ライフサイエンスコーパス: machinery

1 3D, providing a unique insight into cellular machinery.

2 ell as the components of the DNA replication machinery.

3 of Hsp90 without inhibiting the entire Hsp90 machinery.

4 ultiprotein nucleotide excision repair (NER) machinery.

5 nteracting components of the DNA methylation machinery.

6 mage and simplifying the delivery of editing machinery.

7 gnaling components with the root iron-uptake machinery.

8 translation repression and mRNA degradation machinery.

9 e regulator for YAP-mediated transcriptional machinery.

10 of therapeutics targeting the mitochondrial machinery.

11 nter of the neural stimulus-control learning machinery.

12 selective recognition by the macroautophagy machinery.

13 teins in general are part of the core fusion machinery.

14 reserve pool and the presynaptic endocytosis machinery.

15 ut already have elements of its biosynthetic machinery.

16 teractions between Ubp10 and the SIR complex machinery.

17 ly independently of the beta-barrel assembly machinery.

18 hanges within the transcriptional regulatory machinery.

19 cytosolic iron-sulfur protein assembly (CIA) machinery.

20 le that engages the transcription elongation machinery.

21 cts with regulation of the host's epigenetic machinery.

22 ue-specifically to remodel the core polarity machinery.

23 atory information to the basal transcription machinery.

24 ore component of the synaptic vesicle fusion machinery.

25 of uncoupled mitochondria to the autophagic machinery.

26 mimic membrane interactions with the fission machinery.

27 capacity of the mitochondrial Ca(2+) uptake machinery.

28 oning of the viral transcription/replication machinery.

29 bution and interacts with the LPS biogenesis machinery.

30 g juxtamembrane signaling to mitotic spindle machinery.

31 e PTEN from elements of the PTEN degradation machinery.

32 essential for recognition by the maturation machinery.

33 adapter between the virus and the host cell machinery.

34 g a host of known and as yet unknown protein machinery.

35 chromosome ends from the DNA damage response machinery.

36 ion by the human mitochondrial transcription machinery.

37 s endocytosis is distinct from the resealing machinery.

38 ous protection from the cellular degradation machinery.

39 ning of the essential presequence processing machinery.

40 factor in the assembly of the core splicing machinery.

41 g domain of PB2 to inhibit the cap-snatching machinery.

42 d cells to set up the functional replication machinery.

43 f the PtdIns 3-kinase complex, and the ESCRT machinery.

44 RNA polymerase (RNAP) and the translational machinery.

45 een auxin and the poly(A) signal recognition machinery.

46 lease component of the cytoplasmic RNA decay machinery.

47 function independently of the host ubiquitin machinery.

48 Rab5-positive early endosomes via the ESCRT machinery.

49 e-patterned fibers using convetional weaving machinery.

50 uted to noise in the brain's decision-making machinery.

51 assembled RpL4 from the cellular degradation machinery.

52 the first component of the mtDNA separation machinery.

53 malfunction and damage of the photosynthetic machinery.

54 ism, and cell cycle to the core pluripotency machinery.

55 understood, especially for the translational machinery.

56 and Dab2, which are partners in the tubular machinery.

57 s in mitochondrial oxidative phosphorylation machinery.

58 of the protein components of the translation machinery.

59 d expression of genes encoding the endocytic machinery.

60 how these interact with the cancer cellular machinery.

61 omal sorting complex required for transport) machinery.

62 ot an inability to couple with the signaling machinery.

63 ly removed by the nucleotide excision repair machinery.

64 cking route to amoebic lysosomal degradation machinery.

65 +) activation of the synaptic vesicle fusion machinery.

66 sions through interactions with the splicing machinery.

67 cular, their interactions with the host cell machinery.

68 tes entry sites for the long-range resection machinery.

69 NEDD8 conjugation through the ubiquitylation machinery.

70 on-sulfur cluster assembly (ISC) and the CIA machineries.

71 tabolic cell wall recycling and biosynthetic machineries.

72 configured organelle- and transport-related machineries.

73 imported into the organelles via specialized machineries.

74 viral proteins efficiently utilize cellular machineries.

75 l codon by means of Sec-specific translation machineries.

76 hannel, shielding them from other DNA repair machineries.

77 uding the gene-silencing and innate immunity machineries.

78 across membranes using a range of transport machineries.

79 y neurons organize distinct types of sensory machinery [1].

80 gnaling [18.1% (80/442)], and the cell-cycle machinery [10.4% (46/442)].

81 encing pathway are involved in plant defense machinery against microbial pathogens in Arabidopsis tha

82 that components of the classical cell death machinery also have important non-cell-death (non-apopto

83 anconi anemia and nucleotide excision repair machinery, although the mechanisms of these activities a

84 The distribution of the transcription machinery among different sub-nuclear domains raises the

85 tion compartment allow the virus replication machinery an access to plentiful ATP, facilitating robus

86 granule release by binding to the exocytosis machinery, an effect that is enhanced by prior cAMP-depe

87 a pivotal component of the replication fork machinery and a main regulator of the DNA damage toleran

88 essential component of the mtDNA replication machinery and as the first component of the mtDNA separa

89 anism requires the presence of translational machinery and associated mRNAs in circuit-integrated bra

90 elieved to have gained access to the nuclear machinery and caused increased stress leading to genotox

91 ant regulation of the mitochondrial dynamics machinery and characterizing the regulating signaling pa

92 rolled by cytosolic actin-based constriction machinery and dynamin-related protein 1 (Drp1) on mitoch

93 alization of antibodies targeting the fusion machinery and for engineering next-generation subunit va

94 ng to BRD4, which recruits the pause release machinery and increases RNAPII pause release.

95 YN in the astrocytes affects their lysosomal machinery and induces mitochondrial damage.

96 poisomerase activity, binds mRNA translation machinery and interacts with an RNA-binding protein, FMR

97 te with upregulated expression of glycolytic machinery and is essential for inflammatory responses to

98 ZNF804A co-fractionates with translational machinery and modulates the translational efficiency as

99 Comparing the DNA replication machinery and processes of parasites and their hosts may

100 genic signaling pathways with the cell cycle machinery and promoting optimal cell cycle progression i

101 aggregates requires the mitochondrial import machinery and proteases.

102 t the dynamins are part of the cell division machinery and that they mediate their effects on Z-ring

103 an unexpected link between the mRNA capping machinery and the Hh signaling pathway, unveils a new fa

104 ic perturbation of the cellular proteostatic machinery and the IRE1-alpha-MKK4 arm of the endoplasmic

105 ce of a possible direct link between the CIA machinery and the mitoNEET cluster transfer repair pathw

106 y described that target the general splicing machinery and thus have low specificity for individual g

107 compatible with the cell's own transcription machinery and, thus, expressable inside cells.

108 ypoxia-inducible factor (HIF) ubiquitination machinery, and consequently suppressing the oxygen-indep

109 porters, receptors, and membrane-trafficking machinery, and increased adenine nucleotide levels.

110 the recruitment of the mitochondrial fission machinery, and subsequent division.

111 essed with components of the DNA replication machinery, and that Donson is essential for early embryo

112 cell is primed to activate the translational machinery, and that hormones likely play a minor role in

113 platform for assembly of the DNA replication machinery, and that unloading of Rad51 by Srs2 helicase

114 Mutations in the splicing machinery are predominantly found in PMF and are implica

115 yoxylate pathway and amino acid biosynthetic machinery are required for mucin utilization.

116 hanical forces and tune the force-generating machinery as needed.

117 ing membrane component of the core autophagy machinery, as a specific AP-4 cargo.

118 ling with lysosome trafficking, the cellular machinery associated with lysosomal vesicles that regula

119 wever, it is not known how the core-scaffold machinery associates in protein-interaction networks or

120 d by the protein insertion and translocation machineries at the time of initial membrane insertion an

121 calization of RNAs and the protein synthesis machinery at synaptic sites.

122 The beta-barrel assembly machinery (BAM) is a conserved multicomponent protein co

123 rstand, mediated by the beta-barrel assembly machinery (BAM).

124 ceding the activation of the differentiation machinery because its DR makes cells more prone to adipo

125 s in morphological, molecular and biogenesis machinery between exosomes derived from these two immune

126 he cellular protein folding and pro-survival machinery by heat shock transcription factor 1 (HSF1) am

127 in a nonnative heterologous host, a minimal machinery capable of building Tfp.

128 ia depletion of the cleavage/polyadenylation machinery, circular RNA levels were similarly increased.

129 omologues of eukaryotic membrane-trafficking machinery components, including Sec23/24 and TRAPP domai

130 (Ccm) is carried out by a membrane-integral machinery composed of nine proteins (CcmA to I).

131 lls is mediated by the conserved core fusion machinery, composed of the fusogen gB and the receptor-b

132 ssing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins.

133 The molecular mechanisms by which protein machineries control force transmission along this molecu

134 functioning of the mitochondrial translation machinery depend on Mss116 interplay with its protein co

135 and a profound perturbation of the endocytic machinery, despite preserved absolute expression of the

136 incorrect polymerases at the fork, the clamp machinery directs quality control on the lagging strand

137 , not the vacuole, by targeting pH-sensitive machinery downstream of the Rab-GTPase Ypt7 needed for S

138 effectors such as the actomyosin contractile machinery drive embryo morphogenesis.

139 Thus, the cellular and molecular machinery driving hepatic functions is of utmost relevan

140 t component of the Sec protein translocation machinery embedded in the bacterial membrane, which is a

141 mmary, we provide a detailed map of the host machinery engaged by arenavirus NPs and identify an anti

142 snoRNAs by PAPs may function to recruit the machinery essential for snoRNA processing.

143 omponent of the cell protein quality control machinery essential to circumvent stress-induced degrada

144 rved, essential function, yet genome defense machinery evolves rapidly.

145 These data suggest that functional RNAi machinery exists in ALB and a potential RNAi-based metho

146 s could have primed development of metabolic machineries for their degradation, especially in microor

147 tracellular parasites that rely on host cell machineries for their replication and survival.

148 oute is very promising, but MSCs are missing machinery for diapedesis through blood-brain barrier.

149 stream of those encoding the T6SS structural machinery for effector delivery.

150 e of adenovirus on the host pre-RNA splicing machinery for expression of its complete genome potentia

151 Consequently, the biosynthetic machinery for Fe/S clusters is evolutionarily conserved,

152 An inflammasome-based surveillance machinery for Gram-negative bacterial infections has bee

153 ealed profound upregulation of the enzymatic machinery for hydrolysis of extracellular adenosine trip

154 A remarkable property of the machinery for import of peroxisomal matrix proteins is t

155 osynthetic apparatus, also adjustment of the machinery for protein folding, degradation, and homeosta

156 They are major components of the ribosomal machinery for protein synthesis and they also serve in n

157 n the membrane that have clustered molecular machinery for secretion [15], organized in part by the l

158 e species, has evolved sophisticated protein machinery for the binding and uptake of DNA.

159 ression the nonhomologous end-joining (NHEJ) machinery from the closely related archaeon, Methanocell

160 erefore, it is not surprising that the Hsp90 machinery has become an attractive therapeutic target fo

161 rely on canonical microRNA/siRNA processing machinery (i.e., independent of DICER-LIKE proteins).

162 gp350(+) particles may divert the cytolytic machinery, impairing its direct action on the plasma mem

163 onds to days, involving different regulatory machineries in different processes.

164 istic link between the RNA and protein decay machineries in human cells.

165 ranslocon on the inner chloroplast membrane) machineries in the outer and inner envelope membranes, r

166 n small RNA pathways and the transcriptional machinery in Caenorhabditis elegans.

167 e in coordinating the adhesion and migration machinery in cancer progression.

168 olding of G-quadruplex inside the polymerase machinery in cells.

169 in vivo through inhibition of the autophagic machinery in DCs in a cytotoxic T-lymphocyte-associated

170 mes, thereby generally implicating the ESCRT machinery in EV biogenesis.

171 onserved miRNA families as well as small RNA machinery in land plants.

172 ng a role for peroxisomal retrotranslocation machinery in oil body utilization.

173 and demonstrates how analysis of autophagic machinery in the absence of flux can identify new regula

174 me-lysosome fusion by modulating the traffic machinery in the cell host.

175 hepatic function, including bile acid system machinery in the liver and brain.

176 ling restricts expression of the elastogenic machinery in the lung mesenchyme to control orderly form

177 nical environments suggests that the protein machinery in this process has evolved to take advantage

178 HSV-1's replication machinery includes a trimeric helicase-primase composed

179 losneuviruses encode an expanded translation machinery, including aminoacyl transfer RNA synthetases

180 translation of mRNAs that encode translation machinery, including ribosomal proteins, was upregulated

181 f several components of the synaptic vesicle machinery, including the vesicular glutamate transporter

182 ectories of the Cx43 microtubule trafficking machinery, increasing delivery of Cx43 hemichannels to c

183 ia and Sericytochromatia lack photosynthetic machinery, indicating that phototrophy was not an ancest

184 rting complex required for transport (ESCRT) machinery into endosome intralumenal vesicles (ILVs) for

185 plasma membrane recruitment of the molecular machinery involved in Rim101 processing and activation o

186 Assembly of the endocytic machinery is a constitutively active process that is imp

187 Deregulation of the cell cycle machinery is a hallmark of cancer.

188 This axonal translational machinery is associated with Fragile X granules (FXGs),

189 Although some of the NMD machinery is conserved between kingdoms, little is known

190 Dysregulation of cell cycle machinery is implicated in a number of neuronal death co

191 e components of the rabies virus replication machinery is incomplete.

192 which temperature mammalian transcriptional machinery is largely inactive, thereby effectively 'free

193 e proteome, and deregulation of the splicing machinery is linked to several age-related chronic illne

194 that binding of TDP-43 to the translational machinery is mediated by an interaction with a specific

195 n, the dynamics of its fascinating injection machinery is not understood.

196 In contrast, in mouse this machinery is only observed in juvenile hippocampal axons

197 e and postsynaptic neurotransduction-related machinery is present in both plexiform layers by fetal w

198 it is established that the host's epigenetic machinery is sensitive to levels of endogenous metabolit

199 Axonal translational machinery is thus a feature of adult CNS neurons.

200 recruitment of the homologous recombination machinery is well characterized, it is not known how its

201 ps4, the key regulator of the cellular ESCRT machinery, is necessary for efficient entry and egress o

202 cts, structural aspects of the assembly-line machinery itself are considered.

203 ing for proteins involved in the translation machinery, known to be highly codon biased and using pre

204 defects in the mRNA template or translation machinery, leading to the production of incomplete prote

205 exit at the time when the CENP-A deposition machinery localizes to centromeres.

206 The ESCRT machinery mediates reverse membrane scission.

207 e-synthesis of resected DNA, the replication machinery must catch up with the preceding processing nu

208 26 with peroxisome-associated ubiquitination machinery mutants, suggesting that ubiquitinated PEX5 is

209 es are variations of a unifying mathematical machinery - network propagation - suggesting that it is

210 conjugation, de-conjugation, and recognition machinery now identified as key factors in DSB repair.

211 omotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that pro

212 Anomalies in dismantling the machinery of DNA replication can compromise genome integ

213 f visceral leishmaniasis, and the autophagic machinery of human macrophages.

214 ein folding requires assistance by a complex machinery of molecular chaperones.

215 vestigating the chemical logic and enzymatic machinery of natural product biosynthesis, including ant

216 dination with other viral components and the machinery of the cell.

217 dium parasites are targeted by the autophagy machinery of the host cell, and the PV membrane (PVM) be

218 A-1 is also needed to polarize the cytotoxic machinery of the NK cell toward the target cell.

219 A promising donor organism for the molecular machinery of this mechanism is the eukaryotic alga Chlam

220 eased the effect of protumorigenic oxidative machinery on androgen-independent PCa growth, suggesting

221 d on-farm activities (e.g. fertilization and machinery operation).

222 unclear how they are recruited to the export machinery or how the intron-containing but unspliced M1

223 esulting from mutations in the translational machinery or inappropriate activation of the integrated

224 RLKs could be components of the ROS sensing machinery or ROS sensors.

225 investigated whether the 5' to 3' RNA decay machinery participated in the regulation of this process

226 Thus ANTs and the OXPHOS machinery physically interact and functionally cooperate

227 genes, enhancer elements, and transcription machinery plays an essential role in tissue development

228 dence suggests that active DNA demethylation machinery plays important epigenetic roles in mammalian

229 on-coding RNA, helps the dosage compensation machinery preferentially find X sequences.

230 tylates homologous recombination (HR) repair machinery proteins, including NBS1 and Rad51.

231 bunit of the vitamin B6 biosynthesis protein machinery, PYRIDOXINE BIOSYNTHESIS PROTEIN1.

232 to gain a global view of the transcriptional machinery regulated by C/EBPepsilon, we performed whole-

233 nd propose a model describing how the fusion machinery regulates fragment formation during lysosome f

234 nravels the molecular mechanism and cellular machinery regulating Gli ciliary localization and identi

235 Both US9 and APP processing machinery rely on their ability to shuttle between endos

236 Malfunctioning of this machinery renders virions incapable of infecting cells.

237 target subcellular organelles to access host machineries required for replication and spread.

238 The host machinery required for silencing in human EC cells is di

239 Indeed, inhibition of the cellular machinery required for the assembly and maintenance of S

240 g both the transcriptional and translational machinery required for the proper growth of the myelin s

241 creens to identify components of the sorting machinery required for vacuole membrane protein degradat

242 The protein machinery required to build, maintain, and define many m

243 hondrial iron-sulfur (Fe/S) cluster assembly machinery resides to mature mitochondrial Fe/S cluster-c

244 NCE Tumor viruses are known to interact with machinery responsible for detection and repair of double

245 roach in Drosophila to study the presynaptic machinery responsible for these vesicular processes in v

246 r basolateral membrane currents and synaptic machinery retain a prehearing phenotype.

247 ring carbon is prevented and the radical SAM machinery sits adjacent rather than opposite to the Me-C

248 Key signalling components of the senescence machinery, such as p16(INK4a), p21(CIP1) and p53, as wel

249 s in genes involved in the DNA recombination machinery, such as recombination-activating gene 1 (RAG1

250 a core component of the spindle orientation machinery that binds the cytosolic tail of E-cadherin.

251 Overall, water flow is detected by molecular machinery that can vary between hair cells of different

252 The molecular machinery that controls secondary necrosis stands out as

253 oded genomes and introducing new translation machinery that function together without compromising vi

254 re of the ATPase regulation of the chaperone machinery that maintains protein homeostasis.

255 se new SR-TT junctions contain the molecular machinery that mediate SOCE: stromal interaction molecul

256 d proteins are widely conserved, the protein machinery that mediates their biogenesis is not.

257 mportant modulator of the energy homeostasis machinery that operates through the regulation of multip

258 ceptor (SNARE) proteins comprise the minimal machinery that triggers fusion of transport vesicles wit

259 on have tissue-specific consequences for the machinery that ultimately governs copper homeostasis, an

260 Over the past two decades, the molecular machinery that underlies autophagic responses has been c

261 ion to maintain components of the autophagic machinery that would otherwise be consumed during prolon

262 mechanisms, rather than lower-level sensory machinery, that benefit most from rest.

263 s occurs through interactions with host cell machinery, the cytoplasmic tail (CT) of F is a likely in

264 integral part of the locomotor coordination machinery, the development of their electrophysiological

265 As the central hub of the metabolism machinery, the mammalian target of rapamycin complex 2 (

266 a novel component of the chloroplast import machinery, the regulatory kinase at the outer chloroplas

267 ens have developed strategies to hijack this machinery, thereby interfering with host immunity.

268 Viruses exploit cellular machineries to penetrate a host membrane and cause infec

269 ntial recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

270 netic landscapes and often exploit chromatin machinery to activate oncogenic gene expression programs

271 S share common building blocks and molecular machinery to construct and maintain them.

272 hosphotransferase system (PTS) as regulatory machinery to control the energy conditions of the cell.

273 hus, P. aeruginosa exploits the ParS sensing machinery to defend itself against the host in response

274 must successfully evade this host RNA decay machinery to establish a productive infection.

275 dinates with the histone and DNA methylation machinery to establish a repressive chromatin environmen

276 Salmonella have developed a sophisticated machinery to evade immune clearance and promote survival

277 alian cell non-classical microRNA processing machinery to further process bacterial small non-coding

278 How ZIKV interacts with the host molecular machinery to impact neurogenesis in vivo is not well und

279 ved a mechanism to manipulate the host m(6)A machinery to its advantage in promoting lytic replicatio

280 ne-bound force sensor to recruit the fission machinery to mechanically strained sites.

281 wer interacts with proteins of the endocytic machinery to mediate granule endocytosis.

282 Y peptide motif to manipulate the autophagic machinery to prevent autophagic degradation and to promo

283 at the T cell might use its force-generation machinery to probe the mechanical properties of the oppo

284 viral mRNAs and the cellular nuclear export machinery to promote their nuclear export.IMPORTANCE Inf

285 giant viruses (Mimiviridae) and hijack their machinery to replicate.

286 l-shape changes is the ability of the cell's machinery to sense mechanical forces and tune the force-

287 ruses are completely dependent upon cellular machinery to support replication and have therefore deve

288 ether Ssa1 associates with the translocation machinery to target protein substrates to the membrane i

289 esults in the translocation of the autophagy machinery to the phagosome and ultimately LC3 conjugatio

290 ms to be to allow the olfactory transduction machinery to work at a precisely regulated range of resp

291 onstrate that perturbations of this assembly machinery trigger complex cellular responses that preven

292 ys to study how the neurotransmitter release machinery triggers Ca(2+)-dependent synaptic vesicle fus

293 omestication, as well as about the molecular machineries underlying them.

294 Although much of the basic actin machinery was intact, Cdc42 null cells lacked the abilit

295 eted glycine substitutions in the Env fusion machinery, we defined a general approach that disfavors

296 To find acidic cluster sorting machinery, we performed a gene-trap screen and identifie

297 ities but are connected to each other and to machineries with functions in energetics, membrane organ

298 While we know much about the molecular machinery within each compartment, we are only beginning

299 f the immediate product of the rearrangement machinery without an impact of selection, we discovered

300 Pathogens and symbionts employ similar machinery, yet symbionts can minimize host damage.