ライフサイエンスコーパス: lytic

1 expression but do not inhibit several other lytic activation pathways.

2 hat VLVs induced the expression of the viral lytic activator RTA, initiating KSHV lytic gene expressi

3 non-autolytic and exhibits lysozyme-mediated lytic activity against several bacterial species.

4 Kd </= 2 nm) with lysozyme and abrogated its lytic activity completely, thereby conferring protection

5 The degree of such residual lytic activity depended on the strength of the complemen

6 The lytic activity previously attributed to ESAT-6 is due to

7 first time, we found that TTPA also exhibits lytic activity towards capsular exopolysaccharide (EPS)

8 This peptide exhibits no cellular lytic activity, but electron microscopy and fluorescence

9 llular entry can also elicit potent membrane-lytic activity, limiting their use in delivery applicati

10 oligomeric state of the endolysin and reduce lytic activity.

11 cell walls and cellulosic materials without lytic activity.

12 f released autolysins and preventing further lytic activity.

13 Here we show that during lytic amplification of KSHV DNA, the Ku70/80 heterodimer

14 cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.

15 enzyme-linked immunosorbent assays-both HHV8 lytic and latent antigen based) and 2 molecular assays w

16 HSV) are human pathogens that switch between lytic and latent infection.

17 ow both are deposited on HCMV genomes during lytic and latent infections suggesting similar mechanism

18 (miRNAs), that may play roles in regulating lytic and latent infections.

19 egalovirus (HCMV) is a herpesvirus with both lytic and latent life cycles.

20 rus makes a key decision between two states: lytic and lysogenic fate.

21 Both lytic and temperate bacteriophages (phages) can be appli

22 systems that interfere with the infection of lytic and temperate phages that are either closely relat

23 genes including genes encoding latent, early lytic, and tegument proteins, such as substitutions with

24 The best performance was obtained by 2 lytic antigen-based IFAs that showed almost perfect agre

25 is a well-established therapeutic target for lytic bone diseases, the currently available bisphosphon

26 -year-old woman presented with bone pain and lytic bone lesions in April 2010.

27 mbrane vesicles that were able to induce the lytic cascade in EBV-positive B cells.

28 es a caspase-1/gasdermin D (Gsdmd)-dependent lytic cell death called pyroptosis that promotes antimic

29 MD pore in the plasma membrane, resulting in lytic cell death called pyroptosis.

30 rms of cell death with a special emphasis on lytic cell death pathways of pyroptosis and necroptosis

31 lead to unconventional protein secretion and lytic cell death.

32 Modification of a triple-acting lytic construct with a protein transduction domain signi

33 EhV-207 displayed a shorter lytic cycle and increased production potential than EhV-

34 in the intracellular phase of the parasites lytic cycle and provide a robust new tool for imaging pa

35 respond against EBV-infected B cells in the lytic cycle and to control the viral infection involving

36 Although the EBV lytic cycle can be triggered by certain agents in vitro,

37 We also discuss evidence that lytic cycle gene expression can be uncoupled from the fu

38 BPLF1 is a late lytic cycle gene, but the protein is also packaged in th

39 sociated episome, and transcription of viral lytic cycle genes is largely suppressed through epigenet

40 ect latency-associated transcripts and HSV-1 lytic cycle genes within the brain stem, the ependyma (E

41 nome springs back to active transcription of lytic cycle genes.

42 milar results were also observed during KSHV lytic cycle induction in TREX-BCBL-1 cells with the doxy

43 ll established that reactivation of the KSHV lytic cycle is associated with KS pathogenesis.

44 Consistent with this, the lytic cycle of a conditional mutant of TgPEPCKmt in the

45 ferentiation and susceptibility for the full lytic cycle of HCMV.

46 plasm in different cell types undergoing the lytic cycle of replication after de novo primary infecti

47 a hydroxyethylamine scaffold interrupts the lytic cycle of T. gondii at submicromolar concentration

48 tioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxop

49 sis or oxidative phosphorylation arrests the lytic cycle of the glycolysis-deficient mutant, which is

50 cell cycle and without any induction of KSHV lytic cycle reactivation.

51 Conversely, the lytic cycle regulatory protein (BoHV-1 infected cell pro

52 to maintain latent infection, (ii) a latency-lytic cycle switch operated by K-Rta, and (iii) a molecu

53 -BCBL-1 cells with the doxycycline-inducible lytic cycle switch replication and transcription activat

54 a key transcriptional regulator of the viral lytic cycle that is homologous to AP-1.

55 ilize the innate immune sensor IFI16 to keep lytic cycle transcription in dormancy.

56 Dexamethasone stimulates lytic cycle viral gene expression in sensory neurons of

57 ivation of productive viral replication (the lytic cycle) is necessary for the pathogenesis of KS.

58 cellular DNA repair factors during the viral lytic cycle, contributing to efficient infectious virion

59 The lytic cycle, driven by the tachyzoite life stage, is res

60 of cellular proteins that regulate the KSHV lytic cycle, which has implications for our understandin

61 life cycle-viral latency and the productive lytic cycle-and it is well established that reactivation

62 or functions against infected B cells in the lytic cycle.

63 t steps in the sequential cascade of the EBV lytic cycle.

64 genes, leading to reactivation of the entire lytic cycle.

65 in its host cells is achieved by consecutive lytic cycles, which necessitates biogenesis of significa

66 e failure load of human femur with simulated lytic defects.

67 Lateral chest radiograph demonstrated lytic destruction of the xiphisternum.

68 essed lysis where established models predict lytic dynamics are favoured.

69 -transformed B cells and was associated with lytic EBV gene expression, resulting in increased tumor

70 transcription factors KLF4 and BLIMP1 induce lytic EBV reactivation in epithelial cells by synergisti

71 Evidence of elevated lytic EBV replication was also found in EBV/KSHV dually

72 -associated tumorigenesis via stimulation of lytic EBV replication.

73 3 inhibits fungal growth and exerts a direct lytic effect on C. neoformans extracellular vesicles (EV

74 Unexpectedly, lytic effects required significantly higher titers of th

75 is achieved by a large set of synthetic and lytic enzymes with varying substrate specificities.

76 x degradation, through recruitment of matrix-lytic enzymes, particularly of matrix metalloproteinases

77 the understanding of how PG is processed by lytic enzymes.

78 onlytic exocytosis while having no effect on lytic exocytosis.

79 sed a panel of proinflammatory cytokines and lytic factors, like soluble FasL and granzyme B, and eli

80 CT, as compared to radiography, in detecting lytic foci obscured by other structures or with a small

81 lves inhibition of the expression of ICP0, a lytic gene activator, by a viral microRNA, miR-H2, which

82 fuse MT reorganization during peak stages of lytic gene expression and virion production.

83 timulated monocytes are partially permissive lytic gene expression but did not have long term impact

84 or miR-H2 activity and for the repression of lytic gene expression during latency deserve investigati

85 hypothesis to help explain the repression of lytic gene expression during latency.

86 While the mechanisms for activating lytic gene expression have received much attention, how

87 Additionally, transfected miR-138 reduced lytic gene expression in infected cells more effectively

88 , which has previously been shown to inhibit lytic gene expression in infected ganglia by targeting I

89 14+ monocytes are usually non-permissive for lytic gene expression which can lead to the establishmen

90 expression but can also trigger a switch to lytic gene expression.

91 e viral lytic activator RTA, initiating KSHV lytic gene expression.

92 y, are required for different early steps of lytic gene expression.

93 Overexpression of IFI16 reduced lytic gene induction by the chemical agent 12-O-tetradec

94 tency entails the repression of productive ("lytic") gene expression.

95 rastically inhibited the expression of viral lytic genes and the production of infectious virions, su

96 onsiderably enhanced the expression of viral lytic genes and the production of infectious virions, wh

97 latent virus undergoes reactivation whereby lytic genes are activated and viral replication occurs.

98 nisms governing the initial transcription of lytic genes are distinct from those of de novo infection

99 e virus for the expression of ICP0 and other lytic genes in acutely and latently infected mouse trige

100 H2 represses the expression of ICP0 or other lytic genes in cells or mice infected with HSV-1.

101 xpressed significantly higher levels of KSHV lytic genes in hyperglycemic mice than in normal mice.

102 s ability to drive the expression of various lytic genes, leading to reactivation of the entire lytic

103 Unexpectedly, HSV-1 lytic genes, usually identified during acute infection,

104 ulting in epigenetic transactivation of KSHV lytic genes.

105 su et al. use live-cell imaging to show that lytic granule convergence protects bystander cells from

106 in patients with CHS and how LYST regulates lytic granule exocytosis is very limited.

107 were positive for the proteins essential for lytic granule exocytosis.

108 n, as is the precise role of Munc18-2 during lytic granule exocytosis.

109 y immunodeficiency characterized by impaired lytic granule exocytosis.

110 R signal propagation, more efficient initial lytic granule release, and more sustained cytokine and c

111 R signal propagation, more efficient initial lytic granule release, and more sustained nonlytic cytok

112 at the immunologic synapse or decreasing the lytic granule size restored the ability of LYST-deficien

113 Thus, NK cells converge lytic granules and thereby improve the efficiency of tar

114 portant factor limiting the release of large lytic granules from NK cells from patients with CHS and

115 solution microscopy to visualize F-actin and lytic granules in normal and LYST-deficient NK cells.

116 Further, CD25, an IL-2R alpha chain, and lytic granules of NK cells in social microwells were pol

117 Live cell imaging of lytic granules revealed their dynamic and prolonged pola

118 retion, namely translocation of the MTOC and lytic granules to the IS, respectively.

119 uding the presence of significantly enlarged lytic granules with defective exocytosis and impaired in

120 ls through directed secretion of specialized lytic granules.

121 is essential in the developmental switch to lytic growth, whereas pRM repression by Cro at relativel

122 (2+)-dependent cell egress during Toxoplasma lytic growth.

123 ation and sensitivity to Vhs cleavage during lytic HSV infections.

124 ition of EGFR increases the transcription of lytic IE1/IE2 mRNA while curbing the expression of laten

125 h lipid mediator and cytokine production and lytic IEC death.

126 Serological assays, specifically lytic IFAs, were the best methodological approach to ide

127 In contrast, lytic IL-2/Fc or IL-10/Fc had no effect.

128 Recipients were treated with lytic IL-2/Fc, nonlytic IL-2/Fc, TGF-beta/Fc, or IL-10/F

129 mplex 2 (mTORC2) contributes to BCR-mediated lytic induction and that FK506-binding protein 12 (FKBP1

130 hematologic malignancies, block BCR-mediated lytic induction at clinically relevant doses.

131 ine and tacrolimus also inhibit BCR-mediated lytic induction but find that rapamycin does not inhibit

132 we show that BCR signaling can activate EBV lytic induction in freshly isolated B cells from periphe

133 that rapamycin does not inhibit BCR-mediated lytic induction.

134 ardless of whether these diseases are due to lytic infection (such as oral hairy leukoplakia) or late

135 ) (collectively vIL-10) are expressed during lytic infection and cause immunosuppressive effects that

136 for initiation of herpes simplex virus (HSV) lytic infection and for reactivation from latency in sen

137 roteins is critical for the establishment of lytic infection and reactivation from viral latency.

138 , the JNK pathway plays an important role in lytic infection and reactivation of VZV in physiological

139 K, the c-Jun N-terminal kinase (JNK), in VZV lytic infection and reactivation.

140 viral gene expression, virus replication and lytic infection and restricts murine CMV replication in

141 oth traffic to epithelial sites of recurrent lytic infection and to ganglia and persist at the dermal

142 eracts extensively with the HSV-1 DNA during lytic infection by ChIP-seq, and its knockdown results i

143 (JCPyV) in immunosuppressed individuals and lytic infection by neurotropic JCPyV in glial cells.

144 Lytic infection by the Epstein-Barr virus (EBV) poses nu

145 gers a monocyte phenotype permissiveness for lytic infection directly correlating with LPS concentrat

146 Whether a herpesvirus initiates a lytic infection in a host cell or establishes quiescence

147 Finally, we show that BCR activation of lytic infection occurs not only in tumor cell lines but

148 o the type of cellular functions affected by lytic infection of Herpes Simplex Virus type I in Human

149 nterestingly, we observe that this effect on lytic infection of monocytes is transient, appears to be

150 ling in targeted cells and facilitated viral lytic infection via activation of the RTA promoter.

151 Lytic infection with herpes simplex virus type 1 (HSV-1)

152 al hairy leukoplakia (OHL) lesions that have lytic infection, frequently express the viral latent mem

153 During lytic infection, herpes simplex virus (HSV) DNA is repli

154 distinct roles for pUL103 across the arc of lytic infection, including interactions with proteins in

155 polyadenylated nuclear (PAN) RNA facilitates lytic infection, modulating the cellular immune response

156 We show that LMP1 enhances the lytic infection-inducing effects of epithelial cell diff

157 reactivation or renders them permissive for lytic infection.

158 ithelial cells prevents the development of a lytic infection.

159 y gene in the blood indicative of active EBV lytic infection.

160 A/m epitranscriptomes during KSHV latent and lytic infection.

161 the cytoplasm of cells undergoing permissive lytic infections and latently infected cells in which th

162 th occasional reactivation causing recurrent lytic infections.

163 hes from its latent (quiescent) phase to the lytic, infectious state.

164 characterize the small RNAs expressed during lytic JMRV infection using deep sequencing.

165 repression of lytic transcripts, and a late lytic KSHV gene product(s) targets IFI16 for degradation

166 d the number of cells permissive for primary lytic KSHV infection.

167 tion, and how these may differ in latent and lytic KSHV infections are poorly understood.

168 TPA- or doxycycline-induced cells expressing lytic KSHV proteins.

169 KS tumors support both latent and lytic KSHV replication.

170 detecting cases of small foci suspicious of lytic lesions on skull radiographs, seen as arachnoid gr

171 Multiple lytic lesions with an increased uptake were also detecte

172 enal tubules, and highly characteristic bone lytic lesions.

173 ensities more consistent with temperate than lytic life cycles at increasing microbial abundance.

174 fore needed to understand the drivers of the lytic-lysogenic decision in viral communities and to tes

175 e or negative host density dependence to the lytic-lysogenic switch.

176 t models of the host density-dependent viral lytic-lysogenic switch.

177 The role of oxidative stress in the TLF-1 lytic mechanism has been controversial.

178 ectron microscopy (TEM) suggested a membrane lytic mechanism of action for these peptides.

179 ensing) pathways, viral fate determinations (lytic or latent), and to anticipate how artificially mod

180 BET proteins also localize to the lytic origin of replication (OriLyt) genetic elements, a

181 Eculizumab inhibits the terminal, lytic pathway of complement by blocking the activation o

182 sitive block for acid-triggered display of a lytic peptide to promote trafficking to the cell cytosol

183 By using a non-lytic PFO derivative, we showed that the sensitivity of

184 predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival and enab

185 Using Escherichia coli biofilms and the lytic phage T7 as models, we discovered that an amyloid

186 t and different proportions of temperate and lytic phages are distributed in either mode depending on

187 e into high and low gene flux modes, whereas lytic phages share only the lower gene flux mode.

188 esults also suggest that during infection by lytic phages that are susceptible to CRISPR interference

189 preferentially directed against cells in the lytic phase and was associated with surface expression o

190 Onset of the lytic phase in the KSHV life cycle is accompanied by the

191 to reactivate from latency and re-enter the lytic phase is challenging to investigate and control, i

192 ecruits activated pTyr(705)-STAT3 during the lytic phase of infection.

193 Subsequently, during the lytic phase of the life cycle, the maturing viral partic

194 ponse, and influence the transition into the lytic phase of viral replication.

195 ds placed upon the protein in the latent and lytic phases.IMPORTANCE The K15P protein of Kaposi's sar

196 idative cleavage of carbohydrate polymers by lytic polysaccharide mono-oxygenases (LPMOs).

197 9,003 sequences for glycoside hydrolases and lytic polysaccharide mono-oxygenases targeting cellulose

198 functional traits and the high frequency of lytic polysaccharide mono-oxygenases, as well as other p

199 vity on crystalline chitin was enhanced by a lytic polysaccharide monooxygenase that increases substr

200 Bacterial lytic polysaccharide monooxygenases (LPMO10s) use redox

201 Lytic polysaccharide monooxygenases (LPMOs) are a class

202 Copper-dependent lytic polysaccharide monooxygenases (LPMOs) are enzymes

203 Lytic polysaccharide monooxygenases (LPMOs) are industri

204 Lytic polysaccharide monooxygenases (LPMOs) catalyze the

205 for HjLPMO9A, belonging to the AA9 family of lytic polysaccharide monooxygenases (LPMOs).

206 ption of oxygen activation by substrate free lytic polysaccharide monooxygenases and provide insights

207 Lytic polysaccharide monooxygenases have attracted vast

208 er, since C5b-7 and C5b-8 complexes form non lytic pore, it may also plays biological functionality.

209 membranes through a membrane strain-related lytic process, and this knowledge has important implicat

210 ophils fed CA-MRSA underwent a novel form of lytic programmed cell death via a mechanism that require

211 lytic state, CI is inactivated, and the two lytic promoters are de-repressed allowing for expression

212 he low level of Cro initially stimulates the lytic promoters while CI repressor is still present, sti

213 tern, thus blocking the transcription at two lytic promoters, PL and PR, and auto-regulating the prom

214 In a lysogen, CI represses the two lytic promoters, pR and pL, and activates its own transc

215 on of endogenous SUMOylation that uses alpha-lytic protease, WaLP.

216 ture also reveals atomic details of membrane-lytic protein VI and genome-condensing protein VII and s

217 sed to analyse the kinetic properties of the lytic PRV transcripts and to then classify them accordin

218 context of the null virus, and all produced lytic rather than syncytial sites of infection.

219 mphoma BCBL-1 and BC-3 cell lines results in lytic reactivation and increases in levels of KSHV lytic

220 Following lytic reactivation by sodium butyrate, the levels of the

221 lso demonstrate that LMP1 promotes efficient lytic reactivation in EBV-infected epithelial cells by e

222 stood, and its potential roles in regulating lytic reactivation in epithelial cells are as yet unexpl

223 Finally, we observed increased lytic reactivation of KSHV from latently infected cells

224 Similar results were seen when lytic reactivation was stimulated by the KSHV protein re

225 RID3B led to an enhancement or inhibition of lytic reactivation, respectively.

226 sively understand the mechanisms that govern lytic reactivation, to better understand disease progres

227 nd transcription activator (RTA) can promote lytic reactivation.

228 hether it plays any role in regulating viral lytic reactivation.

229 3B [ARID3B]) that we show is able to temper lytic reactivation.

230 ls in 3-D also demonstrated a higher rate of lytic reactivation.

231 duct(s) targets IFI16 for degradation during lytic reactivation.

232 ion and that blockade of this pathway limits lytic replication (as occurs during primary infection).

233 ghly permissive nature of this cell type for lytic replication allows virus amplification and exchang

234 n of the cytoplasmic isoforms of LANA during lytic replication and extends the function of LANA from

235 s, they show two stages in their life cycle: lytic replication and latency.

236 wever, a percentage of spindle cells support lytic replication and production of virus and these cell

237 Epstein-Barr virus (EBV) infection and lytic replication are known to induce a cellular DNA dam

238 e shown that soluble HIV-1 Vpr inhibits KSHV lytic replication by activating NF-kappaB signaling foll

239 Knockdown of YTHDF2 enhanced lytic replication by impeding KSHV RNA degradation.

240 they maintain latent infection and switch to lytic replication by K-Rta remains unclear.

241 ce of latency and suggest that repression of lytic replication by kLANA, as previously shown with KSH

242 ses, while inhibition of AMPK enhances, KSHV lytic replication by regulating the expression of viral

243 of LANA from its role during latency to the lytic replication cycle.

244 The minimal requirements to achieve lytic replication in cultured cells included (i) either

245 posi's sarcoma-associated herpesvirus (KSHV) lytic replication in primary human umbilical vein endoth

246 ts for productive KSHV infection, we induced lytic replication in the presence of inhibitors of diffe

247 KSHV lytic replication induces dynamic reprogramming of epitr

248 ggested that the KSHV switch from latency to lytic replication is primarily controlled at the chromat

249 he virus-host interactions that occur during lytic replication of KSHV and provides a deeper insight

250 turtle cells, which is indicative of active lytic replication of the virus.

251 modulates these cellular pathways during its lytic replication phase was previously lacking.

252 associated herpesvirus (KSHV) has latent and lytic replication phases that are essential for the deve

253 lytic replication.IMPORTANCE KSHV productive lytic replication plays a pivotal role in the initiation

254 The induction of lytic replication was characterized by high-level expres

255 dant m(6)A/m modifications during latent and lytic replication, and these modifications are highly co

256 as tegument proteins involved in regulating lytic replication, but lacked capsid proteins.

257 Current HCMV therapeutics target lytic replication, but not the latent viral reservoir; t

258 etabolic pathways are required for efficient lytic replication, providing novel therapeutic avenues f

259 eliminate latently infected cells and block lytic replication, thereby inhibiting infection of new c

260 ppaBalpha and reduced Vpr inhibition of KSHV lytic replication, while overexpression of miR-942-5p en

261 nscriptome, regulating pathways that control lytic replication.

262 KSHV lytic switch protein, and halted viral lytic replication.

263 t Langerhans cells, which support full HHV-8 lytic replication.

264 increased substantially upon stimulation for lytic replication.

265 oplasmic LANA and nuclear ORF59, a marker of lytic replication.

266 egument protein with vital roles during KSHV lytic replication.

267 f miR-942-5p enhanced Vpr inhibition of KSHV lytic replication.

268 fic miR-200 family of microRNAs promotes EBV lytic replication.

269 e of KSHV latent infection and the switch to lytic replication.

270 ng host cell responses and facilitating KSHV lytic replication.IMPORTANCE Cells lytically infected wi

271 (6)A machinery to its advantage in promoting lytic replication.IMPORTANCE KSHV productive lytic repli

272 KSHV to favor the transition from latency to lytic replication.IMPORTANCE Posttranslational histone m

273 ctors such as patient's age, type of lesion (lytic/sclerotic or mixed), matrix mineralization, multip

274 ibacterial strategies (1) , especially small lytic single-stranded DNA (the microviruses) and RNA pha

275 DSS3Phi8 is a lytic siphovirus.

276 ced upon the protein in the viral latent and lytic stages.

277 During induction from the lysogenic to lytic state, CI is inactivated, and the two lytic promot

278 nd transcription activator (RTA) is the KSHV lytic switch protein due to its ability to drive the exp

279 on transcription activator (RTA), a key KSHV lytic switch protein, and halted viral lytic replication

280 ergizing with CD95 blocked the activation of lytic switch proteins and the gene expression of gammahe

281 led that mixtures of StnI and StnII are more lytic than equivalent preparations of the corresponding

282 r for ORF50, the gene that encodes the major lytic transactivator protein RTA, while mLANA did not, s

283 ese results suggest that CTCF promotes HSV-1 lytic transcription by facilitating the elongation of RN

284 from Pacific Biosciences to characterize the lytic transcriptome of HCMV strain Towne varS.

285 for quantifying the poly(A) fraction of the lytic transcriptome of pseudorabies virus (PRV) througho

286 16 to maintain its latency and repression of lytic transcripts, and a late lytic KSHV gene product(s)

287 reactivation and increases in levels of KSHV lytic transcripts, proteins, and viral genome replicatio

288 An enzyme superfamily, the lytic transglycosylases (LTs), occupies the space betwee

289 c focus on LytM-like endopeptidases, soluble lytic transglycosylases and amidases.

290 In addition, we identify two lytic transglycosylases and an amidase as new divisome c

291 nctions autophagy, phagosome maturation, and lytic vacuole/lysosome, and contained the vacuolar H(+)-

292 BCR signaling pathway inhibit activation of lytic viral expression but do not inhibit several other

293 ion of the B cell receptor pathway activates lytic viral expression in cell lines.

294 al role of this virus-encoded pathway during lytic viral infection.

295 by differentiation and positively regulates lytic viral reactivation.

296 The lysogen-lytic viral reproduction switch is central to viral ecol

297 Moreover, lytic virus growth requires a close interplay between fi

298 Influenza A virus (IAV) is a lytic virus in primary cultures of many cell types and i

299 PRD1 and nearly identical well-characterized lytic viruses, the second one includes more variable tem

300 e (ATPase) determines the rate at which the 'lytic water' molecule is activated and OH- nucleophile i