ライフサイエンスコーパス: lysophosphatidic acid

1 ds, the acylation of G3P to form 1-acyl G3P (lysophosphatidic acid).

2 ovarian cancer cells after stimulation with lysophosphatidic acid.

3 g cells and in starved cells stimulated with lysophosphatidic acid.

4 tors of the extracellular signaling molecule lysophosphatidic acid.

5 llagen induced by TGF-beta1, endothelin, and lysophosphatidic acid.

6 or stimulated to migrate on collagen I with lysophosphatidic acid.

7 constituted basement membrane in response to lysophosphatidic acid.

8 s cofilin phosphorylation that is induced by lysophosphatidic acid.

9 on of the carbon-carbon double bond within a lysophosphatidic acid.

10 Rac1 upon stimulation of HEK-293 cells with lysophosphatidic acid.

11 ATX) transforms lysophosphatidylcholine into lysophosphatidic acid.

12 esponse to stimulation with the GPCR agonist lysophosphatidic acid.

13 incorporation of CPA at the sn-2 position of lysophosphatidic acid.

14 ro-2-(3-phenylproplyamino) benzoic acid, and lysophosphatidic acids.

15 eptors to assess, we found that oxytocin and lysophosphatidic acid 1 receptors are translated and act

16 (GPATs) acylate the sn-1 position to produce lysophosphatidic acid (1-acyl-LPA).

17 plsC316, and plsC3498) that are annotated as lysophosphatidic acid (1-acyl-sn-glycerol-3-phosphate) a

18 rted endogenous PPARgamma ligands, including lysophosphatidic acid (16:0 and 18:1), 15-deoxy-Delta12,

19 The G protein-coupled lysophosphatidic acid 2 (LPA(2)) receptor elicits prosur

20 dom migration and following stimulation with lysophosphatidic acid, a known activator of cell motilit

21 Stimulation of chromaffin cells with lysophosphatidic acid, a nonsecretory stimulus that stro

22 Lysophosphatidic acid, a physiological activator of YAP

23 , and 2) prevented impaired efferocytosis by lysophosphatidic acid, a potent inducer of RhoA.

24 position could be restored by treatment with lysophosphatidic acid, a Rho stimulator.

25 Serum levels of lysophosphatidic acid, a well-characterized modulator of

26 gated the assembly of soluble fibronectin by lysophosphatidic acid-activated platelets adherent to fi

27 Lysophosphatidic acid activates Akt that in turn acts in

28 with the mitogens epidermal growth factor or lysophosphatidic acid activates the extracellular signal

29 en proposed to have an enzymatic activity (a lysophosphatidic acid acyl transferase or LPAAT activity

30 by the mutation, suggesting that Loa1p is a lysophosphatidic acid acyltransferase (LPA AT) with a pr

31 We have previously shown that lysophosphatidic acid acyltransferase (LPAAT)-beta inhib

32 se D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT).

33 Lysophosphatidic acid acyltransferase (LPAT) catalyzes a

34 Coexpression of a Sterculia foetida lysophosphatidic acid acyltransferase (SfLPAT) increases

35 e amount of ATS2 mRNA encoding the plastidic lysophosphatidic acid acyltransferase catalyzing the sec

36 However, the predicted apicoplast-targeted lysophosphatidic acid acyltransferase gene was refractor

37 pat1, which encodes the chloroplast acyl-ACP:lysophosphatidic acid acyltransferase.

38 se, glycerol 3-phosphate acyltransferase and lysophosphatidic acid acyltransferase.

39 -gene approaches, as a hypomorphic allele of lysophosphatidic acid acyltransferase1 (lpat1), lpat1-3.

40 These include lysophosphatidic acid acyltransferases (LPAT) and diacyl

41 anel of asthma-relevant GPCR ligands such as lysophosphatidic acid, adenosine triphosphate, and aller

42 re dependent on a platelet activator such as lysophosphatidic acid, amount of fibronectin cross-linke

43 The inhibitory effects were bypassed by lysophosphatidic acid, an activator of RhoA GTPase.

44 s of AGPAT1 and AGPAT2 are quite similar for lysophosphatidic acid and acyl-CoA.

45 ormation by TGFbeta1, TGFbeta2, TGFbeta3 and lysophosphatidic acid and altered Rho activity stimulate

46 ubating cells with the two products of PLA2 (lysophosphatidic acid and arachidonic acid) mimicked tre

47 ated iPLA(2) (amino acids 514-806) generates lysophosphatidic acid and arachidonic acid.

48 lasma fatty acids increased, whereas hepatic lysophosphatidic acid and diacylglycerol levels were sim

49 The dynamics of lysophosphatidic acid and eicosanoids display similar pa

50 lipase that catalyzes phosphatidic acid into lysophosphatidic acid and free fatty acid (both implicat

51 ein-coupled receptor signalling triggered by lysophosphatidic acid and had a function in oncogenic tr

52 MBOAT2 also prefers oleoyl-CoA, using lysophosphatidic acid and lysophosphatidylethanolamine a

53 Liver lysophosphatidic acid and PA levels were increased appro

54 that overexpression of AGPAT6 increased both lysophosphatidic acid and phosphatidic acid levels in ce

55 ates YAP nuclear translocation downstream of lysophosphatidic acid and serum as a result of constitut

56 Thrombin and the lysophospholipids lysophosphatidic acid and sphingosine 1-phosphate (S1P)

57 lipids phosphatidylinositol 4,5-biphosphate, lysophosphatidic acid, and cholesterol, bind to TRPV1 wi

58 Wounding, lysophosphatidic acid, and heparin-binding EGF-like grow

59 We found that LplT cannot transport lysophosphatidic acid, and its substrate binding was not

60 Certain lipids (lysophosphatidylcholine, lysophosphatidic acid, and prostaglandin E2) recapitulat

61 Thrombin, lysophosphatidic acid, and S1P increase COX-2 protein ex

62 ment with serum, epidermal growth factor, or lysophosphatidic acid, and this soluble form of CR-1 exh

63 [reaction: see text] Lysophosphatidic acids bearing a benzophenone group in e

64 by ionophores, sphingosine 1-phosphate, and lysophosphatidic acid but not by fMLP or thapsigargin, w

65 imod phosphate, sphingosine 1-phosphate, and lysophosphatidic acid but not by phosphate-free fingolim

66 catalyzes acylation of the sn-2 position on lysophosphatidic acid by an acyl CoA substrate to produc

67 Lysophosphatidic acids C16:0 and C18:1 failed to increas

68 We hypothesized that ATX-lysophosphatidic acid could promote inflammation/mineral

69 position from PC and likely a channeling of lysophosphatidic acid, derived from PC, into the Kennedy

70 sition consisting of phosphoglycerol (GroP), lysophosphatidic acid (GroP bearing C12:0, C16:0, or C16

71 Both kynurenic acid and 2-acyl lysophosphatidic acid have been postulated to be the end

72 epidermal growth factor receptor ligands and lysophosphatidic acid, have been identified.

73 pholipase D autotaxin (ATX) and its product, lysophosphatidic acid, have diverse functions in develop

74 Recent observations on the importance of lysophosphatidic acid in fibrosis suggest that this may

75 new study identifies an unexpected role for lysophosphatidic acid in modulating the strength of both

76 s, we have also investigated the role of ATX-lysophosphatidic acid in the mineralization of isolated

77 In a signaling pathway screen, lysophosphatidic acid increased phosphorylation of AKT,

78 Lysophosphatidic acid induced chemokinesis in T cells.

79 an activator of G-protein coupled receptors (lysophosphatidic acid) induced rapid ATP release, result

80 ne abolished the ability of MEKK3 to mediate lysophosphatidic acid-induced optimal IKKbeta/NF-kappaB

81 PM-recruited GRK2ct-KERE inhibits lysophosphatidic acid-induced phosphorylation of Akt, wh

82 Lysophosphatidic acid-induced RhoA activity was reduced

83 ed thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle con

84 Lysophosphatidic acid is a class of bioactive phospholip

85 lly), suggesting that binding and removal of lysophosphatidic acid is a potential mechanism for the i

86 Lysophosphatidic acid is an important lipid ligand regul

87 ular cAMP response to serum factors, such as lysophosphatidic acid, is a potential cause for this phe

88 lasmalogenase was competitively inhibited by lysophosphatidic acid (K(i) approximately 20 mum).

89 also report that lysophosphatidylcholine and lysophosphatidic acid levels are elevated in mutant Dros

90 persons with idiopathic pulmonary fibrosis, lysophosphatidic acid levels in bronchoalveolar lavage f

91 We show that lysophosphatidic acid levels increase in bronchoalveolar

92 mediates for the preparation of ester-linked lysophosphatidic acid (LPA) 1 and 3 were obtained in one

93 ross all tumour stages, is the lipid agonist lysophosphatidic acid (LPA) acting through the LPA recep

94 ive Galpha(13), p115RhoGEF, or RhoA mimicked lysophosphatidic acid (LPA) action, stimulating the inte

95 nderlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in s

96 (q) protein-coupled receptor in oocytes with lysophosphatidic acid (LPA) also stimulated the B and C

97 sophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline.

98 Autotaxin produces the bioactive lipid lysophosphatidic acid (LPA) and is a drug target of cons

99 Recent studies suggest that lysophosphatidic acid (LPA) and its G protein-coupled re

100 The bioactive phospholipid lysophosphatidic acid (LPA) and its receptors LPA(1-3) a

101 Serum-borne lysophosphatidic acid (LPA) and sphingosine 1-phosphopha

102 Lysophosphatidic acid (LPA) and sphingosine-1-phosphate

103 taII, PKCdelta, PKCepsilon, and PKCzeta with lysophosphatidic acid (LPA) and their inhibition with bi

104 nces responsiveness of retinal neovessels to lysophosphatidic acid (LPA) and to elucidate the underly

105 gnaling effects of lysophospholipids such as lysophosphatidic acid (LPA) are mediated by G protein-co

106 We recently identified lysophosphatidic acid (LPA) as a potent antiapoptotic ag

107 ts platelet-derived growth factor (PDGF) and lysophosphatidic acid (LPA) both stimulate human fibrobl

108 also bind the more hydrophilic phospholipid, lysophosphatidic acid (LPA) but with a higher affinity t

109 ripotent platelet growth factor and mediator lysophosphatidic acid (LPA) controls key regenerative re

110 of endothelial cell agonists, we found that lysophosphatidic acid (LPA) dramatically down-regulated

111 phospholipase A2 with resultant synthesis of lysophosphatidic acid (LPA) driving chemotaxis through L

112 Lysophosphatidic acid (LPA) enhances cell migration and

113 Lysophosphatidic acid (LPA) enhances urokinase plasminog

114 activity that generates the bioactive lipid lysophosphatidic acid (LPA) from lysophosphatidylcholine

115 Lysophosphatidic acid (LPA) functions through activation

116 Isoform-selective antagonists of the lysophosphatidic acid (LPA) G-protein coupled receptors

117 e tracking methodology, we determined that a lysophosphatidic acid (LPA) gradient induces a spatiotem

118 Lysophosphatidic acid (LPA) has been recognized recently

119 Lysophosphatidic acid (LPA) has wide-ranging effects on

120 P2) is the main source of the lipid mediator lysophosphatidic acid (LPA) in biological fluids.

121 me playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis

122 D activity controls physiological levels of lysophosphatidic acid (LPA) in blood.

123 we report a key role for the lipid mediator lysophosphatidic acid (LPA) in decidualization, acting t

124 and release and IL-13-dependent signaling by lysophosphatidic acid (LPA) in primary cultures of human

125 We recently implicated lysophosphatidic acid (LPA) in the pathogenesis of pulmo

126 Evidence suggests a proinflammatory role of lysophosphatidic acid (LPA) in various pathologic abnorm

127 Additionally, oral administration of lysophosphatidic acid (LPA) increased NHE3 activity and

128 In this study, we show that lysophosphatidic acid (LPA) induces alphavbeta6-mediated

129 at the activation of Fas or stimulation with lysophosphatidic acid (LPA) induces cytoskeletal reorgan

130 Lysophosphatidic acid (LPA) is a bioactive lipid capable

131 Lysophosphatidic acid (LPA) is a bioactive lipid that se

132 Lysophosphatidic acid (LPA) is a bioactive lysophospholi

133 Lysophosphatidic acid (LPA) is a bioactive phospholipid

134 Lysophosphatidic acid (LPA) is a bioactive phospholipid

135 Lysophosphatidic acid (LPA) is a common product of glyce

136 Lysophosphatidic acid (LPA) is a growth factor-like medi

137 Lysophosphatidic acid (LPA) is a highly potent endogenou

138 Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of

139 Lysophosphatidic acid (LPA) is a ligand for three endoth

140 Lysophosphatidic acid (LPA) is a ligand of multiple G pr

141 Lysophosphatidic acid (LPA) is a lipid mediator that fun

142 Lysophosphatidic acid (LPA) is a major lysophospholipid

143 Lysophosphatidic acid (LPA) is a membrane-derived lysoph

144 Lysophosphatidic acid (LPA) is a natural bioactive lipid

145 Emerging evidence suggests that lysophosphatidic acid (LPA) is a physiological regulator

146 Lysophosphatidic acid (LPA) is a pleiotropic lipid molec

147 Lysophosphatidic acid (LPA) is a pleiotropic lipid that

148 Lysophosphatidic acid (LPA) is a potent inducer of colon

149 The lipid mediator lysophosphatidic acid (LPA) is a potent regulator of vas

150 Lysophosphatidic acid (LPA) is a serum component that ca

151 Lysophosphatidic acid (LPA) is an extracellular lipid me

152 Lysophosphatidic acid (LPA) is an important bioactive li

153 Lysophosphatidic acid (LPA) is an important mediator of

154 Lysophosphatidic acid (LPA) is both a potential marker a

155 he G protein-coupled receptor (GPCR) agonist lysophosphatidic acid (LPA) lead to synergistic cyclo-ox

156 Lysophosphatidic acid (LPA) levels are elevated in ascit

157 a)] is important in regulating extracellular lysophosphatidic acid (LPA) levels around human epitheli

158 Lysophosphatidic acid (LPA) modulates vascular cell func

159 We investigated the effect of lysophosphatidic acid (LPA) on Na(+)/H(+) exchanger acti

160 n of inositol lipid hydrolysis by endogenous lysophosphatidic acid (LPA) or thrombin receptors was ma

161 nal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have potential as an

162 The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both

163 Lysophosphatidic acid (LPA) promotes cell survival throu

164 sphorylation is induced by activation of the lysophosphatidic acid (LPA) receptor (LPAR) via SRC-depe

165 Previously, we showed that lysophosphatidic acid (LPA) receptor 1 regulates prolife

166 internalization of N-cadherin downstream of lysophosphatidic acid (LPA) receptor 2.

167 Activation of Rho kinase (ROCK) via the lysophosphatidic acid (LPA) receptor elicits clathrin-de

168 The lysophosphatidic acid (LPA) receptor LPA1/Edg2 is the fi

169 ecular influence on implantation through the lysophosphatidic acid (LPA) receptor LPA3.

170 tors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the do

171 The endogenous phospholipid lysophosphatidic acid (LPA) regulates fundamental cellul

172 his study we report that the bioactive lipid lysophosphatidic acid (LPA) regulates hepatocyte glucose

173 We describe novel findings that lysophosphatidic acid (LPA) regulates PLC-beta1 and PLC-

174 We previously showed that lysophosphatidic acid (LPA) signaling controls the chang

175 There has been much recent interest in lysophosphatidic acid (LPA) signaling through one of its

176 The lipid mediator lysophosphatidic acid (LPA) signals via six distinct G p

177 Lysophosphatidic acid (LPA) stimulates cells by activati

178 Lysophosphatidic acid (LPA) stimulates the formation of

179 ble for the transient activation of YAP upon lysophosphatidic acid (LPA) stimulation and the inhibiti

180 n of either lysophosphatidylcholine (LPC) or lysophosphatidic acid (LPA) to cells restored their oxid

181 nversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid and a clo

182 Lysophosphatidic acid (LPA), a bioactive lipid mediator

183 Lysophosphatidic acid (LPA), a bioactive phospholipid, i

184 In MeOH, lysophosphatidic acid (LPA), a biomarker for several pat

185 In contrast, lysophosphatidic acid (LPA), a glycerol backbone phospho

186 In this study, we demonstrate that lysophosphatidic acid (LPA), a growth factor-like mediat

187 Lysophosphatidic acid (LPA), a growth factor-like phosph

188 Lysophosphatidic acid (LPA), a lipid by-product of autot

189 Lysophosphatidic acid (LPA), a major tumor-promoting fac

190 Lysophosphatidic acid (LPA), a naturally produced phosph

191 pholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth-factor

192 Lysophosphatidic acid (LPA), a potent bioactive lipid fo

193 Recent findings indicate that lysophosphatidic acid (LPA), a potent neuronal activator

194 and tissue stiffening, while the addition of lysophosphatidic acid (LPA), a rhoA activator, stimulate

195 Here, we show that lysophosphatidic acid (LPA), a signaling molecule derive

196 We show that lysophosphatidic acid (LPA), a ubiquitous phospholipid t

197 Lysophosphatidic acid (LPA), an endogenous lipid widely

198 Importantly, an injury signal initiated by lysophosphatidic acid (LPA), an upstream regulator of Ya

199 ctivated T cells 2 (NFAT1), autotaxin (ATX), lysophosphatidic acid (LPA), and beta-catenin that contr

200 te that the GPCR agonists endothelin (ET-1), lysophosphatidic acid (LPA), and thrombin, acting throug

201 vels of autotaxin and its enzymatic product, lysophosphatidic acid (LPA), are elevated during HCV inf

202 pholipase, autotaxin (ATX), and its product, lysophosphatidic acid (LPA), as potential mediators of c

203 tion and MTOC reorientation are triggered by lysophosphatidic acid (LPA), but are regulated independe

204 Thus, serum and lysophosphatidic acid (LPA), by unknown pathways, have b

205 protein and a major source for extracellular lysophosphatidic acid (LPA), in regulation of IOP in a r

206 ydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), initiating signaling cascad

207 enced cell migration via the signaling lipid lysophosphatidic acid (LPA), linking it with GPAM to cel

208 or lipin to increase the cellular content of lysophosphatidic acid (LPA), phosphatidic acid (PA), or

209 holipase D that generates the lipid mediator lysophosphatidic acid (LPA), playing a key role in diver

210 sses the hypothesis that the bioactive lipid lysophosphatidic acid (LPA), prevalent in the EOC microe

211 ng the multiple cellular effects mediated by lysophosphatidic acid (LPA), the effect on cell prolifer

212 und that a wide variety of agonists, such as lysophosphatidic acid (LPA), uridine triphosphate, growt

213 ing relied on lost axonal sensitivity toward lysophosphatidic acid (LPA), which failed to repel PRG-2

214 This growth in knowledge is epitomized by lysophosphatidic acid (LPA), which functions through int

215 ein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate

216 The proinflammatory lysophospholipid, lysophosphatidic acid (LPA), which is elevated in multip

217 Treatment of osteoclasts with lysophosphatidic acid (LPA), which phosphorylates TRIP6

218 and demonstrate specific expression of this lysophosphatidic acid (LPA)-generating enzyme in embryon

219 central intermediate signaling component in lysophosphatidic acid (LPA)-induced activation of the nu

220 a focal adhesion molecule known to regulate lysophosphatidic acid (LPA)-induced cell migration throu

221 agonist-dependent manner and, thus, enhances lysophosphatidic acid (LPA)-induced cell migration.

222 Lysophosphatidic acid (LPA)-induced ERK phosphorylation

223 cerol and PKC activator), hypertonic stress, lysophosphatidic acid (LPA)-induced G protein-coupled re

224 We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8)

225 This is required for p27(KIP1) to enhance lysophosphatidic acid (LPA)-induced ovarian cancer cell

226 ay consisting of G(i)-Ras-NF-kappaB mediates lysophosphatidic acid (LPA)-induced urokinase plasminoge

227 artially blocks RhoA activation, it inhibits lysophosphatidic acid (LPA)-stimulated migration as effi

228 tic diseases by producing the lipid mediator lysophosphatidic acid (LPA).

229 adipose triglyceride lipase and acylation of lysophosphatidic acid (LPA).

230 the conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA).

231 that generates the bioactive lipid mediator lysophosphatidic acid (LPA).

232 onsible for synthesis of the bioactive lipid lysophosphatidic acid (LPA).

233 ed form of lysophospholipase D that produces lysophosphatidic acid (LPA).

234 1 pathway is also activated, for example, by lysophosphatidic acid (LPA).

235 (UDP), platelet activating factor (PAF), or lysophosphatidic acid (LPA).

236 PDGF interacts extensively with lysophosphatidic acid (LPA).

237 Autotaxin (ATX) generates the lipid mediator lysophosphatidic acid (LPA).

238 lysophospholipase D activity that generates lysophosphatidic acid (LPA).

239 y homologous G protein-coupled receptors for lysophosphatidic acid (LPA).

240 e that hydrolyzes lysophosphatidylcholine to lysophosphatidic acid (LPA).

241 e cell surface in response to treatment with lysophosphatidic acid (LPA).

242 ms, destabilization/regression was driven by lysophosphatidic acid (LPA).

243 zed to generate the lipid signaling molecule lysophosphatidic acid (LPA).

244 ion of G-protein-coupled receptors [e.g., by lysophosphatidic acid (LPA)]--are molecularly connected

245 croM oleic acid or 100 microM oleoyl-L-alpha-lysophosphatidic acid (LPA; 18:1).

246 Isolated photoreceptors were treated with lysophosphatidic acid (LPA; a RhoA activator) or Y27632

247 G protein-coupled receptor agonists, notably lysophosphatidic acid (LPA; acting through the LPA1 rece

248 ostaglandin D2 (PGD2) as well as some of the lysophosphatidic acids (LPA) in the small intestine were

249 in 4 of 20 patients with increased levels of lysophosphatidic acid [LPA(16:0)], where it correlated w

250 ic acid (PA) (long-chain fatty acyl-CoAs and lysophosphatidic acid [LPA]) were not decreased, we did

251 genic lysophosphatidylcholine (LPC 18:1) and lysophosphatidic acids (LPAs) in the intestine and plasm

252 or reversed damage due to arachidonic acid, lysophosphatidic acid, lysophosphatidylcholine, diacylgl

253 lating activity toward glycerol 3-phosphate, lysophosphatidic acid, lysophosphatidylinositol, and dia

254 ate that adenosine inhibits endothelin-1 and lysophosphatidic acid-mediated HSC contraction.

255 critical intermediate signaling molecule in lysophosphatidic acid-mediated nuclear factor-kappaB (NF

256 onounced increase in phosphatidylcholine and lysophosphatidic acid metabolites, which coincided with

257 glucose-derived glycerol-3-phosphate to form lysophosphatidic acid, mono- and diacylglycerols, and ot

258 gulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility

259 Lysophosphatidic acid, one of the known stimuli transduc

260 nt of G protein or stimulation of cells with lysophosphatidic acid or endothelin-1, which activate th

261 ic acid from oleoyl-CoA to glycerophosphate, lysophosphatidic acid, or diacylglycerol, suggesting tha

262 mature utricles, exogenous stimulation with lysophosphatidic acid overcame this maturational block a

263 latory gene modules driving HCC risk and the lysophosphatidic acid pathway as a central chemopreventi

264 s essential for dephosphorylating substrates lysophosphatidic acid, phosphatidic acid, or sphingosine

265 2 modulated the levels of phosphatidic acid, lysophosphatidic acid, phosphatidylinositol species, as

266 ng injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.

267 00/100)/IGFII mice, ATX is overexpressed and lysophosphatidic acid promotes a strong deposition of hy

268 ATX-lysophosphatidic acid promotes inflammation and minerali

269 We showed that ATX-lysophosphatidic acid promotes the mineralization of the

270 This included inhibitory effects on lysophosphatidic acid, purinergic (ATP), bradykinin, and

271 cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1), leading to enh

272 ection of unidirectional flow; inhibition of lysophosphatidic acid receptor 1 restored the flow-depen

273 (-7), beta = 0.16), which is downstream from lysophosphatidic acid receptor 1.

274 intercellular gaps, which were abolished by lysophosphatidic acid receptor 1/2 inhibition.

275 emonstrate that this activity is mediated by lysophosphatidic acid receptor 3 (Lpar3).

276 nduced activation of pro-apoptotic pathways (lysophosphatidic acid receptor and caspase-domain signal

277 Lysophosphatidic acid receptor antagonists are currently

278 riptionally down-regulates expression of the lysophosphatidic acid receptor EDG2 and this down-regula

279 n 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonar

280 The lysophosphatidic acid receptor type 1 (LPA1) is 1 of 6 k

281 GPR92 was confirmed to be a lysophosphatidic acid receptor with weaker responses to

282 ctivation is impaired downstream of both the lysophosphatidic acid receptor, a G-protein-coupled rece

283 e retraction evoked by Galpha12/13-dependent lysophosphatidic acid receptors was augmented in R7BP-ex

284 secretagogue stimulation in the presence of lysophosphatidic acid resulted in reduced evoked secreto

285 This study characterizes the autotaxin-lysophosphatidic acid signaling axis as a modulator of O

286 LPA (lysophosphatidic acid) specific endothelial differentiat

287 t the identification of an integral membrane lysophosphatidic acid-specific acyltransferase, LPAAT3,

288 in this issue, Schmidt and Brown report that lysophosphatidic acid-specific acyltransferase, LPAAT3,

289 ed to be activated by lipid ligands, such as lysophosphatidic acid, sphingosine 1-phosphate (S1P), an

290 nous G protein-coupled receptors (GPCRs) for lysophosphatidic acid, sphingosine 1-phosphate, and thro

291 Serum, lysophosphatidic acid, sphingosine-1-phophate (S1P), and

292 acious for RhoA activation include thrombin, lysophosphatidic acid, sphingosine-1-phosphate, and thro

293 last cells blocked cell migration induced by lysophosphatidic acid through G protein-coupled receptor

294 AGPAT2 catalyzes acylation of lysophosphatidic acid to phosphatidic acid, a precursor

295 Jun N-terminal kinase blocked the ability of lysophosphatidic acid to sequester the beta(2)-adrenergi

296 light chains (MLC20) were phosphorylated by lysophosphatidic acid to the same extent in Palladin nul

297 After lysophosphatidic acid treatment, 85% of the mature suppo

298 trimeric G proteins to downstream effectors, lysophosphatidic acid was shown to regulate the function

299 hosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery

300 Extracellularly administered lysophosphatidic acid, which activates its signaling cas