ライフサイエンスコーパス: lysyl oxidase

1 activation of PI3K/AKT, GSK3beta, Snail, and lysyl oxidase.

2 es proteolytic activation of the zymogen for lysyl oxidase.

3 increased aortic levels of tropoelastin and lysyl oxidase.

4 ases, procollagen C-proteinase enhancer, and lysyl oxidase.

5 echanism of the tumor suppressor activity of lysyl oxidase.

6 amine oxidases, and lysine tyrosylquinone in lysyl oxidase.

7 y in the collagen cross-linking cupro-enzyme lysyl oxidase.

8 ysyl oxidase and mature approximately 30-kDa lysyl oxidase.

9 f mechanism-based inactivators selective for lysyl oxidase.

10 ur or selenium lactones that fully inhibited lysyl oxidase.

11 a property driven by the oxidative action of lysyl oxidase.

12 he result of posttranslational processing of lysyl oxidase.

13 cofactor formation in amine oxidases such as lysyl oxidase.

14 with a predicted protein sequence similar to lysyl oxidase.

15 s interaction also increases the activity of lysyl oxidase.

16 ced angiogenesis via activation of Cu enzyme lysyl oxidase.

17 and a member of an emerging family of human lysyl oxidases.

18 trix (ECM) components and high expression of lysyl oxidases.

19 etylation and deacetylimination catalyzed by lysyl oxidases.

20 x proteins such as MMP2, vimentin, uPAR, and lysyl oxidase 2.

21 growth factor (PDGF)-BB, angiopoietin-1, and lysyl oxidase-2 and the cerebrovascular-selective protei

22 cted an interaction between fibromodulin and lysyl oxidase (a major collagen cross-linking enzyme) an

23 We also identified lysyl oxidase, a phenotypic inhibitor of the ras oncogen

24 ctly assess the roles of BMP-1 and mTLL-1 in lysyl oxidase activation by connective tissue cells, fib

25 Lysyl oxidase activity contributes to collagen stabiliza

26 Media lysyl oxidase activity decreased consistent with steady-

27 Lysyl oxidase activity in biological samples is traditio

28 mples and can be successfully used to detect lysyl oxidase activity in cell culture experiments.

29 evels to dynamic and proportional changes in lysyl oxidase activity in connective tissue.

30 e extracellular matrix enzymes revealed that lysyl oxidase activity is required for cross-linking of

31 ribes a more sensitive fluorescent assay for lysyl oxidase activity that utilizes 1,5-diaminopentane

32 ibrillin-1 microfibril assembly and secreted lysyl oxidase activity were normal in ARCL2 cells.

33 p.Ser348Arg resulted in significantly lower lysyl oxidase activity when compared with the wild-type

34 creases in extracellular matrix rigidity and lysyl oxidase activity, which can be prevented by inhibi

35 l aldehyde-derived cross-links introduced by lysyl oxidase activity, which, in turn, only weakly infl

36 tivity, which can be prevented by inhibiting lysyl oxidase activity.

37 hypoxia-inducible factor-1alpha, syndecan-1, lysyl oxidase, adamalysin metalloproteinase-17, tissue i

38 They also activate lysyl oxidase, an enzyme necessary to the covalent cross

39 (b) lysyl topa quinone of the copper protein lysyl oxidase, an enzyme required for proper cross-linki

40 protein (MMP-2) and unchanged expression of lysyl oxidase and a second metalloproteinase, MMP-9, in

41 roduced predominantly unprocessed 50-kDa pro-lysyl oxidase and had lysyl oxidase enzyme activity dimi

42 may also mediate biosynthetic processing of lysyl oxidase and laminin 5.

43 WS9-14 protein has a 48% identity with both lysyl oxidase and lysyl oxidase-like protein at a region

44 ion and purification of recombinant forms of lysyl oxidase and lysyl oxidase-like proteins have been

45 enzyme activity and for accumulation of pro-lysyl oxidase and mature approximately 30-kDa lysyl oxid

46 turbations of the near UV-visible spectra of lysyl oxidase and of a model of its lysine tyrosylquinon

47 null for Bmp1 or Tll1 all produced both pro-lysyl oxidase and processed lysyl oxidase at similar lev

48 The identification of lysyl oxidase and the extracellular matrix as critical r

49 and VI and the collagen crosslinking enzyme lysyl oxidase and up-regulates in vitro expression of th

50 out the cement proteome, as well as multiple lysyl oxidases and peroxidases, establish homology with

51 Aldosterone and CTGF increased lysyl oxidase, and aldosterone enhanced miR-21 expressio

52 ismutase, cytochrome oxidase, ceruloplasmin, lysyl oxidase, and dopamine beta-hydroxylase.

53 creases in the pro-synthetic elastin enzyme, lysyl oxidase, and increases in the elastin-degrading en

54 alpha-amylase, concanavalin, Pichia pastoris lysyl oxidase, and Klebsiella pneumoniae acetolactate sy

55 specifically RhoA activity as well as CTGF, lysyl oxidase, and microRNA-21 expression.

56 as those encoding hypoxia-inducible gene-2, lysyl oxidase, and vascular endothelial growth factor, a

57 Thus, lysyl oxidase appears critical during embryogenesis for

58 tatus does not influence the accumulation of lysyl oxidase as protein or lysyl oxidase steady state m

59 lasts, whereas in vitro studies identify pro-lysyl oxidase as the first known substrate for mTLL-2.

60 roduced both pro-lysyl oxidase and processed lysyl oxidase at similar levels, indicating apparently n

61 all four proteinases productively cleave pro-lysyl oxidase at the correct physiological site but that

62 Bovine lysyl oxidase (BLO) contains two different cofactors, co

63 en identified as the active site cofactor in lysyl oxidase by isolation and characterization of a der

64 ority of processing leading to activation of lysyl oxidase by murine embryonic fibroblasts, whereas i

65 tion of the underivatized cofactor in native lysyl oxidase by resonance Raman (RR) spectrometry.

66 Lysyl oxidase catalyzes oxidative deamination of peptidy

67 Lysyl oxidase catalyzes the final enzymatic step require

68 Lysyl oxidase catalyzes the final known enzymatic step r

69 e, a known inhibitor of the copper-dependent lysyl oxidases, causes notochord distortion in the zebra

70 We show that the RR spectrum of lysyl oxidase closely matches that of a synthetic LTQ mo

71 A model for the lysyl oxidase cofactor (LTQ), 3,3-dimethyl-2,3-dihydroin

72 hese spectra and their shifts shows that the lysyl oxidase cofactor and the model LTQ compound have t

73 some differentially expressed genes such as lysyl oxidase, copper transporter ATP7A, EphB6, RUNX2 an

74 in-4), collagens (types I, III, and IV), and lysyl oxidase crosslinking enzymes (LOX, LOXL1, LOXL2) w

75 By contrast, ectopic antisense lysyl oxidase demonstrated that lysyl oxidase gene expre

76 Lysyl oxidase-dependent elastin fiber assembly was asses

77 Lysyl oxidase differs from other copper amine oxidases i

78 oteins, we have characterized the Drosophila lysyl oxidases Dmloxl-1 and Dmloxl-2.

79 Lysyl oxidase (EC 1.4.3.13) oxidizes peptidyl lysine to

80 Similarly, d-penicillamine, which inhibits lysyl oxidase enzymatic activity by depleting intracereb

81 hree enzymes, respectively, were assayed for lysyl oxidase enzyme activity and for accumulation of pr

82 unprocessed 50-kDa pro-lysyl oxidase and had lysyl oxidase enzyme activity diminished by 70% compared

83 Lysyl oxidase enzyme activity is critical for the biosyn

84 The importance of lysyl oxidase enzyme activity to normal bone development

85 inopropionitrile, the selective inhibitor of lysyl oxidase enzyme activity, was remarkably unable to

86 from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme activity.

87 ame 18O shift of the C=O stretch in both the lysyl oxidase enzyme and the LTQ cofactor model compound

88 hydroxylysine would enhance the activity of lysyl oxidase enzyme to form collagen cross-links, incre

89 at the lysyl oxidase propeptide, and not the lysyl oxidase enzyme, inhibits ras-dependent transformat

90 resulted in more than a 10-fold increase in lysyl oxidase expression and proenzyme production.

91 st growth factor-2 (FGF-2) antibody enhanced lysyl oxidase expression in the absence of suramin.

92 ase reverts ras-mediated transformation, and lysyl oxidase expression is down-regulated in human canc

93 utocrine growth factor pathways maintain low lysyl oxidase expression levels in c-H-ras-transformed f

94 a significant upregulation in both SMAD2 and Lysyl oxidase expression, compared to HCFs.

95 ormed cell lines is accompanied by increased lysyl oxidase expression.

96 ition, correlating with a marked increase in lysyl oxidase expression.

97 The lysyl oxidase family is made up of five members: lysyl o

98 We also established that LOXL2 is the main lysyl oxidase family member present in the glomerular ex

99 Among all lysyl oxidase family members, lysyl oxidase-like-2 (LOXL

100 d more recently periostin and members of the lysyl oxidase family of enzymes have been documented in

101 ysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase family, as a Snail1 regulator and EMT indu

102 tigation have important implications for the lysyl oxidase family.

103 yielding sufficient amounts of a recombinant lysyl oxidase for detailed characterization.

104 extracellular proteolytic processing of pro-lysyl oxidase, functions to inhibit ras-dependent cell t

105 The lysyl oxidase gene (LOX) inhibits Ras signaling in trans

106 Expression of the lysyl oxidase gene (LOX) was found to inhibit the transf

107 ic antisense lysyl oxidase demonstrated that lysyl oxidase gene expression mediated phenotypic revers

108 ng to exons 2-6, implying the existence of a lysyl oxidase gene family.

109 f extracellular matrix-modifying factors and lysyl oxidase genes and by facilitating EMT.

110 Characterization of the zebrafish lysyl oxidase genes reveals eight unique sequences, seve

111 elial cell migration through upregulation of lysyl oxidase genes.

112 In addition, lysyl oxidase has been identified as a possible tumor su

113 In addition, lysyl oxidase has tumor suppressor activity that has bee

114 Pharmacological inhibition of lysyl oxidases improved drug delivery in various tumor m

115 Lysyl oxidase in addition has tumor suppressor activity,

116 enotype of transformed cells and the role of lysyl oxidase in mediating these effects.

117 does inhibit the expression and activity of lysyl oxidase in osteoblasts, thereby contributing to pe

118 growth factor signaling pathways and induces lysyl oxidase in ras-transformed NIH3T3 cells (RS485 cel

119 lt of decreased expression and activation of lysyl oxidase in the infarcts of MMP-28(-/-) mice.

120 The mechanism of low expression of lysyl oxidase in tumor cells is unknown.

121 e deficiency of LOX in mice or inhibition of lysyl oxidases in turkeys and rats causes aortic dissect

122 Inhibition of collagen crosslinking by lysyl oxidase inhibitor alleviated unilateral ureteral o

123 The lysyl oxidase inhibitor beta-aminopropionitrile disrupts

124 AB0023 outperformed the small-molecule lysyl oxidase inhibitor beta-aminoproprionitrile.

125 Lysyl oxidase is an extracellular enzyme critical for th

126 dietary copper on the functional activity of lysyl oxidase is clear.

127 found that the collagen cross-linking enzyme lysyl oxidase is expressed in all vascular cells and tha

128 viously shown that proteolytic activation of lysyl oxidase is much reduced in cultures of FN-null mou

129 Pro-lysyl oxidase is processed by procollagen C-proteinase a

130 Pro-lysyl oxidase is secreted as a 50-kDa proenzyme and is t

131 Since lysyl oxidase is synthesized as a 50 kDa precursor and p

132 Protein-lysine 6-oxidase (lysyl oxidase) is a cuproenzyme that is essential for st

133 ll-known irreversible inhibitor of mammalian lysyl oxidases, is also a potent inhibitor of rDmLOXL-1.

134 e inhibitor of the enzymatic activity of all lysyl oxidases, is unable to abolish the LOXL2-induced i

135 Lysyl oxidase-like 1 proved to be the major lysyl oxidase isoform in the normal lamina cribrosa in a

136 st, expression levels of collagens and other lysyl oxidase isoforms were not affected.

137 s correlating with a 10-fold upregulation of lysyl oxidase like-1 gene expression (P < 0.001).

138 mbly components, including fibulins 4 and 5, lysyl oxidase like-1, and fibrillin-1.

139 Lysyl oxidase-like (LOXL) protein is a novel copper-cont

140 domains of both lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) protein.

141 ression of LOX and other LOX family members [lysyl oxidase-like (LOXL), LOXL2, LOXL3, and LOXL4] was

142 A mouse lacking lysyl oxidase-like (LOXL)-1, an enzyme essential for ela

143 as reported that mice with null mutations in lysyl oxidase-like 1 (LOXL1) develop pelvic organ prolap

144 Here we show that mice lacking the protein lysyl oxidase-like 1 (LOXL1) do not deposit normal elast

145 Two single nucleotide polymorphisms in the lysyl oxidase-like 1 (LOXL1) gene (rs1048661 and rs38259

146 Coding variants in the lysyl oxidase-like 1 (LOXL1) gene are strongly associate

147 ation between common genetic variants in the lysyl oxidase-like 1 (LOXL1) gene with pseudoexfoliation

148 Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) gene, but additional comodu

149 ey of the expression of lysyl oxidase (LOX), lysyl oxidase-like 1 (LOXL1), and lysyl oxidase-like 2 (

150 sms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1).

151 trong familial association and recently, the lysyl oxidase-like 1 gene has been strongly associated w

152 However, the exact relationship between lysyl oxidase-like 1 polymorphisms and the development o

153 is an important risk factor for glaucoma and lysyl oxidase-like 1 polymorphisms are strongly associat

154 Lysyl oxidase-like 1 proved to be the major lysyl oxidas

155 up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 (LOXL1-LOXL4).

156 Human lysyl oxidase-like 2 (hLOXL2) is highly up-regulated in

157 This article investigates the role of lysyl oxidase-like 2 (LOXL-2) in the biology of HCC meta

158 essed the steady-state enzymatic activity of lysyl oxidase-like 2 (LOXL2) against the substrates 1,5-

159 derived 3D matrix system and identified anti-lysyl oxidase-like 2 (LOXL2) antibodies that alter the n

160 Lysyl oxidase-like 2 (LOXL2) catalyses collagen cross-li

161 ase (LOX), lysyl oxidase-like 1 (LOXL1), and lysyl oxidase-like 2 (LOXL2) has yet to be performed.

162 Lysyl oxidase-like 2 (LOXL2) is involved in a wide range

163 We previously described lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxid

164 oxyphenolics required the presence of active lysyl oxidase-like 2 (LOXL2), thereby limiting effects t

165 show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstiti

166 oss-linking domains in elastin and decreased lysyl oxidase-like 2 expression leads to decreased amoun

167 The inclusion of exon 23 in elastin mRNA and lysyl oxidase-like 2 mRNA levels was significantly reduc

168 to be due to disruption of regulatory genes (lysyl oxidase-like and clusterin) that are involved in b

169 ic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent p

170 sm within intron 4 was used to map the mouse lysyl oxidase-like gene (Loxl) to mouse Chromosome 9 in

171 ntify and map the mouse homologue of a human lysyl oxidase-like gene (LOXL).

172 ed domains within exons 4 and 5 of the human lysyl oxidase-like gene were used to amplify the corresp

173 te hypermethylated genes, including LOXL1, a lysyl oxidase-like gene, in human bladder cancer cells.

174 tide identity) to exons 4 and 5 of the human lysyl oxidase-like gene.

175 rrent study suggests for the first time that lysyl oxidase-like genes can act as tumor suppressor gen

176 Additionally, lysyl oxidase-like protein 3 expression was up-regulated

177 sors histone deacetylases 1 and 2 as well as lysyl oxidase-like protein 3 with Snail1 was impaired wh

178 s a 48% identity with both lysyl oxidase and lysyl oxidase-like protein at a region corresponding to

179 The lysyl oxidase-like protein LOXL2 has been suggested to c

180 on of recombinant forms of lysyl oxidase and lysyl oxidase-like proteins have been reported in the li

181 Lysyl oxidase-like-1 (LOXL1), a protein essential for th

182 identified a new role for the matrix enzyme lysyl oxidase-like-2 (LOXL2) in the creation and mainten

183 Lysyl oxidase-like-2 (LOXL2) induces tumor progression a

184 Lysyl oxidase-like-2 (LOXL2) is an enzyme secreted into

185 Among all lysyl oxidase family members, lysyl oxidase-like-2 (LOXL2) was identified as the isofo

186 sequenced a cDNA fragment that encoded mouse lysyl oxidase (LO) and was induced by transforming growt

187 Lysyl oxidase (LO) stabilizes the extracellular matrix b

188 Lysyl oxidase (LO), which catalyzes the oxidation of lys

189 In addition, lysyl oxidase (LOX) and LOX-like proteins, which are sec

190 In addition, lysyl oxidase (LOX) and LOX-like proteins, which are sec

191 Elastin is a substrate for lysyl oxidase (LOX) and LOXL1, and LOXL1 interacts with

192 l oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 (LOXL1-LO

193 copper-binding and catalytic domains of both lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) pr

194 analysis of the hypoxic secretome identified lysyl oxidase (LOX) as significantly associated with bon

195 domains and the highly conserved C-terminal lysyl oxidase (LOX) catalytic domain.

196 pression of the collagen crosslinking enzyme lysyl oxidase (LOX) compared with PyMT(fl/fl) mammary ca

197 levation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease a

198 of the extracellular matrix modifying enzyme lysyl oxidase (LOX) correlates with metastatic dissemina

199 Lysyl oxidase (LOX) enzyme activity was evaluated by WB

200 helial-mesenchymal transition marker levels, lysyl oxidase (LOX) expression, and metastatic capacity.

201 We identified previously an up-regulation in lysyl oxidase (LOX) expression,an extracellular matrix r

202 pled with deacetylimination as a function of lysyl oxidase (LOX) family members.

203 as a result of collagen crosslinking by the lysyl oxidase (LOX) family of enzymes.

204 through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, a

205 ed by the enzymatic action of members of the lysyl oxidase (LOX) family.

206 ved human MSCs promote de novo production of lysyl oxidase (LOX) from human breast carcinoma cells, w

207 AD, we identified a missense mutation in the lysyl oxidase (LOX) gene (c.893T > G encoding p.Met298Ar

208 The lysyl oxidase (LOX) gene encodes an enzyme (LOX) critica

209 The lysyl oxidase (LOX) gene reverted Ras transformation of

210 such pathologies, and recently, the protein lysyl oxidase (LOX) has been implicated in proliferation

211 The extracellular, matrix-modifying enzyme lysyl oxidase (LOX) has recently been linked to colorect

212 Here, we show a critical role for lysyl oxidase (LOX) in establishing a milieu within fibr

213 We find that reduction of lysyl oxidase (Lox) in Lkb1-deficient lung ADC decreases

214 d mast cell protease expression, and induced lysyl oxidase (LOX) in the aortic wall, improved systemi

215 ession and localization of LOXL1, LOXL2, and lysyl oxidase (LOX) in tissues of PEX syndrome/glaucoma

216 Expression of lysyl oxidase (LOX) inhibits RAS transforming activity.

217 Lysyl oxidase (LOX) is a copper-containing amine oxidase

218 Lysyl oxidase (LOX) is a multifunctional protein require

219 Lysyl oxidase (LOX) is a potent chemokine inducing the m

220 Lysyl oxidase (LOX) is a secreted copper-dependent amine

221 Lysyl oxidase (LOX) is a transcriptional target of HIF1a

222 Lysyl oxidase (LOX) is an enzyme responsible for the cro

223 of the extracellular matrix-modifying enzyme lysyl oxidase (LOX) is essential for stimulating endothe

224 Mammalian lysyl oxidase (LOX) is essential for the catalysis of ly

225 Lysyl oxidase (LOX) is overexpressed in various patholog

226 Lysyl oxidase (LOX) is synthesized and secreted as a 50-

227 We have previously shown that lysyl oxidase (LOX) mRNA is up-regulated in invasive bre

228 ast cancer cells increased the expression of lysyl oxidase (LOX) mRNA.

229 Lysyl oxidase (LOX) remodels the tumour microenvironment

230 roarray studies have shown the expression of lysyl oxidase (LOX) to be elevated in hypoxic human tumo

231 We studied the functional contribution of lysyl oxidase (LOX) to collagen stabilization and hepati

232 The gene encoding lysyl oxidase (LOX) was identified as the ras recision g

233 d is then cleaved to a 30-kDa mature enzyme (lysyl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxi

234 ypothesized that HG-induced up-regulation of lysyl oxidase (LOX), a collagen-cross-linking enzyme, in

235 d whether altered expression and activity of lysyl oxidase (LOX), a cross-linking enzyme, may comprom

236 Lysyl oxidase (LOX), a matrix cross-linking protein, is

237 the dramatic reduction in the expression of lysyl oxidase (LOX), a metastasis-promoting, matrix-remo

238 Lysyl oxidase (LOX), an amine oxidase critical for the i

239 Previously, fibulin-4 was shown to bind lysyl oxidase (LOX), an elastin/collagen cross-linking e

240 A key regulator of collagen homeostasis is lysyl oxidase (LOX), an enzyme responsible for cross-lin

241 Lysyl oxidase (LOX), an extracellular amine oxidase, cat

242 ng inhibited by a known suicide inhibitor of lysyl oxidase (LOX), beta-aminopropionitrile, which we f

243 0b; miR-200b directly inhibits expression of lysyl oxidase (LOX), leading to decreased invasion.

244 Distinct from the prototypic lysyl oxidase (LOX), LOXL1 localizes specifically to sit

245 a comprehensive survey of the expression of lysyl oxidase (LOX), lysyl oxidase-like 1 (LOXL1), and l

246 A series of studies examined the effects of lysyl oxidase (LOX), the enzyme responsible for the form

247 GFbeta1 stimulation increased collagen I and lysyl oxidase (LOX), the enzyme that cross-links soluble

248 cognized targets of the extracellular enzyme lysyl oxidase (LOX), the level of which is increased in

249 supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus function

250 5q23.2, overlapping the gene coding for the lysyl oxidase (LOX).

251 yrosylquinone (LTQ), the organic cofactor of lysyl oxidase (LOX).

252 the LTQ (lysine tyrosyl quinone) cofactor of lysyl oxidase (LOX).

253 Lysyl oxidases (LOXs) are a family of copper-dependent o

254 ntermolecular cross-links formed through the lysyl oxidase mechanism.

255 accompanying intermolecular cross-linking by lysyl oxidase-mediated bonds, is vital to the structural

256 electively affects the extent and pattern of lysyl oxidase-mediated collagen cross-linking by sterica

257 ing as a potential contributor, we inhibited lysyl oxidase-mediated collagen cross-linking, which sig

258 trix compliance in vitro and by manipulating lysyl oxidase-mediated collagen crosslinking in vivo.

259 Consistently, reduction of lysyl oxidase-mediated collagen crosslinking prevented M

260 This suggests that lysyl oxidase-mediated cross-linking plays a significant

261 Elastin and lysyl oxidase mRNA levels and alternative splicing of el

262 Steady-state lysyl oxidase mRNA levels decreased to 30% of control af

263 s completely reversed suramin stimulation of lysyl oxidase mRNA levels.

264 However, expression of tropoelastin or lysyl oxidase mRNA was unaffected in fibulin-4-/- mice.

265 -terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and

266 ltures with inhibitors of TGFbeta signaling, lysyl oxidase, or integrin beta1-mediated mechanosignali

267 relationship exists between fibromodulin and lysyl oxidase, potentially imparting a specific collagen

268 ativum amine oxidase (PSAO), Pichia pastoris lysyl oxidase (PPLO), bovine plasma amine oxidase (BPAO)

269 li amine oxidase (ECAO), and Pichia pastoris lysyl oxidase (PPLO).

270 amino-acid propeptide domain (LOX-PP) of the lysyl oxidase precursor protein.

271 propeptide region (LOX-PP) derived from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme

272 t study is the first to directly compare pro-lysyl oxidase processing by these four related proteinas

273 The propeptide region of the lysyl oxidase proenzyme (LOX-PP) has been shown to inhib

274 The secreted lysyl oxidase proenzyme is processed to a propeptide (LO

275 t the transcriptional level determined using lysyl oxidase promoter/reporter gene assays.

276 LOX has complex roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro

277 syl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxidase propeptide (LOX-PP)).

278 Here we report, for the first time, that the lysyl oxidase propeptide, and not the lysyl oxidase enzy

279 cally increases intranuclear localization of lysyl oxidase propeptide, which interferes with NF-kappa

280 Thus, the lysyl oxidase propeptide, which is released during extra

281 as accompanied by a significant reduction of lysyl oxidase protein levels and enzyme activity.

282 is, enzyme assays, and chemical analyses for lysyl oxidase reaction products that this enzyme is pres

283 step, a lysyl group at the active center of lysyl oxidase reacts with TOPA or its precursor to form

284 For lysyl oxidase, recent evidence indicates that as an addi

285 LOR2 encodes a novel lysyl oxidase-related protein of 757 amino acid residues

286 studies demonstrate that the mature form of lysyl oxidase retains many of its functions in the absen

287 In addition, lysyl oxidase reverts ras-mediated transformation, and l

288 ed on the possibility that copper efflux and lysyl oxidase secretion from cells may share a common pa

289 lloproteinases, IL-8, PDGFs, caveolin 1, and lysyl oxidase), several of which were associated with po

290 accumulation of lysyl oxidase as protein or lysyl oxidase steady state messenger RNA concentrations,

291 Likewise, partial knockdown of the lysyl oxidase substrate col2a1 results in notochord dist

292 method exists that employs nonpeptidyl amine lysyl oxidase substrates and measures hydrogen peroxide

293 on is unlikely to affect the efficacy of the lysyl oxidase, suggesting that the defect is in the mole

294 ollagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cros

295 er280Arg), was identified in LOX, encoding a lysyl oxidase, that segregated with disease in the famil

296 alyses revealed that the mRNA expression for lysyl oxidase, the determining enzyme required for colla

297 ort that an FGF-2 autocrine pathway inhibits lysyl oxidase transcription in the tumorigenic-transform

298 rk (TGN) is necessary for proper activity of lysyl oxidase, which is the predominant cuproenzyme whos

299 nt loss of col8a1a function or inhibition of Lysyl oxidases with drugs during embryogenesis was suffi

300 o be competitive, irreversible inhibitors of lysyl oxidase, with KI values of 21 +/- 3 microM, 8.3 +/