ライフサイエンスコーパス: lysine acetyltransferase

1 fs for interacting with and activating three lysine acetyltransferases.

2 the nucleus in human cell lines and binds to lysine acetyltransferase 2A (KAT2A, also known as GCN5)

3 increased H3K9Ac through recruitment of the lysine acetyltransferase 2B (KAT2B) and WD repeat-contai

4 The lysine acetyltransferase 6 (KAT6) histone acetyltransfer

5 MOZ, MORF, and HBO1, which are also known as lysine acetyltransferase 6A (KAT6A), KAT6B, and KAT7, re

6 heterozygous truncating mutations in KAT6B (lysine acetyltransferase 6B, formerly known as MYST4 and

7 K (lysine) acetyltransferase 8 (KAT8), an important compone

8 K(lysine) acetyltransferase 8 (KAT8, also known as MOF) me

9 and long-lasting) activation of two distinct lysine acetyltransferase activities along with the ERK/M

10 estigated short- and long-term regulation of lysine acetyltransferase activity and the ERK/mitogen-ac

11 P-ZNF384 fusions resulted in loss of histone lysine acetyltransferase activity in a dominant-negative

12 usal relationship between ERK activation and lysine acetyltransferase activity in insular cortex.

13 ence that these TFs, in conjunction with the lysine acetyltransferase activity of p300/CBP, facilitat

14 RVBs are required for the lysine acetyltransferase activity of TIP60.com but not f

15 Both proteins display acetyl-CoA:lysine acetyltransferase activity, can interact with and

16 selective small molecule inhibitors of their lysine acetyltransferase activity, we validate CBP/p300

17 The Mtb Rv2170 protein shows lysine acetyltransferase activity, which is capable of p

18 Nuclear receptors use lysine acetyltransferases and lysine deacetylases (KDACs

19 The MYST protein lysine acetyltransferases are evolutionarily conserved t

20 tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2.

21 We now demonstrate that the lysine acetyltransferases cAMP-response element-binding

22 The lysine acetyltransferases CBP and p300 function as princ

23 es a reaction mechanism different from other lysine acetyltransferases characterized to date.

24 NuA4 is the only essential lysine acetyltransferase complex in Saccharomyces cerevi

25 that may also function independently of the lysine acetyltransferase complex.

26 We previously reported that the lysine acetyltransferase CREB-binding protein (CBP) is r

27 ntrast the role of missense mutations in the lysine acetyltransferase domain that are more frequently

28 chain lysine substrate that is acetylated by lysine acetyltransferase enzymes such as Gcn5.

29 le substrates for the cAMP-dependent protein lysine acetyltransferase from Mycobacterium tuberculosis

30 ucleosome remodelers INO80 or ISW1A, and the lysine acetyltransferases Gcn5 and Esa1 each contribute

31 Lysine acetyltransferases have been shown to regulate va

32 anism of FadD33 by the mycobacterial protein lysine acetyltransferase in a cAMP-dependent manner.

33 Lysine acetyltransferases interact with steroid receptor

34 comprise the KAT3 family of histone/protein lysine acetyltransferases, interact with over 50 T-lymph

35 NuA4, the major H4 lysine acetyltransferase (KAT) complex in Saccharomyces

36 tion between native nucleosomes and the NuA4 lysine acetyltransferase (KAT) complex.

37 , reversible binding of the inhibitor to the lysine acetyltransferase (KAT) domain of p300 is largely

38 Here, we explore an emerging concept that lysine acetyltransferase (KAT) enzymes drive cellular pl

39 However, no lysine acetyltransferase (KAT) has been definitively loc

40 nal lysine acetylation and the corresponding lysine acetyltransferase (KAT) in RC nucleosome assembly

41 The p300, CBP, and pCAF lysine acetyltransferase (KAT) proteins have been report

42 ing clinically targeted, the role of histone lysine acetyltransferases (KAT) in malignancy is less we

43 characterize cellular functions of the human lysine acetyltransferases KAT2A (GCN5) and KAT2B (PCAF),

44 1 can be acetylated at its N terminus by the lysine acetyltransferases KAT2B and KAT3B.

45 ydroxynaphthoquinone-based inhibitors of the lysine acetyltransferase KAT3B (p300), such as plumbagin

46 4 nucleosome-binding domains and activates 3 lysine acetyltransferases (KAT6A, KAT6B, and KAT7), sugg

47 Mis18 complex is to transiently recruit the lysine acetyltransferase KAT7 to centromeres to facilita

48 ion was observed after the inhibition of the lysine acetyltransferase KATB3/p300.

49 Lysine acetyltransferases (KATs) are key mediators of ce

50 Histone deacetylases (HDACs) and lysine acetyltransferases (KATs) catalyze dynamic histon

51 The MYST family of lysine acetyltransferases (KATs) function in a wide vari

52 ogical and pathological functions of protein lysine acetyltransferases (KATs) greatly depends on the

53 Lysine acetyltransferases (KATs) play a critical role in

54 Lysine acetyltransferases (KATs) play a unique role in r

55 The next challenge is connecting lysine acetyltransferases (KATs) to their cellular targe

56 plex with the double PHD finger (DPF) of the lysine acetyltransferase MOZ/MYST3/KAT6A.

57 Compared with other lysine acetyltransferases of known structure, alpha-tubu

58 oyl-CoA, function as efficient substrates of lysine acetyltransferase p300 and serve as sensitive rea

59 g highlights an expanded landscape of orphan lysine acetyltransferases present in the human genome an

60 Thus, lysine acetyltransferases represent a potential therapeu

61 acetylation of H3 lysine 56 catalyzed by the lysine acetyltransferase Rtt109.

62 Indeed the mycobacterial Pat (protein lysine acetyltransferase), Rv0998, specifically acetylat

63 regulate the lysine acetylation of a 42 kDa lysine acetyltransferase substrate, suggesting a causal

64 Rtt109 is a lysine acetyltransferase that acetylates histone H3 at l

65 Tip60 is a lysine acetyltransferase that acetylates histones and ot