ライフサイエンスコーパス: lysyl-tRNA synthetase

1 ein A) and LysN (anticodon binding domain of lysyl tRNA synthetase).

2 n the mammalian cells by S207-phosphorylated Lysyl-tRNA synthetase.

3 base pair reduces mischarging by the E. coli lysyl-tRNA synthetase.

4 he synthesis of asparaginyl-tRNA and a novel lysyl-tRNA synthetase.

5 n shown to contain an unrelated class I-type lysyl-tRNA synthetase.

6 rgdorferi contains a functional class I-type lysyl-tRNA synthetase.

7 (Trp)(CCA) to be aminoacylated by A.thaliana lysyl-tRNA synthetase.

8 RS1 and LysRS2, the two different M. barkeri lysyl-tRNA synthetases.

9 h lysine but is not closely related to known lysyl-tRNA synthetases.

10 bases indicated high homology to a family of lysyl-tRNA synthetases.

11 he amino acid level to archaeal class I-type lysyl-tRNA synthetases.

12 Lysyl-tRNA synthetase, a class II enzyme, edits homocyst

13 We examined lysyl-tRNA synthetase, a close structural homologue of t

14 Here, we examine an N(epsilon)-acetyl-lysyl-tRNA synthetase (AcKRS), which is polyspecific (i.

15 o the production of a protein with canonical lysyl-tRNA synthetase activity in vitro.

16 Lysyl-tRNA synthetase aminoacylates CoA-SH with lysine,

17 69 base pair to G4:C69 and overproduction of lysyl-tRNA synthetase and methionyl-tRNA transformylase

18 jeK, encoding truncated homologs of class II lysyl-tRNA synthetase and of lysine-2,3-aminomutase, res

19 r results on recognition of tRNAs by E. coli lysyl-tRNA synthetase and on competition in cells among

20 Two proteins, lysyl-tRNA synthetase and translocon-associated protein

21 stem eliminated misacylation by the E. coli lysyl tRNA synthetase, and led to the development of a f

22 molar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, and exhibits activity against bot

23 In bacteria and eukarya, all known lysyl-tRNA synthetases are subclass IIc-type aminoacyl-t

24 blem, Hoepfner et al. uncover the parasite's lysyl-tRNA synthetase as a druggable target.

25 The Arabidopsis thaliana lysyl tRNA synthetase (AtKRS) structurally and functiona

26 ination factor Rho, bacterial and eukaryotic lysyl-tRNA synthetases, bacteriophage T4 endonuclease VI

27 Thus, isoleucyl-, valyl-, and lysyl-tRNA synthetases behave as aminoacyl-S-CoA synthet

28 , our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the

29 significant similarity to any class II-type lysyl-tRNA synthetase could be detected.

30 lso encode G73, the motif 2 loop sequence of lysyl-tRNA synthetase differs at multiple positions from

31 r, the capacity of tRNA3Lys to interact with lysyl-tRNA synthetase does not entirely explain the enha

32 They are synthesized by lysyl-tRNA synthetases (EC 6.1.1.6), a group of enzymes

33 lysis of B. burgdorferi mRNA showed that the lysyl-tRNA synthetase-encoding gene is highly expressed,

34 Lysyl-tRNA synthetase from Escherichia coli belongs to t

35 The genomic lysyl-tRNA synthetase gene consisted of 15 exons.

36 tely 30%, of the mature transcripts from the lysyl-tRNA synthetase gene.

37 gene lies immediately adjacent to the cKARS (lysyl-tRNA synthetase) gene with the two genes in a head

38 Expression of the two lysyl-tRNA synthetase-green fluorescent protein gene fus

39 Two cDNAs encoding human lysyl-tRNA synthetase have been identified.

40 hydrolyze lysyl-adenylate generated by human lysyl-tRNA synthetase (hLysRS) by proceeding through an

41 Human lysyl-tRNA synthetase (hLysRS), the only cellular factor

42 f the anticodon in tRNA recognition by human lysyl-tRNA synthetase (hLysRS).

43 The detection of an archaeal-type lysyl-tRNA synthetase in B. burgdorferi and other pathog

44 udies have demonstrated that the presence of lysyl-tRNA synthetase in HIV-1 virions might account for

45 Lysyl-tRNA synthetase is a member of the class II aminoa

46 Human lysyl-tRNA synthetase is bound to the multi-tRNA synthet

47 ases, we report here that the class II human lysyl-tRNA synthetase is relatively insensitive to the n

48 is, p.Tyr173SerfsX7, and p.Ile302Met) in the lysyl-tRNA synthetase (KARS) gene in two patients from t

49 Lysyl-tRNA synthetase (KARS), an enzyme required for pro

50 e identified at highly conserved residues of lysyl-tRNA synthetase (KARS): the c.1129G>A (p.Asp377Asn

51 some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium.

52 an methionyl-tRNA synthetase (MRS) and human lysyl-tRNA synthetase (KRS) were expressed in human-deri

53 d a trans pQTL relationship between the KARS lysyl-tRNA synthetase locus and levels of the DIDO1 prot

54 Yeast two-hybrid screens suggested that lysyl-tRNA synthetase (LysRS) also associates with LeuRS

55 nscription primer via an interaction between lysyl-tRNA synthetase (LysRS) and the HIV-1 Gag polyprot

56 f the transcription factors MITF or USF2 and lysyl-tRNA synthetase (LysRS) are associated with human

57 into two unrelated structural classes, with lysyl-tRNA synthetase (LysRS) being the only enzyme repr

58 previously shown that the essential protein lysyl-tRNA synthetase (LysRS) exists in two unrelated fo

59 Human lysyl-tRNA synthetase (LysRS) is also specifically packa

60 unrelated aminoacyl-tRNA synthetase classes, lysyl-tRNA synthetase (LysRS) is the only example known

61 The alpha(2) homodimeric lysyl-tRNA synthetase (LysRS) is tightly bound in the MS

62 Lysyl-tRNA synthetase (LysRS), a class II enzyme whose m

63 Gag and GagPol, as well as host cell factor lysyl-tRNA synthetase (LysRS), are required for specific

64 horamidates and lysyl-adenylate generated by lysyl-tRNA synthetase (LysRS).

65 res lysyl-tRNA(Lys), which is synthesized by lysyl-tRNA synthetase (LysRS).

66 Alternatively, class I and class II lysyl-tRNA synthetases (LysRS1 and LysRS2) together form

67 Lysyl-tRNA synthetases (LysRSs) are unique amongst the a

68 The crystal structure of the constitutive lysyl-tRNA synthetase (LysS) from Escherichia coli has b

69 Crystals of the thermo-inducible E. coli lysyl-tRNA synthetase LysU which diffract to 2.1 A resol

70 This difference between the lysyl-tRNA synthetases of spirochetes and their hosts ma

71 nal modification with (R)-beta-lysine by the lysyl-tRNA synthetase paralog PoxA.

72 A putative lysyl-tRNA synthetase resistance gene was identified in

73 the sequence of the loop of motif 2 of human lysyl-tRNA synthetase specifies a structural variation t

74 RNA, we discovered that the Escherichia coli lysyl tRNA synthetase was responsible for misacylating t

75 syl-AMP generated by either E. coli or human lysyl-tRNA synthetase were partially transferable by C-t

76 Nonautoantigenic aspartyl-tRNA and lysyl-tRNA synthetases were not chemotactic.

77 ural classes, the only known exception being lysyl-tRNA synthetase which exists in both classes I (Ly