ライフサイエンスコーパス: mRNA export

1 trosome integrity do not result from loss of mRNA export.

2 es mRNA export, RCF1 does not play a role in mRNA export.

3 lay (about 16 min in the mouse) being due to mRNA export.

4 -mRNA processing such as polyadenylation and mRNA export.

5 lowed a refinement of the current models for mRNA export.

6 (matrix) protein, another viral inhibitor of mRNA export.

7 epletion of any of these components inhibits mRNA export.

8 links transcription/processing with nuclear mRNA export.

9 P27 is a shuttling protein involved in viral mRNA export.

10 ell nucleus, indicating that NPM1 influences mRNA export.

11 nting the splicing requirement for efficient mRNA export.

12 ogenic stresses, leading to an inhibition of mRNA export.

13 a double mutant is temperature-sensitive for mRNA export.

14 ene expression and coupling translation with mRNA export.

15 that is required for herpes simplex virus 1 mRNA export.

16 tion on the activities of the REF protein in mRNA export.

17 e noncoding nuclear RNA in the regulation of mRNA export.

18 Dbp5's activity can be modulated to regulate mRNA export.

19 SDE5 is involved in basal plant defense and mRNA export.

20 slocation, thereby contributing to efficient mRNA export.

21 e REF1/Aly mRNA export adaptor to facilitate mRNA export.

22 e at a time, akin to a ratchet mechanism for mRNA export.

23 icating that RBM15 is required for efficient mRNA export.

24 ling a novel function of an F-box protein in mRNA export.

25 ght to remodel mRNA/protein complexes during mRNA export.

26 y is a nuclear speckle protein implicated in mRNA export.

27 bstantially decreases cell proliferation and mRNA export.

28 n introduced into host cells, disrupts viral mRNA export.

29 zosaccharomyces pombe Uap56p is critical for mRNA export.

30 e gene expression pathway, transcription and mRNA export.

31 egulatory event preventing inappropriate pre-mRNA export.

32 in DNA replication distinct from its role in mRNA export.

33 partially due to the NSs dependent block in mRNA export.

34 s, and expose new avenues for future work in mRNA export.

35 etraprolin nor HuR is required for TNF-alpha mRNA export.

36 icase function of Uap56p is not required for mRNA export.

37 ron-induced NPC protein with a major role in mRNA export.

38 ization of serine/arginine-rich proteins and mRNA export.

39 elicase activity in spliceosome assembly and mRNA export.

40 of Nup98 did not result in an inhibition of mRNA export.

41 activity in vitro and in vivo to facilitate mRNA export.

42 nucleus, leading to elevated eIF4E-dependent mRNA export.

43 to define how these factors control Dbp5 and mRNA export.

44 gene expression including transcription and mRNA export.

45 adaptors that couple pre-mRNA processing to mRNA export.

46 expression but did not alter Rex-3-dependent mRNA export.

47 cts their expression upstream of its role in mRNA export.

48 on to its more broadly characterized role in mRNA export.

49 ts gene-NPC interactions, transcription, and mRNA export.

50 nuclear import is separate from its role in mRNA export.

51 lasmic face of NPCs, is crucial to terminate mRNA export.

52 and the hGle1 role in SGs is independent of mRNA export.

53 is involved in transcription elongation and mRNA export.

54 d is involved in promoting transcription and mRNA export.

55 with Aly/REF contributes to efficient viral mRNA export.

56 rize the mechanism underlying IPMK-regulated mRNA export.

57 R proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent fro

58 ubnuclear residency, cell proliferation, and mRNA export activities through nuclear Akt phosphorylati

59 The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich

60 to identify the binding sites of ALYREF, an mRNA export adaptor in TREX, in human cells.

61 ICP27 also interacts with the mRNA export adaptor protein Aly/REF, which binds cellula

62 Ser2P CTD and recruits Iws1 and the REF1/Aly mRNA export adaptor to facilitate mRNA export.

63 Here we show that one CTA, Luzp4, is an mRNA export adaptor.

64 rs a Uap56 binding motif, conserved in other mRNA export adaptors.

65 Messenger RNA (mRNA) export adaptors play an important role in the tran

66 er previously described mutants with altered mRNA export affect cold signaling in a similar manner.

67 al analysis of the FG domain requirements in mRNA export also finds a requirement for two NPC substru

68 reas the deletion of residues 1-250 impaired mRNA export and also generated longer lag times when glu

69 lex couples nuclear pre-mRNA processing with mRNA export and contains multiple protein components, in

70 les reflect defective mRNP remodeling during mRNA export and during cytoplasmic mRNA metabolism.

71 ter photobleaching to measure the binding of mRNA export and EJC core proteins in nuclear complexes.

72 the periphery has been suggested to improve mRNA export and favor optimal transcription.

73 pressed and activated GAL1 and also produced mRNA export and growth defects.

74 ne SUS1, which encodes a protein involved in mRNA export and histone H2B deubiquitination, contains t

75 How Rae1 functions in mRNA export and how M protein targets both Rae1 and Nup9

76 D-box ATPase Dbp5 (human DDX19) functions in mRNA export and is thought to remodel mRNPs at the nucle

77 quired for optimal transcription elongation, mRNA export and perhaps nucleotide excision repair.

78 e active PI3 kinase/AKT pathway can regulate mRNA export and promote the nuclear retention of some mR

79 Gle1(InsP6), Nup159 and Dbp5 collaborate in mRNA export and provide a general mechanism for DEAD-box

80 in-like protein 1 (Mlp1), which functions in mRNA export and quality control.

81 The last steps in mRNA export and remodeling are performed by the Nup82 co

82 ion activity of ALKBH5 significantly affects mRNA export and RNA metabolism as well as the assembly o

83 components functionally interact, affecting mRNA export and splicing as well as plant development.

84 components functionally interact, affecting mRNA export and splicing as well as plant development.

85 discovery of links between components of the mRNA export and splicing machineries and Sem1/Dss1, a co

86 We demonstrate that TgUAP56 is crucial for mRNA export and that functional interference leads to si

87 hough the molecular roles of Gle1 in nuclear mRNA export and translation have been documented, no ani

88 le1 is uniquely positioned to coordinate the mRNA export and translation mechanisms.

89 P(6)-binding mutants recapitulate all of the mRNA export and translation termination defects found in

90 Gle1 is the primary target of IP(6) for both mRNA export and translation termination in vivo.

91 ntiation of Dbp5 ATPase activity during both mRNA export and translation termination.

92 d the poly(A)-tail is required for efficient mRNA export and translation.

93 tifunctional regulator of DBPs with roles in mRNA export and translation.

94 ATPase proteins, with critical roles in both mRNA export and translation.

95 n to mediate postsplicing activities such as mRNA export and translation.

96 equired for DEAD-box protein function during mRNA export and translation.

97 One factor investigated is an essential mRNA export and TREX complex component, Yra1.

98 ne expression requires proper messenger RNA (mRNA) export and translation.

99 credence for Nup functions in transcription, mRNA export, and genome organization.

100 Mex67p and Crm1p jointly promote YRA1 pre-mRNA export, and once in the cytoplasm, the pre-mRNA is

101 of gene expression, including transcription, mRNA export, and post- transcriptional and translational

102 ssociates with the nuclear pores to regulate mRNA export, and regulates the circadian clock and flowe

103 ed that Aly/REF is not required for cellular mRNA export, and similar knockdown studies during HSV-1

104 spliceosome assembly, pre-mRNA splicing, and mRNA export, and the phosphorylation process of the RS r

105 ins function in nuclear pre-mRNA processing, mRNA export, and translation.

106 A metabolism, including pre-mRNA processing, mRNA export, and translation.

107 Tho1 is known to function in mRNA export, and we provide evidence that CIP29 likewise

108 ate that both the kinetics and efficiency of mRNA export are enhanced 6- to 10-fold (depending on the

109 Key steps in mRNA export are the nuclear assembly of messenger ribonu

110 at Sem1 has a proteasome-independent role in mRNA export as a functional component of the Sac3-Thp1 c

111 nd HYPB/Setd2, in a megacomplex that affects mRNA export as well as the histone modification state of

112 This reversal of mRNA export block allowed expression of antiviral factor

113 The release of NS1-mediated mRNA export block by DHODH inhibition also occurred in t

114 down of Alyref and Chtop results in a potent mRNA export block.

115 und to mRNA in vivo and also causes a severe mRNA export block.

116 ased levels of NXF1, p15, or Rae1 revert the mRNA export blockage induced by NS1.

117 Stress conditions inhibit mRNA export, but mRNAs encoding heat shock proteins cont

118 enzyme is required for efficient viral late mRNA export, but neither the relevant substrates nor the

119 ement for proper Gle1 oligomerization during mRNA export, but not for Gle1's roles in translation.

120 is shared by multiple mutants with aberrant mRNA export, but not in a mutant attenuated in nucleo-cy

121 virus 1 (HSV-1) protein ICP27 enables viral mRNA export by accessing the cellular mRNA export recept

122 sphosphate (IP(6)) play an essential role in mRNA export by activating the ATPase activity of the DEA

123 ta indicate that TREX provides a license for mRNA export by driving Nxf1 into a conformation capable

124 lasmic mRNA levels, suggesting that enhanced mRNA export by SRSF5 is required for the expression of p

125 Viral inhibition of cellular mRNA export can enhance viral access to the cellular tra

126 rfaces that can contribute to recognition in mRNA export cargo selection and fate.

127 leus and cytoplasm are important features of mRNA export carriers such as HIV-Rev.

128 sphoinositide(s) regulates processes such as mRNA export, cell cycle progression, gene transcription,

129 for signal transduction pathways regulating mRNA export complex assembly, we used fluorescence recov

130 The conserved TREX mRNA export complex is known to contain UAP56, Aly, Tex1

131 It associates with the TREX mRNA export complex subunit Uap56 and harbours a Uap56 b

132 and MOS11 we detected interactions with the mRNA export complex TREX-2 and multiple spliceosomal com

133 bunit of the TRanscription-EXport-2 (TREX-2) mRNA export complex, promotes selective nuclear export o

134 result in efficient packaging into the TREX mRNA export complex, thereby supplanting the splicing re

135 , SAGA (Spt-Ada-Gcn5-Acetyltransferase), and mRNA export complex, TREX-2 (Transcription-export 2), an

136 factor that binds both SAGA and the THO/TREX mRNA export complex.

137 codes a subunit of the highly conserved TREX mRNA-export complex, cause syndromic intellectual disabi

138 A polyadenylation signal, TREX mRNA export components, and the mRNA export receptor TAP

139 ZC3H3 by small interfering RNA results in an mRNA export defect in human cells as well.

140 ertheless, in tex1 mos11 double-mutants, the mRNA export defect was clearly enhanced relative to mos1

141 sed mRNA accumulation was observed, while no mRNA export defect was detected with tex1 cells.

142 se-causing Matrin 3 mutations led to nuclear mRNA export defects of both global mRNA and more specifi

143 ic96 binding sites in vivo yields growth and mRNA export defects, revealing their critical role in pr

144 ctive versions of Yra1 engendered growth and mRNA export defects.

145 1, mutant NS1 polypeptides unable to promote mRNA export did neither.

146 e is implicated in crucial processes such as mRNA export, DNA editing, and phosphorus storage in plan

147 facilitate the coupling of transcription and mRNA export during gene expression.

148 te a pathway for the selective regulation of mRNA export during stress via retrotransposon activation

149 as a nucleotide-dependent switch to control mRNA export efficiency and release the mRNP from the NPC

150 resent many roles in cells, participating in mRNA export, embryonic development, and apoptosis.

151 These results suggest that HSP mRNA export escapes stress inhibition via HSF1-mediated

152 mRNA export factor 1 (Rae1) and nucleoporin 98 (Nup98) a

153 its 45% sequence similarity to human nuclear mRNA export factor 5.

154 ranslated region of RAD51 transcripts by the mRNA export factor ALY requires IPMK.

155 processes by reporting a novel role for the mRNA export factor Ddx19/Dbp5 in nuclear import of MKL1,

156 4 complex assembly positions the cytoplasmic mRNA export factor docking sites and messenger ribonucle

157 y with other TREX complex components and the mRNA export factor Mex67.

158 gion (Sac3 approximately 1-100), which binds mRNA export factor Mex67:Mtr2; the M-region, in which Th

159 efective in the THO component TEX1 or in the mRNA export factor MOS11 (orthologue of human CIP29) are

160 In human cells, the mRNA export factor NXF1 resides in the nucleoplasm and a

161 antly reduced following the silencing of the mRNA export factor Rae1, indicating that Rae1 is necessa

162 r Aly in mammals, to nuclear pore-associated mRNA export factor Rae1p.

163 local homology to FG nucleoporins, the yeast mRNA export factor Sac3p, and the mammalian MCM3 acetylt

164 DEAD-box protein Rat8p/Dbp5p is an essential mRNA export factor that functions at the nuclear pore co

165 SDE5, encodes a putative mRNA export factor that is indispensable for transgene s

166 Gle1 is an essential, conserved mRNA export factor whose export function is dependent on

167 We investigated recruitment of the yeast mRNA export factor Yra1 to the transcription elongation

168 nteracts genetically and physically with the mRNA export factor Yra1.

169 ve defined a pathway by which Yra1p, a yeast mRNA export factor, controls its own expression.

170 otein, myosin-like protein 1 (Mlp1), and the mRNA export factor, Gfd1.

171 has sequence features shared by TAP, a human mRNA export factor, we propose that its role could be in

172 nucleus and cytoplasm in its role as a viral mRNA export factor.

173 s a posttranscriptional regulator of a major mRNA export factor.

174 translation initiation factor eIF3g and the mRNA-export factor DBP5.

175 n addition to the RNA helicase UAP56 and the mRNA export factors ALY2-4 and MOS11 we detected interac

176 is mediated by interactions between soluble mRNA export factors and distinct binding sites on the NP

177 First, we show that mRNA export factors are highly enriched at the NPCs asso

178 Although essential mRNA export factors are known, the precise mechanism for

179 y which the MAP kinase Slt2 and Mlp1 control mRNA export factors during heat shock stress.

180 e cytoplasmic side of the NPC, the conserved mRNA export factors Gle1 and inositol hexakisphosphate (

181 e nuclear envelope as well as the binding to mRNA export factors NXF1 and Aly/REF.

182 , an effect augmented by the presence of the mRNA export factors TAP, p15, or Rae1.

183 Rae1) and Nup98 are evolutionarily conserved mRNA export factors that are targeted by the vesicular s

184 UAP56, ALY/REF, and NXF1 are mRNA export factors that sequentially bind at the 5' end

185 ncluding UL69's ability to interact with the mRNA export factors UAP56 and URH49 to facilitate the sh

186 binding factors, 3' end processing factors, mRNA export factors, hnRNPs and other RNA binding protei

187 onservation analysis of yeast and Drosophila mRNA export factors, we expose the evolutionary divergen

188 ly(A)-binding protein, Pab1p, and additional mRNA export factors.

189 eins (hnRNPs), which are thought to serve as mRNA export factors.

190 98, a nucleoporin that is a docking site for mRNA export factors.

191 Essential messenger RNA (mRNA) export factors execute critical steps to mediate d

192 results revealed not only a critical role of mRNA-export factors in transcriptional anti-silencing bu

193 (VSV-mp53) or enable [VSV-M(mut)-mp53] host mRNA export following infection of susceptible cells.

194 t block influenza A virus neuraminidase (NA) mRNA export from the nucleus and inhibit cytoplasmic NA

195 mRNA export from the nucleus depends on the ATPase activ

196 rs required for polyadenylated [poly-(A(+))] mRNA export from the nucleus in Drosophila cells.

197 mRNA export from the nucleus is an essential step in the

198 mRNA export from the nucleus requires the RNA helicase U

199 the nuclear pore complex required for mature mRNA export from the nucleus to the cytoplasm, which mak

200 ly of the ribonucleoprotein complex prior to mRNA export from the nucleus.

201 ere, we show that UAP56 is required for bulk mRNA export from the nurse cell nuclei that supply most

202 Messenger RNA (mRNA) export from the nucleus is essential for eukaryoti

203 esults identify a mechanistic step in Gle1's mRNA export function at nuclear pore complexes and direc

204 cytoplasm, and significantly compromised its mRNA export function.

205 gnaling mediates both cell proliferation and mRNA export functions of Aly.

206 ally interacts with alleles of two essential mRNA export genes, MEX67 and YRA1.

207 While mRNA export has been studied in yeast, the complexity of

208 on structure of the cytoplasmic nuclear pore-mRNA export holo-complex, challenging our textbook depic

209 response element (RRE) responsible for viral mRNA export, how it recruits multiple HIV Rev proteins t

210 svirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selective manner to control

211 We show that HDM2 mRNA export in breast cancer cells is promoted by overex

212 8, has recently been proposed to function in mRNA export in conjunction with the export protein, Tap/

213 It mediates mRNA export in interphase, and has roles in kinetochore

214 We conclude that splicing promotes mRNA export in mammalian cells and that the functional c

215 amined the relationship between splicing and mRNA export in mammalian cells by using FISH, in combina

216 ese et al. identify an alternate pathway for mRNA export in muscle cells where ribonucleoprotein comp

217 ear pore-associated steps of sumoylation and mRNA export in plants and that defects in these processe

218 to verify if these factors were involved in mRNA export in T. gondii.

219 sional, coarse-grained, agent-based model of mRNA export in the nanosecond regime to gain insight int

220 as we find evidence supporting Ran-dependent mRNA export in trypanosomes, similar to protein transpor

221 ctural elements are important for growth and mRNA export in vivo.

222 of Dbp5 at the NPC by Gle1 is essential for mRNA export in vivo; however, the mechanistic role of Db

223 data provide in vivo evidence for a model of mRNA export in which Nab2 is important for targeting mRN

224 r RNA binding are dominant-negative (DN) for mRNA export in yeast and human cells.

225 demonstrate that Mdm30p selectively controls mRNA export independently of mitochondrial fusion, revea

226 ligase, these viral proteins stimulate viral mRNA export, inhibit cellular mRNA export, promote viral

227 Messenger RNA (mRNA) export involves the unidirectional passage of ribo

228 the functional coupling between splicing and mRNA export is a conserved and general feature of gene e

229 rbance of the canonical molecular pathway of mRNA export is compatible with life but results in alter

230 mRNA export is highly conserved and ubiquitous.

231 Nuclear mRNA export is highly regulated to ensure accurate cellu

232 Our data support a model in which altered mRNA export is important for the manifestation of hos1 c

233 or investigating the means by which Dbp5 and mRNA export is modulated by regulatory factors.

234 However, such an impaired mRNA export is not dependent on mitochondrial fusion, as

235 On running the model, we observed that mRNA export is sensitive to the number and distribution

236 The TREX complex, which functions in mRNA export, is recruited to mRNA during splicing.

237 e been best characterized for their roles in mRNA export, leaving their potential roles in splicing l

238 n at the posttranscriptional level including mRNA export/localization, stability, and translation.

239 NP as an integral component of the mammalian mRNA export machinery and suggest a model whereby GANP f

240 ription Export) complex, other components of mRNA export machinery are not well conserved in divergen

241 rising in light of the observations that the mRNA export machinery colocalizes with splicing factors

242 d E1B-AP5, which are key constituents of the mRNA export machinery that interact with both mRNAs and

243 uclear pore complexes when components of the mRNA export machinery were mutated.

244 -2 as an integral component of the mammalian mRNA export machinery where it links transcription and n

245 AR-E, associates with components of the TREX mRNA export machinery, the Prp19 complex and U2AF2.

246 RNA by sequence-dependent recruitment of the mRNA export machinery.

247 The first is in the nucleus for mRNA export of most transcripts from the nucleus.

248 the yeast Gle1 involved in the same poly(A) mRNA export pathway as Nup159, also result in seed abort

249 ngs implicate IPMK in a transcript-selective mRNA export pathway controlled by phosphoinositide turno

250 WNK1 (with no lysine [K] 1) in the mammalian mRNA export pathway even though it was previously establ

251 UAP56, and provides insight into a divergent mRNA export pathway in apicomplexans.

252 the Rev ARM and the successive Rev-dependent mRNA export pathway.

253 th TAP/NXF, providing a link to the cellular mRNA export pathway.

254 y binds to the mRNP at several stages of the mRNA export pathway.

255 nhibition of MNK1 suppresses endogenous HDM2 mRNA export pathways.

256 se the evolutionary divergence of eukaryotic mRNA export pathways.

257 tion factor 4E (eIF4E) promotes translation, mRNA export, proliferation, and oncogenic transformation

258 timulate viral mRNA export, inhibit cellular mRNA export, promote viral gene expression, and direct t

259 In Saccharomyces cerevisiae, the mRNA export protein Yra1 (ALY/RNA export factor in metaz

260 the RNA pol II degradation factor Def1, the mRNA export protein Yra1 and the HECT E3 ligase Tom1.

261 we identified Yra1, a transcription-coupled mRNA export protein, as a Dia2 interaction partner.

262 LLY RESPONSIVE GENES4 [LOS4]) that regulates mRNA export, RCF1 does not play a role in mRNA export.

263 Under normal conditions, we find that the mRNA export receptor Mex67 and Nab2 directly interact.

264 The conserved mRNA export receptor NXF1 (Mex67 in yeast) assembles wit

265 Luzp4 binds the principal mRNA export receptor Nxf1, enhances its RNA binding acti

266 hibition of the synthesis or activity of the mRNA export receptor Nxf1, which was observed to colocal

267 signal, TREX mRNA export components, and the mRNA export receptor TAP are required for accumulation o

268 viral mRNA export by accessing the cellular mRNA export receptor TAP/NXF, which guides mRNA through

269 ICP27 interacts with the mRNA export receptor TAP/NXF1 and binds RNA through an R

270 with TAP (Tip-associated protein; the major mRNA export receptor), and is a dynamic nuclear-cytoplas

271 Nxf1 is an mRNA export receptor, which binds processed mRNA and tra

272 f Aly results in cell growth suppression and mRNA export reduction.

273 lly paralleling the increasing complexity in mRNA export regulation and the evolution of new nuclear

274 n which SG function requires hGle1A, whereas mRNA export requires hGle1B.

275 al network of factors involved in Drosophila mRNA export, reveal specificity in the export requiremen

276 p5 molecules, the RNA helicase essential for mRNA export, revealed that Dbp5 most often approached th

277 onucleoprotein, Nab2, which is essential for mRNA export, specifically recognizes poly(A) RNA and bin

278 ologically relevant parameter regimes, a pre-mRNA export step can decrease steady-state variability a

279 n gene expression, whether splicing enhances mRNA export still remains controversial.

280 its Mediator-interacting surface to regulate mRNA export suggesting a mechanism for coupling transcri

281 pore inner basket filaments, are involved in mRNA export, telomere organization, spindle pole assembl

282 bp5 ATPase activity is required for cellular mRNA export that is not met by the unstimulated enzyme,

283 plicing and polyadenylation to NXF1-mediated mRNA export, thereby controlling the cytoplasmic abundan

284 ndicate that THO regulates pluripotency gene mRNA export to control ESC self-renewal and differentiat

285 ultimately shifts NMD that takes place after mRNA export to the cytoplasm to NMD that occurs before m

286 This in turn facilitates mRNA export to the cytoplasm.

287 tein complex that is necessary for efficient mRNA export to the cytoplasm.

288 om the chromatin template and messenger RNA (mRNA) export to the cytoplasm.

289 Thus, Ddx19 participates in mRNA export, translation and nuclear import of a key tra

290 s gene expression at multiple steps: nuclear mRNA export, translation initiation, and translation ter

291 A comparison of messenger RNA (mRNA) export versus protein import reveals unique subset

292 rast, EIAV Gag polyproteins synthesized from mRNA exported via either Rev-dependent or PRE-dependent

293 A interference, the efficiency of viral late mRNA export was reduced to a corresponding degree.

294 Given the importance of Nab2 and Mlp1 to mRNA export, we have examined the Nab2/Mlp1 interaction

295 ed biophysical and biochemical parameters of mRNA export, we implemented a three-dimensional, coarse-

296 In the context of mRNA export, we propose that a given mRNA segment, after

297 4-7] in higher eukaryotes efficiently blocks mRNA export, whereas knockdown of REF only causes a mode

298 ic analysis to identify orthologs related to mRNA export, which show a remarkable low level of conser

299 teractions in yeast causes severe defects in mRNA export, while the severing of a single interaction

300 GANP depletion inhibits mRNA export, with retention of mRNPs and NXF1 in punctat