ライフサイエンスコーパス: mGluR7

1 n for the metabotropic glutamate receptor 7 (mGluR7).

2 ty of orthosteric and allosteric agonists at mGluR7.

3 uR1, and the group III receptors, mGluR4 and mGluR7.

4 subunits mGluR1, mGluR3, mGluR4, mGluR5, and mGluR7.

5 mGluR1 alpha, mGluR2/3, mGluR4a, mGluR5, and mGluR7.

6 Ser(862) or the regulation of CaM binding to mGluR7.

7 eractions with the carboxyl-terminal tail of mGluR7.

8 kinase-mediated inhibition of CaM binding to mGluR7.

9 In naive slices, mGluR7 activation during HFS generates MF-SLIN LTD, depr

10 mGluR7 activation during high-frequency stimulation (HFS

11 immunocytochemical results demonstrated that mGluR7 activation increased cofilin activity and F-actin

12 Fil VGCC depression results from HFS-induced mGluR7 activation leading to persistent P/Q-type VGCC in

13 mGluR7-RIM1alpha interaction is regulated by mGluR7 activation, and mice lacking RIM1alpha are defici

14 Rather, mGluR7 activation/internalization controls plasticity po

15 ansmission has been shown to be modulated by mGluR7 activity.

16 We also discovered an association between mGluR7 and RIM1alpha, an active zone molecule required f

17 um mobilization assays in cells coexpressing mGluR7 and the promiscuous G protein G alpha(15).

18 ted the in vitro characterization of a novel mGluR7 antagonist called 6-(4-methoxyphenyl)-5-methyl-3-

19 ximal dendrites were strongly labeled by the mGluR7 antibody.

20 Distinct levels of mGluR7 are found at different synapses made by individua

21 aled that immunoreactivities for mGluR4a and mGluR7 are widely but differentially distributed through

22 -, PKA-, or PKG-dependent phosphorylation of mGluR7 at a single serine residue, Ser(862), in the carb

23 However, the postsynaptic localization of mGluR7 at selected synapses indicates that mGluR7 is not

24 The presence of mGluR7 at these multiple sites in the basal ganglia sugg

25 These data suggest that mGluR7, by affecting the cofilin/actin signaling, regula

26 Addition of the mGluR7 C-terminal sequence to mGluR2 or to the unrelated

27 ibits kinase-mediated phosphorylation of the mGluR7 carboxyl terminus and reverses kinase-mediated in

28 R1a, mGluR2, and D2 were comparable, whereas mGluR7 currents were somewhat smaller.

29 The mGluR7 cytoplasmic domain appended to the transmembrane

30 Truncation of the mGluR7 cytoplasmic tail produces a protein that is restr

31 n and surface expression are diminished, and mGluR7-dependent plasticity at mossy fiber-interneuron h

32 mGluR7 differs from mGluR4 and other group III mGluR in

33 horylation and inhibit CaM interactions with mGluR7 does not affect receptor function.

34 ated that mutating this residue to lysine in mGluR7 enhances the potency of L-SOP.

35 While naive surface mGluR7 expressing MF-SLIN synapses are insensitive to cA

36 mGluR7 has low affinity and efficacy for activation by b

37 opic glutamate receptors (mGluRs) mGluR4 and mGluR7 have been postulated to serve as presynaptic auto

38 Strong mGluR7 hybridization signals are found in cerebral corte

39 aining was most abundant in IPL sublamina 1; mGluR7 immunoreactivity was organized in four bands, cor

40 compounds differentially inhibit coupling of mGluR7 in different cellular backgrounds and may not ant

41 tial mechanism for understanding the role of mGluR7 in mental health and disorders.

42 ng bulbectomy, consistent with expression of mGluR7 in mitral cell axon terminals.

43 sis of this region confirmed the presence of mGluR7 in multiple axon terminals.

44 es of mGluRs: mGluRla, mGluR2/3, mGluR5, and mGluR7 in the dorsal and ventral autonomic nuclei of the

45 onsistent with a largely presynaptic role of mGluR7 in the hippocampus and suggest that mGluR4 may ha

46 To investigate the immunolocalization of mGluR7 in the olfactory system, we used a polyclonal ant

47 show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the pres

48 However, following mGluR7 internalization HFS produces presynaptic LTP.

49 l studies in human and mouse and showed that mGluR7 is expressed in hair cells and in spiral ganglion

50 exclusion of mGluR2 versus axon targeting of mGluR7 is mediated by their 60 amino acid C-terminal cyt

51 Thus, the cytoplasmic tail domain of mGluR7 is necessary but not sufficient for polarized tar

52 f mGluR7 at selected synapses indicates that mGluR7 is not targeted exclusively to axonal compartment

53 Our results indicate that mGluR7 is primarily presynaptic at olfactory bulb synaps

54 o dendrites and excluded from axons, whereas mGluR7 is targeted to axons and dendrites.

55 t metabotropic glutamate receptor subtype 7 (mGluR7) is a metaplastic switch at MF-SLIN synapses, who

56 Because ablation of mGluR7 leads to a variety of behavioral symptoms related

57 AMPA receptors and activation of presynaptic mGluR7-like receptors.

58 Thus, mGluR7 localization to MF-SLIN terminals and not MFBs al

59 PFC pyramidal neurons, which was mediated by mGluR7 localized at postsynaptic neurons and involved th

60 econd messenger-dependent kinases to inhibit mGluR7-mediated activation of GIRK current is not depend

61 suggest that CaM binding is not required for mGluR7-mediated activation of GIRK current.

62 onding to lysine in mGluR4 and asparagine in mGluR7 might play a key role, and, indeed, mutagenesis e

63 ptic metabotropic glutamate receptor (mGluR) mGluR7 modulates excitatory neurotransmission by regulat

64 The mGluR7 modulation of NMDAR currents was prevented by age

65 We have examined the localization of the mGluR7 mRNA and mGluR7a protein in the basal ganglia of

66 eled the previously reported distribution of mGluR7 mRNA.

67 identified by computational docking produced mGluR7 mutants that respond with dramatically enhanced p

68 al mechanisms are likely required to mediate mGluR7 neuronal polarization and synaptic clustering.

69 Phosphorylation of mGluR7 on serine 862 (S862) inhibits CaM binding, thereb

70 KC phosphorylation act together to stabilize mGluR7 on the cell surface in vivo.

71 ce lacking PICK1, PKC-dependent increases in mGluR7 phosphorylation and surface expression are dimini

72 g glutamate release through infusions of the mGluR7 presynaptic receptor antagonist MMPIP had no effe

73 Furthermore, mGluR7 reduced the association of NMDARs with the scaffo

74 Immunoreactivity for mGluR7 revealed largely presynaptic localization of this

75 Importantly, the mGluR7-RIM1alpha interaction is regulated by mGluR7 acti

76 ate-dependent cAMP sensitivity controlled by mGluR7-RIM1alpha interactions underlies MF-SLIN metaplas

77 P elevation, synapses that have internalized mGluR7 robustly potentiate following cAMP increases.

78 lucidum interneuron (SLIN) synapses, mGluR7 serves as a metaplastic switch controlling bidire

79 g metabotropic glutamate receptor subtype 7 (mGluR7) suggest that antagonists of this receptor may be

80 62) inhibits CaM binding, thereby increasing mGluR7 surface expression and receptor binding to PICK1.

81 Although the dynamic regulation of mGluR7 surface expression governs a form of metaplastici

82 We now show that mGluR7 surface expression is stabilized by both PKC phos

83 Thus, selective mGluR7 targeting to MF terminals contacting SLINs and no

84 least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cel

85 ted inhibition of the functional coupling of mGluR7 to G protein-coupled inward rectifier potassium (

86 wn about the molecular mechanisms regulating mGluR7 trafficking.

87 Following agonist exposure, mGluR7 undergoes internalization, unmasking the ability

88 In contrast, mGluR7 was expressed primarily in fibers and terminals i

89 Immunoreactivity for mGluR7 was variable in different brain regions and close

90 mGluR2/3, mGluR4a, mGluR5, and mGluR7 were also expressed in meningeal microvasculature

91 ntrast, mGluR1 alpha, mGluR2/3, mGluR4a, and mGluR7 were expressed in leptomeninges from adult rats.

92 Instead, we found that mGluR4 and mGluR7 were located close to bipolar cell ribbons.

93 dies that specifically react with mGluR4a or mGluR7 were produced and used for immunocytochemical loc

94 b express mRNA for several mGluRs, including mGluR7, which has been suggested as a presynaptic glutam

95 teractions of presynaptic mGluRs, especially mGluR7, with multiple protein kinases and putative regul