ライフサイエンスコーパス: lysyl

1 subunit (U2AF65) undergoes posttranslational lysyl-5-hydroxylation catalyzed by the Fe(II) and 2-oxog

2 Hint3-1 and hHint3-2 were found to hydrolyze lysyl-adenylate generated by human lysyl-tRNA synthetase

3 he hydrolysis of purine phosphoramidates and lysyl-adenylate generated by lysyl-tRNA synthetase (LysR

4 ytic reversal involving a transient C6orf130 lysyl-(ADP-ribose) intermediate.

5 nization into plywood-like stacks depends on lysyl aldehyde-derived cross-links introduced by lysyl o

6 DNA phosphate negative charge is balanced by lysyl amines (3.2%), polyamines (5.8%), and monovalent c

7 d monovalent cations (40%); and (iii) 11% of lysyl amines, 40% of -NH(2) groups of polyamines, and 80

8 e ubiquitin carboxy terminus and a substrate lysyl amino group.

9 he ability of hHint1 and echinT to hydrolyze lysyl-AMP generated by either E. coli or human lysyl-tRN

10 on homodimerization and 2) the hydrolysis of lysyl-AMP generated by LysRS is not dependent on homodim

11 the C-terminal deletion mutants to hydrolyze lysyl-AMP generated by LysU was greatly impaired.

12 Lysyl and prolyl hydroxylations are well-known post-tran

13 Bronchial challenge with lysyl-aspirin can be used as a confirmatory diagnostic t

14 efore and following bronchial challenge with lysyl-aspirin.

15 tor XIIIa-catalyzed epsilon-(gamma-glutamyl)-lysyl bonds between glutamine and lysine residues on fib

16 Nase P, we synthesized hexa-guanidinium and -lysyl conjugates of neomycin B and compared their inhibi

17 c 110kDa polypeptide (Co-hArgI x3) and (iii) lysyl conjugation of 5kDa PEG-N-hydroxysuccinimide (NHS)

18 yzes the formation of gamma-glutamyl-epsilon-lysyl cross-links within the fibrin blood clot network.

19 ) introduces covalent gamma-glutamyl-epsilon-lysyl crosslinks into the blood clot network.

20 The discovery of lysyl demethylases using flavin (amine oxidases) or Fe(I

21 that LOXL2 readily promoted the formation of lysyl-derived cross-links in the 7S dodecamer but not in

22 ontrast, inclusion of the positively charged lysyl-dioleoyl-phosphatidylglycerol exclusively on the c

23 Investigation of hydroxyl-(beta)-lysyl-EF-P showed 30% increased puromycin reactivity but

24 recombinant EF-P preparation containing beta-lysyl-EF-P stimulated N-formyl-methionyl-puromycin synth

25 ions containing unmodified EF-P and/or alpha-lysyl-EF-P.

26 se, whereas Lc-Lys-2 is a gamma-D-glutamyl-L-lysyl endopeptidase.

27 terminal phosphopeptides upon treatment with lysyl endoproteinase.

28 sults from mutations in the genes coding for lysyl hydroxylase (LH) 2 or peptidyl-prolyl cis-trans is

29 oband bone tissue, consistent with decreased lysyl hydroxylase 1 in proband osteoblasts.

30 in B with the P-domain of calreticulin, with lysyl hydroxylase 1, and probably other proteins, such a

31 Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of

32 on of the alternatively spliced long form of lysyl hydroxylase 2 (LH2), a collagen telopeptide LH.

33 signaling in macrophages to the induction of lysyl hydroxylase 2 (LH2), an enzyme that directs persis

34 Lysyl hydroxylase 2 (LH2), an important alternatively sp

35 -function studies in tumor cells showed that lysyl hydroxylase 2 (LH2), which hydroxylates telopeptid

36 se associated with inactivating mutations in lysyl hydroxylase 2 (LH2/PLOD2) or FK506 binding protein

37 T3-E1 (MC)-derived clones stably suppressing lysyl hydroxylase 3 (LH3) (short hairpin (Sh) clones) an

38 Lysyl hydroxylase 3 (LH3), encoded by Plod3, is the mult

39 molecule responsible for the recruitment is lysyl hydroxylase 3 (LH3).

40 th its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newl

41 ing hypoxia-inducible factor 1 [HIF-1]), the lysyl hydroxylase JMJD6, and the RNA hydroxylase TYW5 bu

42 R may also act as an arginine demethylase, a lysyl hydroxylase, or an RNA-binding protein through its

43 m of clinical phenotypes than the absence of lysyl-hydroxylase 1 and additionally includes myopathy,

44 which can also be caused by a deficiency in lysyl-hydroxylase 1.

45 acting as both an arginine demethylase and a lysyl-hydroxylase.

46 he alpha-subunit of prolyl 4-hydroxylase and lysyl hydroxylases.

47 -hydroxylation of alpha1(I)Pro986 but excess lysyl hydroxylation and glycosylation along the collagen

48 post-translationally modified by prolyl and lysyl hydroxylation and subsequently by glycosylation of

49 dependent oxygenase, catalyzes carbon 4 (C4) lysyl hydroxylation of eRF1.

50 ory deprotonation of enzyme-bound methylated lysyl intermediates, which along with binding and releas

51 6-[(2E)-1- oxo-3-(3-pyridinyl-2-propenyl)]-l-lysyl-l-2-aminohexanedioyl-(1-amino-1-cyclohexa ne)carbo

52 IsoK/LG-lysyl-lactam adducts are measured by liquid chromatograp

53 r HIS(6x)-HA(3x)-IAA1, suggesting additional lysyl-linked ubiquitin on this protein.

54 The beta-lysyl-lysine isopeptide was identified in the exhaustive

55 ere we present biochemical evidence for beta-lysyl-lysine modification in Escherichia coli EF-P and f

56 ert a specific lysine to a hypothetical beta-lysyl-lysine.

57 peptides" like alpha-alanyl-lysine and alpha-lysyl-lysine.

58 as follows: S-hydroxylysyl-methionine and S-lysyl-methionine cross-links, which stabilize the alpha3

59 Deuteration of the lysyl methyls results in identical kinetic isotope effec

60 Mass spectrometric analyses confirmed the lysyl modification at lysine 34 in native and recombinan

61 on between Phe-19 of the pore module and the lysyl moiety anchored to the phosphatidylglycerol headgr

62 of LigA with NAD(+) to form a covalent LigA-(lysyl-Nzeta)-AMP intermediate (step 1); transfer of AMP

63 along the reaction pathway-covalent ligase-(lysyl-Nzeta)-AMP*Mn(2+) intermediate; ligase*ATP*(Mn(2+)

64 cted an interaction between fibromodulin and lysyl oxidase (a major collagen cross-linking enzyme) an

65 In addition, lysyl oxidase (LOX) and LOX-like proteins, which are sec

66 In addition, lysyl oxidase (LOX) and LOX-like proteins, which are sec

67 Elastin is a substrate for lysyl oxidase (LOX) and LOXL1, and LOXL1 interacts with

68 l oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 (LOXL1-LO

69 analysis of the hypoxic secretome identified lysyl oxidase (LOX) as significantly associated with bon

70 domains and the highly conserved C-terminal lysyl oxidase (LOX) catalytic domain.

71 pression of the collagen crosslinking enzyme lysyl oxidase (LOX) compared with PyMT(fl/fl) mammary ca

72 of the extracellular matrix modifying enzyme lysyl oxidase (LOX) correlates with metastatic dissemina

73 Lysyl oxidase (LOX) enzyme activity was evaluated by WB

74 helial-mesenchymal transition marker levels, lysyl oxidase (LOX) expression, and metastatic capacity.

75 pled with deacetylimination as a function of lysyl oxidase (LOX) family members.

76 as a result of collagen crosslinking by the lysyl oxidase (LOX) family of enzymes.

77 through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, a

78 ed by the enzymatic action of members of the lysyl oxidase (LOX) family.

79 ved human MSCs promote de novo production of lysyl oxidase (LOX) from human breast carcinoma cells, w

80 AD, we identified a missense mutation in the lysyl oxidase (LOX) gene (c.893T > G encoding p.Met298Ar

81 The lysyl oxidase (LOX) gene encodes an enzyme (LOX) critica

82 The lysyl oxidase (LOX) gene reverted Ras transformation of

83 such pathologies, and recently, the protein lysyl oxidase (LOX) has been implicated in proliferation

84 The extracellular, matrix-modifying enzyme lysyl oxidase (LOX) has recently been linked to colorect

85 Here, we show a critical role for lysyl oxidase (LOX) in establishing a milieu within fibr

86 We find that reduction of lysyl oxidase (Lox) in Lkb1-deficient lung ADC decreases

87 d mast cell protease expression, and induced lysyl oxidase (LOX) in the aortic wall, improved systemi

88 ession and localization of LOXL1, LOXL2, and lysyl oxidase (LOX) in tissues of PEX syndrome/glaucoma

89 Expression of lysyl oxidase (LOX) inhibits RAS transforming activity.

90 Lysyl oxidase (LOX) is a multifunctional protein require

91 Lysyl oxidase (LOX) is a potent chemokine inducing the m

92 Lysyl oxidase (LOX) is a secreted copper-dependent amine

93 Lysyl oxidase (LOX) is a transcriptional target of HIF1a

94 of the extracellular matrix-modifying enzyme lysyl oxidase (LOX) is essential for stimulating endothe

95 Lysyl oxidase (LOX) is overexpressed in various patholog

96 Lysyl oxidase (LOX) is synthesized and secreted as a 50-

97 ast cancer cells increased the expression of lysyl oxidase (LOX) mRNA.

98 Lysyl oxidase (LOX) remodels the tumour microenvironment

99 We studied the functional contribution of lysyl oxidase (LOX) to collagen stabilization and hepati

100 The gene encoding lysyl oxidase (LOX) was identified as the ras recision g

101 d is then cleaved to a 30-kDa mature enzyme (lysyl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxi

102 ypothesized that HG-induced up-regulation of lysyl oxidase (LOX), a collagen-cross-linking enzyme, in

103 d whether altered expression and activity of lysyl oxidase (LOX), a cross-linking enzyme, may comprom

104 Lysyl oxidase (LOX), a matrix cross-linking protein, is

105 the dramatic reduction in the expression of lysyl oxidase (LOX), a metastasis-promoting, matrix-remo

106 Lysyl oxidase (LOX), an amine oxidase critical for the i

107 Previously, fibulin-4 was shown to bind lysyl oxidase (LOX), an elastin/collagen cross-linking e

108 A key regulator of collagen homeostasis is lysyl oxidase (LOX), an enzyme responsible for cross-lin

109 ng inhibited by a known suicide inhibitor of lysyl oxidase (LOX), beta-aminopropionitrile, which we f

110 0b; miR-200b directly inhibits expression of lysyl oxidase (LOX), leading to decreased invasion.

111 A series of studies examined the effects of lysyl oxidase (LOX), the enzyme responsible for the form

112 GFbeta1 stimulation increased collagen I and lysyl oxidase (LOX), the enzyme that cross-links soluble

113 cognized targets of the extracellular enzyme lysyl oxidase (LOX), the level of which is increased in

114 supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus function

115 5q23.2, overlapping the gene coding for the lysyl oxidase (LOX).

116 yrosylquinone (LTQ), the organic cofactor of lysyl oxidase (LOX).

117 propeptide region (LOX-PP) derived from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme

118 x proteins such as MMP2, vimentin, uPAR, and lysyl oxidase 2.

119 Lysyl oxidase activity contributes to collagen stabiliza

120 e extracellular matrix enzymes revealed that lysyl oxidase activity is required for cross-linking of

121 ibrillin-1 microfibril assembly and secreted lysyl oxidase activity were normal in ARCL2 cells.

122 p.Ser348Arg resulted in significantly lower lysyl oxidase activity when compared with the wild-type

123 creases in extracellular matrix rigidity and lysyl oxidase activity, which can be prevented by inhibi

124 l aldehyde-derived cross-links introduced by lysyl oxidase activity, which, in turn, only weakly infl

125 tivity, which can be prevented by inhibiting lysyl oxidase activity.

126 protein (MMP-2) and unchanged expression of lysyl oxidase and a second metalloproteinase, MMP-9, in

127 The identification of lysyl oxidase and the extracellular matrix as critical r

128 and VI and the collagen crosslinking enzyme lysyl oxidase and up-regulates in vitro expression of th

129 in-4), collagens (types I, III, and IV), and lysyl oxidase crosslinking enzymes (LOX, LOXL1, LOXL2) w

130 Similarly, d-penicillamine, which inhibits lysyl oxidase enzymatic activity by depleting intracereb

131 Lysyl oxidase enzyme activity is critical for the biosyn

132 The importance of lysyl oxidase enzyme activity to normal bone development

133 from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme activity.

134 hydroxylysine would enhance the activity of lysyl oxidase enzyme to form collagen cross-links, incre

135 a significant upregulation in both SMAD2 and Lysyl oxidase expression, compared to HCFs.

136 ition, correlating with a marked increase in lysyl oxidase expression.

137 The lysyl oxidase family is made up of five members: lysyl o

138 We also established that LOXL2 is the main lysyl oxidase family member present in the glomerular ex

139 Among all lysyl oxidase family members, lysyl oxidase-like-2 (LOXL

140 d more recently periostin and members of the lysyl oxidase family of enzymes have been documented in

141 ysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase family, as a Snail1 regulator and EMT indu

142 The lysyl oxidase gene (LOX) inhibits Ras signaling in trans

143 Expression of the lysyl oxidase gene (LOX) was found to inhibit the transf

144 f extracellular matrix-modifying factors and lysyl oxidase genes and by facilitating EMT.

145 Characterization of the zebrafish lysyl oxidase genes reveals eight unique sequences, seve

146 elial cell migration through upregulation of lysyl oxidase genes.

147 In addition, lysyl oxidase has tumor suppressor activity that has bee

148 lt of decreased expression and activation of lysyl oxidase in the infarcts of MMP-28(-/-) mice.

149 Inhibition of collagen crosslinking by lysyl oxidase inhibitor alleviated unilateral ureteral o

150 The lysyl oxidase inhibitor beta-aminopropionitrile disrupts

151 AB0023 outperformed the small-molecule lysyl oxidase inhibitor beta-aminoproprionitrile.

152 found that the collagen cross-linking enzyme lysyl oxidase is expressed in all vascular cells and tha

153 viously shown that proteolytic activation of lysyl oxidase is much reduced in cultures of FN-null mou

154 Pro-lysyl oxidase is secreted as a 50-kDa proenzyme and is t

155 Lysyl oxidase-like 1 proved to be the major lysyl oxidase isoform in the normal lamina cribrosa in a

156 st, expression levels of collagens and other lysyl oxidase isoforms were not affected.

157 s correlating with a 10-fold upregulation of lysyl oxidase like-1 gene expression (P < 0.001).

158 mbly components, including fibulins 4 and 5, lysyl oxidase like-1, and fibrillin-1.

159 ntermolecular cross-links formed through the lysyl oxidase mechanism.

160 Elastin and lysyl oxidase mRNA levels and alternative splicing of el

161 -terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and

162 amino-acid propeptide domain (LOX-PP) of the lysyl oxidase precursor protein.

163 The propeptide region of the lysyl oxidase proenzyme (LOX-PP) has been shown to inhib

164 The secreted lysyl oxidase proenzyme is processed to a propeptide (LO

165 LOX has complex roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro

166 syl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxidase propeptide (LOX-PP)).

167 cally increases intranuclear localization of lysyl oxidase propeptide, which interferes with NF-kappa

168 Likewise, partial knockdown of the lysyl oxidase substrate col2a1 results in notochord dist

169 lloproteinases, IL-8, PDGFs, caveolin 1, and lysyl oxidase), several of which were associated with po

170 Aldosterone and CTGF increased lysyl oxidase, and aldosterone enhanced miR-21 expressio

171 creases in the pro-synthetic elastin enzyme, lysyl oxidase, and increases in the elastin-degrading en

172 alpha-amylase, concanavalin, Pichia pastoris lysyl oxidase, and Klebsiella pneumoniae acetolactate sy

173 specifically RhoA activity as well as CTGF, lysyl oxidase, and microRNA-21 expression.

174 as those encoding hypoxia-inducible gene-2, lysyl oxidase, and vascular endothelial growth factor, a

175 ltures with inhibitors of TGFbeta signaling, lysyl oxidase, or integrin beta1-mediated mechanosignali

176 relationship exists between fibromodulin and lysyl oxidase, potentially imparting a specific collagen

177 ollagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cros

178 er280Arg), was identified in LOX, encoding a lysyl oxidase, that segregated with disease in the famil

179 growth factor (PDGF)-BB, angiopoietin-1, and lysyl oxidase-2 and the cerebrovascular-selective protei

180 Lysyl oxidase-dependent elastin fiber assembly was asses

181 A mouse lacking lysyl oxidase-like (LOXL)-1, an enzyme essential for ela

182 as reported that mice with null mutations in lysyl oxidase-like 1 (LOXL1) develop pelvic organ prolap

183 Two single nucleotide polymorphisms in the lysyl oxidase-like 1 (LOXL1) gene (rs1048661 and rs38259

184 Coding variants in the lysyl oxidase-like 1 (LOXL1) gene are strongly associate

185 ation between common genetic variants in the lysyl oxidase-like 1 (LOXL1) gene with pseudoexfoliation

186 Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) gene, but additional comodu

187 sms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1).

188 trong familial association and recently, the lysyl oxidase-like 1 gene has been strongly associated w

189 However, the exact relationship between lysyl oxidase-like 1 polymorphisms and the development o

190 is an important risk factor for glaucoma and lysyl oxidase-like 1 polymorphisms are strongly associat

191 Lysyl oxidase-like 1 proved to be the major lysyl oxidas

192 up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 (LOXL1-LOXL4).

193 Human lysyl oxidase-like 2 (hLOXL2) is highly up-regulated in

194 This article investigates the role of lysyl oxidase-like 2 (LOXL-2) in the biology of HCC meta

195 essed the steady-state enzymatic activity of lysyl oxidase-like 2 (LOXL2) against the substrates 1,5-

196 derived 3D matrix system and identified anti-lysyl oxidase-like 2 (LOXL2) antibodies that alter the n

197 Lysyl oxidase-like 2 (LOXL2) catalyses collagen cross-li

198 Lysyl oxidase-like 2 (LOXL2) is involved in a wide range

199 We previously described lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxid

200 oxyphenolics required the presence of active lysyl oxidase-like 2 (LOXL2), thereby limiting effects t

201 show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstiti

202 oss-linking domains in elastin and decreased lysyl oxidase-like 2 expression leads to decreased amoun

203 The inclusion of exon 23 in elastin mRNA and lysyl oxidase-like 2 mRNA levels was significantly reduc

204 to be due to disruption of regulatory genes (lysyl oxidase-like and clusterin) that are involved in b

205 ic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent p

206 te hypermethylated genes, including LOXL1, a lysyl oxidase-like gene, in human bladder cancer cells.

207 rrent study suggests for the first time that lysyl oxidase-like genes can act as tumor suppressor gen

208 Additionally, lysyl oxidase-like protein 3 expression was up-regulated

209 sors histone deacetylases 1 and 2 as well as lysyl oxidase-like protein 3 with Snail1 was impaired wh

210 The lysyl oxidase-like protein LOXL2 has been suggested to c

211 identified a new role for the matrix enzyme lysyl oxidase-like-2 (LOXL2) in the creation and mainten

212 Lysyl oxidase-like-2 (LOXL2) induces tumor progression a

213 Lysyl oxidase-like-2 (LOXL2) is an enzyme secreted into

214 Among all lysyl oxidase family members, lysyl oxidase-like-2 (LOXL2) was identified as the isofo

215 accompanying intermolecular cross-linking by lysyl oxidase-mediated bonds, is vital to the structural

216 electively affects the extent and pattern of lysyl oxidase-mediated collagen cross-linking by sterica

217 ing as a potential contributor, we inhibited lysyl oxidase-mediated collagen cross-linking, which sig

218 trix compliance in vitro and by manipulating lysyl oxidase-mediated collagen crosslinking in vivo.

219 Consistently, reduction of lysyl oxidase-mediated collagen crosslinking prevented M

220 This suggests that lysyl oxidase-mediated cross-linking plays a significant

221 activation of PI3K/AKT, GSK3beta, Snail, and lysyl oxidase.

222 increased aortic levels of tropoelastin and lysyl oxidase.

223 es proteolytic activation of the zymogen for lysyl oxidase.

224 a property driven by the oxidative action of lysyl oxidase.

225 s interaction also increases the activity of lysyl oxidase.

226 ced angiogenesis via activation of Cu enzyme lysyl oxidase.

227 Lysyl oxidases (LOXs) are a family of copper-dependent o

228 out the cement proteome, as well as multiple lysyl oxidases and peroxidases, establish homology with

229 Pharmacological inhibition of lysyl oxidases improved drug delivery in various tumor m

230 e deficiency of LOX in mice or inhibition of lysyl oxidases in turkeys and rats causes aortic dissect

231 nt loss of col8a1a function or inhibition of Lysyl oxidases with drugs during embryogenesis was suffi

232 e, a known inhibitor of the copper-dependent lysyl oxidases, causes notochord distortion in the zebra

233 e inhibitor of the enzymatic activity of all lysyl oxidases, is unable to abolish the LOXL2-induced i

234 etylation and deacetylimination catalyzed by lysyl oxidases.

235 trix (ECM) components and high expression of lysyl oxidases.

236 The lysyl oxidation product adipic semialdehyde (allysine, A

237 the synthesis and translocation of membrane lysyl-phosphatidylglycerol (an mprF-dependent function)

238 of teichoic acids, (ii) the incorporation of lysyl-phosphatidylglycerol in the bacterial membrane and

239 nthase (A-PGS) or by Lys-tRNA(Lys)-dependent lysyl-phosphatidylglycerol synthase (L-PGS) enables bact

240 In parallel, the structure of the related lysyl-phosphatidylglycerol-specific L-PGS domain from Ba

241 coding collagen prolyl (P4HA1 and P4HA2) and lysyl (PLOD2) hydroxylases.

242 e the activity of sirtuins toward additional lysyl posttranslational modifications, and show that sir

243 silicotic rats with N-acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) inhibits myofibroblast different

244 i-fibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) using proteomic profile analysis

245 antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP).

246 as the tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), play a significant role in contr

247 man carcinoma HEp2 cells show that the 15(2)-lysyl regioisomers accumulate the most within cells, and

248 otonation of the epsilon-amine of the target lysyl residue and subsequent methylation.

249 rs three methyl groups to a highly conserved lysyl residue at position 115 in calmodulin (CaM).

250 residues of histone H3, with a dimethylated lysyl residue at position 4.

251 The probe design exploits a lysyl residue in EGFP that is essential for chromophore

252 glycolysis, are trimethylated at a conserved lysyl residue located close to the C terminus.

253 Lysyl residues 12, 233, 276, and 525 were previously rep

254 ive towards tri- and dimethylated histone H3 lysyl residues 9 and 36 (H3K9me3/me2 and H3K36me3/me2),

255 uncharged and that at least one of the other lysyl residues be charged for catalysis.

256 nd 2-oxoglutarate-dependent hydroxylation of lysyl residues in arginine-serine-rich domains of RNA sp

257 deaminases that can modify the side chain of lysyl residues in collagen and elastin, thereby leading

258 at catalyze the site-specific methylation of lysyl residues in histone and non-histone proteins.

259 aches desthiobiotin to one or more conserved lysyl residues in the ATP-binding sites of protein kinas

260 diminished hydroxylation of the telopeptide lysyl residues involved in intermolecular cross-link for

261 f lipid peroxidation that rapidly react with lysyl residues of proteins to form stable protein adduct

262 ifferential methylation of histone H3 and H4 lysyl residues regulates processes including heterochrom

263 structural data suggest how JMJD6 binds its lysyl residues such that it can catalyse C-5 hydroxylati

264 and both are capable of methylating multiple lysyl residues with broad sequence specificity.

265 o groups alpha and epsilon (the latter being lysyl residues) on the intact proteins by acetylation.

266 st-translational hydroxylation of prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dep

267 via hydroxylation) of N()-methylated histone lysyl residues, as well as hydroxylation of multiple oth

268 the enzyme that hydroxylates the telopeptide lysyl residues.

269 , the aminolysis reactivity of each modified lysyl side chain revealed a preference for reacting with

270 Reductive methylation of lysyl side-chain amines has been a successful tool in th

271 The Arabidopsis thaliana lysyl tRNA synthetase (AtKRS) structurally and functiona

272 RNA, we discovered that the Escherichia coli lysyl tRNA synthetase was responsible for misacylating t

273 ein A) and LysN (anticodon binding domain of lysyl tRNA synthetase).

274 stem eliminated misacylation by the E. coli lysyl tRNA synthetase, and led to the development of a f

275 Here, we examine an N(epsilon)-acetyl-lysyl-tRNA synthetase (AcKRS), which is polyspecific (i.

276 hydrolyze lysyl-adenylate generated by human lysyl-tRNA synthetase (hLysRS) by proceeding through an

277 Human lysyl-tRNA synthetase (hLysRS), the only cellular factor

278 is, p.Tyr173SerfsX7, and p.Ile302Met) in the lysyl-tRNA synthetase (KARS) gene in two patients from t

279 Lysyl-tRNA synthetase (KARS), an enzyme required for pro

280 e identified at highly conserved residues of lysyl-tRNA synthetase (KARS): the c.1129G>A (p.Asp377Asn

281 some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

282 nscription primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprot

283 The alpha(2) homodimeric lysyl-tRNA synthetase (LysRS) is tightly bound in the MS

284 Gag and GagPol, as well as host cell factor lysyl-tRNA synthetase (LysRS), are required for specific

285 horamidates and lysyl-adenylate generated by lysyl-tRNA synthetase (LysRS).

286 jeK, encoding truncated homologs of class II lysyl-tRNA synthetase and of lysine-2,3-aminomutase, res

287 blem, Hoepfner et al. uncover the parasite's lysyl-tRNA synthetase as a druggable target.

288 Human lysyl-tRNA synthetase is bound to the multi-tRNA synthet

289 d a trans pQTL relationship between the KARS lysyl-tRNA synthetase locus and levels of the DIDO1 prot

290 nal modification with (R)-beta-lysine by the lysyl-tRNA synthetase paralog PoxA.

291 A putative lysyl-tRNA synthetase resistance gene was identified in

292 syl-AMP generated by either E. coli or human lysyl-tRNA synthetase were partially transferable by C-t

293 ural classes, the only known exception being lysyl-tRNA synthetase which exists in both classes I (Ly

294 molar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against bot

295 n the mammalian cells by S207-phosphorylated Lysyl-tRNA synthetase.

296 Alternatively, class I and class II lysyl-tRNA synthetases (LysRS1 and LysRS2) together form

297 However, decreased lysyl-tRNA(Lys) in the lysS mutant provides a possible r

298 ynthetases (LysRS1 and LysRS2) together form lysyl-tRNA(Pyl), a potential intermediate to pyrrolysyl-

299 cells expressing Fet3-Ftr1 lacking cytosolic lysyl ubiquitin acceptor sites, Fet3-Ftr1 is constitutiv

300 expression of SNAT2 in which seven putative lysyl-ubiquitination sites in the cytoplasmic N-terminal