ライフサイエンスコーパス: lysosomal

1 tubule fission in lysosome function, similar lysosomal abnormalities were seen in cellular models lac

2 Lysosomal-accumulated MPO can be both cell-protective, b

3 P(E693Q) (Dutch) mutation have intraneuronal lysosomal accumulation of APP carboxylterminal fragments

4 or NPC2 with decreased functions leading to lysosomal accumulation of cholesterol and sphingolipids.

5 Of note, lysosomal acid lipase (LAL) deficiency facilitates melan

6 e studied the effect of lalistat, a specific lysosomal acid lipase (LAL/Lipa) inhibitor on LD degrada

7 Lysosomal acid lipase deficiency-which can be diagnosed

8 ex vivo activities of debranching enzyme and lysosomal acid maltase, two major hepatic alpha-glucosid

9 rial clearance by differential regulation of lysosomal acidification and enzymatic activity.

10 Defective lysosomal acidification contributes to virtually all lys

11 sely affecting v-ATPase function dysregulate lysosomal acidification in other LSDs and common neurode

12 wever, lysosomal-delivered MPO also disrupts lysosomal acidification in RPE cells, which coincides wi

13 Loss of lysosomal acidification through inhibition of the vacuol

14 zed cell was shown to be degraded due to the lysosomal activation in both cells whereas the disintegr

15 sed autophagosome biogenesis and compromised lysosomal activity.

16 Lysosomal alterations have been implicated as one of the

17 E transcription factors-master regulators of lysosomal and melanosomal biogenesis and autophagy-contr

18 TMEM175 plays a direct and critical role in lysosomal and mitochondrial function and PD pathogenesis

19 biochemical studies have implicated impaired lysosomal and mitochondrial function in the pathogenesis

20 Ks) are well characterized for their role in lysosomal and mitochondrial trafficking in cells, especi

21 including specific branches of the endosomal-lysosomal and ubiquitin-proteasome systems, in maintaini

22 roteins are exosomal; the remainder are from lysosomal and vacuolar compartments.

23 lation in the lumen of enlarged perinuclear, lysosomal-associated membrane protein 1 (LAMP1)-positive

24 With respect to one of the target genes, lysosomal beta A mannosidase (MANBA), we observed that g

25 ) through the induction of genes involved in lysosomal biogenesis and exocytosis.

26 , a master regulator of lipid metabolism and lysosomal biogenesis and function.

27 teins occurs by the concurrent activation of lysosomal biogenesis and up-regulation of macroautophagy

28 increased concomitantly with the increase of lysosomal biogenesis induced by lysosome alkalizers or s

29 nted the increase in cellular energy levels, lysosomal biogenesis, and endocytic uptake, suggesting t

30 aster transcriptional regulator of autophagy-lysosomal biogenesis, we can reverse the autophagy dysfu

31 gs suggest that TRPML1 may function as a key lysosomal Ca(2+) channel controlling both lysosome bioge

32 We recently have demonstrated that the lysosomal Ca(2+) release channel P2X4 regulates lysosome

33 tivation are suppressed by up-regulating the lysosomal Ca(2+) release channel transient receptor pote

34 ion of lysosomal membrane are accompanied by lysosomal Ca(2+) release.

35 Inhibition of either lysosomal Ca(2+) signaling or Cathepsin B release preven

36 In contrast, Akt suppresses lysosomal catabolism of ingested proteins when free amin

37 in several proteins linked to autophagy and lysosomal catabolism reflecting vesicular transport obst

38 into autophagic vacuoles and was blocked by lysosomal cathepsin B and L inhibition.

39 microglia (DAM), which encodes an endosomal/lysosomal cathepsin inhibitor named Cystatin F.

40 PorB increases the level of OVA in the endo-/lysosomal cellular compartment of BMDCs, increases antig

41 In addition to lysosomal changes at 12 months of age, these mice develo

42 ed, fluorescent chloride reporter to measure lysosomal chloride in Caenorhabditis elegans as well as

43 Thus, lysosomal cholesterol drives mTORC1 activation and growt

44 the mammalian target of rapamycin, enhanced lysosomal clearance of C99.

45 echanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy.

46 ce cleaved, the drug escapes the acidic endo-lysosomal compartment into the cytosol and traffics to i

47 g the disulphide amino acid cystine from the lysosomal compartment into the cytosol.

48 me samples, time-dependent activation of the lysosomal compartment with no changes in LC3 expression

49 Internalized Siglec-8 localized to the lysosomal compartment.

50 the most prevalent nuclease activity in endo-lysosomal compartments and that additional stabilization

51 ority of dendrimers are directed to the endo-lysosomal compartments in both cell types.

52 by FBP, aldolases promote the formation of a lysosomal complex containing at least v-ATPase, ragulato

53 AMP-2) immunolabeling showed higher neuronal lysosomal counts in brain of 12-months-old APP(E693Q) as

54 function as a low-affinity Cu transporter, a lysosomal Cu exporter, or a regulator of Ctr1 activity,

55 Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversi

56 ragine endopeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid pr

57 was designed to be cleaved by cathepsin B, a lysosomal cysteine protease.

58 Our findings indicate that lysosomal damage by Yersinia translocon proteins promote

59 Here we show that in response to lysosomal damage, the prototypical cytosolic secretory a

60 Given the deeper genetic understanding of lysosomal defects in neurodegeneration, we explore why s

61 However, the mechanism underlying lysosomal deficits in AD remains poorly understood.

62 capture unwanted intracellular material for lysosomal degradation (2) .

63 mpetent DCVs in BON neuroendocrine cells and lysosomal degradation (crinophagy) of insulin-containing

64 between GLP-1R plasma membrane recycling and lysosomal degradation and, in doing so, determine the ov

65 by a double-membrane autophagic process via lysosomal degradation called mitophagy is critical for m

66 ggest an unanticipated function for parasite lysosomal degradation in chronic infection, and identify

67 in-7 and targeted it for internalization and lysosomal degradation in conjunction with claudin-7.

68 ase C inhibitory peptide or bafilomycin A (a lysosomal degradation inhibitor) each blocked the Ang II

69 llows a defined trafficking route to amoebic lysosomal degradation machinery.

70 Unexpectedly, defective lysosomal degradation of bacteria also attenuated furthe

71 f hepatic autophagy, a process that leads to lysosomal degradation of cellular components.

72 amine environment, when macropinocytosis and lysosomal degradation of extracellular proteins are used

73 Rather than preventing the lysosomal degradation of HIF1alpha, disrupting the V-ATP

74 continuous uptake of bacteria is preceded by lysosomal degradation of microbes.

75 To investigate the involvement of lysosomal degradation of neutral lipids, we studied the

76 overcompensation by RhoB because of reduced lysosomal degradation of RhoB in Gamma-aminobutyric acid

77 ly endosome-to-Golgi trafficking and induced lysosomal degradation of STx2.

78 tween mutant and wild-type APP, enhanced the lysosomal degradation of the mutant APP, and inhibited g

79 ated factor (PCAF)-dependent acetylation and lysosomal degradation of the pyruvate kinase-M2 isoform

80 uronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and he

81 NA sensor cyclic GMP-AMP synthase (cGAS) for lysosomal degradation to avoid the detection of mitochon

82 intron of genes that regulate autophagosome/lysosomal degradation, mitochondrial trafficking, and am

83 linked genes play a direct role in autophagy/lysosomal degradation, one of the most important pathway

84 idoglycans restored phagocytic uptake in the lysosomal degradation-defective mutants via a pathway re

85 arget aggregated Golgi membrane proteins for lysosomal degradation.

86 estive of FcRn-directed albumin salvage from lysosomal degradation.

87 QP2 to multivesicular bodies and facilitates lysosomal degradation.

88 aggregation of a Golgi protein leads to its lysosomal degradation.

89 and engagement leads to depalmitoylation and lysosomal degradation.

90 triggering for membrane fusion, resulting in lysosomal degradation.

91 the processes of autophagosome synthesis and lysosomal degradation.

92 nding Notch1, rescuing it from Numb-mediated lysosomal degradation.

93 ted exosomes, but had minimal effects on APP lysosomal degradation.

94 endocytic event that targets the channel to lysosomal-degradative compartments.

95 However, lysosomal-delivered MPO also disrupts lysosomal acidific

96 ul enzyme from the extracellular space, with lysosomal-delivered MPO exhibiting a half-life of 10 h.

97 ow that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor o

98 Autophagy coordinates lysosomal destruction of cytosolic constituents and is s

99 Moreover, lysosomal destruction or damage abolishes these TFEB-dep

100 l as murine and human cell culture models of lysosomal diseases.

101 gene therapy) or applicable to more than one lysosomal disorder (haemopoietic stem cell transplantati

102 ivery to the CNS is now the primary focus in lysosomal disorder research.

103 ase 2 clinical trials) might be for specific lysosomal disorders (enzyme replacement therapy via intr

104 Lysosomal disorders have been an area of interest since

105 and mammalian cell culture models of diverse lysosomal disorders, where previously only lysosomal pH

106 Lysosomal distribution is linked to the role of lysosome

107 of TFEB in JAK2-deficient podocytes reversed lysosomal dysfunction and restored albumin permselectivi

108 In Drosophila and mammalian macrophages, lysosomal dysfunction due to loss of the endolysosomal C

109 Mitochondrial and lysosomal dysfunction have been implicated in substantia

110 Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparabl

111 an important link between mitochondrial and lysosomal dysfunction in PD pathogenesis.

112 id metabolism associated with late endosomal/lysosomal dysfunction may play a role in the pathogenesi

113 LP-1 receptor agonist exendin-4 reversed the lysosomal dysfunction, relieving the impairment in autop

114 blockage in autophagic flux associated with lysosomal dysfunction.

115 ive accumulation of autophagic vacuoles, and lysosomal dysfunction.

116 Inhibition of mTOR strongly reduced the lysosomal efflux of most essential amino acids, converti

117 n lysosomal pH, which leads to impairment of lysosomal enzyme activity and disruption of autophagic p

118 ulti-system disorder caused by deficiency of lysosomal enzyme alpha-L-iduronidase, and patients treat

119 used by mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase (GCase).

120 link between mutations in GBA1, encoding the lysosomal enzyme glucocerebrosidase, and the synucleinop

121 ysosomal genes and decreased activity of the lysosomal enzyme, cathepsin D.

122 (WT) decreases lysotracker signal, secreted lysosomal enzymes and SNAP23-mediated lysosome exocytosi

123 This review focuses on some of these lysosomal enzymes and transporters, as well as current t

124 106b(-/-) mice, we show that, while multiple lysosomal enzymes are increased in Grn(-/-) brain at bot

125 ysosome and impedes the activity of specific lysosomal enzymes indicating a broader role for chloride

126 ndrome, MPS IIIA-D, results from deficits in lysosomal enzymes that specifically degrade heparan sulf

127 M106B deficiency causes reduction in several lysosomal enzymes.

128 noparticle (NP) enabling excellent endosomal/lysosomal escape and efficient siRNA decomplexation insi

129 usly showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcript

130 expel their contents outside of the cell via lysosomal exocytosis.

131 endocytosis of protein-bound Cbl followed by lysosomal export of free Cbl to the cytosol and further

132 a secretory lysosomal protein that regulates lysosomal function and biogenesis by controlling the aci

133 tinophagy, suggesting that alpha-syn impairs lysosomal function by disrupting the trafficking of lyso

134 In addition, suppressing lysosomal function with bafilomycin A1 reduced the isopr

135 e suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved

136 es indicating a broader role for chloride in lysosomal function.

137 ons with key factors for executing autophagy-lysosomal function.

138 tive payloads, strategies aimed at restoring lysosomal functionality might overcome resistance to ADC

139 Recent data show that lysosomal functions are transcriptionally regulated by t

140 ing role for lysosomes and shed new light on lysosomal functions during intracellular Ca(2+) homeosta

141 An increase in PV-endosomal/lysosomal fusion accompanied by augmented PV degradation

142 naling plays a crucial role in inhibition of lysosomal fusion and autolysosomal destruction of ehrlic

143 vesicles called autophagosomes, followed by lysosomal fusion and degradation.

144 early endosome-like vacuoles and circumvents lysosomal fusion through an unknown mechanism, thereby a

145 ptor signaling component Dishevelled induced lysosomal fusion with ehrlichial inclusions correspondin

146 demonstrate that neuronal activity triggers lysosomal fusion with the plasma membrane in dendrites.

147 eceptor recruitment, vesicle maturation, and lysosomal fusion.

148 with Wnt5a demonstrated increased endosomal/lysosomal fusions with parasite-containing vacuoles (par

149 r insufficiency of PGRN led to the increased lysosomal gene expression and protein levels, while PGRN

150 ile PGRN overexpression led to the decreased lysosomal gene expression and protein levels.

151 d led to downregulation in the expression of lysosomal genes and decreased activity of the lysosomal

152 ng enzymes, glucosylceramide synthase (GCS), lysosomal glucosylceramidase (GBA), and the cytosolic re

153 r of saposin peptides that are essential for lysosomal glycosphingolipid degradation.

154 an important mechanism of how p97 maintains lysosomal homeostasis, and implicate the pathway as a mo

155 demonstrate that hENT3 is indispensable for lysosomal homeostasis, and that mutations in hENT3 can r

156 Here we dissected the lysosomal HOPS complex as a tethering complex with just

157 Here, we studied CTSB regulation by another lysosomal hydrolase, cathepsin D (CTSD), using mice with

158 some fusion (PLF) results in the delivery of lysosomal hydrolases into phagosomes and in digestion of

159 al function by disrupting the trafficking of lysosomal hydrolases.

160 Moreover, inhibition of fusion or of lysosomal hydrolysis activity significantly reduced vira

161 This study suggests that endo-lysosomal impairment in neurons might play an important

162 13 induces cytoplasmic vacuolization that is lysosomal in nature.

163 ances BACE1 turnover, which is suppressed by lysosomal inhibition.

164 internalized proteopathic seeds, and suggest lysosomal integrity as a significant rate-determining st

165 TMEM175 is a lysosomal K(+) channel that is important for maintaining

166 Transmembrane protein 175 (TMEM175), the lysosomal K(+) channel, is centered under a major genome

167 of alpha-SYN in the astrocytes affects their lysosomal machinery and induces mitochondrial damage.

168 Lysosomal malfunction has been implicated in several pat

169 tor NBR1, the autophagy protein LC3, and the lysosomal marker LAMP1 to Mtb-associated structures and

170 lichial vacuoles did not colocalize with the lysosomal marker LAMP2, and lysosomes were redistributed

171 Morphometric quantification using the lysosomal marker protein 2 (LAMP-2) immunolabeling showe

172 Together, our data suggest a lysosomal mechanism of mHtt secretion and offer potentia

173 ibility loci and reinforce the importance of lysosomal mechanisms in Parkinson's disease pathogenesis

174 LP-1 mediates beta-cell survival via the key lysosomal-mediated process of autophagy is unknown.

175 permeation pathway for glutamine across the lysosomal membrane and it is required for growth of canc

176 Both fusion and fission of lysosomal membrane are accompanied by lysosomal Ca(2+) r

177 findings indicate that while autophagosomal-lysosomal membrane fusion is sensitive to inhibition of

178 Lysosomal membrane fusion mediates the last step of the

179 The lysosomal membrane is the locus for sensing cellular nut

180 mutant form of Bax is sufficient to increase lysosomal membrane permeability and restore autophagic c

181 Interestingly, cells with endo-lysosomal membrane permeabilization (LMP) are more vulne

182 as well as induction of ER stress, leads to lysosomal membrane permeabilization (LMP), a sustained a

183 Accumulation of defective lysosomes leads to lysosomal membrane permeabilization and release of cathe

184 ginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid t

185 Intracellular lysosomal membrane trafficking, including fusion and fis

186 d AP-3, respectively, for trafficking to the lysosomal membrane.

187 had previously been observed to localize to lysosomal membranes.

188 Thus, through SLC38A9, arginine serves as a lysosomal messenger that couples mTORC1 activation to th

189 r potential mucolipin 1 (TRPML1) but not the lysosomal Na(+) release channel two-pore channel 2 (TPC2

190 lian TPC channels have been shown to be endo/lysosomal Na(+)-selective or Ca(2+)-release channels.

191 Abnormalities of the endosomal-lysosomal network (ELN) are a signature feature of Alzhe

192 chains to these proteins to target them for lysosomal or proteasomal destruction.

193 key role for proteolysis within the parasite lysosomal organelle (the vacuolar compartment or VAC) in

194 ing RagA GTPase recruitment of mTORC1 to the lysosomal outer surface, enabling activation of mTOR by

195 Lysosomal p38 MAPK directly phosphorylates the CMA recep

196 ry pathways and identified an unconventional lysosomal pathway as an important mechanism for mHtt sec

197 endoplasmic reticulum (ER) to the endosomal/lysosomal pathway by transiently binding DP(84Gly) via a

198 urons and in the regulation of the autophagy-lysosomal pathway in the aging brain.

199 Autophagy is a lysosomal pathway involved in degradation of intracellul

200 uction of Cst7 leads to an impairment in the lysosomal pathway.

201 of the amyloid precursor protein via the MVB/lysosomal pathway.

202 es involved in the endocytotic and endosomal/lysosomal pathways, and disruption of miR-153 expression

203 tion factor EB (TFEB), a master regulator of lysosomal pathways.

204 Finally, increasing lysosomal permeability through a lysomotropic detergent

205 e lysosomal disorders, where previously only lysosomal pH dysregulation has been described, massive r

206 In these clones, lysosomal pH was increased and the proteolytic activity

207 as also shown to cause additional changes in lysosomal pH, which leads to impairment of lysosomal enz

208 d v-ATPase activity correlates with elevated lysosomal pH.

209 Alterations in lysosomal positioning contribute to different human path

210 for pff uptake in primary neurons, implicate lysosomal processing as the major fate of internalized p

211 Further, lysosomal processing of transmitted seeds may represent

212 We identified the activity of the lysosomal protease cathepsin B in macrophages as a rate-

213 bitor, and leupeptin plus E64 (inhibitors of lysosomal proteases).

214 al axis involves suppression of proapoptotic lysosomal protein cathepsin D by promotion of the ER-ass

215 and YopD colocalized with the late endosomal/lysosomal protein LAMP1 and that the frequency of YopD a

216 mTOR and the lysosomal protein LAMP2 were highly co-localised in basa

217 m106b deletion from Grn(-/-) mice normalizes lysosomal protein levels and rescues FTLD-related behavi

218 is required for the efficient sorting of the lysosomal protein prosaposin.

219 Here, we show PGRN is a secretory lysosomal protein that regulates lysosomal function and

220 on, CSPalpha aggregates, increased levels of lysosomal proteins and lysosome enzyme activities.

221 termates, and western blots showed increased lysosomal proteins including LAMP-2, cathepsin D and LC3

222 n host cells deficient for late endosomal or lysosomal proteins revealed that the Niemann-Pick type C

223 This prompted us to look for lysosomal proteins that are involved in lal(-/-) EC dysf

224 suggesting a potential approach for rescuing lysosomal proteolysis deficits in AD.

225 Lysosomal proteolysis is essential for the quality contr

226 C38A9 is necessary for leucine generated via lysosomal proteolysis to exit lysosomes and activate mTO

227 rotease deficiency in lysosomes and impaired lysosomal proteolysis, as evidenced by aberrant accumula

228 First, CYCLO stimulated lysosomal proteolytic activity by increasing cathepsin D

229 ultiple mechanisms, one of which is impaired lysosomal proteolytic activity.

230 se transport to lysosomes, thereby restoring lysosomal proteolytic activity.

231 The lysosomal Ragulator complex regulates cell metabolism an

232 We also found mislocalization of the CMA lysosomal receptor LAMP2A and impaired substrate translo

233 omal biogenesis and autophagy-control mTORC1 lysosomal recruitment and activity by directly regulatin

234 conjugation, a monodisperse drug loading, a lysosomal release functionality and monomethyl auristati

235 d for both OGD-induced GluA2 endocytosis and lysosomal sorting.

236 the pathway lead to harmful accumulation of lysosomal sphingolipid species, which are associated wit

237 demonstrated defects in autophagic flux and lysosomal staining in human samples of type 2 diabetes.

238 The lysosomal storage disease cystinosis, caused by cystinos

239 current therapies that have emerged from the lysosomal storage disease field.

240 ype IV mucolipidosis, an autosomal recessive lysosomal storage disease.

241 Several proteins that are mutated in lysosomal storage diseases are linked to neurodegenerati

242 een previously associated with the endosomal/lysosomal storage diseases Niemann-Pick and neuronal cer

243 ts with Gaucher disease and, possibly, other lysosomal storage diseases.

244 gies, such as cancer, neurodegeneration, and lysosomal storage diseases.

245 Niemann-Pick disease, type C1 (NPC1) is a lysosomal storage disorder characterised by progressive

246 ype C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1

247 significant burden of rare, likely damaging lysosomal storage disorder gene variants in association

248 used to interrogate variant burden among 54 lysosomal storage disorder genes, leveraging whole exome

249 encodes TRPML1, cause the neurodegenerative lysosomal storage disorder mucolipidosis type IV, and a

250 expression and lead to the neurodegenerative lysosomal storage disorder neuronal ceroid lipofuscinosi

251 rare autosomal recessive, neurodegenerative lysosomal storage disorder, which presents with a range

252 PML1 lead to mucolipidosis type IV, a severe lysosomal storage disorder.

253 l acidification contributes to virtually all lysosomal storage disorders (LSDs) and to common neurode

254 nced mTORC1 signaling arrests bone growth in lysosomal storage disorders (LSDs).

255 Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegen

256 as been implicated in human diseases such as lysosomal storage disorders, neurodegenerative diseases

257 tations in hENT3 can result in a spectrum of lysosomal storage-like disorders.

258 lts in hydrolase hypersecretion and profound lysosomal storage.

259 uscin deposits, and cytotoxic, by triggering lysosomal stress and cell death.

260 nfirmed by our in vitro studies, may relieve lysosomal stress due to accumulated substrates.

261 coincides with nuclear translocation of the lysosomal stress-sensing transcription factor EB and, ev

262 ivation by starvation or cholesterol-induced lysosomal stress.

263 embrane protein TMEM55B recruits JIP4 to the lysosomal surface, inducing dynein-dependent transport o

264 to promote the localization of mTORC1 to the lysosomal surface, its site of activation.

265 o promote the translocation of mTORC1 to the lysosomal surface, its site of activation.

266 and recruits GATOR1, but not GATOR2, to the lysosomal surface; and is necessary for the interaction

267 Here we identify a lysosomal switch that enhances germline proteostasis bef

268 The autophagy-lysosomal system plays a key role in the maintenance of

269 Lysosomal-targeted MPO exerts both cell-protective and c

270 We show here that OGD causes endocytosis, lysosomal targeting and consequent degradation of GluA2-

271 3 complex was impaired, leading to increased lysosomal targeting and reduced surface levels on CD4(+)

272 Importantly, we found that late endosomal/lysosomal targeting and secretion of mHtt could be inhib

273 ngs identify new mechanisms whereby impaired lysosomal targeting can impact the activity and recyclin

274 Finally, we showed that ABCD4 lysosomal targeting depends on co-expression of, and int

275 This lysosomal targeting is independent of canonical autophag

276 an unanticipated role of Cln1 in regulating lysosomal targeting of V0a1 and suggest that varying fac

277 ilize a carbohydrate-dependent mechanism for lysosomal targeting.

278 subcellular redistribution of CTSD from the lysosomal to the zymogen-containing subcellular compartm

279 we demonstrate that dense core vesicles and lysosomal trafficking dynamics are affected in fibroblas

280 In contrast, FM-induced lysosomal trafficking of the Golgi protein galactosyltra

281 Sortilin 1 (SORT1) is a lysosomal trafficking receptor that was identified by ge

282 isorder caused by biallelic mutations in the lysosomal trafficking regulator gene (LYST), resulting i

283 , using Lyst-mutant beige mice, we show that lysosomal trafficking regulator Lyst links endolysosomal

284 nal water channel aquaporin-2 (AQP2) and the lysosomal trafficking regulator-interacting protein LIP5

285 tor in growth factor- and nutrient-regulated lysosomal trafficking.

286 is reported to have a role in regulation of lysosomal trafficking.

287 We found that the lysosomal transmembrane protein TMEM55B recruits JIP4 to

288 The lysosomal transmembrane protein, SLC38A9, is required fo

289 rl8b, along with its effectors, orchestrates lysosomal transport and fusion.

290 ysosomes, limiting our understanding of post-lysosomal transport steps.

291 complex (BORC), previously shown to regulate lysosomal transport, is required to recruit and activate

292 7 (SNAT7), encoded by the SLC38A7 gene, as a lysosomal transporter highly selective for glutamine and

293 t at pH 7.4, hENT3 is an acidic pH-activated lysosomal transporter partially localized to mitochondri

294 This assay was used to screen candidate lysosomal transporters, leading to the identification of

295 esicular transport obstruction and defective lysosomal turnover resulting from NPC1 deficiency.

296 the protein is secreted via a late endosomal/lysosomal unconventional secretory pathway.

297 ate endosome/lysosome and interacts with the lysosomal v-ATPase to negatively regulate mTORC1 activat

298 ing to accumulation of immature vesicles, or lysosomal vesicle degradation.

299 king, the cellular machinery associated with lysosomal vesicles that regulates their docking and secr

300 protein Vamp-7 is associated with Lamp-1(+) lysosomal vesicles, which are recruited and docked at th