ライフサイエンスコーパス: mGluR8

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1 pic glutamate receptors, mGluR1a, mGluR2, or mGluR8.

2 at, except for the mouse cDNA clone encoding mGluR8.

3 pha-methyl-amino-phosphonobutyrate inhibited mGluR8.

4 ng either mGluR4, mGluR8, or both mGluR4 and mGluR8.

5 xpress either group II mGluR2/3 or group III mGluR8.

6 mGluR8 activation by the group III mGluR agonists l-2-am

7 analyzed the mechanism of action underlying mGluR8 activity and modulation of the cytosolic Ca2+ con

8 ated the biological effects of the selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine ((S)-3,4-D

9 rents in Xenopus laevis oocytes coexpressing mGluR8 and G protein-coupled inwardly rectifying potassi

10 at hippocampal slices supporting the role of mGluR8 as a presynaptic autoreceptor.

11 We isolated a rat mGluR8 cDNA that encodes a protein of 908 amino acids.

12 gh percentage of single-labeled mGluR2/3 and mGluR8 cells, there is a considerable population of doub

13 Mouse mGluR8 couples weakly to the inhibition of adenylate cyc

14 pression, with 75.0% of DRG cells expressing mGluR8, followed by group II, with 51.6% expressing mGlu

15 ic glutamate receptor (mGluR), type 8 mGluR (mGluR8), has been identified functionally as a presynapt

16 mGluR8 immunoreactivity was evident in the OFF plexus of

17 These data provide a potential role for mGluR8 in anxiety and suggest that mGluR8 may not be a t

18 between Gi2 and/or Gt protein/transducin and mGluR8 in photoreceptors.

19 tory function and pharmacologic targeting of mGluR8 in photoreceptors.

20 localization of the group III mGluR subtype, mGluR8, in the human body and investigated the biologica

21 The pharmacological profile of mGluR8 is distinct among mGluRs but closely matches that

22 mGluR8 is expressed by small, medium, and large diameter

23 role for mGluR8 in anxiety and suggest that mGluR8 may not be a therapeutic target for schizophrenia

24 In situ hybridization revealed prominent mGluR8 mRNA expression in olfactory bulb, pontine gray,

25 In addition, mGluR8 null mutant mouse behavioral phenotyping revealed

26 These results suggest that the function of mGluR8 of modulating the cytosolic Ca2+ concentration an

27 cally engineered mice lacking either mGluR4, mGluR8, or both mGluR4 and mGluR8.

28 ists may in some cases reflect activation of mGluR8 rather than multiple mGluR subtypes.

29 glutamate activates presynaptic mGluR2/3 and mGluR8 receptors but not mGluR4, although this receptor

30 mGluR8 was also activated by the group III-specific agon

31 bands, corresponding to sublaminae 1-4; and mGluR8 was localized in two broad bands, one each in the

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