ライフサイエンスコーパス: macaque

1 from blood were harvested from each juvenile macaque.

2 ures with mesoscale connectomes of mouse and macaque.

3 s reference genomes of Chimpanzee and Rhesus Macaque.

4 the BNSTALG from the mouse, rat, and rhesus macaque.

5 4B neurons projecting to V2 thick stripes in macaque.

6 haracterize drusenoid lesions in aged rhesus macaques.

7 utralizing antibodies in Zika-virus-infected macaques.

8 ansmission through mucosal contact in rhesus macaques.

9 a cell frequency in vaccinated female rhesus macaques.

10 cell culture and in experimentally infected macaques.

11 s of Gag-specific immune responses in rhesus macaques.

12 ulating CD4(+) T cells in the six controller macaques.

13 y Virus (SIV)-infected and uninfected rhesus macaques.

14 /kg, oral, twice daily) and untreated rhesus macaques.

15 ully MHC-matched Mauritian-origin cynomolgus macaques.

16 e protection from a SHIV challenge in rhesus macaques.

17 KV replication to peak viral loads in rhesus macaques.

18 owth and clearance of ZIKV within individual macaques.

19 effects of lesions to homologous regions in macaques.

20 munodeficiency virus (SHIV)-SF162P3-infected macaques.

21 lined to undetectable levels in 6 controller macaques.

22 RD-Ad vectors in Syrian hamsters and rhesus macaques.

23 uated strain, protected against lethal TB in macaques.

24 , and performed a protection study in rhesus macaques.

25 d protection against ZIKV in mice and rhesus macaques.

26 th their expression patterns as described in macaques.

27 ain the unconventional responses observed in macaques.

28 enic SIV infection in a cohort of vaccinated macaques.

29 -mimetic miniprotein (gp140-M64U1) in rhesus macaques.

30 on upon repeat intrarectal challenge in male macaques.

31 ignatures of selection during replication in macaques.

32 ust and durable immune responses in mice and macaques.

33 neffective in accelerating plasma VL loss in macaques.

34 ralizing sera from immunized mice and rhesus macaques.

35 em while monitoring PIT activity in two male macaques.

36 lizing antibodies, or sera from SIV-infected macaques.

37 istance to antibodies and sera from infected macaques.

38 se progression to AIDS in SIV-infected adult macaques.

39 wn functional distinctions in M-P streams in macaque: (1) color versus luminance, (2) binocular dispa

40 asured noise correlations (rnoise) in rhesus macaque A1 during task performance.

41 LT) and synchronous (SYNC) tone sequences in macaque A1.

42 The macaque A2*05 allotype prefers the basic amino acid argi

43 Thus, the macaque A2*05 gene encodes a specialized MHC class I mol

44 collected from controls and T-cell-depleted macaques after rVSV-EBOV vaccination and EBOV challenge.

45 stock in vitro, protected 6 out of 7 rhesus macaques against infection while the antibody 3BNC117, w

46 SIV-infected non-CD8(+) lymphocyte-depleted macaques also provides a unique opportunity to investiga

47 Idiopathic chronic diarrhea (ICD) in rhesus macaques also resembles ulcerative colitis, one form of

48 rom vaccine-draining lymph nodes from rhesus macaques also showed expression of HLA-DR and were capab

49 ematopoiesis, given the similarities between macaque and human physiologies.

50 s for three species (brown kiwi, crab-eating macaque and Malayan flying lemur); eight updated genome

51 on of the Kv3.1b expression in sections from macaque and rat motor cortex, using two different antibo

52 accine-induced antibodies, from mice, rhesus macaques and human clinical trials, for their functional

53 nal fluid after intranasal administration in macaques and humans and modulates amygdala reactivity in

54 iting HBV infection in cynomolgus and rhesus macaques and in pigs.

55 -reactive V3 NAbs elicited by vaccination in macaques and natural infections in humans illustrate com

56 finding paves the way for the development of macaques and pigs as immunocompetent animal models to st

57 Here, by using two-photon imaging in awake macaques and systematically characterizing V1 neuronal r

58 vectors into the cerebellar cortex of rhesus macaques and tested vector efficacy in three ways.

59 er of days of ZIKV viremia compared to naive macaques and that the previous exposure to DENV may resu

60 Materials and Methods Gravid rhesus macaques and their offspring (n = 10) were maintained, a

61 Ethological research has recently shown that macaques and wild vervet monkeys respond strongly to par

62 and mortality affecting the supply of rhesus macaques and, potentially, their responses to experiment

63 us macaques, the heart of one treated rhesus macaque, and adjacent to a peripheral nerve of an untrea

64 ved single-cell transcriptome data of human, macaque, and mouse preimplantation embryogenesis.

65 s to the anatomical brain networks of human, macaque, and mouse, successfully predicting simulation a

66 eat lentivirus infections in humanized mice, macaques, and humans.

67 nscriptase (RT-SHIV), compared to uninfected macaques, and interestingly, there was extensive colocal

68 e isolated and identified exosomes in rhesus macaques, and investigated their effects on cell tropism

69 hepatocytes from cynomolgus macaques, rhesus macaques, and pigs became fully susceptible to HBV upon

70 Here, we describe an immunization-elicited macaque antibody (CA45) that clamps the internal fusion

71 ned a 2.24-A crystal structure of pig-tailed macaque APOBEC3H with bound RNA.

72 Rhesus macaques are used to model human immunodeficiency virus

73 this prediction by recording from neurons in macaque area MSTd that integrate visual and vestibular c

74 n from the population activity of neurons in macaque area MSTd.

75 experiments using a single female pig-tailed macaque as a model for M. genitalium infection, we cervi

76 r findings further support female pig-tailed macaques as a model of M. genitalium infection, persiste

77 lternating exotropia was induced in two male macaques at age 1 month by sectioning the tendons of the

78 r face responses are indeed generated within macaque auditory cortex, we recorded FPs and concomitant

79 xt of previously reported face-evoked FPs in macaque auditory cortex.

80 nd 10 CFU/ml F. tularensis in both human and macaque blood.

81 FU of F. tularensis was spiked into human or macaque blood.

82 Our collection procedure obtained sufficient macaque brain and optic nerve tissues to detect PrP.

83 rons within fMRI-defined face patches of the macaque brain exhibit shared categorical responses to fl

84 ges of mixing long and short pathways in the macaque brain, we used cortical cooling to silence input

85 f 16 regions of adult human, chimpanzee, and macaque brains.

86 e-specific antibody responses in rabbits and macaques, but so far failed to induce broadly neutralizi

87 ding ZEBOV-Makona pathogenesis in cynomolgus macaques by measuring changes in immune cell frequencies

88 with the restored pentameric complex, rhesus macaques can develop broadly neutralizing antibodies tar

89 Here, we show that male rhesus macaques can learn categories by a transitive inference

90 Vaccine-induced macaque CD4bs antibodies neutralize 7% of HIV-1 strains,

91 ons with diverse viruses in a captive rhesus macaque colony and identifies several viruses positively

92 ural homology were observed between selected macaque cross-reactive V3 NAbs elicited by vaccination a

93 Experiments in macaques demonstrate an extraordinarily simple transform

94 C cells recorded from male and female rhesus macaques during a complex task show a moderate level of

95 isease was observed in only half of infected macaques during late-stage infection (LSI).

96 A single immunization of rhesus macaques elicited a rapid and robust antibody response,

97 both PMd and PMv simultaneously while rhesus macaques engaged in a reach-to-grasp task.

98 ent conferred 100% survival of RAVV-infected macaques, even when treatment began just 1 day prior to

99 Here we report that uninfected infant rhesus macaques exhibited a higher physiological baseline monoc

100 We observed that uninfected infant rhesus macaques exhibited higher physiologic baseline monocyte

101 sied the frontal lobes and optic nerves of a macaque experimentally infected with variant CJD.

102 We studied cynomolgus macaques exposed to Ebola virus Makona via different rou

103 y reported that in mice, gerbils, and rhesus macaques, expression of babA is lost, either by phase va

104 nd that personally familiar faces engage the macaque face-processing network more than unfamiliar fac

105 Here, we investigate whether the macaque face-processing system, a three-level hierarchy

106 old rhesus macaques (Macaca mulatta) viewing macaque faces varying in their distance from the prototy

107 human infants and adults tested with infant macaque faces) and showed no prototype preferences, sugg

108 ces (i.e., macaque infants tested with adult macaque faces; human infants and adults tested with infa

109 All 39 macaques fed with single high doses ranging from 10(7) t

110 g serial in utero MRI measurements of rhesus macaque fetuses, from which macroscopic and cellular inf

111 s longitudinally characterized in the rhesus macaque, focusing on gestation day (G85) through G135 of

112 similar to humans, may be better suited than macaques for the identification of virulence determinant

113 V clinical isolate (HS-2015-BA-01) in rhesus macaques for up to 142 d.

114 ultiple virus and vaccine antigens in rhesus macaques for years after sustained memory B cell depleti

115 and following SIV infection protected rhesus macaques from developing AIDS and partially from vaginal

116 e to distinguish intracranially BSE-infected macaques from healthy ones, with SERPINA3 showing the mo

117 tion of 55% of pentavalent-vaccine-immunized macaques from simian-human immunodeficiency virus (SHIV)

118 threshold electrical microstimulation of the macaque frontal eye fields (FEF) modulates the pupillary

119 In macaques, granulomas had higher [(64)Cu]-LLP2A uptake th

120 Accordingly, low-viremic macaques had a higher frequency of both bone marrow IRF4

121 related with plasma viremia and unvaccinated macaques had increased plasma cells and plasmablasts com

122 Recent work in macaques has suggested the lateral orbitofrontal cortex

123 Previous investigations in macaques have shown these anatomical differences are acc

124 These in vivo macaque HBV infections are characterized by longitudinal

125 e of JEM, Wu et al. use genetic barcoding of macaque hematopoietic stem cells to demonstrate that, af

126 these results show that expressing hNTCP on macaque hepatocytes renders them susceptible to HBV infe

127 vation (peer-rearing, PR) in archived rhesus macaque hippocampal samples (male, n = 13).

128 As in macaques, human lOFC and mOFC/vmPFC are necessary for co

129 The use of stone tools by macaques in Thailand has reduced the size and population

130 nchoalveolar lavage fluid of AGMs and rhesus macaques (in which CD4 downregulation is not observed).

131 nal magnetic resonance imaging (fMRI) of the macaque indicating that space is predominantly represent

132 Very young human and macaque infants are sensitive to absolute disparity, but

133 Like human infants, macaque infants looked longer to faces closer to the ave

134 d with unfamiliar categories of faces (i.e., macaque infants tested with adult macaque faces; human i

135 logy to assess visual attention in human and macaque infants to faces naturally varying in their dist

136 of the equine IgG over 5 days to cynomolgus macaques infected 24 hours previously with a lethal dose

137 iral kinetics and immune responses in rhesus macaques infected with a clinical ZIKV Brazilian isolate

138 se, the assay was tested on blood drawn from macaques infected with F. tularensis Schu S4 at daily in

139 , was enhanced in lymph nodes from pigtailed macaques infected with simian immunodeficiency virus (SI

140 CD8(+) lymphocyte-depleted macaques infected with simian immunodeficiency virus (SI

141 fection and treatment interruption data from macaques infected with simian/human immunodeficiency vir

142 Infant humans and rhesus macaques infected with the human or simian immunodeficie

143 spects of human infections.IMPORTANCE Rhesus macaque infection with simian immunodeficiency virus (SI

144 ype SIVmac (simian immunodeficiency virus of macaques) infection of myeloid cells, even in the presen

145 ciency virus type 1 (HIV-1)-human and SIVmac-macaque infections.

146 The recent discovery of "color patches" in macaque inferotemporal (IT) cortex, the part of the brai

147 ss to faces, scrambled faces, and objects in macaque inferotemporal cortex (IT) from 1 month to 2 yea

148 ectrical microstimulation of face patches in macaque inferotemporal cortex affects perception of face

149 n the middle patch of face processing in the macaque IT cortex may be closely related to mixture of s

150 suggest that the nonpathologic infection of macaque lungs by DeltasigH was not reactivated by simian

151 mining a much simpler society in the Tibetan macaque (Macaca thibetana), which we have tracked for 30

152 ssisted foraging on shellfish by long-tailed macaques (Macaca fascicularis) in Khao Sam Roi Yot Natio

153 Consistent with MVT, rhesus macaques (Macaca mulatta) spent more time foraging for s

154 sured the looking time of 3-month-old rhesus macaques (Macaca mulatta) viewing macaque faces varying

155 scratching in a group of free-ranging rhesus macaques (Macaca mulatta).

156 s also replicated in vitro, in cocultures of macaque macrophages and CD4(+) T cells.

157 functional in both infected MA104 cells and macaque macrophages.

158 We sought to determine if the same macaques maintained high mucosal plasma cell frequencies

159 acaques (RM) and Mauritian-origin cynomolgus macaques (MCM).

160 obacterium tuberculosis Mauritian cynomolgus macaques (MCMs) are a unique group of animals that have

161 Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide bette

162 have shown remarkable efficacy in the rhesus macaque model of acquired immune deficiency syndrome, en

163 We used a rapidly progressing SIV/pigtailed macaque model of HIV to examine enteropathy and microbia

164 In a macaque model of inhalation TB, suppression of IDO activ

165 Here, we describe a macaque model of tDCS that allows us to simultaneously e

166 Using the rhesus macaque model we show that prior infection with Zika vir

167 We applied this strategy in a Cynomolgus macaque model.

168 rns of these cells in a myeloablative rhesus macaque model.

169 irus type 1 (HIV-1) in humans and SIV in the macaque model; however, few have attempted to examine th

170 ns is readily accessible in the SIV-infected macaque models of neuro-AIDS.

171 -1 and SHIV infection in humanized mouse and macaque models, respectively, including in vivo neutrali

172 irus (SHIV) infection in humanized mouse and macaque models, respectively, including in vivo neutrali

173 ing from single neurons in the cortex of the macaque monkey and using computational models from mathe

174 In the macaque monkey brain, posterior inferior temporal (PIT)

175 vity in the middle temporal (MT) area of the macaque monkey to study the neural mechanisms that under

176 onal groups in areas V1 and V2 of six female macaque monkeys (Macaca nemestrina) made amblyopic by ar

177 y applying caudate electrical stimulation in macaque monkeys (n = 3) to bias decision-making in a tas

178 f the vestibulo-spinal circuitry of behaving macaque monkeys during temporally precise activation of

179 To explore their specializations, we trained macaque monkeys on two tasks: one required updating repr

180 ion-selective neurons in V1 and V2 while two macaque monkeys performed a fine orientation discriminat

181 ity from populations of neurons in PMd/M1 as macaque monkeys performed a visually guided reaching tas

182 previous experiments on squirrel monkeys and macaque monkeys showed that social isolation [2, 3], dea

183 pulation of V1 neurons in alert and behaving macaque monkeys trained on an attention-demanding contra

184 visual categories can be ordered serially by macaque monkeys using a behavioral paradigm that provide

185 nderstand this interaction, we tested 3 male macaque monkeys using both [(11)C]DASB and [(18)F]MPPF,

186 o-photon imaging with genetic tools in awake macaque monkeys will enable fundamental advances in our

187 ordings from medial premotor cortex (MPC) in macaque monkeys, and computational modeling, to establis

188 ain functional magnetic resonance imaging in macaque monkeys, we discovered a network centered in the

189 es for long-term two-photon imaging in awake macaque monkeys.

190 the primary visual cortex of awake behaving macaque monkeys.

191 uency, contrast, and size) in V1 of two male macaque monkeys.

192 In macaque motor cortex, a large sample of pyramidal neuron

193 In this study, we used male cynomolgus macaques (n=15) living in established social groups to e

194 fection, EBOTAb was tested in the cynomolgus macaque non-human primate model of lethal EBOV infection

195 hematopoietic stem and progenitor cells in 4 macaques observed for up to 49 months posttransplantatio

196 SIGNIFICANCE STATEMENT: The macaque occipitotemporal cortex contains clusters of neu

197 a to the development of neuronal activity in macaque OFC and MFC related to rewards and the stimuli t

198 Here, we investigated how neurons in macaque OFC and MFC signaled rewards and the stimuli tha

199 vy drinking produces neuroadaptations in the macaque OFC.

200 tielectrodes across auditory cortex in three macaques (one female), and applied current source densit

201 Five rhesus macaques per group received two DNA primes at weeks 0 an

202 ions in primary auditory cortex while rhesus macaques performed a novel feature-selective attention t

203 eural activity from motor cortex while three macaques performed a novel neurofeedback task.

204 activity in PMd and PMv simultaneously while macaques performed a reach-to-grasp task.

205 of visuomotor gain in motor cortex while two macaques performed a reaching task in which the gain sca

206 Macaques performed a task that required them to evaluate

207 prefrontal cortex (dlPFC) of two male rhesus macaques performing a task that elicited key aspects of

208 ed activity for neurons in visual area V2 of macaques performing fine disparity discrimination, as ye

209 s in dorsolateral PFC (DLPFC) of male rhesus macaques performing rule-guided prosaccades and antisacc

210 hNTCP on hepatocytes in vivo renders rhesus macaques permissive to HBV infection.

211 Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P cynomolgi, can infec

212 ance, with more pronounced effects where the macaque population size is larger.

213 djacent islands inhabited by different-sized macaque populations and demonstrate potential effects on

214 IFICANCE STATEMENT This study focuses on how macaque premotor and primary motor cortices transform se

215 ous system (CNS) infiltrates in cART-treated macaques primarily comprised CD20(+) B cells and CD3(+)

216 olate cotransporting polypeptide (hNTCP), on macaque primary hepatocytes facilitates HBV infection in

217 igated Granger-causal influences among awake macaque primary visual area V1, higher visual area V4, a

218 sis of recordings from superficial layers of macaque primary visual cortex.

219 eceptors on dendritic cells (DCs), in rhesus macaques primed with a poxvirus vector (NYVAC-KC) expres

220 red and contrasted pathogenic (in pig-tailed macaques [PTMs]) and nonpathogenic (in African green mon

221 trophysiological differences between rat and macaque pyramidal neurons.

222 e there are reports that they are present in macaque pyramids.

223 We provide evidence that once technological macaques reach a large enough group size, they enter a f

224 Four rhesus macaques received a single vaccination with a mixture of

225 Two groups of macaques received two doses of the corresponding NYVAC-C

226 olation is achieved in the motor cortex when macaques received visual feedback signaling a movement p

227 thologic review of 30 SIV-infected pigtailed macaques receiving combination antiretroviral therapy (c

228 4 postinfection in 21%, 17%, 60%, and 83% of macaques, respectively, compared to conventional qPCR po

229 , ARVs administered to mice and SIV-infected macaques resulted in neuronal damage and BACE1 up-regula

230 irus directly to the tonsils of three rhesus macaques results in detectable plasma viremia in all ani

231 m peripheral blood and the jejunum in rhesus macaques, revealing distinct expression patterns in naiv

232 Contrarily, hepatocytes from cynomolgus macaques, rhesus macaques, and pigs became fully suscept

233 nhuman primate species, Indian-origin rhesus macaques (RM) and Mauritian-origin cynomolgus macaques (

234 Rhesus macaques (RMs) were immunized with NPs containing TLR4 a

235 nduced a similar antibody response in rhesus macaques (RMs), which are commonly used as an animal mod

236 petitively presented stimuli, we studied the macaque's ability to determine the relative order of mul

237 Secondly, when macaques scratched, subsequent interactions were less li

238 gh the lymphocytic CNS inflammation in these macaques shared morphologic characteristics with uncommo

239 G result in global redistribution of PFV and macaque simian foamy virus (SFVmac) integration sites to

240 the impact of stem cell transplantation in a macaque simian/HIV (SHIV) system.

241 show that early administration of bNAbs in a macaque simian/human immunodeficiency virus (SHIV) model

242 ved in elite control in human HIV type 1 and macaque SIV infections, respectively.

243 to long-term structural stability in Tibetan macaque society.

244 ong duration action potentials, while in the macaque, some pyramidal neurons exhibit short duration "

245 ajor simian immunodeficiency virus of rhesus macaque, sooty mangabey, and HIV-2 (SIVsmm/SIVmac/HIV-2)

246 In different macaque species, the MHC A2*05 gene is present in abunda

247 first time, we test the predictions made by macaque studies in an experiment with humans with fronta

248 bserved in lymph nodes of infected pigtailed macaques, suggesting productive infection of CD169(+) ce

249 nalysis of memory B cells from the immunized macaque suggests that elicitation of broadly neutralizin

250 scape, the high prevalence of CNS lesions in macaques suggests that persistent adaptive immune respon

251 ion of plasma cells and plasmablasts between macaques that exhibited high or low viremia.

252 of visual space within ventral IT cortex of macaques that included scene-selective cortex.

253 in a unique cohort of SIV-controlling rhesus macaques that maintained low to undetectable levels of v

254 combination with the bnAb PGT121, in rhesus macaques that were chronically infected with SHIV.

255 , in closed-loop experiments with two rhesus macaques, that after the loss of approximately 60% of re

256 We find that in the awake macaque the modulatory effect of serotonin is surprising

257 In infected macaques, the assay detected F. tularensis on days 1 to

258 observed in the brains of two treated rhesus macaques, the heart of one treated rhesus macaque, and a

259 w levels of gadolinium are found in juvenile macaque tissues after in utero exposure to two doses of

260 and validated in rodents and then applied in macaques to assess its feasibility in larger species.

261 Here, we found that, in macaques trained to perform a fine disparity discriminat

262 In contrast, macaques treated for 15 weeks with combination anti-retr

263 actors in primary CD4(+) T cells from rhesus macaques under various conditions, finding dynamic chang

264 We recorded activity in macaques using functional magnetic resonance imaging dur

265 und superior and durable B-cell responses in macaques vaccinated with an occluded CD4 binding site on

266 nces in the middle temporal area (MT) of the macaque visual cortex, using electrophysiological record

267 reams are fundamental to the organization of macaque visual cortex.

268 Prior research training macaques (vocal non-learners) to tap to an auditory or v

269 ononuclear cells (PBMC) from both humans and macaques was increased following the experimental additi

270 cation in cell culture but that evolution in macaques was limited.

271 In three cohorts (two human, one macaque), we find that the resulting morphometric simila

272 bserved in SIV-noncontrolling and uninfected macaques, we aimed to identify markers and activities of

273 Using fMRI in macaques, we detected that a cortical network, activated

274 Here, using ART-treated, SIV-infected rhesus macaques, we show that CTLA-4(+)PD-1(-) memory CD4(+) T

275 In the macaques, we tested immunotoxins (ITs), consisting of pr

276 Macaques were aerosol-vaccinated with DeltasigH and subs

277 and chemotaxis in vitro Six infected rhesus macaques were infused with differentially fluorescent dy

278 mechanism of action of Rh-alpha4beta7, naive macaques were infused with Rh-alpha4beta7 and sampled in

279 rences among NK cells of the three groups of macaques were observed in tissue-resident cells.

280 ly utilizes human CD4 than the CD4 of rhesus macaques, whereas the closely related virus SIVmac316 us

281 sted foraging is no longer beneficial to the macaques, which in return may lessen or extinguish the r

282 sease in experimentally infected crab-eating macaques, while simian hemorrhagic fever virus (SHFV) ca

283 S inflammation in cART-treated, SIV-infected macaques will advance our understanding of the consequen

284 show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but t

285 n primate cell cultures and then crab-eating macaques with either simian hemorrhagic fever virus (SHF

286 n which we studied binocular interactions in macaques with experimentally induced amblyopia.

287 beta7 may mediate its effect in SIV-infected macaques with implications for understanding the effect

288 ults demonstrate that immunization of rhesus macaques with NP adjuvants mixed with soluble SIV Env or

289 eukocyte populations from SIVmac251-infected macaques with or without CD8(+) lymphocyte depletion.

290 prevention of Ebola virus disease in rhesus macaques with regards to reduction of viral load, morbid

291 Here, we infected rhesus macaques with simian-human immunodeficiency viruses (SHI

292 We propose that infections of rhesus macaques with SIVmac239 G382R/H442Y might better model s

293 After infection of rhesus macaques with SIVmac239, the expression of most confirme

294 terium-antigen murine inflammation model and macaques with TB to identify [(64)Cu]-labeled CB-TE1A1P-

295 We find that immunization of rhesus macaques with the pentavalent vaccine results in protect

296 By contrasting NK responses of these macaques with those observed in SIV-noncontrolling and u

297 tudy, we evaluated the performance of rhesus macaques with ventral striatum (VS) lesions on a two-arm

298 We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV

299 phages and in the lungs of animals (mice and macaque) with active disease.

300 ies to multiple neutralizing sites in rhesus macaques, with quality attributes comparable to those of