its functional importance in

134 lysine isosteres that each interact with the lysine-binding sites in K2hPg Further, the adoption of a

135 tophan metabolism, phenylalanine metabolism, lysine biosynthesis and degradation, and bile acid biosy

136 Lysine biosynthesis is restored when saccharopine dehydr

137 The ultimate step in lysine biosynthesis, the NAD(+)-dependent dehydrogenatio

138 ied a xxxxxxKSxxxxx modification motif where lysine can serve as an ADP-ribose acceptor site.

139 A lack of APP C-terminal lysines caused APP redistribution from endosomal intralu

140 ursors of AGEs and N(epsilon)-(carboxymethyl)lysine (CML) found to be predominantly higher in the dia

141 N(epsilon)-carboxymethyl-lysine (CML) is measured in food, but there is a controv

142 hyde would have correlate well with reactive lysine content if the advanced stages of the reaction ha

143 to posttranslational modifications of these lysines contributed to gB/gH-gL cell-cell fusion.

144 at p66Shc is a direct target of the Sirtuin1 lysine deacetylase (Sirt1), and Sirt1-regulated acetylat

145 t lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1.5 to t

146 inamide adenine dinucleotide (NAD)-dependent lysine deacylases, catalyzes the removal of fatty acylat

147 time-dependent, irreversible inactivator of lysine decarboxylase from Hafnia alvei.

148 atty acylation and sirtuin-catalyzed protein lysine defatty-acylation.

149 ts phosphorylated form (pNCC) as well as WNK lysine deficient protein kinase 4 (WNK4) and STE20/SPS1-

150 a relevant proportion affecting genes of the lysine demethylase (KDM) family.

151 G) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, a

152 GSK2879552, a lysine demethylase 1 inhibitor currently in clinical tri

153 Recently, we showed that lysine demethylase KDM1A is overexpressed in GBM.

154 lar analysis of chromatin recognition by the lysine demethylase KDM2A.

155 changes in epigenetic regulators such as the lysine demethylase KDM4.

156 Histone lysine demethylases (KDMs) are of critical importance in

157 pecific lysine methyltransferases (KMTs) and lysine demethylases (KDMs) have been implicated in the d

158 We describe the use of a generation 5 l-lysine dendrimer that has been part-modified with a poly

159 en activator and plasminogen, via an exposed lysine-dependent mechanism, to efficiently generate plas

160 SIRT5 is a lysine desuccinylase known to regulate mitochondrial fat

161 The lysine displacement is proposed here to open up a channe

162 Condensation with other allysines or lysines drives the formation of inter- and intramolecula

163 The di-lysine ER retention motif of AnkB-Paris is indispensable

164 YAP motif, which resembles the eukaryotic di-lysine ER-retention motif (KxKxx).

165 flammatory products is impaired when biofilm lysine falls below the minimal content of normal blood p

166 ngs highlight the biological significance of lysine fatty acylation and sirtuin-catalyzed protein lys

167 Lysine fatty acylation promotes the plasma membrane loca

168 -Ras splice variants, K-Ras4a, is subject to lysine fatty acylation, a previously under-studied prote

169 ne, but not a phosphomimetic, competes for a lysine from a preexisting salt bridge, initiating a part

170 site core, whereas the two other active site lysines from the two other domains are not able to move.

171 ening the cyanuric acid ring, and the mobile lysine guides products through the exit channel.

172 pulse, rats (n = 5) were fed (13)C6-labeled lysine ("heavy") feed for 23 days to label proteins.

173 JMJD6-regulated splicing, and JMJD6-mediated lysine hydroxylation of U2AF65 could account for, at lea

174 tn1p efficiently accessed only nascent-chain lysines immediately proximal to the ribosome exit tunnel

175 A mild method for the arylation of lysine in an unprotected peptide is presented.

176 e have quantified, in total, more than 9,000 lysines in human cell proteomes and have identified seve

177 mediated acetylation on two conserved tandem lysines in the cohesin Smc3 subunit.

178 Attachment of SUMO moieties to internal lysines in Ubc9 itself can further lead to the formation

179 relates with acetylation of specific histone lysines in WAT but not in the liver.

180 that, in two organisms, the PBPs incorporate lysine into cellular peptidoglycan and that, further, th

181 dependent dehydrogenation of saccharopine to lysine, is another NAD(+)-dependent reaction performed i

182 Arginine, lysine, isoleucine, leucine, methionine, phenylalanine,

183 clude that VKK38 provides two conformational lysine isosteres that each interact with the lysine-bind

184 licase DNA-binding protein 7 (CHD7(LOF)) and lysine (K) methyltransferase 2D (KMT2D(LOF)), respective

185 s through upregulation of TRAF6-mediated and lysine(K) 63-linked ubiquitination of EZH2 for degradati

186 harged peptides-deca-arginine (R10) and deca-lysine (K10).

187 induce auto-oxidation of a LOXL2/3-specific lysine (K731) in a time-dependent reaction that irrevers

188 es peptides containing SUMO-remnant diglycyl-lysine (KGG) at the site of SUMO modification.

189 With-no-lysine kinase 4 (WNK4) regulates electrolyte homeostasis

190 ubiquitin-modified substrates by combining a lysine-less internally tagged ubiquitin (INT-Ub.7KR) wit

191 In Arabidopsis (Arabidopsis thaliana), the lysine (Lys) aminotransferase AGD2-LIKE DEFENSE RESPONSE

192 When lysine (Lys) residues of the hD4R are substituted with a

193 shows a large displacement of the catalytic lysine (Lys163) in domain 2 away from the active site co

194 The metabolomic analysis indicated that l-lysine, mellein, and gallic acid were significantly more

195 xtra amine group such as arginine, cysteine, lysine, methionine, and tryptophan had the strongest ant

196 esults emphasize the significance of histone lysine methylation in normal human development and the i

197 dings provide additional mechanisms by which lysine methylation signaling impacts on cell fate decisi

198 Histone lysine methylation, mediated by mixed-lineage leukemia (

199 Here, we show that the protein lysine methyltransferase G9a (also known as EHMT2) and G

200 A lysine methyltransferase regulates both the magnitude an

201 ltifaceted oncogenic function of the protein lysine methyltransferase WHSC1L1 in SCCHN, which is medi

202 For example, specific lysine methyltransferases (KMTs) and lysine demethylases

203 Histone lysine methyltransferases (KMTs) represent an important

204 (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately

205 eins associated with Set1) family of histone lysine methyltransferases are associated with a large nu

206 the specific functions of the different MLL lysine methyltransferases.

207 Acetyl-lysine modifications create docking sites for bromodomai

208 ts, we found deficient LH3-specific collagen lysine modifications in patients' urine and skin fibrobl

209 Hsp90beta subfamily lacks the dual lysine motif and the extracellular function.

210 ACTKs investigated, N-methylpyrroletetrazole-lysine (mPyTK) was found to give robust and site-selecti

211 nhibited catalytic activity and labeled four lysines; mutagenesis demonstrated that two of these, Lys

212 nd confirmed by ectopic expression of TRP120 lysine mutants in cells.

213 action (furosine, Nepsilon-(carboxymethyl)-l-lysine, Nepsilon-(carboxyethyl)-l-lysine, total lysine).

214 with three regular hydrogen bonds formed by lysine NH3(+) group (angle C(epsilon)-N(zeta)-acceptor a

215 cation of a recurring structural motif where lysine NH3(+) group interacts with backbone carbonyl.

216 5 coordination complex lowers the pKa of the lysine nucleophile and stabilizes the transition state o

217 sopeptide bonds are restricted to a specific lysine of ubiquitin, resulting in a chain possessing mor

218 roteins using chemical reagents specific for lysine or cysteine residues, identification of gas-phase

219 ased cytotoxic moiety covalently linked, via lysine or cysteine residues, to a monoclonal antibody (m

220 ng arginine of CP2 to N-varepsilon-trimethyl-lysine or methylated arginine results in cyclic peptide

221 These effects were suppressed by lysine or rapamycin treatment, suggesting that the enhan

222 an oxidized histidine and intact histidine, lysine, or cysteine residues were discovered and charact

223 se for alanine, valine, leucine, methionine, lysine, phenylalanine, tyrosine, and tryptophan.

224 orbic acid, gold chroloauric acid and poly-l-lysine (PLL) through modified layer-by-layer (LbL) metho

225 ing alternating N--trifluoroacetyllysine and lysine provide a degenerate (19) F NMR signal.

226 ptides and proteins and quantify heavy/light lysine ratios.

227 of laboratory evolution, apparently enhances lysine reactivity and facilitates efficient proton shuff

228 understanding of BRD9 function beyond acetyl-lysine recognition.

229 blocks the functional readout of acetylated lysines, reduced heroin self-administration and cue-indu

230 lycine-glycine remnant bound to the modified lysine residue (K-epsilon-GG) that can be recognized by

231 A lysine residue (Lys(1112)) at the C-terminal tail of mGl

232 Here, we report that the conserved lysine residue 714 in the ErbB4 ICD undergoes SUMO modif

233 decarboxylation of propionate 4, but with a lysine residue as an essential proton shuttle.

234 Abs that reacted with a linear epitope at a lysine residue at position 169 (K169) in the HIV-1 envel

235 We conclude that a transmembrane embedded lysine residue is essential for electrogenic transport i

236 Previous data indicated that the domain 2 lysine residue plays a role in activating an adjacent se

237 ther undergoes ubiquitylation on a conserved lysine residue.

238 t Imd is rapidly Lys-63-polyubiquitinated at lysine residues 137 and 153 by the sequential action of

239 ylase 1 (LSD1) demethylates at both of these lysine residues and has been shown to disrupt neuronal m

240 er peptides are produced via modification of lysine residues by carbamylation of proteins.

241 prevents spurious discharge of Ub from E2 to lysine residues by: (1) harboring structural elements th

242 u-84, and Glu-87) form salt bridges with key lysine residues in ER-alpha (Lys-299, Lys-302, and Lys-3

243 morphic missense mutations affecting crucial lysine residues in histone H3 genes significantly contri

244 hyl group from S-adenosylmethionine (SAM) to lysine residues in histone tails and core histones.

245 for the global and quantitative analysis of lysine residues in native biological systems.

246 Here, we acylated a fraction of lysine residues in SOD1 with groups of variable hydropho

247 eutralization of the positive charges of the lysine residues in the N-terminal domain of APE1 induces

248 An ATP analogue that reacts with lysine residues inhibited catalytic activity and labeled

249 za A virus nucleoprotein (NP), including the lysine residues K77, K113 and K229.

250 lex II suggested that several SIRT5-targeted lysine residues lie at the protein-lipid interface of su

251 Recent studies indicate that acetylated lysine residues mainly exhibit low acetylation occupancy

252 changes in the methylation level at specific lysine residues of histone H3 (H3K27 and H3K4) in the ch

253 is capable of post-translationally modifying lysine residues of the ICDH protein leading to a reducti

254 Bromodomains bind to acetylated lysine residues on histone tails and thereby facilitate

255 acetylases (HDACs) remove acetyl groups from lysine residues on histone tails, promoting transcriptio

256 We identified three SpGAPDH lysine residues that were instrumental in defining the k

257 We needed to mutate two lysine residues to abolish trypsin inhibition, suggestin

258 Critically, the positive charge of the lysine residues was necessary for fusion regulation, as

259 ydrolysed forms of the hapten bound to eight lysine residues was used to detect hapten-specific IgG 1

260 nt on essential redox-sensitive cysteine and lysine residues within N-terminus of channel protein.

261 RK clusters (clusters enriched for arginine-lysine residues).

262 introduced specifically at three individual lysine residues, generate distinct PRE profiles, indicat

263 tylation of NEIL1 within the same C-terminal lysine residues.

264 cohesive properties of simple aromatic- and lysine-rich peptides rival those of the strong reversibl

265 e an E2 enzyme for substrate ubiquitination, lysine selection, and polyubiquitin chain formation.

266 ual occurrence revealed a positively charged lysine side chain, conserved in other flavin mediated ox

267 y 51% loss), and its reactivity with epsilon-lysine side chains ( approximately 40.77% loss).

268 of prokaryotic ubiquitin-like protein Pup to lysine side chains of the target protein via an isopepti

269 and deacetyliminate Stat3 on multiple acetyl-lysine sites.

270 The lysine specific demethylase 1 (LSD1) demethylates at bot

271 Lysine specific demethylase 1 KDM1A (LSD1) regulates his

272 Here, we report that lysine-specific demethylase 1 (LSD1) upregulates hypoxia

273 Lysine-specific demethylase 1 (LSD1), which has been con

274 Here we identified that the lysine-specific demethylase KDM3A played a dual role in

275 Besides as an H3K4 demethylase, lysine-specific demethylase-1 (LSD1) has been shown to p

276 he RE1-silencing transcription factor (REST)-lysine-specific histone demethylase 1 (LSD1) co-represso

277 Deprotonation of alphaY190 by a nearby lysine strengthens the interaction between this aromatic

278 ilk-like units, 15 elastin-like units, and 1 lysine-substituted elastin-like unit) with GAG GM-0111,

279 emonstrated that both lysine acetylation and lysine succinylation can be installed selectively in ubi

280 Lysine succinylation is a recently identified post-trans

281 RT5 largely reversed the succinyl-CoA-driven lysine succinylation.

282 ing, read-through of poly(A) produces a poly-lysine tag, which might alter the localization and solub

283 concentrations, highlighting the utility of lysine-targeted sulfonyl fluoride probes in demanding ch

284 hat an increase in the number of substituted lysines tends to increase APP metabolism.

285 essential for both decarboxylations, while a lysine that salt bridges to propionate 4 is required sol

286 equence-related properties studied, relative lysine to arginine content was found to be higher in CH1

287 An amino acid substitution, lysine to glutamine, at position 166 (H3 numbering) in t

288 ity to transfer the primary epsilon-amine of lysine to peptidoglycan.

289 golysines to 0.5:1 N:P (ratio of nitrogen in lysine to phosphorus in DNA), are stable in low salt and

290 of mIDH2 (mouse mitochondrial IDH2), we used lysine-to-glutamine (KQ) mutants to mimic acetylated lys

291 re than 80% of these tumors and results in a lysine-to-methionine substitution (H3K27M).

292 ymethyl)-l-lysine, Nepsilon-(carboxyethyl)-l-lysine, total lysine).

293 omolog 2 (EZH2), an enzyme that catalyzes H3 lysine trimethylation and associates with oncogenic func

294 h3 and Sc65 knock-out mice revealed a common lysine under-hydroxylation effect at helical domain cros

295 An APP mutant lacking all C-terminal lysines underwent the most pronounced increase in proces

296 Biofilm lysine was 0.19 +/- 0.10 and 0.20 +/- 0.09 mumol/mg in G

297 e depleted in biofilm from smokers, but only lysine was depleted in biofilm from non-smokers.

298 yer (PEM) approach using alginate and poly-l-lysine was employed to coat cell spheroids.

299 we show that substitution of APP C-terminal lysines with arginine disrupts APP ubiquitination and th

300 Lysines within the lyase domain are required for process