ライフサイエンスコーパス: lysophospholipid

1 are phospholipids with one fatty acid tail (lysophospholipids).

2 free fatty acid, e.g., arachidonate, and a 2-lysophospholipid.

3 at were modified by the incorporation of the lysophospholipid.

4 lglyerol, thus forming triacylglycerol and a lysophospholipid.

5 acid (LPA), a pleiotropic growth-factor-like lysophospholipid.

6 and structure by altering phospholipids and lysophospholipids.

7 fied through the asymmetric incorporation of lysophospholipids.

8 transfers fatty acids from phospholipids to lysophospholipids.

9 ), a precursor of prostaglandins, as well as lysophospholipids.

10 protected isoprostanes to the corresponding lysophospholipids.

11 ht subjects had different profiles of plasma lysophospholipids.

12 2 and DeltaC2 both had activity on monomeric lysophospholipids.

13 ed an increase in phosphatidic acid (PA) and lysophospholipids.

14 es of neutrophils to release fatty acids and lysophospholipids.

15 ty acids including arachidonic acid (AA) and lysophospholipids.

16 drug did not appear to block reacylation of lysophospholipids.

17 l membranes, liberating free fatty acids and lysophospholipids.

18 incorporation with a significant decrease in lysophospholipids.

19 ipids to yield nonesterified fatty acids and lysophospholipids.

20 opology through the generation of asymmetric lysophospholipids.

21 y adding a palmitate to the sn-2 position of lysophospholipids.

22 o acids, nucleobase-containing compounds and lysophospholipids.

23 ane phospholipids to release fatty acids and lysophospholipids.

24 st SocA dehydrogenase activity contained the lysophospholipid 1-acyl 2-hydroxy-sn-glycerophosphoethan

25 ects resulting from the incorporation of the lysophospholipid 1-myristoyl-2-hydroxy-sn-glycerol-3-pho

26 These results demonstrated that reduction of lysophospholipid absorption enhances insulin-mediated gl

27 he intestinal lumen facilitates postprandial lysophospholipid absorption, which suppresses hepatic fa

28 elet activating factor (PAF) to a variety of lysophospholipid acceptors.

29 ing site to facilitate efficient flipping of lysophospholipid across the cell membrane.

30 t the mechanisms involve both attenuation of lysophospholipid actions at cell surface receptors and o

31 Lysophospholipid activity was dependent on lipid structu

32 sal was found to directly inhibit neutrophil lysophospholipid:acyl-CoA acyltransferase activity at th

33 yl-LPEAT activities but did not affect other lysophospholipid acylating activities.

34 evels of secretory phospholipase A2 (sPLA2), lysophospholipid acyltransferase (LPEAT), lysophosphatid

35 Our findings suggest that lysophospholipid acyltransferase activity is essential f

36 (PG) E2, and PGD2 production, in addition to lysophospholipid acyltransferase activity.

37 ents the identification of a plasma membrane lysophospholipid acyltransferase and establishes the fun

38 cumulation of lysophospholipids induced by a lysophospholipid acyltransferase inhibitor extensively v

39 gene encoding a mammalian acyl-CoA-dependent lysophospholipid acyltransferase with prominent activity

40 The major yeast lysophospholipid acyltransferase, Ale1p, is related to m

41 s shown that this enzyme can also serve as a lysophospholipid acyltransferase.

42 members of a superfamily of enzymes known as lysophospholipid acyltransferases (LPLATs), which are pr

43 Acyl-CoA-dependent lysophospholipid acyltransferases play an important role

44 much less affected, demonstrating that other lysophospholipid acyltransferases than the two LPEATs co

45 transferred to lysophospholipids by acyl-CoA:lysophospholipid acyltransferases.

46 c activity but retain their side activity as lysophospholipid acyltransferases.

47 (Oys), Nessy (Nes), and Farjavit (Frj), are lysophospholipid acyltransferases.

48 Solubilization with lysophospholipids again resulted in drastic losses of en

49 icient route to enantiomerically homogeneous lysophospholipid analogues from D-mannitol 1,2:5,6-bis-a

50 as dependent on the glycerol backbone of the lysophospholipid and increased with acyl chain length, w

51 tivate a carboxylesterase known to hydrolyze lysophospholipids and acylated proteins in eukaryotes.

52 ellular membranes to catalyze the release of lysophospholipids and arachidonic acid.

53 study of fibrotic mediators have centered on lysophospholipids and eicosanoids.

54 Obesity was inversely associated lysophospholipids and ether linked phosphatidylcholines.

55 ndent on phospholipase A2 (PLA2) to mobilize lysophospholipids and free fatty acids to sustain fatty

56 ) hydrolyze glycerophospholipids to liberate lysophospholipids and free fatty acids.

57 bstrates releasing free arachidonic acid and lysophospholipids and giving rise to the generation of d

58 LplT catalyzes the transbilayer movement of lysophospholipids and is the first example of a phosphol

59 Free fatty acids, eicosanoids, lysophospholipids and PAF are potent regulators of infla

60 The relative potencies of lysophospholipids and PUFAs are such that lysophosphatid

61 +)-ATPases evolved as specific receptors for lysophospholipids and support the hypothesis that lysoph

62 ed with the hydrolysis of phospholipids into lysophospholipids and unesterified fatty acids.

63 -position to yield a free fatty acid and a 2-lysophospholipid, and iPLA(2)beta has been reported to p

64 ll as cyprinol sulfate and taurocholic acid, lysophospholipids, and a decrease in sphingosine levels

65 ta) causes accumulation of arachidonic acid, lysophospholipids, and eicosanoids that can promote infl

66 ids (glycerides, fatty acids, phospholipids, lysophospholipids, and galactolipids) and implemented a

67 f LPT1 abrogated the esterification of other lysophospholipids, and overexpression increased lysophos

68 ospholipid hydrolysis, production of choline lysophospholipids, and PAF synthesis.

69 that, in addition to self-glycolipids, self-lysophospholipids are also recognized by type II NKT cel

70 ors for the serine protease thrombin and for lysophospholipids are coupled to G proteins and control

71 hospholipids and support the hypothesis that lysophospholipids are important plant signaling molecule

72 Because lysophospholipids are involved during inflammation, our

73 s including calmodulin, protein kinase C and lysophospholipids are involved in SOC activation.

74 These findings provide insight into how lysophospholipids are presented by human CD1d molecules

75 Lysophospholipids are self-antigens presented by CD1d th

76 ngle chromatographic step, phospholipids and lysophospholipids are separated and recovered for quanti

77 Phospholipids, predominantly lysophospholipids, are present in tears.

78 r glycerol-3-phosphate or a variety of other lysophospholipids as substrates, including lysophosphati

79 Proinflammatory immune mediators, lysophospholipids as well as cytokines such as CXCL10 an

80 ansferase activity toward a variety of other lysophospholipids, as well as neutral lipid substrates,

81 pholipids using a combination of an in vitro lysophospholipid binding assay using purified protein an

82 volves the generation of membrane-associated lysophospholipids by a cytoplasmic Ca2+-independent phos

83 m in which in situ generation of nonlamellar lysophospholipids by ACT-PLA activity into the cell memb

84 A by acyl-CoA synthetases and transferred to lysophospholipids by acyl-CoA:lysophospholipid acyltrans

85 utagenesis to delineate the active domain of lysophospholipid catalytic activity and to examine poten

86 The various lysophospholipids caused the efflux of cellular choleste

87 LC separation of individual phospholipid and lysophospholipid classes.

88 overed by enzymatic degumming contained more lysophospholipids compared to water degumming.

89 Two lysophospholipids comprising approximately 10% of all ph

90 results suggest that LysoPC, an atherogenic lysophospholipid contained in oxidized LDL, rapidly indu

91 phosphatidylcholine (LysoPC), an atherogenic lysophospholipid contained in oxidized low-density lipop

92 36(-/-) myocardium associated with increased lysophospholipid content and a higher proportion of 22:6

93 The elevation in free fatty acids and lysophospholipids correlated with increased expression o

94 A multivariate combination of the 26 lysophospholipids could discriminate between normal-weig

95 ibited by perifosine, an orally active alkyl-lysophospholipid currently being evaluated as an anti-ca

96 A number of lysophospholipids demonstrated increased ion signal in a

97 optosis, suggesting that the accumulation of lysophospholipids did not account for the decrease in Co

98 Activation of the plant pump by lysophospholipids did not involve the penultimate residu

99 s with cultured hepatoma cells revealed that lysophospholipids dose-dependently suppressed insulin-st

100 d residues, e.g. linoleate (C18:2), to yield lysophospholipids, e.g. monolysocardiolipin (MLCL), that

101 but do confer cross sensitivity to the alkyl-lysophospholipid edelfosine, which is known to displace

102 sPLA2-IIA yields inflammatory mediators (ie, lysophospholipids, fatty acids, and mtDNA) that promote

103 Lysophosphatidic acid (LPA) is a major lysophospholipid found systemically, and its levels are

104 Isolated phospholipid and lysophospholipid fractions are available for separation

105 AdPLA generated free fatty acid and lysophospholipid from phosphatidylcholine with a prefere

106 Recovery of phospholipids and lysophospholipids from HPLC averages 80-90%.

107 e now report that lipid fractions containing lysophospholipids from oxidized LDL or phospholipase A2-

108 ll neoantigens, such as free fatty acids and lysophospholipids, from common phosphodiacylglycerides.

109 Sphingosine-1-phosphate (S1P) is a bioactive lysophospholipid generated by the sphingosine kinase (SK

110 Analyses of the lysophospholipids generated during activation reveal tha

111 In these cells, S1P, a biologically active lysophospholipid, greatly enhances increases in intracel

112 Sphingosine 1-phosphate (S1P), a lysophospholipid, has gained relevance to multiple scler

113 Lysophospholipids have emerged as biologically important

114 Plasma lysophospholipids have emerged as signaling molecules wi

115 ion of CD1d contains bound sphingomyelin and lysophospholipids in addition to phosphatidyl choline.

116 However, parental CHO-K1 cells respond to lysophospholipids in in-vitro functional assays, which s

117 on can result from increasing the content of lysophospholipids in membranes, either by stimulation of

118 amount of dietary phospholipids absorbed as lysophospholipids in Pla2g1b-/- mice compared with that

119 against glycerol 3-phosphate or a variety of lysophospholipids, including lysophosphatidylcholine, ly

120 PLA2 enzymes release fatty acids and lysophospholipids, including the precursor of platelet-a

121 blood mononuclear cells with an inflammatory lysophospholipid induced beta-galactosidase and sialidas

122 Moreover, accumulation of lysophospholipids induced by a lysophospholipid acyltran

123 d that neither SPC nor LPC, or other related lysophospholipids, induced internalization of GPR4 from

124 The lysophospholipid-inducible beta-galactosidase activity o

125 ing membrane spontaneous curvature by adding lysophospholipids inhibits the lipid mixing observed for

126 hosphate (SPP), a platelet-derived bioactive lysophospholipid, is a regulator of angiogenesis.

127 When both lysophospholipid isomers are present in a 1:1 mixture un

128 Elevating plasma lysophospholipid levels in Pla2g1b-/- mice via intraperi

129 reoperative plasma samples were analyzed for lysophospholipid levels using liquid chromatography mass

130 h coincided with reduced postprandial plasma lysophospholipid levels.

131 A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properti

132 that might also encode receptors for related lysophospholipid ligands.

133 AR of LPA(5) using LPA analogs and other non-lysophospholipid ligands.

134 bioactive lipid species that is part of the lysophospholipid (LP) family.

135 ne phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-p

136 reated macrophages suggest that ethanolamine lysophospholipid (LPE) is an sPLA2-V-derived product tha

137 The lysophospholipid (LPL) mediators lysophosphatidic acid (

138 A platform for comprehensive analysis of lysophospholipid (LPL) species based on shotgun lipidomi

139 Lysophospholipids (LPLs) (lysophosphatidylcholine, lysop

140 ervations prompted the hypothesis that other lysophospholipids (lyso-PLs) may also signal for human n

141 Lysophospholipids (lyso-PLs), including various glycerol

142 Phospholipid vesicles and lysophospholipid (lysolipid) micelles were employed as m

143 Thrombin and the lysophospholipids lysophosphatidic acid and sphingosine

144 The proinflammatory lysophospholipid, lysophosphatidic acid (LPA), which is

145 taxis; whereas, another structurally related lysophospholipid, lysophosphatidic acid, did not compete

146 The lysophospholipids, lysophosphatidic acid (LPA) and sphin

147 The lysophospholipids, lysophosphatidic acid, sphingosine-1-

148 which liberates large amounts of AA and the lysophospholipid lysophosphatidylcholine (LPC), from mem

149 plicated G2A as a receptor for the bioactive lysophospholipid, lysophosphatidylcholine (LPC).

150 gests a role for GPR55 as a receptor for the lysophospholipid lysophosphatidylinositol (LPI).

151 Further, lysophospholipids may be cytotoxic and/or impair the fun

152 The unique mode of signaling of this lysophospholipid mediator is providing novel opportuniti

153 Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that acts through G protein-co

154 Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cell

155 (LPA) and sphingosine-1-phosphate (S1P) are lysophospholipid mediators of diverse cellular processes

156 l challenge to better understand the role of lysophospholipid metabolism in the progression of obesit

157 ting that obesity impairs the sensitivity of lysophospholipid metabolism to n-3 PUFAs.

158 Obesity has a substantial impact on lysophospholipid metabolism, altering the plasma lysopho

159 Zwitterionic lysophospholipid micelles are able to induce the beta-sh

160 ter for construction of the optically active lysophospholipid molecule, (2) tetrahydropyranylation of

161 Stimulation by lysophospholipids occurs through G(i), whereas thrombin

162 Our findings extend the influence of lysophospholipids on immune function and suggest that al

163 from the accumulation of anionic lipids and lysophospholipids on the particle surface and/or from pr

164 A2 products (polyunsaturated fatty acids and lysophospholipids) on the cold-sensitive channel transie

165 and EDG-4 suggested that its ligand may be a lysophospholipid or lysosphingolipid.

166 pids as well as other family lipids, such as lysophospholipids or sphingomyelin, were found significa

167 transacylations between various phospholipid-lysophospholipid pairs, it showed the highest rate for t

168 epG2 cells affected the secretion pattern of lysophospholipids, partially resembling the changes obse

169 eacetylase inhibitors (HDACIs) and the alkyl-lysophospholipid perifosine were examined in human leuke

170 various glycerol-based and sphingosine-based lysophospholipids, play important roles in many biochemi

171 Sphingosine 1-phosphate (S1P), a lysophospholipid, plays an important chemotactic role in

172 alpha-chloro fatty aldehydes and unsaturated lysophospholipids, possess proatherogenic properties, as

173 sed in yeast, these MBOATs esterify specific lysophospholipids preferentially with unsaturated fatty

174 n, and characterization of phospholipids and lysophospholipids present in complex biological samples.

175 PLA I may play an important role in removing lysophospholipids produced by both phospholipase A1 and

176 Lysophospholipids produced by Pla2g1b hydrolysis suppres

177 at cell surface receptors and opposition of lysophospholipid production.

178 Both AA and lysophospholipid, products of the enzymic reaction, can

179 phospholipid metabolism, altering the plasma lysophospholipid profile and abolishing its sensitivity

180 ds with positive intrinsic curvature such as lysophospholipids promoted membrane permeabilization, wh

181 Polyunsaturated fatty acids and lysophospholipids protect the brain against global ischa

182 for this idea by showing that inhibition of lysophospholipid reacylation by a novel Golgi-associated

183 g the G protein-coupled receptor LPA1/VZG-1 (lysophospholipid receptor A1/ventricular zone gene-1), r

184 nding the biological roles of this enlarging lysophospholipid receptor family.

185 derlying lysophosphatidic acid signaling and lysophospholipid receptor gene evolution, these results

186 affinity ligand, belongs to a newly defined lysophospholipid receptor subfamily.

187 ese results confirm LPA(5) to be a bona fide lysophospholipid receptor.

188 d receptors, encoded by genes designated lp (lysophospholipid) receptor or edg (endothelial different

189 S1P4, and S1P5), collectively referred to as lysophospholipid receptors (lpR).

190 his brief review, we note cogent features of lysophospholipid receptors, including the current nomenc

191 protein-coupled, alpha/beta-adrenergic, and lysophospholipid receptors.

192 ysLT synthesis and arachidonic acid (AA) and lysophospholipid release by eosinophils mediated by reco

193 dicate that sPLA(2)-X participates in AA and lysophospholipid release, resulting in CysLT synthesis i

194 that lysophosphatidylcholine (LPC), the main lysophospholipid released in response to sPLA2-X activit

195 Compared with other known factors, lysophospholipids represent the major activator of calci

196 essential for embryogenesis by supplying the lysophospholipid S1P, which regulates embryonic vascular

197 zone depends on responsiveness to the blood lysophospholipid S1P, with S1P(1) signaling overcoming t

198 e implicating LPPs as negative regulators of lysophospholipid signaling and suggest that the mechanis

199 f neurons and oligodendrocytes and implicate lysophospholipid signaling as a potential regulator of m

200 mplicate G protein-coupled receptor-mediated lysophospholipid signaling as a significant mechanism in

201 Our results provide evidence that endogenous lysophospholipid signaling requires an lp receptor gene

202 , we have identified an intricate network of lysophospholipid signalling by splenic macrophages that

203 Importantly, the following lysophospholipid species are significantly increased in

204 Exogenous sPLA(2)-X released lysophospholipid species that arise from phospholipids e

205 or an acyltransferase that uses a variety of lysophospholipid species, including 1-acyl-sn-glycerol-3

206 Here we show that lysophospholipids specifically activate a plant plasma m

207 lacking Ale1p and studied their acyl-CoA and lysophospholipid specificities using novel mass spectrom

208 OSE OF REVIEW: Lipid mediators including the lysophospholipids, sphingolipids and eicosanoids have lo

209 The lysophospholipid sphingosine 1-phosphate (S1P) is a plei

210 The lysophospholipid sphingosine 1-phosphate (S1P) promotes

211 hat lymphocyte trafficking is altered by the lysophospholipid sphingosine-1-phosphate (S1P) and by a

212 S1PR1), a G protein-coupled receptor for the lysophospholipid sphingosine-1-phosphate (S1P), is eleva

213 A new study shows that HDL-associated lysophospholipids stimulate the production of the potent

214 This effect was specific in terms of lysophospholipid structure.

215 to form a hydrophobic channel through which lysophospholipid substrates enter and leave the active s

216 The signaling effects of lysophospholipids such as lysophosphatidic acid (LPA) ar

217 hesis that Pla2g1b and its lipolytic product lysophospholipid suppress hepatic fat utilization and en

218 hosphatidic acid (LPA) is a membrane-derived lysophospholipid that can induce pleomorphic effects in

219 Sphingosine-1-phosphate (S1P) is a lysophospholipid that evokes a variety of biological res

220 Sphingosine 1-phosphate (S1P) is a lysophospholipid that exerts a variety of responses in c

221 Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that signals through G protein-coupled

222 ciated endogenous antigenic lipids including lysophospholipids that are generated by HBV-induced secr

223 sis of phospholipids to inverted-cone-shaped lysophospholipids that contribute to membrane curvature

224 The many biological responses documented for lysophospholipids that include lysophosphatidic acid and

225 s study was to assess the response of plasma lysophospholipids to obesity, n-3 PUFA consumption, and

226 These were termed as PAF:lysoplasmalogen (lysophospholipid) transacetylase and PAF:sphingosine tra

227 The tafazzin gene encodes a phospholipid-lysophospholipid transacylase involved in cardiolipin me

228 Lysophospholipid transporter (LplT) was previously found

229 This work identifies and characterizes a lysophospholipid transporter gene (lplT, formally ygeD)

230 However, lysophospholipid treatment of peripheral blood mononucle

231 ependent manner but hydrolyzes ceramides and lysophospholipids via bile salt-independent mechanisms.

232 on following exposure to LPA but not related lysophospholipids was observed.

233 The profile of secreted lysophospholipids was studied in HepG2 cells under palmi

234 Plasma levels of lysophospholipids were evaluated as potential biomarkers

235 nent activity toward ethanolamine-containing lysophospholipids, which we termed acyl-CoA:lysophosphat

236 The abundant lysophospholipid with the mass m/z 450 (molecular ion [M

237 esteryl esters (CE), triglycerides (TG), and lysophospholipids, with CE and TG hydrolysis stimulated

238 To show that lysophospholipids within an intact lipoprotein were acti

239 studies showed that injected PLA2 generates lysophospholipids within human skin in vivo, and polyclo