ライフサイエンスコーパス: mRNA translation

1 ress responses and an important regulator of mRNA translation.

2 rough the modulation of apolipoproteinB/Apob mRNA translation.

3 found that RNA hydroxymethylation can favor mRNA translation.

4 ancreatic cancer proliferation by regulating mRNA translation.

5 ntial for maturation of functional tRNAs and mRNA translation.

6 cellular processes, including cap-dependent mRNA translation.

7 s and relieves its inhibitory activity on RP mRNA translation.

8 all, noncoding RNA that negatively regulates mRNA translation.

9 s with hnRNP-Q1 as a means to inhibit Gap-43 mRNA translation.

10 tely elevating Ccnd1 transcription and Ccnd1 mRNA translation.

11 n, Torin1, and amino acid deprivation on TOP mRNA translation.

12 messenger RNA (mRNA) degradation and repress mRNA translation.

13 ental role in terminal oligopyrimidine (TOP) mRNA translation.

14 Puf3p has widespread, but modest, impact on mRNA translation.

15 ontrol synaptic physiology via activation of mRNA translation.

16 HX33 more preferentially promoted structured mRNA translation.

17 late 5'-terminal oligopyrimidine tract (TOP) mRNA translation.

18 c target of rapamycin complex 1 activity and mRNA translation.

19 , whereas knockdown of RBM38 inhibits, PPM1D mRNA translation.

20 zymatic activator DHS, which in turn impacts mRNA translation.

21 programmed changes in gene transcription and mRNA translation.

22 bition of sulphate transport cause errors in mRNA translation.

23 limiting host defenses and stimulating virus mRNA translation.

24 ng tumor progression due to stress-resistant mRNA translation.

25 e and helicase involved in the initiation of mRNA translation.

26 led changes in poly(A) tail length influence mRNA translation.

27 ucture with important roles in regulation of mRNA translation.

28 gulates glycaemia, lipogenesis and increases mRNA translation.

29 about whether m(6)A modification influences mRNA translation.

30 n system to directly monitor the velocity of mRNA translation.

31 d effect and show that FQ inhibit HIF-1alpha mRNA translation.

32 ing RNAs that target mRNA leading to reduced mRNA translation.

33 recedented opportunities for the analysis of mRNA translation.

34 p53 family and modulates p53 expression via mRNA translation.

35 factor (eIF2alpha), and derepressing GM-CSF mRNA translation.

36 y stage, ranging from chromatin packaging to mRNA translation.

37 of total RNA, consistent with an increase in mRNA translation.

38 s is a conserved mechanism to promote target mRNA translation.

39 asing 4E-BP1 binding to eIF4E and inhibiting mRNA translation.

40 ally involved in ribosomal RNA synthesis and mRNA translation.

41 ategy to treat cancers driven by deregulated mRNA translation.

42 in cancer cell proliferation by controlling mRNA translation.

43 conversely, HuD overexpression enhanced ATG5 mRNA translation.

44 hence resulting in increased eiF4E-dependent mRNA translation.

45 for RNA-binding proteins, which can control mRNA translation.

46 inding that RNA hydroxymethylation can favor mRNA translation.

47 ignal suppresses miR-148a to derepress DNMT1 mRNA translation.

48 through reprogramming gene transcription and mRNA translation.

49 IT complex binding, and driving robust VEGFA mRNA translation.

50 expression potentially through enhanced p53 mRNA translation.

51 p53 activation and a resultant inhibition of mRNA translation.

52 2 from a repressor to an activator of target mRNA translation.

53 HFV nucleocapsid protein (CCHFV-NP) augments mRNA translation.

54 hosphorylation of eIF2alpha, an inhibitor of mRNA translation.

55 vation of ERK and mTOR signaling upstream of mRNA translation.

56 a transient adaptive reprogramming of global mRNA translation.

57 P2), rendering it unable to repress ferritin mRNA translation.

58 ss116 with Pet309 but also do not allow COX1 mRNA translation.

59 nts (ribosome profiling) maps and quantifies mRNA translation.

60 rated by alternative splicing promote axonal mRNA translation.

61 nuanced ligand response observed during bulk mRNA translation.

62 erved and related to enhanced messenger RNA (mRNA) translation.

63 feron (IFN) induction and ISG messenger RNA (mRNA) translation.

64 the retina was dependent on the repressor of mRNA translation 4E-BP1.

65 tions of tRNA fragments in the regulation of mRNA translation, a critical component of cellular stres

66 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer developm

67 rting the role of ABCF1 in m(6)A-facilitated mRNA translation, ABCF1-sensitive transcripts largely ov

68 ly, two functional start codons initiate fis mRNA translation and both are repressed by RgsA.

69 of p21 in Ola1(-/-) MEFs is due to enhanced mRNA translation and can be prevented by either reconsti

70 ntified CK1epsilon as a pivotal regulator of mRNA translation and cell proliferation that acts by inh

71 for 4E-BP1 inactivation along with increased mRNA translation and cell proliferation.

72 strategy used by viruses to repress cellular mRNA translation and concomitantly allow the efficient t

73 characterized by persistently elevated uORF mRNA translation and concurrent gene expression reprogra

74 demonstrated that hnRNP-Q1 represses Gap-43 mRNA translation and consequently GAP-43 function.

75 he mRNA 5'-cap are useful tools for studying mRNA translation and degradation, with emerging potentia

76 , enter the cytoplasm, and function there in mRNA translation and degradation.

77 ic WNT3 further regulates the specificity of mRNA translation and development of neurons and oligoden

78 ase activity links development with maternal mRNA translation and ensures irreversibility of the oocy

79 g protein 1 (JAKMIP1) in regulating neuronal mRNA translation and establish JAKMIP1 knockout mice as

80 lation of HIF-2alpha through eIF4E-dependent mRNA translation and examined the effects of p22(phox)-b

81 NA repair, apoptosis, metabolism, autophagy, mRNA translation and feedback mechanisms.

82 tivated protein kinase (AMPK) that regulated mRNA translation and glutamine-dependent mitochondrial m

83 des an important resource for studying local mRNA translation and has the potential to reveal both co

84 which cells sense and restore dysfunctional mRNA translation and how this is linked to cell prolifer

85 lates both cap-dependent and cap-independent mRNA translation and induces a bulk increase in protein

86 late host gene expression by inhibiting host mRNA translation and inducing the degradation of host mR

87 Neurons lacking FMRP show aberrant mRNA translation and intracellular signalling.

88 of PPR proteins and the mechanisms governing mRNA translation and intron splicing in plant mitochondr

89 nding eIF4F complex that regulates selective mRNA translation and is synchronized by a specific eIF3

90 Restoration of mRNA translation and modulation of SG dynamics may be an

91 thermore, we showed that PPM1D modulates p53 mRNA translation and p53-dependent growth suppression th

92 G4DNA in the cytoplasm are known to modulate mRNA translation and participate in stress granule forma

93 (mTORC1) has an essential role in dendritic mRNA translation and participates in mechanisms underlyi

94 activity of CPEB3 on the GluR2 3'UTR at both mRNA translation and polyadenylation levels.

95 cially proteins involved in DNA replication, mRNA translation and proteasome function.

96 he p53 transcriptional network to regulating mRNA translation and protein stability.

97 vated IRP1 RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation.

98 , which invert the programmed local speed of mRNA translation and provide direct evidence for the cen

99 They regulate gene expression by suppressing mRNA translation and reducing mRNA stability.

100 these uS12 variants impaired the accuracy of mRNA translation and rendered cells highly sensitive to

101 However, as infection progresses, viral mRNA translation and replication becomes increasingly re

102 Neurons exploit local mRNA translation and retrograde transport of transcripti

103 t leaders (TLs) can have profound effects on mRNA translation and stability.

104 ation is a conserved mechanism that controls mRNA translation and stability.

105 ve molecular switch for turning off or on RP mRNA translation and subsequent ribosome biogenesis.

106 eillance mechanism that monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature

107 lts suggest that palmitate acutely activates mRNA translation and that this increase in protein load

108 essed both the acute effects of palmitate on mRNA translation and the chronic effects on the UPR.

109 an equol-mediated increase in IRES-dependent mRNA translation and the expression of specific oncogeni

110 We show that the IFNL3 3' UTR represses mRNA translation and the rs4803217 allele modulates the

111 ote carcinogenesis by effects on both global mRNA translation and upregulated expression of specific

112 oding RNAs of approximately 24 nt that block mRNA translation and/or negatively regulate its stabilit

113 nger RNAs (mRNAs), leading to alterations of mRNA translation and/or stability.

114 nd suggests a physiological role for nuclear mRNA translation, and also helps explain how the immune

115 d by the balance between gene transcription, mRNA translation, and protein degradation, among other f

116 atypical brain amino acid profile, abnormal mRNA translation, and severe neurological abnormalities.

117 NP L, synergizes with miR-297, reduces VEGFA mRNA translation, and triggers apoptosis, thereby suppre

118 RNA levels, but HuD silencing decreased ATG5 mRNA translation, and, conversely, HuD overexpression en

119 ) LARP1 binds the 5'TOP motif to repress TOP mRNA translation; and (iv) LARP1 competes with the eukar

120 ere, we report that markers of initiation of mRNA translation are activated during training for conte

121 T The elongation and/or termination steps of mRNA translation are emerging as important control point

122 global protein synthesis and increased uORF mRNA translation are followed by normalization of protei

123 n transcriptional factors, genes involved in mRNA translation are highly represented in our interacto

124 ion, but the mechanisms that regulate axonal mRNA translation are not well understood.

125 xes and the timed specificity of neocortical mRNA translation are poorly understood.

126 These findings highlight gamma-globin mRNA translation as a novel mechanism for regulating HbF

127 omains of DNA-based life, where they mediate mRNA translation as part of polyribosomes in animals.

128 itant with up-regulated cap-independent VEGF mRNA translation, as assessed by a bicistronic luciferas

129 FMRP regulates mRNA translation at dendritic spines where synapses are

130 l cues by regulating ribosome biogenesis and mRNA translation at multiple levels to sustain prolifera

131 in 2 (CYFIP2) has been suggested to regulate mRNA translation at synapses and this may include local

132 actions have been recognized as important in mRNA translation, barley yellow dwarf virus employs a no

133 striking upregulation of pathways linked to mRNA translation both in CLL cells derived from lymph no

134 Evidence also exists for clock control of mRNA translation, but the extent and mechanisms for this

135 (N) with this conserved sequence facilitates mRNA translation by a unique N-mediated translation stra

136 MicroRNAs repress mRNA translation by guiding Argonaute proteins to partia

137 tion of the protein, but rather to decreased mRNA translation by nonsense-mediated decay regulation o

138 s and islets with palmitate and then studied mRNA translation by polyribosomal profiling and analyzed

139 Post-transcriptional regulation of COX-2 mRNAs translation by SGs indicates a role in IL-1beta-me

140 n-independent and that mechanisms regulating mRNA translation, cell cycle progression, and gene expre

141 h control vital cellular functions including mRNA translation, cell proliferation, cell growth, diffe

142 We show that active mRNA translation complexes (polysomes) contain ribosomal

143 ediating mGluR-LTD through the regulation of mRNA translation complexes stalled at the level of elong

144 rates of protein synthesis and cap-dependent mRNA translation concomitant with up-regulated cap-indep

145 Such specific bidirectional control of mRNA translation could be particularly useful in the fie

146 Mechanistically, mGluR activation induced mRNA translation-dependent increase of Cyfip2 in wild-ty

147 shift from cap-dependent to cap-independent mRNA translation did not occur in cells lacking 4E-BP1.

148 Inhibition of axonal beta-actin mRNA translation disrupts arbor dynamics primarily by re

149 Excessive mRNA translation downstream of group I metabotropic glut

150 at LARP1 functions as a key repressor of TOP mRNA translation downstream of mTORC1.

151 1 functions as an important repressor of TOP mRNA translation downstream of mTORC1.

152 sphorylation site, are unable to repress p53 mRNA translation due to loss of interaction with eukaryo

153 Exacerbated mRNA translation during brain development has been linke

154 Exacerbated mRNA translation during brain development is associated

155 s a three-element RNA switch, enabling VEGFA mRNA translation during combined hypoxia and inflammatio

156 the sea urchin is essential for: (1) general mRNA translation during embryogenesis, (2) developmental

157 de microarray approach to measure changes in mRNA translation during ER stress.

158 tress granule formation is known to regulate mRNA translation during oxidative stress.

159 nt and further highlight pathways regulating mRNA translation during synaptogenesis in the genesis of

160 Here, we profiled global mRNA translation dynamics in the mouse primary macrophag

161 uding positional thermodynamic stability and mRNA translation efficiency.

162 n Ser51 to regulate global and gene-specific mRNA translation, eIF2alpha is dephosphorylated by the b

163 n system to directly compare the velocity of mRNA translation elongation.

164 for gp60 synthesis, but also during regular mRNA translation for reading frame selection during init

165 nscription factors, regulators of chromatin, mRNA translation, GTPases, vesicle trafficking, and the

166 convallatoxin as a novel antiviral, limiting mRNA translation has a dramatic impact on CMV infection

167 The finding that Rbfox proteins regulate mRNA translation has implications for Rbfox-related dise

168 for eIF4F components in HCMV replication and mRNA translation has not been directly tested.

169 e-wide studies of circadian transcription or mRNA translation have been hindered by the presence of h

170 ses; however, the dynamics of messenger RNA (mRNA) translation have yet to be addressed.

171 As that promote mRNA degradation and inhibit mRNA translation, have been shown to be important in car

172 nitiation, cell growth and induction of GCN4 mRNA translation in a manner suggesting incomplete assem

173 thways that regulate protein homeostasis and mRNA translation in a manner that was both rapamycin-sen

174 cell type (neutrophils) directly regulating mRNA translation in another (macrophages).

175 oping brain and further confirms the role of mRNA translation in autism pathogenesis.

176 We describe a simple strategy to control mRNA translation in both prokaryotic and eukaryotic cell

177 ontrol of ribosome composition and selective mRNA translation in complex developing systems like the

178 s a small non-coding RNA that regulates ompA mRNA translation in Escherichia coli.

179 Local mRNA translation in growing axons allows for rapid and p

180 gnaling and the spatiotemporal regulation of mRNA translation in highly complex developing systems.

181 intricate regulation of compartment-specific mRNA translation in mammalian CNS axons supports the for

182 Here we demonstrate that the timing of Ccnb1 mRNA translation in mouse oocytes is dependent on the pr

183 iRNAs) are important regulators of localized mRNA translation in neuronal dendrites.

184 ngaging the signaling pathways that regulate mRNA translation in neurons.

185 Anti-IgM also increased mRNA translation in normal blood B cells, but without cl

186 n impaired cap-dependent and cap-independent mRNA translation in pancreatic cancer cells.

187 Anti-IgM significantly increased mRNA translation in primary CLL cells, measured using bu

188 lpha) controls transcriptome-wide changes in mRNA translation in stressed cells.

189 its secretion is dependent on activation of mRNA translation in synchrony with the cell cycle and th

190 ur findings demonstrate an important role of mRNA translation in the cell-autonomous Stat1 functions,

191 own as a mechanism for controlling mammalian mRNA translation in the cytoplasm, but what would be the

192 on activated mTORC1 and downstream events in mRNA translation in the kidney cortex.

193 ow that GADD34 drives substantial changes in mRNA translation in unstressed cells, particularly targe

194 Overexpression of W73V suppressed reporter mRNA translation in vitro and in vivo and reduced the le

195 IRP1 is the principal regulator of HIF2alpha mRNA translation in vivo and provide evidence that trans

196 on is functionally coupled to messenger RNA (mRNA) translation in bacteria, but how this is achieved

197 tether function assays, 4E-T represses bound mRNA translation, in a manner independent of these local

198 ), ribonucleoprotein complexes that regulate mRNA translation, in the delayed translation of COX-2 mR

199 t a stress granule response, heighten GM-CSF mRNA translation, increase inflammatory cell recruitment

200 droxyphenylglycine, the rate of Venus-PSD-95 mRNA translation increased rapidly in dendrites of WT hi

201 gene (Eif4ebp2), encoding the suppressor of mRNA translation initiation 4E-BP2, leads to an imbalanc

202 Dynamic regulation of mRNA translation initiation and elongation is essential

203 nally, Mss116 is required for efficient COX1 mRNA translation initiation and elongation.

204 plex 1 (mTORC1) that represses cap-dependent mRNA translation initiation by sequestering the translat

205 educed activity of mTORC1 and its downstream mRNA translation initiation factors eIF4B and 4EBP1, as

206 nternal ribosome entry site (IRES)-dependent mRNA translation initiation pathway results in continued

207 veal a newly recognized function of DHX33 in mRNA translation initiation, further solidifying its cen

208 that the deletion of a negative regulator of mRNA translation initiation, the eukaryotic initiation f

209 behavioral alterations caused by exacerbated mRNA translation initiation.

210 tends to autism models involving exacerbated mRNA translation initiation.

211 DEAD/DEAH box RNA helicase, DHX33, promotes mRNA translation initiation.

212 t 80S ribosome assembly at the late stage of mRNA translation initiation.

213 Among the three phases of mRNA translation-initiation, elongation, and termination

214 mRNA translation is a key step of gene expression, but t

215 Regulation of mRNA translation is a major control point for gene expre

216 ation, but it remains unclear whether Gap-43 mRNA translation is also regulated.

217 Our data suggest that efficient mRNA translation is determined by a triplet-of-triplet g

218 Taken together, dysregulation of mRNA translation is emerging as a unifying mechanism und

219 out neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive produ

220 onto COX1 mRNA can occur, activation of COX1 mRNA translation is impaired.

221 t the mechanism by which mTORC1 controls TOP mRNA translation is incompletely understood.

222 mRNA translation is likely to be an important mediator o

223 ck entrainment is controlled at the level of mRNA translation is not well understood.

224 The regulation of mRNA translation is of fundamental importance in biologi

225 During neuronal development, local mRNA translation is required for axon guidance and synap

226 Although messenger RNA (mRNA) translation is a fundamental biological process, i

227 make it a powerful new tool for quantifying mRNA translation kinetics.

228 Despite the importance of dendritic mRNA translation, little is known about which mRNAs can

229 possesses RNA topoisomerase activity, binds mRNA translation machinery and interacts with an RNA-bin

230 Precise spatiotemporal control of mRNA translation machinery is essential to the developme

231 Local mRNA translation mediates the adaptive responses of axon

232 These data show that CPEB control of TAK1 mRNA translation mediates the inflammatory immune respon

233 Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer

234 Local mRNA translation occurs in growing axons enabling precis

235 ssential roles for SKAR in the regulation of mRNA translation of IFN-sensitive genes and induction of

236 1 (PTBP1), involved in the stabilization and mRNA translation of insulin, was identified as the most

237 Herein, we show that Aven stimulates the mRNA translation of the mixed lineage leukemia (MLL) pro

238 factor 4F complex (eIF4F) and initiation of mRNA translation of type II interferon-stimulated genes.

239 ort for morpholino reagents, used to inhibit mRNA translation or splicing and binding to regulatory m

240 on cause of DBA, can lead to decreased GATA1 mRNA translation, possibly resulting from a higher thres

241 Accordingly, PARP12 was found to block mRNA translation, possibly upon association to the trans

242 in numerous RNA metabolic processes, such as mRNA translation, pre-mRNA splicing, ribosome biogenesis

243 tion was primarily due to reduced proinsulin mRNA translation primarily because of defective glucose-

244 reporter assay, we investigated how rates of mRNA translation, protein synthesis and degradation cont

245 efore hnRNP-Q1-mediated repression of Gap-43 mRNA translation provides an additional mechanism for re

246 well-documented attenuation of cap-dependent mRNA translation, rapamycin can augment NMD of certain t

247 Here we measured the host mRNA translation rate during a vaccinia virus-induced ho

248 In-silico mRNA translation rates were compared for each mRNA in bo

249 We found that the mRNAs' translation rates were repressed, by up to 530-fo

250 ta and inhibiting Akt, mTORC1, and events in mRNA translation regulated by mTORC1 and ERK.

251 ryo transition involves extensive changes in mRNA translation, regulated in Drosophila by the PNG kin

252 Emerging evidence demonstrates that mRNA translation regulation pathways are key factors in

253 ished roles as an inhibitor of cap-dependent mRNA translation, relatively little is known about its e

254 The diversity of MTOR-regulated mRNA translation remains unresolved.

255 tivator of TGF-beta, eIF4E confers selective mRNA translation, reprogramming nonmalignant cells to an

256 binding to the CARE and stimulation of VEGFA mRNA translation, simultaneously permitting miR-297-medi

257 We here show that mRNA translation stress in cis triggered by the gly-ala

258 These data illustrate an mRNA translation stress-response pathway for E2F1 activa

259 or micro RNAs (miRNAs) repressing "resident" mRNA translation suggests that they can influence the ph

260 eps regulating spatiotemporal specificity of mRNA translation that govern neocortical development.

261 mor suppressor and an important modulator of mRNA translation that is regulated by a number of mechan

262 hat N(6)-methyladenosine (m(6)A) facilitates mRNA translation that is resistant to eIF4F inactivation

263 ormation and caused the global inhibition of mRNA translation that was rescued with wild-type DHX33 b

264 Regulation of mRNA translation, the process by which ribosomes decode

265 the scope and mechanism of eIF4F-independent mRNA translation, these findings reshape our current per

266 Besides enforcing viral mRNA translation, these processes profoundly impact host

267 te no evidence of a reduction in the rate of mRNA translation, these uS12 variants impaired the accur

268 Mechanistically, METTL3 enhances mRNA translation through an interaction with the transla

269 These results suggest that repression of bim mRNA translation through binding to the 3'UTR constitute

270 processes is the repression of initiation of mRNA translation through GCN2 phosphorylation of eIF2alp

271 Inhibiting activity-dependent mRNA translation through mechanistic target of rapamycin

272 (phox)-based Nox oxidases in eIF4E-dependent mRNA translation through mTORC2.

273 Thus, we propose that ARF regulates Drosha mRNA translation to prevent aberrant cell proliferation

274 tiation, providing a mechanism for selective mRNA translation under heat shock stress.

275 ntify trans-acting factors that control VEGF mRNA translation under hypoxic conditions we established

276 sms of beta-cell dysfunction at the level of mRNA translation under such conditions.

277 glutamine rapidly and strongly induced IGF2 mRNA translation using reporter constructs transduced in

278 Models of mRNA translation usually presume that transcripts are li

279 ate that Rictor is regulated at the level of mRNA translation via heat-shock transcription factor 1 (

280 We demonstrate that GLD-1 represses ced-3 mRNA translation via two binding sites in its 3' untrans

281 Anti-IgM-induced mRNA translation was associated with increased expressio

282 The circadian oscillation in markers of mRNA translation was lost in memory-deficient transgenic

283 tection of MTOR-dependent changes in non-TOP mRNA translation was obscured by low sensitivity and met

284 Surprisingly, we found that p53 mRNA translation was suppressed by FDXR deficiency via I

285 s the effects of phosphorylated eIF2alpha on mRNA translation, was sufficient to reverse the social d

286 During cell culture, changes in recombinant mRNA translation were consistent with changes in transcr

287 ed a microRNA, miR-129, that repressed Kv1.1 mRNA translation when mTORC1 was active.

288 Inhibition of SGs clearance blocked COX-2 mRNA translation whereas blocking the assembly of SGs by

289 erent mTOR-dependent pathways to control TOP mRNA translation, whereas larger reductions in amino aci

290 ciate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli

291 ocesses in cells, is the elongation phase of mRNA translation, which is controlled by the Ca(2+)/CaM-

292 egulate both mTOR activity and cap-dependent mRNA translation, which overrides their inhibition by hy

293 a target of p53, inhibits p53 messenger RNA (mRNA) translation, which can be reversed by GSK3 protein

294 f BCR stimulation to increase messenger RNA (mRNA) translation, which can promote carcinogenesis by e

295 HAdVs) shut down host cellular cap-dependent mRNA translation while initiating the translation of vir

296 bited both cap-dependent and cap-independent mRNA translation while maintaining mRNA polysomal associ

297 led clear trends toward global reductions in mRNA translation with a significant reduction in the pol

298 lts in PI3Kdelta-dependent induction of E2F1 mRNA translation with the consequent activation of c-Myc

299 d rates of cell population growth and global mRNA translation, with peak rates occurring at normal ph

300 that FASTKD3 is required for efficient COX1 mRNA translation without altering mRNA levels, which res