ライフサイエンスコーパス: mRNA degradation

1 suppresses IL-27 production by promoting p28 mRNA degradation.

2 s (17-25 nt) that control translation and/or mRNA degradation.

3 utput of target genes; they act by promoting mRNA degradation.

4 dies), which concentrate factors involved in mRNA degradation.

5 eased proximity of Ago2 to nascent chain and mRNA degradation.

6 discovery of additional key factors in human mRNA degradation.

7 -exosome interaction, which is important for mRNA degradation.

8 mily 2 (YTHDF2) 'reader' protein to regulate mRNA degradation.

9 SLBP from the histone mRNA prior to histone mRNA degradation.

10 at RRP6 was required for CELF1-mediated Cx43 mRNA degradation.

11 c binding relationships for co-regulation of mRNA degradation.

12 inhibition is the primary event required for mRNA degradation.

13 silence host gene expression via widespread mRNA degradation.

14 dation is temporally correlated with histone mRNA degradation.

15 oth robustly inhibit translation and promote mRNA degradation.

16 tivates both Xbp1 splicing and IRE1-mediated mRNA degradation.

17 and inducing translational repression and/or mRNA degradation.

18 yme 1 (DCP1), a marker of P-bodies; sites of mRNA degradation.

19 ycomb repressive complex 2 and initiation of mRNA degradation.

20 e characterize a novel role for ubiquitin in mRNA degradation.

21 ifferentiation, GRHL3, at low levels through mRNA degradation.

22 n part as a consequence of nonsense-mediated mRNA degradation.

23 ng the antiviral response by promoting IRF-7 mRNA degradation.

24 nd provide a link between ubiquitination and mRNA degradation.

25 lase leading to translational inhibition and mRNA degradation.

26 translated region (3'-UTR), leading to Keap1 mRNA degradation.

27 idine-rich elements in the p19 3'UTR and p19 mRNA degradation.

28 ylation controls AUF1 levels to modulate ARE mRNA degradation.

29 completely abolishes IFN-gamma-mediated p19 mRNA degradation.

30 prevent ribosome binding causing accelerated mRNA degradation.

31 ued to examine the contributions of Hsp27 to mRNA degradation.

32 'UTRs, followed by translation repression or mRNA degradation.

33 tween components involved in translation and mRNA degradation.

34 at controls the subsequent sequence-specific mRNA degradation.

35 Rs) and mediate translational repression and mRNA degradation.

36 K2 phosphorylates PARN, blocking Gadd45alpha mRNA degradation.

37 iated mRNAs results in ribosome stalling and mRNA degradation.

38 nor Delta12 significantly enhanced reporter mRNA degradation.

39 gregated, translationally silenced mRNAs and mRNA degradation.

40 bind 40S ribosomal subunits or promote host mRNA degradation.

41 ted in translational repression, but not CIS mRNA degradation.

42 , resulting in suppression of translation or mRNA degradation.

43 f the Lsm1-7 complex involved in cytoplasmic mRNA degradation.

44 of TNRC6B, a gene involved in miRNA-mediated mRNA degradation.

45 protein synthesis in infected cells through mRNA degradation.

46 cific manner via translational inhibition or mRNA degradation.

47 ly and temporally with the onset of maternal mRNA degradation.

48 e inhibits MSY2 phosphorylation and prevents mRNA degradation.

49 from cytoplasmic processing bodies, sites of mRNA degradation.

50 n to be involved in transcription as well as mRNA degradation.

51 ARE-binding protein essential for rapid ARE-mRNA degradation.

52 portant process in the control of eukaryotic mRNA degradation.

53 CD44-v mRNA levels was not due to increased mRNA degradation.

54 was caused by increased rates of involucrin mRNA degradation.

55 sion that are consistent with regulation via mRNA degradation.

56 nducible 3',5' exoribonuclease that mediates mRNA degradation.

57 cell surface uPAR protein and increased uPAR mRNA degradation.

58 omoter upregulation in the face of increased mRNA degradation.

59 le for the GR in binding to and facilitating mRNA degradation.

60 translational efficiency, mRNA stability and mRNA degradation.

61 lity of siRNAs with lower potency to mediate mRNA degradation.

62 isms by which miRNAs control translation and mRNA degradation.

63 ay therefore play a role in regulating c-myc mRNA degradation.

64 t with membranes to facilitate regulation of mRNA degradation.

65 e daily transfection was required because of mRNA degradation.

66 egulated by inflammatory stimuli, to promote mRNA degradation.

67 esses through gene expression suppression or mRNA degradation.

68 PIP4 act independently in regulation of IL-6 mRNA degradation.

69 identifies samples with different levels of mRNA degradation.

70 the initial and often rate-limiting step in mRNA degradation.

71 enylation activity and is required for MHC-I mRNA degradation.

72 ts down translation initiation and activates mRNA degradation.

73 t bind the mRNAs of some viruses, leading to mRNA degradation.

74 omeostasis and signal-dependent induction of mRNA degradation.

75 o combat oxidative stress by modulating cysB mRNA degradation.

76 e in hydrolyzing the cap structure following mRNA degradation.

77 acts independently in the regulation of IL-6 mRNA degradation.

78 liferation by promoting cell cycle inhibitor mRNA degradation.

79 ression of protein synthesis and ER-specific mRNA degradation.

80 ing against an important cytoplasmic role in mRNA degradation.

81 l suppression or induction of messenger RNA (mRNA) degradation.

82 scriptional regulation via microRNA-mediated mRNA degradation (2/24) or via intercellular protein mov

83 screte miR effector mechanisms: (1) for p21, mRNA degradation; (2) for Bim, translational inhibition.

84 lter protein expression through differential mRNA degradation, a regulatory mechanism that may allow

85 Furthermore, like SARS-CoV nsp1, the mRNA degradation activity of MERS-CoV nsp1, most probabl

86 modified siRNAs are necessary that maintain mRNA degradation activity, but are more stable to nuclea

87 s polyC motif is required and sufficient for mRNA degradation after fertilization.

88 regate level, target binding leads mainly to mRNA degradation, although we also observed some degree

89 This was partly due to increased TNF mRNA degradation, an effect that was reduced by ZFP36 si

90 data revealed that nsp1 indeed promoted host mRNA degradation and contributed to host protein transla

91 et sites on the 3'-UTR of MITF mRNA, causing mRNA degradation and decreased expression and activity o

92 tigated the mechanism of CELF1-mediated Cx43 mRNA degradation and determined whether elevated CELF1 e

93 e revealed a key role for these helicases in mRNA degradation and in earlier remodelling of mRNP for

94 (miRNAs), small noncoding RNAs that promote mRNA degradation and inhibit mRNA translation, have been

95 tively regulate gene expression by promoting mRNA degradation and inhibiting mRNA translation.

96 press host gene expression by promoting host mRNA degradation and inhibiting translation.

97 Lsm1 is required for histone mRNA degradation and is present in a complex containing

98 cations for the interplay of translation and mRNA degradation and models of gene regulation by small

99 bonuclease Xrn1 catalyze successive steps in mRNA degradation and prevent double-stranded RNA (dsRNA)

100 ted evidence for a role of Y14 in regulating mRNA degradation and processing body formation and reinf

101 to understand the role of RNase Y in global mRNA degradation and processing.

102 enoxacin (Penetrex) enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogeno

103 r data suggest that PUF proteins may enhance mRNA degradation and repress expression by both deadenyl

104 riched in cytoplasmic P bodies, the sites of mRNA degradation and storage in yeast and mammalian cell

105 function of individual proteins involved in mRNA degradation and the mechanisms by which yeast P-bod

106 that, in infected cells, nsp1 promotes host mRNA degradation and thereby suppresses host gene expres

107 sion might act through TTP by increasing p19 mRNA degradation and therefore IL-23 inhibition.

108 The control of mRNA degradation and translation are important aspects o

109 The control of mRNA degradation and translation are important for the r

110 RNAs to the general eukaryotic machinery for mRNA degradation and translation control.

111 esses host gene expression by promoting host mRNA degradation and translation inhibition.

112 dose-dependent manner through miRNA-induced mRNA degradation and translation repression.

113 24-3p regulates HO-1 expression through both mRNA degradation and translation repression.

114 Puf proteins regulate mRNA degradation and translation through interactions wi

115 ort interfering RNAs (siRNAs) and can affect mRNA degradation and translation, as well as chromatin s

116 MicroRNAs (miRNAs), which direct mRNA degradation and translational inhibition, influence

117 untranslated region of mRNA, which leads to mRNA degradation and translational repression.

118 The host mRNA degradation and translational suppression activitie

119 ratures, the stem-loop unfolds, allowing for mRNA degradation and turning off expression.

120 tant form of TTP was sufficient for enhanced mRNA degradation and underexpression of inflammatory med

121 amentally different set of ribonucleases for mRNA degradation and whether sRNAs can regulate the acti

122 effects on other cellular processes such as mRNA degradation and, in some cases, can confer a benefi

123 mRNA because of the shorter 3'UTR, and thus, mRNA degradation and/or repression on protein translatio

124 ments in 3'-untranslated regions to regulate mRNA degradation and/or translation.

125 s that reduce expression of proteins through mRNA degradation and/or translational silencing.

126 MicroRNAs (miRNAs) induce messenger RNA (mRNA) degradation and repress mRNA translation.

127 nal inhibition of miR-221 prevented TNFalpha mRNA degradation, and blocking miR-579 and miR-125b prec

128 repressing gene transcription, accelerating mRNA degradation, and impeding pre-ALAS-1 mitochondrial

129 oskeleton, ribosome maturation, translation, mRNA degradation, and more generally in precluding a pot

130 ssion at the levels of alternative splicing, mRNA degradation, and translation.

131 Translation and mRNA degradation are affected by a key transition where

132 Translational repression and mRNA degradation are critical mechanisms of posttranscri

133 However, the processes of human pre-mRNA degradation are not well characterised in the human

134 icularly during stress where translation and mRNA degradation are reprogrammed to stabilize bulk mRNA

135 Translation and messenger RNA (mRNA) degradation are important sites of gene regulation

136 n dendrites and highlight activity-dependent mRNA degradation as a regulatory process involved in syn

137 its target sites on the MITF 3'-UTR, causing mRNA degradation as well as decreased expression and act

138 Both the promoter luciferase assay and mRNA degradation assay clearly showed that depletion of

139 go-2 PAZ domain and can localize into GW-182 mRNA-degradation bodies (GW-bodies).

140 he cytoplasm, for translation inhibition and mRNA degradation but spared exogenous mRNAs introduced d

141 their downregulations are not controlled by mRNA degradation but through different posttranslational

142 by inhibiting mRNA translation and promoting mRNA degradation, but little is known of their potential

143 e dynamic cytoplasmic structures involved in mRNA degradation, but the mechanism that governs their f

144 R and AUF1 and that polyamines modulate JunD mRNA degradation by altering the competitive binding of

145 icroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary sequences in 3

146 CELF1 mediated Cx43 mRNA degradation by binding the UG-rich element in the 3

147 es demonstrate that FGF signals use targeted mRNA degradation by Brf1 to enable rapid posttranscripti

148 Rather, we found that Eap1p accelerates mRNA degradation by promoting decapping, and the ability

149 iple, biologically relevant factors, such as mRNA degradation by RNase enzymes, different phases of t

150 ng transcription factors and protection from mRNA degradation by RNase.

151 time-delay model of protein translation and mRNA degradation by systematically reducing a detailed m

152 ls, epigenetic status, splicing kinetics and mRNA degradation can each contribute to changes in the m

153 dicted to further expand the capacity of the mRNA degradation code by coupling it to dynamic events e

154 ntal gene expression is shaped by a complex 'mRNA degradation code' with high information capacity.

155 protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular pr

156 tion by monocytes depends heavily upon rapid mRNA degradation, conferred by 3' untranslated region-lo

157 ut not the Dis3L2 exonuclease, slows histone mRNA degradation consistent with 3' to 5' degradation by

158 sing bodies (P bodies), cytoplasmic sites of mRNA degradation containing non-translating mRNAs, and m

159 , our study provides evidence for widespread mRNA degradation control in numerous biological processe

160 nstrate that the efficiency of ARE-dependent mRNA degradation declines in the neural lineage because

161 senger RNA (mRNA) to induce its degradation; mRNA degradation depleted occludin from enterocytes, res

162 ict antiviral responses by accelerating host mRNA degradation during poxvirus infection.

163 ze distributions are, in addition, shaped by mRNA degradation during transcription bursts.

164 nitiation factors, molecular chaperones, and mRNA degradation enzymes to the ARE for mRNA destruction

165 However, the mechanism of host mRNA degradation, especially where and how PA-X targets

166 esponse is mediated in part through cytokine mRNA degradation facilitated by RNA-binding proteins, in

167 mutant could still interact with the NMD and mRNA degradation factors and retained partial NMD activi

168 the strong requirement for general 5' to 3' mRNA degradation factors Dcp1, Dcp2, and Xrn1 in Ty1 ret

169 mer, Y14/Magoh, specifically associates with mRNA-degradation factors, including the mRNA-decapping c

170 ocessing bodies, perhaps by sequestering the mRNA-degradation factors.

171 to explore the links between RNA binding and mRNA degradation for both AUF1 and Argonaute 2 (AGO2), w

172 ddition, mapping and sequence analysis of an mRNA degradation fragment that accumulates in the absenc

173 h enzymes results in the appearance of novel mRNA degradation fragments.

174 The mRNA degradation function also ensures rapid cell prolif

175 ves mRNA at ACA sequences, leading to global mRNA degradation, growth arrest, and death.

176 ay and we suggest that the 5'-3' polarity of mRNA degradation has evolved to ensure that the last tra

177 content on the rate of mature, translatable mRNA degradation has not been demonstrated.

178 t mechanism whereby polyamines regulate JunD mRNA degradation has not been elucidated.

179 clease (PARN) deadenylase in miRNA-dependent mRNA degradation has not been elucidated.

180 5' UTR of the translating mRNA and promoting mRNA degradation in a translation-dependent manner.

181 t they cause gene silencing through targeted mRNA degradation in all phases of the life cycle, includ

182 requirements are observed for RppH-dependent mRNA degradation in B. subtilis cells.

183 The molecular mechanisms for target mRNA degradation in Caenorhabditis elegans undergoing RN

184 t revealed a previously unrecognized role of mRNA degradation in cardiomyocyte growth, and suggested

185 tion, we have investigated the importance of mRNA degradation in controlling gene expression downstre

186 ng that there is not a general activation of mRNA degradation in dendrites.

187 can have a major impact on 5' end-dependent mRNA degradation in E. coli and suggest a possible seque

188 y, this master regulator of 5'-end-dependent mRNA degradation in E. coli not only catalyses a process

189 are also manifested during 5'-end-dependent mRNA degradation in E. coli.

190 characterized pathway for the initiation of mRNA degradation in Escherichia coli involves the remova

191 ate-limiting step in the general cytoplasmic mRNA degradation in eukaryotic cells.

192 st rate-limiting step in general cytoplasmic mRNA degradation in eukaryotic cells.

193 for tumor necrosis factor alpha (TNF-alpha) mRNA degradation in monocytes.

194 sRNAs can directly modulate mRNA degradation in Proteobacteria without interfering w

195 ding the transcription factor Xbp1, mediates mRNA degradation in response to ER stress through a path

196 To determine the role of endonucleases in mRNA degradation in Saccharomyces cerevisiae, we mapped

197 pressing constitutively active forms induces mRNA degradation in the absence of maturation and phosph

198 nown to mediate translational repression and mRNA degradation in the cytoplasm.

199 ere, we examine the consequences of enhanced mRNA degradation in the galactose utilization network of

200 oligonucleotides (ASOs) are known to trigger mRNA degradation in the nucleus via an RNase H-dependent

201 Using microarrays, we also measured relative mRNA degradation in the presence and absence of ER stres

202 ression leads to poly(A) tail shortening and mRNA degradation in tissue culture cells, and we detect

203 n and its orthologs regulate translation and mRNA degradation in yeast, C. elegans, D. melanogaster,

204 long-standing assumption that messenger RNA (mRNA) degradation in Escherichia coli begins with endonu

205 d betacoronaviruses can result in widespread mRNA degradation, in each case initiated predominantly b

206 olling mRNA processing and the regulation of mRNA degradation, including the role of microRNAs and RN

207 nding of the molecular mechanisms underlying mRNA degradation indicates that specific mRNA degradatio

208 d that profiles the genome-wide abundance of mRNA degradation intermediates by virtue of their 5'-pho

209 Sequencing of mRNA degradation intermediates revealed that the complet

210 tion of an oligonucleotide to the 5'P end of mRNA degradation intermediates, followed by depletion of

211 By sequencing the ends of 5' phosphorylated mRNA degradation intermediates, we obtain a genome-wide

212 of widespread cytoplasmic polyadenylation of mRNA degradation intermediates.

213 Co-translational mRNA degradation is a widespread process in which 5'-3'

214 mRNA degradation is an important mechanism for controlli

215 The control of translation and mRNA degradation is an important part of the regulation

216 press translation of manY and manZ even when mRNA degradation is blocked.

217 , but the role of NMD on yeast unspliced pre-mRNA degradation is controversial.

218 However, much mRNA degradation is cytoplasmic such that mRNA nuclear e

219 Rapid mRNA degradation is facilitated by the preference of bot

220 Cotranslational mRNA degradation is initiated by decapping and proceeds

221 at it could represent a major means by which mRNA degradation is initiated in E. coli and other organ

222 mRNA degradation is often initiated by deadenylation, wh

223 ation specific transcription factors through mRNA degradation is required for progenitor cell mainten

224 We report that the initial step in histone mRNA degradation is the addition of uridines to the 3' e

225 zymes that function in normal mRNA decay and mRNA degradation is widely thought to occur when mRNAs a

226 downregulation of CAR protein and mRNA (via mRNA degradation); it sensitized doxorubicin-resistant c

227 ntify Stm1 as an additional component of the mRNA degradation machinery and suggest a possible connec

228 contain some translation repressors and the mRNA degradation machinery, and in stress granules, whic

229 ating mRNA, translation repressors, and some mRNA degradation machinery.

230 ctors and heat shock proteins to attract the mRNA degradation machinery.

231 A to form mRNP complexes that evade cellular mRNA degradation machinery.

232 dation containing non-translating mRNAs, and mRNA degradation machinery.

233 s and the general translation repression and mRNA degradation machinery.

234 SCoV nsp1-mediated promotion of host mRNA degradation may play an important role in SCoV path

235 The selectivity of this mRNA degradation mechanism relies on KSRP recognition of

236 ic cells, various translation inhibition and mRNA degradation mechanisms congregate in cytoplasmic pr

237 is repression was accompanied by accelerated mRNA degradation mediated by the major deadenylase, Ccr4

238 mRNA stability and high affinity HuD-target mRNA degradation mediates the bidirectional expression o

239 tic cells, as transcription, translation and mRNA degradation mostly occur in distinct functional com

240 with ribosomes in vivo and facilitated rapid mRNA degradation near the 5' end via cleavage at AAA lys

241 mutant (nsp1-mt) that neither promoted host mRNA degradation nor suppressed host protein synthesis i

242 mRNA degradation occurs through distinct pathways, one p

243 Arc mRNA degradation occurs throughout the dendrite and requ

244 geting the 5'-UTR leads to sequence-specific mRNA degradation of an L1 fusion transcript.

245 ation c.6599-20A>T causes type 1 VWD through mRNA degradation of exon 38 skipping transcripts.

246 S protein or mRNA level (consistent with the mRNA degradation of nNOS by miR-31).

247 YS) translational repression and accelerated mRNA degradation of nNOS leading to a profound reduction

248 The initiation of mRNA degradation often requires deprotection of its 5' e

249 trolling gene expression, either by inducing mRNA degradation or by blocking mRNA translation.

250 hundreds of target genes, leading either to mRNA degradation or suppression of translation.

251 lay important regulatory roles in modulating mRNA degradation or translational efficiency.

252 ite-specific cleavage and non-cleavage-based mRNA degradation or translational repression.

253 complementary target mRNA, thereby mediating mRNA degradation or translational repression.

254 ) are small regulatory molecules that act by mRNA degradation or via translational repression.

255 ome inhibitors rescued MEX-3C-mediated MHC-I mRNA degradation, our findings suggest a new non-proteol

256 Ago2 is localized in mRNA-degradation P-bodies analogous to those that functi

257 shutoff factors have converged upon a common mRNA degradation pathway.

258 difications regulating the decapping step in mRNA degradation pathways are poorly defined.

259 There are two known mRNA degradation pathways, 3' to 5' and 5' to 3'.

260 There are two mRNA degradation pathways: 3' to 5' and 5' to 3'.

261 GFP messenger RNA (mRNA) levels, mRNA degradation patterns, and bacterial growth rates al

262 information on mechanisms that may regulate mRNA degradation, possibly on short timescales.

263 R-dependent transcription and enhancement of mRNA degradation, possibly via regulated IRE1-dependent

264 slational quality control, in which specific mRNA degradation preemptively regulates aberrant protein

265 ion of cellular proteins is due to an active mRNA degradation process.

266 An important route for mRNA degradation produces uncapped mRNAs, and this decay

267 e three proteins act in association with the mRNA degradation protein RNaseY (Rny) to destabilize the

268 des its transcripts through association with mRNA degradation proteins.

269 ing mRNA degradation indicates that specific mRNA degradation rates are primarily encoded within the

270 mRNA degradation represents a critical regulated step in

271 NAs in which AUF1 affects their decay rates, mRNA degradation requires AGO2.

272 is that is compensated by down-regulation of mRNA degradation, resulting in mRNA level buffering.

273 inding activity and, thereby, enhancement of mRNA degradation seems to be the common denominator of m

274 he Drosophila Elav protein family that binds mRNA degradation sequences and prevents RNase-mediated d

275 ess protein expression by promoting specific mRNA degradation steps in addition to or in lieu of inhi

276 Furthermore, RDE-11 is required for mRNA degradation subsequent to target engagement.

277 n of No-go decay factors also slowed histone mRNA degradation, suggesting a role in removing ribosome

278 translation repression during transport, and mRNA degradation suggests the hypothesis that an additio

279 In eukaryotes, a specialized pathway of mRNA degradation termed nonsense-mediated decay (NMD) fu

280 c competition between protein elongation and mRNA degradation that is a central feature of the physio

281 rther amplified by a decrease in the rate of mRNA degradation, the latter being regulated only by EGF

282 binding effects of the RNA helicase MOV10 on mRNA degradation, the potentially different ADAR1 bindin

283 istence of a 5' end-independent mechanism of mRNA degradation, the relative simplicity of the require

284 hLsm1 function other than its involvement in mRNA degradation; therefore, we used expression microarr

285 a truncated subunit, or more likely, trigger mRNA degradation through nonsense-mediated mRNA decay (N

286 t the translation level with minor effect on mRNA degradation, through binding to the coding regions

287 ellular domains and kinase activity, through mRNA degradation to promote immunity.

288 l for cell growth and development, including mRNA degradation, translational repression, and transcri

289 cellular processes, including messenger RNA (mRNA) degradation, translational repression, and transcr

290 gene silencing by means of sequence-specific mRNA degradation, triggered by small double-stranded RNA

291 imultaneously, we find that that accelerated mRNA degradation underlies the rapid clearing of a subse

292 s transcriptional activity and mediating its mRNA degradation via miRNA.

293 as P-bodies during stress did not occur, and mRNA degradation was heterogeneously distributed in the

294 D to block new mRNA synthesis showed that AR mRNA degradation was increased.

295 of gene regulation, splicing, elongation and mRNA degradation were estimated from experimental data o

296 regulating gene expression is messenger RNA (mRNA) degradation, which is initiated by poly(A) tail sh

297 h reduced affinity for the MCP, which allows mRNA degradation while preserving single-molecule detect

298 for mRNA stability and depicts a pathway of mRNA degradation with 5'- to 3'-polarity in cells devoid

299 een both RNA polymerase II transcription and mRNA degradation with growth rates in yeast.

300 ary role of the RNAi machinery is to promote mRNA degradation within the cytoplasm in a microRNA-depe