ライフサイエンスコーパス: lysine demethylase

1 g 2C (JMJD2C), a recently identified histone lysine demethylase.

2 KG-dependent enzyme of the Jumonji family of lysine demethylases.

3 bitors of the KDM4 (JMJD2) family of histone lysine demethylases.

4 entially inhibits the subfamily of trimethyl lysine demethylases.

5 f a cyclopropylamine containing inhibitor of Lysine Demethylase 1 (LSD1), GSK2879552.

6 GSK2879552, a lysine demethylase 1 inhibitor currently in clinical tri

7 iC (JmjC) and ARID domain-containing histone lysine demethylase 1a (JARID1a) formed a complex with CL

8 AOF1, now renamed lysine demethylase 1B (KDM1B) following a new nomenclatu

9 Using histone lysine demethylase 4 (KDM4) as a proof-of-concept, we sh

10 For example, the lysine demethylase 4A/Jumonji domain-containing 2A (KDM4

11 Lysine demethylase 4C (KDM4C), an H3K9me3 demethylase, l

12 Here, we demonstrate that LSD1, a histone lysine demethylase, also participates in the trans-repre

13 ase 1 (LSD1) is the first discovered histone lysine demethylase and, with the help of its cofactor Co

14 ygenase family, including prolylhydroxylase, lysine demethylase, and DNA demethylase, have emerged as

15 Although LSD1 is a histone lysine demethylase, and histone H3K4 was demethylated at

16 tural topology is similar to known oxidases, lysine demethylases, and monooxygenases, but its active

17 us, we suggest that, during gene repression, lysine demethylases can directly interact and function i

18 JMJD2) and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led

19 islands directly recruit the H3K36-specific lysine demethylase enzyme KDM2A.

20 ET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protei

21 Histone lysine demethylases facilitate the activity of oncogenic

22 r of the Jumonji C domain-containing histone lysine demethylase family, specifically targets lower me

23 Enhanced expression of the lysine demethylase FBXL11, which catalyzes the demethyla

24 Other interactors, such as the lysine demethylase Fbxl11/KDM2A, recognize nucleosomes m

25 Initial studies of the histone lysine demethylases focused on their in vitro enzymatic

26 nactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysi

27 ydroxylase FIH and histone N(epsilon)-methyl lysine demethylases, identifies branch points in 2OG-dep

28 Since the discovery of the first histone lysine demethylase in 2004, two protein families with nu

29 nistic understanding of the roles of histone lysine demethylases in eukaryotic transcription, genome

30 ecent insights into the roles of the histone lysine demethylases in multiple aspects of development a

31 the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethyla

32 LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC KDMs, KDM2-7), focusing on the

33 We identify the conserved histone lysine demethylases jmjd-1.2/PHF8 and jmjd-3.1/JMJD3 as

34 m involving OCA-B recruitment of the histone lysine demethylase Jmjd1a to targets such as Il2, Ifng,

35 Upon binding DNA, Oct4 recruits the histone lysine demethylase Jmjd1c.

36 by the lysine methyltransferase PRDM9 or the lysine demethylase JMJD2E.

37 aches, we were able to simultaneously delete Lysine Demethylase (KDM) 5A, 5B and 5C efficiently in vi

38 a relevant proportion affecting genes of the lysine demethylase (KDM) family.

39 es, a series of potent JmjC histone N-methyl lysine demethylase (KDM) inhibitors which bind to Fe(II)

40 G) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, a

41 state cancer, two different types of histone lysine demethylases (KDM), LSD1/KDM1 and JMJD2/KDM4, are

42 g) domain 1 (AOF1), a protein related to the lysine demethylase KDM1 (also known as LSD1), functions

43 Recently, we showed that lysine demethylase KDM1A is overexpressed in GBM.

44 71) determine a crystal structure of histone lysine demethylase KDM2A that specifically targets lower

45 lar analysis of chromatin recognition by the lysine demethylase KDM2A.

46 or that is highly potent towards the histone lysine demethylases KDM2A/7A.

47 The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required fo

48 Here we identified that lysine demethylase KDM3A as a critical regulator of ovar

49 ion in the 15-LOX-1 promoter via the histone lysine demethylase KDM3A was an early and specific histo

50 changes in epigenetic regulators such as the lysine demethylase KDM4.

51 Here, we demonstrate that H3K9/36me3 lysine demethylase KDM4A/JMJD2A overexpression leads to

52 The KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A-KDM4D), which selectively rem

53 on this promoter is to displace the histone lysine demethylase KDM5A, thereby favoring trimethylatio

54 tive removal of broad H3K4me3 domains by the lysine demethylases KDM5A and KDM5B is required for norm

55 More mutations in the histone lysine demethylase KDM6A were present in non-invasive tu

56 The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II

57 Histone lysine demethylases (KDMs) are epigenetic enzymes that c

58 Jumonji C (JmjC) lysine demethylases (KDMs) are Fe(II)-dependent hydroxyl

59 Histone lysine demethylases (KDMs) are of critical importance in

60 The lysine demethylases (KDMs) catalyze the demethylation of

61 pecific lysine methyltransferases (KMTs) and lysine demethylases (KDMs) have been implicated in the d

62 and the lysine methyltransferases (KMTs) and lysine demethylases (KDMs) that regulate them.

63 asing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for

64 e TYW5 but displays limited homology to JmjC lysine demethylases (KDMs).

65 h histone arginine methylases like PRMT5 and lysine demethylases like JARID1B/KDM5B.

66 Thus, our data revealed that histone lysine demethylase LSD1 may negatively regulate TAL1-med

67 We establish a requirement for the histone lysine demethylase, LSD1, in directing specific interchr

68 Here, we report that the histone lysine demethylase, LSD1--a component of the CoREST-CtBP

69 Based on the prediction that histone lysine demethylases may contain the JmjC domain, we exam

70 d and erase the methylated histone residues, lysine demethylases must specifically recognize the hist

71 Lysine demethylases play an important role in epigenetic

72 Here we show that LSD1, a lysine demethylase, regulates histone H3 lysine 4 di-met

73 is a member of the JARID1 family of histone lysine demethylases responsible for the demethylation of

74 ing repressor complexes that include histone lysine demethylases, such as KDM1 in animals and KDM1C i

75 change with the recent discovery of histone lysine demethylases that reversibly remove methyl marks?

76 methylation, as catalysed by two families of lysine demethylases (the flavin-dependent KDM1 enzymes a

77 we show that Oct1 recruits the Jmjd1a/KDM3A lysine demethylase to catalyze the removal of the inhibi

78 PHF8 is a histone lysine demethylase ubiquitously expressed in nuclei.

79 d 2-oxoglutarate-dependent N(epsilon)-methyl lysine demethylase, which acts on histone substrates.