ライフサイエンスコーパス: lysyl-tRNA

1 cleavage of the Pth substrates diacetyl-[14C]lysyl-tRNA and acetyl-[14C]phenylalanyl-tRNA.

2 Lysyl-tRNAs are essential for protein biosynthesis by ri

3 However, decreased lysyl-tRNA(Lys) in the lysS mutant provides a possible r

4 tion during coded protein synthesis requires lysyl-tRNA(Lys), which is synthesized by lysyl-tRNA synt

5 resence of Nepsilon-(5-azido-2-nitrobenzoyl)-lysyl-tRNA, photoreactive lysine residues would be incor

6 ynthetases (LysRS1 and LysRS2) together form lysyl-tRNA(Pyl), a potential intermediate to pyrrolysyl-

7 The Arabidopsis thaliana lysyl tRNA synthetase (AtKRS) structurally and functiona

8 RNA, we discovered that the Escherichia coli lysyl tRNA synthetase was responsible for misacylating t

9 ein A) and LysN (anticodon binding domain of lysyl tRNA synthetase).

10 stem eliminated misacylation by the E. coli lysyl tRNA synthetase, and led to the development of a f

11 Here, we examine an N(epsilon)-acetyl-lysyl-tRNA synthetase (AcKRS), which is polyspecific (i.

12 hydrolyze lysyl-adenylate generated by human lysyl-tRNA synthetase (hLysRS) by proceeding through an

13 Human lysyl-tRNA synthetase (hLysRS), the only cellular factor

14 f the anticodon in tRNA recognition by human lysyl-tRNA synthetase (hLysRS).

15 is, p.Tyr173SerfsX7, and p.Ile302Met) in the lysyl-tRNA synthetase (KARS) gene in two patients from t

16 Lysyl-tRNA synthetase (KARS), an enzyme required for pro

17 e identified at highly conserved residues of lysyl-tRNA synthetase (KARS): the c.1129G>A (p.Asp377Asn

18 some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

19 an methionyl-tRNA synthetase (MRS) and human lysyl-tRNA synthetase (KRS) were expressed in human-deri

20 Yeast two-hybrid screens suggested that lysyl-tRNA synthetase (LysRS) also associates with LeuRS

21 nscription primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprot

22 f the transcription factors MITF or USF2 and lysyl-tRNA synthetase (LysRS) are associated with human

23 into two unrelated structural classes, with lysyl-tRNA synthetase (LysRS) being the only enzyme repr

24 previously shown that the essential protein lysyl-tRNA synthetase (LysRS) exists in two unrelated fo

25 Human lysyl-tRNA synthetase (LysRS) is also specifically packa

26 unrelated aminoacyl-tRNA synthetase classes, lysyl-tRNA synthetase (LysRS) is the only example known

27 The alpha(2) homodimeric lysyl-tRNA synthetase (LysRS) is tightly bound in the MS

28 Lysyl-tRNA synthetase (LysRS), a class II enzyme whose m

29 Gag and GagPol, as well as host cell factor lysyl-tRNA synthetase (LysRS), are required for specific

30 horamidates and lysyl-adenylate generated by lysyl-tRNA synthetase (LysRS).

31 res lysyl-tRNA(Lys), which is synthesized by lysyl-tRNA synthetase (LysRS).

32 The crystal structure of the constitutive lysyl-tRNA synthetase (LysS) from Escherichia coli has b

33 o the production of a protein with canonical lysyl-tRNA synthetase activity in vitro.

34 Lysyl-tRNA synthetase aminoacylates CoA-SH with lysine,

35 69 base pair to G4:C69 and overproduction of lysyl-tRNA synthetase and methionyl-tRNA transformylase

36 jeK, encoding truncated homologs of class II lysyl-tRNA synthetase and of lysine-2,3-aminomutase, res

37 r results on recognition of tRNAs by E. coli lysyl-tRNA synthetase and on competition in cells among

38 Two proteins, lysyl-tRNA synthetase and translocon-associated protein

39 blem, Hoepfner et al. uncover the parasite's lysyl-tRNA synthetase as a druggable target.

40 , our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the

41 significant similarity to any class II-type lysyl-tRNA synthetase could be detected.

42 lso encode G73, the motif 2 loop sequence of lysyl-tRNA synthetase differs at multiple positions from

43 r, the capacity of tRNA3Lys to interact with lysyl-tRNA synthetase does not entirely explain the enha

44 Lysyl-tRNA synthetase from Escherichia coli belongs to t

45 The genomic lysyl-tRNA synthetase gene consisted of 15 exons.

46 tely 30%, of the mature transcripts from the lysyl-tRNA synthetase gene.

47 Two cDNAs encoding human lysyl-tRNA synthetase have been identified.

48 The detection of an archaeal-type lysyl-tRNA synthetase in B. burgdorferi and other pathog

49 udies have demonstrated that the presence of lysyl-tRNA synthetase in HIV-1 virions might account for

50 Lysyl-tRNA synthetase is a member of the class II aminoa

51 Human lysyl-tRNA synthetase is bound to the multi-tRNA synthet

52 ases, we report here that the class II human lysyl-tRNA synthetase is relatively insensitive to the n

53 d a trans pQTL relationship between the KARS lysyl-tRNA synthetase locus and levels of the DIDO1 prot

54 Crystals of the thermo-inducible E. coli lysyl-tRNA synthetase LysU which diffract to 2.1 A resol

55 nal modification with (R)-beta-lysine by the lysyl-tRNA synthetase paralog PoxA.

56 A putative lysyl-tRNA synthetase resistance gene was identified in

57 the sequence of the loop of motif 2 of human lysyl-tRNA synthetase specifies a structural variation t

58 syl-AMP generated by either E. coli or human lysyl-tRNA synthetase were partially transferable by C-t

59 ural classes, the only known exception being lysyl-tRNA synthetase which exists in both classes I (Ly

60 gene lies immediately adjacent to the cKARS (lysyl-tRNA synthetase) gene with the two genes in a head

61 Lysyl-tRNA synthetase, a class II enzyme, edits homocyst

62 We examined lysyl-tRNA synthetase, a close structural homologue of t

63 molar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against bot

64 lysis of B. burgdorferi mRNA showed that the lysyl-tRNA synthetase-encoding gene is highly expressed,

65 Expression of the two lysyl-tRNA synthetase-green fluorescent protein gene fus

66 n the mammalian cells by S207-phosphorylated Lysyl-tRNA synthetase.

67 base pair reduces mischarging by the E. coli lysyl-tRNA synthetase.

68 he synthesis of asparaginyl-tRNA and a novel lysyl-tRNA synthetase.

69 n shown to contain an unrelated class I-type lysyl-tRNA synthetase.

70 rgdorferi contains a functional class I-type lysyl-tRNA synthetase.

71 (Trp)(CCA) to be aminoacylated by A.thaliana lysyl-tRNA synthetase.

72 They are synthesized by lysyl-tRNA synthetases (EC 6.1.1.6), a group of enzymes

73 Alternatively, class I and class II lysyl-tRNA synthetases (LysRS1 and LysRS2) together form

74 Lysyl-tRNA synthetases (LysRSs) are unique amongst the a

75 In bacteria and eukarya, all known lysyl-tRNA synthetases are subclass IIc-type aminoacyl-t

76 Thus, isoleucyl-, valyl-, and lysyl-tRNA synthetases behave as aminoacyl-S-CoA synthet

77 This difference between the lysyl-tRNA synthetases of spirochetes and their hosts ma

78 Nonautoantigenic aspartyl-tRNA and lysyl-tRNA synthetases were not chemotactic.

79 ination factor Rho, bacterial and eukaryotic lysyl-tRNA synthetases, bacteriophage T4 endonuclease VI

80 RS1 and LysRS2, the two different M. barkeri lysyl-tRNA synthetases.

81 h lysine but is not closely related to known lysyl-tRNA synthetases.

82 bases indicated high homology to a family of lysyl-tRNA synthetases.

83 he amino acid level to archaeal class I-type lysyl-tRNA synthetases.