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1 mRNA accumulation in stress granules correlates with lon
2 mRNA and miRNA expression profile frequently performed t
3 mRNA profiling by microarray analysis revealed that the
7 risk cytogenetics (p = 0.002), higher IDO-1 mRNA (p = 0.005), higher composite IDO-1 score (p < 0.00
8 guidance protein, either by targeting slit-1 mRNA or, potentially, by modulating the canonical Notch
9 itro studies confirmed an increase in IL-17C mRNA and protein levels in cells infected with cagA-posi
10 osting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of
12 reased collagen deposition, collagen 1 and 3 mRNA expression, TGF-beta production, and activation of
13 necrosis factor receptor-associated factor 6 mRNAs, whereas concentrations of the T-cell co-activator
14 was a late marker of cell-cycle entry; Ki-67 mRNA oscillated with highest levels in G2 while protein
17 nto the N-terminal coding region and, when a mRNA structure overlaps or partially overlaps with the r
19 ibe for the first time the presence of ACSL6 mRNA in human skeletal muscle and the role that ACSL6 pl
22 components functionally interact, affecting mRNA export and splicing as well as plant development.
25 A accelerated the rate of recruitment of all mRNAs tested, regardless of their degree of structural c
28 e intriguing notion that transcription of an mRNA, despite carrying a canonical coding sequence, can
29 erformed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA copy number, and DNA meth
30 pendent reporter gene (SRE-LUC) activity and mRNA expression of pro-proliferative and pro-migratory M
31 ires identifying the protein composition and mRNA cargos of the ribonucleoprotein particles (RNPs) th
33 red from plasma, and both DNA genotyping and mRNA expression levels in peripheral blood mononuclear c
34 ing cytoplasmic transit, nuclear import, and mRNA synthesis.IMPORTANCE The fates of HIV-1 reverse tra
36 served that SIRT1 repressed LEF1 protein and mRNA expression, ultimately reducing LEF1 transcriptiona
37 tions of these enhanced sgRNAs (e-sgRNA) and mRNA encoding Cas9, we show that a single intravenous in
43 includes a shift from a protein-coding ASCC3 mRNA to a shorter ALE isoform of which the RNA, rather t
44 that Ire1-mediated cleavage of ER-associated mRNAs results in ribosome stalling and mRNA degradation.
45 in GC cells significantly decreased ATP6V1A mRNA and protein expression, while YY1 overexpression in
49 gether, we demonstrate that apolipoprotein B mRNA-editing catalytic polypeptide 3 expression and edit
50 study, we demonstrated that apolipoprotein B mRNA-editing catalytic polypeptide 3A (A3A) and A3G expr
55 tion factors, and overexpression of IFN-beta mRNA and protein were similar in MSK1/2 and DUSP1 knocko
57 possesses RNA topoisomerase activity, binds mRNA translation machinery and interacts with an RNA-bin
58 ped and validated a multivariate whole-blood mRNA-based predictor of melatonin phase which requires f
63 pig embryos via zygotic co-delivery of Cas9 mRNA and dual sgRNAs targeting the PDX1 gene, which when
64 F-alpha, IFN-gamma, IL-1beta, IL-6, and CCL2 mRNAs), and attenuated the wasting syndrome and severity
65 allele (AA) showed significantly lower CD28 mRNA expression ex-vivo than either GG or AG (p < 0.001)
66 this splicing factor alters splicing of cell mRNAs involved in the maturation of many other cell mRNA
68 eals that under favourable growth conditions mRNAs coding for proteins involved in the translation ma
69 ntry channel of the 40S subunit and contacts mRNA via conserved residues whose functional importance
86 ion, with Star-PAP impacting lowly expressed mRNAs and long-noncoding RNAs to the greatest extent.
90 ast growth factor 21 (FGF21), elevated Fgf21 mRNA and protein solely in the heart, and upregulation o
92 driver of clinical symptoms, placental Flt1 mRNA levels strongly correlate with maternal blood press
93 al electrical resistance, paracellular flux, mRNA expression, Western blotting, and immunofluorescenc
95 that Top3beta is the major topoisomerase for mRNAs, and requires both RNA binding and catalytic activ
96 against estimating protein fold-changes from mRNA fold-changes between different cell-types, and high
97 a T7 phage display cDNA library derived from mRNA isolated from bronchoalveolar lavage (BAL) cells an
98 ontrol the supply of full-length, functional mRNAs coding for a variety of proteins essential to cell
99 ed whether kidney tissue expression of GDF15 mRNA correlates with circulating levels of GDF-15 and wh
100 cleavage and polyadenylation (APA) generates mRNA isoforms with different 3' untranslated regions (3'
103 models is that faster translation of a given mRNA is unlikely to generate more of the encoded protein
104 d rates of cell population growth and global mRNA translation, with peak rates occurring at normal ph
106 at IL-34-Mphis possess significantly greater mRNA levels of select restriction factor genes than CSF-
110 the 3'-end processing of thousands of human mRNAs by juxtaposing poly(A) signals (PASs) and cleavage
112 t mice, as marked by decreased Arg1 and Il10 mRNA expression and decreased interleukin (IL)-4, IL10 a
115 fferentiation without concomitant changes in mRNA levels, suggesting that BET proteins are regulated
116 ring macrophages, manifested by elevation in mRNA expression of Tnfalpha and Il1beta, increased intra
117 n transcriptional factors, genes involved in mRNA translation are highly represented in our interacto
120 methyladenosine (m(6)A) RNA modifications in mRNA requires an understanding of when and where in the
121 best characterized for its essential role in mRNA nuclear export, cofunctions with Los1 in tRNA nucle
123 onths of age revealed a dramatic increase in mRNAs encoding various chemokines, cytokines, growth fac
125 bited slower mRNA decay and showed increased mRNAs and levels of protein expression in Mettl3-deficie
128 and consequently reduced translation of Irs1 mRNA, the effects of a post-weaning obesogenic diet on I
130 t diet-induced obese (DIO) rats, the apoA-IV mRNA level is significantly reduced and that the estroge
131 mors than in non-TNBC tumors, and high c-Jun mRNA level was associated with shorter disease-free surv
135 ist L165041 in mice increased hepatic LPCAT3 mRNA abundance and LPCAT enzymatic activity, which is as
136 r how the intron-containing but unspliced M1 mRNA bypasses the normal quality-control checkpoints.
138 430 is crucial for the clearance of maternal mRNA during maternal zygotic transition in embryonic dev
142 result in failure to properly distribute mbp mRNA in oligodendrocytes, indicating a paradoxical role
147 rved a significant correlation between MMP13 mRNA levels and RUNX2 gene expression in human OA chondr
148 t the increased ribosome loading of modified mRNAs renders them more permissive for initiation by fav
153 Instead, p62 delayed the degradation of MYC mRNA by repressing the expression of let-7a and let-7b,
154 ion of let-7a and let-7b, thus promoting MYC mRNA stabilization at the post-transcriptional level.
155 are: (i) sRNAs can potentially bind nascent mRNAs in the nucleoid, and (ii) localization patterns an
157 mporal gene expression changes in a neuronal mRNA pool during an olfactory long-term associative memo
162 oach can facilitate near-infrared imaging of mRNA localization in vivo and in ex-vivo tissue sections
164 ds significant insight into our knowledge of mRNA-specific translational activation and the function
167 dominantly in the 3' untranslated regions of mRNA, and destabilizes target mRNAs through direct recru
169 ctors act primarily to effect the release of mRNA and tRNA from the ribosome, with the splitting of t
170 NA biochemistry, we identified a core set of mRNA m(6) A writer proteins in Arabidopsis thaliana.
176 on the extensive changes in distribution of mRNAs in the cell body and axon compartments of peripher
178 tant miRNAs that regulated a large number of mRNAs in the control group but not in the exposed groups
179 ceptor stimulation influenced recruitment of mRNAs to heavy polysomes and translation of subsets of g
180 ortex of mice, where we identify a subset of mRNAs that are translated in dendrites by neuronal ribos
182 binding effects of the RNA helicase MOV10 on mRNA degradation, the potentially different ADAR1 bindin
184 cinoma (PC), via either somatic mutations or mRNA downregulation, suggesting an important tumour supp
185 but not female, deletion animals overexpress mRNA for dopamine receptor 2 and adenosine receptor 2a i
192 0.045) were also observed between placental mRNA abundance of vitamin D metabolic components and cir
193 Our data suggest that the decay of platelet mRNAs is slowed by the natural loss of the mRNA surveill
194 tified individual and shared defects in PLP1 mRNA expression and splicing, oligodendrocyte progenitor
195 full-length viral RNAs or surrogate gag-pol mRNAs competent for Gag synthesis to non-PM membranes or
196 ardless of diet, decreased fetal liver Pparg mRNA expression and increased placental androgen recepto
201 that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state output of
202 ate that H2A.Z is required for efficient pre-mRNA splicing and indicate a role for H2A.Z in coordinat
204 S proteins via its role in governing MVC pre-mRNA splicing.IMPORTANCE The Parvovirinae are small none
207 y bind to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet unidentified ribonucleop
208 f the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyaden
211 RNA biogenesis components regulate precursor mRNA splicing of P-transposable element transcripts in v
213 Expression of multiple late viral protein mRNAs was lost in the presence of either drug, consisten
215 ryotic cells; their cargo includes proteins, mRNA and microRNA (miR) that can be transferred to recip
216 otes the translation of c-MYC, BCL2 and PTEN mRNAs in the human acute myeloid leukemia MOLM-13 cell l
220 f the CCR4-Not deadenylase complex, restored mRNA levels for a class of downregulated, H3K36me3-rich
223 biofilms, which have potentially higher rRNA:mRNA ratios and higher rRNA carryover during RNA-seq ana
228 We have found that the expression of SGLT2 mRNA and protein is increased in renal biopsies from hum
229 FXS disease model, we found FMRP binds shrub mRNA (human Chmp4) to repress Shrub expression, causing
231 CISH were marked by m(6)A, exhibited slower mRNA decay and showed increased mRNAs and levels of prot
232 and controls showed no differences in SMCHD1 mRNA or protein abundance but revealed regulatory change
233 oli (APC) regulates the localization of some mRNAs at cellular protrusions but the underlying mechani
235 ogression through the regulation of specific mRNA targets, thus strengthening the possibility of a di
236 , some of which are potential stage-specific mRNA interactors that likely reflect the dynamics of RNA
237 ogram involves enhanced decoding of specific mRNAs that are depleted in terminally differentiating/en
238 Homodirectional changes in steady-state mRNA abundance and translation were observed for all but
240 time PCR measurements of SK channel subunits mRNA in supraoptic nucleus punches revealed a diminished
241 ctivation to asparaginase, yet surprisingly, mRNA levels of key ISR gene targets such as Atf5 and Tri
244 ted regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadeny
246 uency of cleavage sequences, putative target mRNAs for these VapCs were identified; these were closel
247 he translation and stability of their target mRNAs, and play key roles in development, homeostasis an
248 ished DGCR8 as a direct interactor of Tcf7l1 mRNA, a core component of the pluripotency network.
249 sed in gonadotrope-precursor cells, but Tet1 mRNA levels decrease markedly with completion of cell di
251 ntegrative omics analyses, and discover that mRNA levels of DTL, DCAF4, 12 and 13 are consistently el
253 Here, we investigate the possibility that mRNA structures facilitate the 3'-end processing of thou
256 red with that of the wild type, however, the mRNA levels of the wild-type and mutant cells were compa
257 st ribosomal protein Rps3/uS3 resides in the mRNA entry channel of the 40S subunit and contacts mRNA
258 osis and necroinflammation and increased the mRNA and protein expression of cytokines and chemokines
260 dose-dependent, and durable silencing of the mRNA encoding glycolate oxidase and increased serum glyc
261 cerevisiae and S. pombe Although >80% of the mRNA genes in each species were found to display APA, S.
263 t mRNAs is slowed by the natural loss of the mRNA surveillance and ribosome rescue factor Pelota.
264 and second, p38-mediated inactivation of the mRNA-destabilizing factor tristetraprolin, which we show
266 ing complete sequence complementarity to the mRNA for the important viral gene activator ICP0, inhibi
271 connectivity of VTA dopamine neurons, their mRNA translational profile, and basic electrophysiologic
274 Top canonical pathways represented by these mRNAs include Wnt/beta-catenin, TGF-beta, and stem cell
275 determine the spatial organization of these mRNAs and proteins, which can be modulated through postt
283 mTORC1 to regulate the translation of 5'TOP mRNAs such as those encoding ribosome proteins (RP).
286 these genomes increased from <0.3% of total mRNA from the oxic zone to a max of 22% under anoxia.
288 as not elevated in serum, and FGF21 and UCP1 mRNAs were not induced in liver or brown adipose tissue
290 global protein synthesis and increased uORF mRNA translation are followed by normalization of protei
291 excessive glutamate transmission upregulated mRNA expression of Fgfrs and their ligands Fgfs Deleting
292 contrast, the translocation of longer 3' UTR mRNAs from RNPs to polysomes correlated with the product
293 ates were repressed, by up to 530-fold, when mRNA structures overlapped with the ribosome's footprint
294 ormed a subtractive screening approach where mRNA from PGE2-G response-positive and -negative cell li
295 ion of SREBP target gene expression, whereas mRNAs involved in glycolysis, gluconeogenesis, and T cel
296 induced by RBM3 and the mechanisms by which mRNAs encoding cold shock proteins escape cooling-induce
297 with downstream targets, transcriptome-wide mRNA 3' UTR interaction sites were experimentally determ
299 the amount of Top3beta that associates with mRNAs, indicating that Top3beta is specifically targeted
300 hrough interactions with target sites within mRNAs, leading to enhanced degradation of the mRNA or in
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