ライフサイエンスコーパス: mRNA stability

1 tability, but instead to a decrease in Cxcl1 mRNA stability.

2 FR2 stimulates Il2 promoter activity and Il2 mRNA stability.

3 y on those targets regulated at the level of mRNA stability.

4 v-FLIP mRNA, at least in part by increasing mRNA stability.

5 y is one feature that contributes greatly to mRNA stability.

6 ough combined increases in transcription and mRNA stability.

7 codon such that their inclusion can decrease mRNA stability.

8 otein previously implicated in regulation of mRNA stability.

9 slational efficiency and, surprisingly, also mRNA stability.

10 anner, and the Alu-derived 3' UTRs can alter mRNA stability.

11 ost-transcriptional mechanisms, particularly mRNA stability.

12 in the 3'-untranslated region to reduce ALK2 mRNA stability.

13 ctures at 3' ends are a major determinant of mRNA stability.

14 , including transcription, RNA splicing, and mRNA stability.

15 g with target mRNAs, altering translation or mRNA stability.

16 cytoplasmic mRNA 3' polyA tails to regulate mRNA stability.

17 on studies, some mutations abrogated TBC1D24 mRNA stability.

18 suppressor of cytokine signaling-1 (SOCS-1) mRNA stability.

19 matopoiesis, and show that it regulates REST mRNA stability.

20 p53 protein, can regulate p21 expression via mRNA stability.

21 xidase 2 (Nox2) resulting from enhanced Nox2 mRNA stability.

22 egulate both CDKN2A-p16INK transcription and mRNA stability.

23 ed MEF2C translation without affecting Mef2c mRNA stability.

24 within MIC-1 3'-UTR and then enhances MIC-1 mRNA stability.

25 promoted by the p97-UBXD8 complex to control mRNA stability.

26 ne (rny) led to a 2-fold increase in overall mRNA stability.

27 iption whereas HuR induction increased MAT2B mRNA stability.

28 e shown to affect not only splicing but also mRNA stability.

29 t transcript is a determinant of cytoplasmic mRNA stability.

30 U2AF65 binds to such a site and controls the mRNA stability.

31 rted a novel regulation of MDM2 by RNPC1 via mRNA stability.

32 on by increasing IL-8 gene transcription and mRNA stability.

33 it surprisingly had little effects on their mRNA stability.

34 ulating pre-mRNA splicing, deadenylation and mRNA stability.

35 tional level rather than an increased IL-1Ra mRNA stability.

36 erefore reduced feedback from IL-10 on cox-2 mRNA stability.

37 and U2AF35 complexes supported their role in mRNA stability.

38 trol every step of RNA metabolism, including mRNA stability.

39 ovel regulation of MDM2 by the RBP RNPC1 via mRNA stability.

40 ich MIC-1 can be regulated through RNPC1 via mRNA stability.

41 gh its posttranscriptional regulation of TNF mRNA stability.

42 anscriptionally regulates HuR expression via mRNA stability.

43 ing possible roles in both transcription and mRNA stability.

44 uggesting that Dcp2 normally modulates IRF-7 mRNA stability.

45 ng the expression of cytokines by modulating mRNA stability.

46 urred concomitantly with an increase in speB mRNA stability.

47 n implicated as a determinant of beta-globin mRNA stability.

48 ect RNA incorporation and an attenuated RRM2 mRNA stability.

49 were mediated by enhanced transcription and mRNA stability.

50 activation without affecting IL-6 storage or mRNA stability.

51 itranscriptomic modification that determines mRNA stability.

52 RNA polymerase II activity, and cytoplasmic mRNA stability.

53 RNA targets to affect protein translation or mRNA stability.

54 important in the control of translation and mRNA stability.

55 polyadenylation, translation initiation, and mRNA stability.

56 lated region is a key determinant of histone mRNA stability.

57 jor role of miRNAs is in reduction of target mRNA stability.

58 Nanopatterned surfaces did not alter IL-6 mRNA stability.

59 nically, the same mutation seems to increase mRNA stability.

60 HuR couples pre-mRNA processing with mature mRNA stability.

61 t roles for Secisbp2 in UGA-redefinition and mRNA stability.

62 n exerting counterregulatory effects on ASBT mRNA stability.

63 he Per2 mRNA rhythm and tonically increasing mRNA stability.

64 the UBE2C promoter, and attenuation of UBE2C mRNA stability.

65 s that slower decoding is coupled to reduced mRNA stability.

66 es of nucleolin and AUF1 in regulating bcl-2 mRNA stability.

67 protein HuR may play a critical role in VEGF mRNA stability.

68 nscript in vitro and in vivo to regulate p21 mRNA stability.

69 f its RNA polymerases constant and increases mRNA stability.

70 tion-related diseases that involve increased mRNA stability.

71 tudied NOX4-mediated regulation of CCR2/CCL2 mRNA stability.

72 using significant dysregulation of host cell mRNA stability.

73 d the essentiality of a conserved 16-mer for mRNA stability.

74 ed the in vivo effect of sequence signals on mRNA stability.

75 by suppressing mRNA translation and reducing mRNA stability.

76 wly synthesized transcripts without inducing mRNA stability.

77 elongation rates are a major determinant of mRNA stability.

78 RNA/pre-mRNA changes suggestive of increased mRNA stability.

79 sting that amino acid composition influences mRNA stability.

80 with no effect on its promoter activity and mRNA stability.

81 g the unfolded-protein response or affecting mRNA stability.

82 UTR harboring miRNA binding sites regulating mRNA stability.

83 interacts with and is regulated by PCBP4 via mRNA stability.

84 P domain is required for FASTKD3 function in mRNA stability.

85 related to an increase in TF messenger RNA (mRNA) stability.

86 trolled in part by changes in messenger RNA (mRNA) stability.

87 H(2)O(2) increased IL-6 mRNA stability 0.145 (0.095-0.27) to 0.345 (0.2-0.48) (n

88 d and plays an essential role in controlling mRNA stability, a key step in the regulation of gene exp

89 rk reveals the promoter-dependent control of mRNA stability, a regulatory mechanism that could be emp

90 esult of increased transcription and greater mRNA stability after LPS treatment.

91 ere that several factors affected glycolytic mRNA stability, among which were glucose sensing, protei

92 enough attention is given to the question of mRNA stabilities and reliabilities of transcriptional da

93 d by several different measures of gH and gL mRNA stability and accumulation with or without ORF57 co

94 lity in the brain, suggesting a link between mRNA stability and Alzheimer's disease."

95 tion N(6)-methyladenosine (m(6)A) influences mRNA stability and cell-type-specific developmental prog

96 ependent effects at the level of both target mRNA stability and chromatin structure.

97 ortance of the nature of the 5' terminus for mRNA stability and depicts a pathway of mRNA degradation

98 We demonstrate that E2F1 mRNA stability and E2F1 protein levels are reduced in ce

99 mRNA cap methylation is essential for mRNA stability and efficient translation.

100 tions in transcriptional activity, splicing, mRNA stability and epigenetic modifications.

101 on-coding regulatory RNAs (sRNAs) that alter mRNA stability and expression by pairing with target mRN

102 receptor NLRP3 or caspase-1, controlled the mRNA stability and expression of Dock2, a guanine nucleo

103 ioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.

104 rotein human antigen R (HuR), regulated XIAP mRNA stability and expression.

105 soforms had slightly but significantly lower mRNA stability and greater translational efficiency than

106 Hence, mTORC1 activity regulation of mRNA stability and high affinity HuD-target mRNA degrada

107 anism by which HuR is regulated by RNPC1 via mRNA stability and HuR is a mediator of RNPC1-induced gr

108 s the first demonstration that HuR-dependent mRNA stability and HuR-independent mRNA translation play

109 signaling in primary human T cells decreased mRNA stability and inhibited secretion of IL-2, IL-4, an

110 have identified factors that regulate Gap-43 mRNA stability and localization, but it remains unclear

111 mRNA stability and luciferase assays demonstrated APA-de

112 ndrion-targeted PPR78 protein in nad5 mature mRNA stability and maize (Zea mays) seed development.

113 global effects, such as translation rate on mRNA stability and mRNA secondary structure on translati

114 gest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in

115 mRNA stability and polysome studies suggest IGF2BP1 medi

116 s interaction, HuR selectively increased CRP mRNA stability and promoted CRP translation.

117 We further document substantial effects on mRNA stability and protein expression using reporter sys

118 cultures and model organisms, this decreases mRNA stability and protein expression.

119 ects on mRNA that were coupled to effects on mRNA stability and protein production.

120 human genes on steady-state mRNA abundance, mRNA stability and protein production.

121 is important for transcription termination, mRNA stability and regulation of gene expression.

122 Furthermore, we found differential Shank3 mRNA stability and SHANK1/2 upregulation in these two li

123 show that local translation is regulated by mRNA stability and that NMD acts locally to influence ax

124 precursor is essential for the regulation of mRNA stability and the initiation of translation.

125 rate that miR-187 directly targets TNF-alpha mRNA stability and translation and indirectly decreases

126 oRNAs (miRNAs) exert regulatory control over mRNA stability and translation and may contribute to loc

127 miR-375 overexpression lowered both HuD mRNA stability and translation and recapitulated the eff

128 accurate stop-start transcription as well as mRNA stability and translation and, therefore, for virus

129 t modulate global and/or transcript-specific mRNA stability and translation contribute to the rapid a

130 onserved "codon optimality code" that shapes mRNA stability and translation efficiency across vertebr

131 These 5'-UTR sequences confer distinct mRNA stability and translation efficiency to the Prrxl1

132 rily conserved regulatory RNAs that modulate mRNA stability and translation in a wide range of cell t

133 ates alternative splicing in the nucleus and mRNA stability and translation in the cytoplasm.

134 Analysis of manXYZ mRNA stability and translation in the presence and absen

135 a pro-inflammatory and cancer marker, whose mRNA stability and translation is regulated by the CUG-b

136 hat undefined trans-acting factors governing mRNA stability and translation may also contribute to xC

137 MicroRNAs (miRNAs) regulate mRNA stability and translation through the action of the

138 on levels of multiple proteins by decreasing mRNA stability and translation, and could therefore be k

139 mRNA poly(A) tails are important for mRNA stability and translation, and enzymes that regulat

140 Cytoplasmic Rbfox1 binding increased target mRNA stability and translation, and Rbfox1 and miRNA bin

141 , little is known about the regulation of AR mRNA stability and translation, two central processes th

142 sRNAs) and the RNA chaperone Hfq to regulate mRNA stability and translation.

143 l target to regulate inflammatory cytokines' mRNA stability and translation.

144 the 3'UTR and increased MYCN 3'UTR-mediated mRNA stability and translation.

145 mRNAs and RNA-binding proteins that regulate mRNA stability and translation.

146 many post-transcriptional levels, including mRNA stability and translation.

147 MicroRNAs are well known regulators of mRNA stability and translation.

148 asis and responses through the regulation of mRNA stability and translation.

149 TRs) regulate gene expression by controlling mRNA stability and translation.

150 Although it was once thought that mRNA stability and translational efficiency were directl

151 dent mechanisms determine GRN expression via mRNA stability and translational efficiency.

152 ns (UTRs) are regulatory signals determining mRNA stability and translational efficiency.

153 A:mRNA base-pairing often results in altered mRNA stability and/or altered translation initiation.

154 ted an important role for the enhancement of mRNA stability and/or the translation of mRNA for these

155 roRNAs influence gene expression by altering mRNA stability and/or translation and have been implicat

156 ammation are those responsible for modifying mRNA stability and/or translation.

157 with their mRNA targets to elicit changes in mRNA stability and/or translation.

158 ), a factor involved in splicing regulation, mRNA stability, and mRNA transport.

159 d negative (pilus operon mRNA) regulation of mRNA stability, and negative regulation of mRNA translat

160 NLHL2 by creating mouse mimics and examining mRNA stability, and protein function in mouse hypothalam

161 cluding epigenetic control of transcription, mRNA stability, and protein localization.

162 ated in processes such as vesicle formation, mRNA stability, and protein ubiquitination and trafficki

163 gulatory RNAs may positively regulate target mRNA stability, and to how CRISPR RNAs are processed fro

164 the relative contribution of transcription, mRNA stability, and translation efficiency on cytokine p

165 e expression through modulation of splicing, mRNA stability, and translation.

166 Pre-mRNA splicing and mRNA stability are fundamentally altered under some stre

167 se connections between protein synthesis and mRNA stability are widespread or whether other modes of

168 ty that YlbF, YmcA and YaaT broadly regulate mRNA stability as part of an RNase Y-containing, multi-s

169 that targeting these three 3'-UTRs increased mRNA stability, as predicted by the reporter assay, whil

170 e effects of drugs on protein expression and mRNA stability, as well as minimizing costs and the requ

171 enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an

172 n 3'UTR luciferase reporter, immunoblot, and mRNA stability assays, each miRNA directly attenuates Ru

173 al (nuclear run-on) and posttranscriptional (mRNA stability) assays confirmed that transcriptional re

174 mRNA in the nucleus, 2) directly regulating mRNA stability at late times of activation, and 3) formi

175 We found that miR-155 affected TNFalpha mRNA stability because miR-155 inhibition decreased wher

176 stimulates NRT1.1 transcription and probably mRNA stability both in primary root tissues and in LRPs,

177 ce silencing nucleolin did not change target mRNA stability, but decreased the size of polysomes form

178 y is a conserved mechanism to shape maternal mRNA stability by affecting deadenylation rate in a tran

179 Our results suggest that Snf1 may influence mRNA stability by altering the recruitment activity of t

180 ggest that Zfand5 can enhance ARE-containing mRNA stability by competing with tristetraprolin for mRN

181 terial RNAs (sRNAs) regulate translation and mRNA stability by pairing with target mRNAs, dependent u

182 We conclude that tight control of IL23 mRNA stability by TTP is critical to avoid severe inflam

183 SBT expression is controlled at the level of mRNA stability by way of its 3'UTR, but also identify Hu

184 to play a critical role in the regulation of mRNA stability, cellular localization and translation ef

185 We conclude that the increased speB mRNA stability contributes to the rapid accumulation of

186 with DGCR8/Drosha and DGCR8/Drosha-regulated mRNA stability control, suggesting unique RNA regulation

187 demonstrate that the temporal regulation of mRNA stability coordinates vital cellular pathways and i

188 Following LPS stimulation, this increased mRNA stability correlated to an elevated induction of bo

189 ssion can be achieved through the control of mRNA stability, cytoplasmic compartmentalization, 3' UTR

190 applying this framework to genome-wide human mRNA stability data, we reveal eight highly significant

191 egulate AU-rich elements containing cytokine mRNA stability/degradation and translation.

192 ed how codon identity and translation affect mRNA stability during development and homeostasis.

193 ESA to identify sequence elements modulating mRNA stability during zebrafish embryogenesis.

194 hylated cap structure, which is required for mRNA stability, efficient translation, and evasion of an

195 ic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer grow

196 on mediate a regulatory interaction with the mRNA stability factor HuR (Hu antigen R) in the context

197 line was used to isolate mutants of the petA mRNA stability factor MCA1 and the translation factor TC

198 NA levels alter, suggesting Puf3p determines mRNA stability for only a limited subset of its target m

199 duction was characterized by remarkably high mRNA stability for this cytokine.

200 lated their mRNA concentration by uncoupling mRNA stability from the transcription rate.

201 While mRNA stability has been demonstrated to control rates of

202 anisms involved in epigenetic regulation and mRNA stability have emerged as important processes for r

203 gnaling modulates translation efficiency and mRNA stability in a transcript-specific manner.

204 earch for post-transcriptional modulators of mRNA stability in breast cancer by conducting whole-geno

205 -27b caused reciprocal alterations in CX3CL1 mRNA stability in liver epithelial cells.

206 view is an update to our 2001 Gene review on mRNA stability in mammalian cells, and we survey the eno

207 se with deadenylation activity that controls mRNA stability in part and therefore regulates expressio

208 ation, which is critical for maintaining TNF mRNA stability in part by contributing microRNAs (miRNAs

209 his is the first demonstration of a role for mRNA stability in regulating the key C. albicans virulen

210 and Hog1 controlling ribosome biogenesis via mRNA stability in response to glucose availability in th

211 We evaluated the prevalence of changes in mRNA stability in response to sodium arsenite in human f

212 r RNAs can be used as a surrogate marker for mRNA stability in the absence of transcription.

213 ntial mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between m

214 for nonsense-mediated decay (NMD) regulating mRNA stability in the cytoplasm.

215 We show that mRNA stability, in addition to transcription, is key in

216 m(6)A predominantly and directly reduces mRNA stability, including that of key naive pluripotency

217 Our work suggests that sinR mRNA stability is an additional posttranscriptional cont

218 Control over mRNA stability is an essential part of gene regulation t

219 Our data indicate that E47 and AID mRNA stability is lower in stimulated B cells from elder

220 scription is unaffected in sld mice, whereas mRNA stability is markedly decreased.

221 Decreased mRNA stability is not due to a defect in 3'-end processi

222 Instead, IL-4 mRNA stability is reduced in IRE1alpha KO T cells.

223 Here, we found that p73 mRNA stability is regulated by RNPC1, an RNA binding pro

224 We conclude that arsenite modification of mRNA stability is relatively uncommon, but in some insta

225 ether other modes of regulation dominate the mRNA stability landscape in higher organisms.

226 roteins and four microRNAs that modulate the mRNA stability landscape of the brain, which suggests a

227 ession in part by specifically enhancing its mRNA stability, leading to cell proliferation and tumori

228 s system, many pathways are regulated at the mRNA stability level.

229 on is extensively regulated at the levels of mRNA stability, localization and translation.

230 Mechanistically, results obtained using mRNA stability measurements as well as intronic RNA expr

231 effect on protein expression independent of mRNA stability mechanisms.

232 se Y is a pleiotropic regulator required for mRNA stability, mRNA processing, and removal of read-thr

233 To examine the role of splicing factors in mRNA stability, mutations were introduced into the polyp

234 ere no differences in nucleosome remodeling, mRNA stability, NF-kappaB activation, or MAPK signaling

235 small interfering RNA (siRNA) increases the mRNA stability of all five core histone mRNAs and the st

236 This effect is due to decreased mRNA stability of both targets.

237 m involving polyamine influx which modulates mRNA stability of heat-inducible genes under heat stress

238 ibited the AIM2 inflammasome by reducing the mRNA stability of IFN regulatory factor 7, which regulat

239 protein tristetraprolin (TTP) in influencing mRNA stability of IL12p35, IL12/23p40, and IL23p19 subun

240 i-inflammatory genes, and through increasing mRNA stability of inflammatory genes.

241 nhibited the Lcn2 promoter by regulating the mRNA stability of Nfkbiz, encoding the IkappaBzeta trans

242 They control the mRNA stability of several inflammatory cytokines, includ

243 R they would be able to selectively regulate mRNA stability of specific genes such as c-Myc.

244 that regulates translation initiation and/or mRNA stability of target transcripts.

245 in that regulates translation initiation and mRNA stability of target transcripts.

246 on induced TTP, a physiological regulator of mRNA stability of the transcription factor E47, which is

247 inding sites supporting a regulatory role in mRNA stability of these transcripts.

248 R inhibitor rapamycin (RAPA) could alter the mRNA stability of VEGF in 786-0 and Caki-1 renal cancer

249 Cytokine treatment increased mRNA stability only for CCL2 and CCL8, and transient sil

250 entifying cis-acting sequences that serve as mRNA stability or instability elements, the proteins tha

251 arrangements had no apparent effects on flgM mRNA stability or predicted mRNA secondary structures.

252 nct proteins or contribute to variability of mRNA stability or protein translation efficiency.

253 paB and IFN regulatory factors, nor for Ccl5 mRNA stability or splicing.

254 nduced genes lowered mRNA levels by reducing mRNA stability or the transcription rate, respectively.

255 mRNA stability or translatability can be regulated by th

256 tion of all small RNAs (sRNAs) that regulate mRNA stability or translation by limited base pairing in

257 eliminated changes in globin messenger RNA (mRNA) stability or cellular location and reduction of ad

258 t effects on transcription, mRNA processing, mRNA stability, or protein stability.

259 e quite diverse and include DNA replication, mRNA stability, protein synthesis, cell-wall biosynthesi

260 ditional functions of capping are to promote mRNA stability, protein translation, and concealment fro

261 globin coding mRNA construct for analysis of mRNA stability (rASBT3-betaglobin).

262 declined at the mRNA level via a decrease in mRNA stability rather than by the caspase-mediated degra

263 is maintained by a feed-forward loop between mRNA stability regulated by PABPN1 and protein turnover

264 usion model with a source simulated to model mRNA stability regulation, our results establish that th

265 properties and identify TGF-beta as a novel mRNA stability regulator in intestinal epithelium throug

266 The RBP LARP1 is an mRNA stability regulator, and elevated expression of the

267 ough these interactions, AUF1 lowered DICER1 mRNA stability, since silencing AUF1 lengthened DICER1 m

268 e describe an increase in TNF-alpha message, mRNA stability, soluble protein release, and membrane ex

269 ted strongly with total mRNA expression, not mRNA stability, suggesting transcriptional rather than p

270 he long RPB2 mRNA is not caused by increased mRNA stability, supporting the preferential usage of the

271 , SWI5 and CLB2, exhibit a mitosis-dependent mRNA stability switch.

272 ockdown resulted in a marked decrease in the mRNA stability that resulted in lowered CD40L surface ex

273 two factors competing for influence on stim1 mRNA stability: the mRNA-stabilizing protein HuR and the

274 coholic liver injury and regulates CCR2/CCL2 mRNA stability thereby promoting recruitment of inflamma

275 L-23 expression by selectively targeting p19 mRNA stability through its 3'-untranslated region (3'UTR

276 x maintains the balance between splicing and mRNA stability through methylation of ZNF326.

277 PARN regulates TP53 mRNA stability through not only an ARE but also an adjac

278 impact of TTP on IL23 production and IL23p19 mRNA stability through several AREs in the 3' untranslat

279 PUF proteins regulate translation and mRNA stability throughout eukaryotes.

280 on, whereas Bank1(-/-) had no effect on IL-6 mRNA stability, thus suggesting that BANK1 has no effect

281 In parallel the 5' UTR also affects mRNA stability; thus two independent mechanisms determin

282 ghlighting the importance of regulating Ifng mRNA stability to maintain CD8(+) T cell homeostasis and

283 ndamental aspects of mRNA metabolism, mainly mRNA stability, to determine stem cell fates.

284 protein content, whereas FUS does not affect mRNA stability/translation of its targets.

285 regulator of myogenesis, while leaving MYOD mRNA stability unaffected.

286 ion site, and defined the role the 3'-UTR in mRNA stability using a luciferase reporter assay.

287 ugh a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-bin

288 also showed that PCBP2 is necessary for p73 mRNA stability via the CU-rich elements in p73 3'-UTR.

289 Moreover, we show that pseudogenes regulate mRNA stability via the piRNA pathway.

290 observation revealed that the increased speB mRNA stability was mainly due to progressive acidificati

291 s and nuclear processing of the mRNA, though mRNA stability was not affected.

292 olved in translational control as well as in mRNA stability, we compared the expression of GRN in cel

293 However, TTP's effects on AU-rich mRNA stability were negligible and limited by constituti

294 itogen-activated protein kinases (MAPKs) and mRNA stability, whereas the Act1-TRAF6-transcription fac

295 P1, mediates the autogenous control of 5'TOP mRNA stability, whose disruption is implicated in the pa

296 induced Bcl-2 expression by increasing Bcl-2 mRNA stability with no discernible changes in promoter a

297 y can be estimated alongside individual gene mRNA stability with the help of a Bayesian reversible ju

298 the RNA-binding protein HuR, which increases mRNA stability, with malignant transformation.

299 sion of iNOS, IL-8 and TNF-alpha by reducing mRNA stability without inhibition of the promoter activi

300 ed two proteins involved in regulating MCP-1 mRNA stability: Y-box binding protein 1 (YB-1), a multif