ライフサイエンスコーパス: macroautophagy

1 of lysosomal biogenesis and up-regulation of macroautophagy.

2 ing catabolic pathways, particularly that of macroautophagy.

3 Their clearance requires macroautophagy.

4 lglycerol, and their metabolizing enzymes in macroautophagy.

5 naive T cells, two physiological inducers of macroautophagy.

6 nly proteasome-mediated proteolysis but also macroautophagy.

7 the ER-Golgi fusion machinery are needed for macroautophagy.

8 n functionally links ER stress responses and macroautophagy.

9 reby mitochondria are turned over is through macroautophagy.

10 e show that the N-end rule pathway modulates macroautophagy.

11 e proteins via mechanisms acting upstream of macroautophagy.

12 complex, which is required for initiation of macroautophagy.

13 asome, tauDeltaC is cleared predominantly by macroautophagy.

14 ivation of AMPK, which activates prosurvival macroautophagy.

15 pite an initial activation of cytoprotective macroautophagy.

16 from an unexpected ability of PSA to enhance macroautophagy.

17 of autophagy in compensation for the loss of macroautophagy.

18 es of selective autophagy or for nonspecific macroautophagy.

19 reticulum stress is also a potent inducer of macroautophagy.

20 ion factors and is an important regulator of macroautophagy.

21 l lysosomes from autolysosomes formed during macroautophagy.

22 ion, the cell activates one or more forms of macroautophagy.

23 in B cell LAMP-2C expression did not impact macroautophagy.

24 apoptotic pathway requires the inhibition of macroautophagy.

25 iseases are associated with dysregulation of macroautophagy.

26 ly to its role in the degradative process of macroautophagy.

27 onserved and essential mediator of canonical macroautophagy.

28 cation compartment formation; and micro- and macroautophagy.

29 and intracellular components sequestered by macroautophagy.

30 tants were defective in ER-Golgi traffic and macroautophagy.

31 tion of the phagophore and in the process of macroautophagy.

32 shortage or organelle damage, cells undergo macroautophagy.

33 tion of the proteasome (bortezomib), but not macroautophagy (3-methyladenine), markedly increased PNP

34 When macroautophagy, a catabolic process that rids the cells

35 ER stress is also a strong inducer of macroautophagy, a cell-protective mechanism of self-degr

36 east partially attributable to regulation of macroautophagy, a highly conserved protein catabolism pa

37 Macroautophagy, a homeostatic process that shuttles cyto

38 udy, we found that GFAP accumulation induces macroautophagy, a key clearance mechanism for prevention

39 Macroautophagy, a major pathway for organelle and protei

40 us for this purpose, we assessed the role of macroautophagy, a process in which cytosolic proteins ar

41 Macroautophagy, a tightly orchestrated intracellular pro

42 has shown that WNV growth was independent of macroautophagy activation, but the role of the evolution

43 n of intraneuronal aggregates containing the macroautophagy adapter proteins p62 and NBR1 in the neur

44 Up-regulation of macroautophagy alone is not sufficient to induce connexi

45 o regulate the cellular catabolic process of macroautophagy, although the precise mechanism whereby t

46 We investigated whether macroautophagy, an evolutionarily conserved cellular mec

47 In the absence of macroautophagy, an up-regulation of chaperone-mediated a

48 ave pronounced effects on the fusion step of macroautophagy and affect the overall activity of this i

49 loroquine treatment enhanced markers of both macroautophagy and apoptosis in MEFs but ultimately impa

50 dysfunction was accompanied by impairment of macroautophagy and chaperone-mediated autophagy, increas

51 Although some level of basal macroautophagy and CMA activities has been described in

52 ss is mediated by distinct functions of both macroautophagy and CMA, indicating that impaired functio

53 degradation in mediating cross-talk between macroautophagy and CMA.

54 , we report a functional interaction between macroautophagy and Corticotropin Releasing Hormone (Crh)

55 found that ubiquilin is degraded during both macroautophagy and during chaperone-mediated autophagy (

56 cle fibers show a high level of constitutive macroautophagy and express MHC class II molecules upon i

57 Sec22 is also reported to function in macroautophagy and in formation of endoplasmic reticulum

58 anism through which TNF-alpha regulates both macroautophagy and MHC class II expression and suggest t

59 P-2B regulates lysosome maturation to impact macroautophagy and phagocytosis.

60 que roles for GABARAP and LC3 subfamilies in macroautophagy and selective autophagy and demonstrates

61 id is targeted for lysosomal degradation via macroautophagy and suggest that the autophagy pathway sh

62 macroautophagic machinery, the regulation of macroautophagy and the process of cargo recognition in s

63 of plasma membrane connexin 43 targeted for macroautophagy and the sequence of events that trigger t

64 Ypt1 and its mammalian homolog Rab1 regulate macroautophagy and two other trafficking events: endopla

65 al tau levels, coincident with activation of macroautophagy and ubiquitin-proteosome pathways.

66 endritic pruning, elevated mTORC1 signaling, macroautophagy, and autism spectrum disorder.

67 Influenza infection triggered productive macroautophagy, and autophagy-dependent presentation was

68 as/TNF-alpha treatment failed to up-regulate macroautophagy, and in fact, decreased activity at late

69 cles, organelle degradation by mitophagy and macroautophagy, and in some cases transfer to glial cell

70 gosome formation is the most complex part of macroautophagy, and it is a dynamic event that likely in

71 3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for

72 improves clearance of the mutant protein by macroautophagy, and reverses the toxic effects of mutant

73 Aggregate-prone proteins are cleared by macroautophagy, and upregulating this process by rapamyc

74 e proton pump, whereas Atg genes involved in macroautophagy are dispensable for crinophagy.

75 ly, a reduction in LC3 flux and dampening of macroautophagy are observed in dendritic cells from Anxa

76 oteolysis and autophagosome clearance during macroautophagy are prevented as a result of a selective

77 These findings have identified macroautophagy as a previously unappreciated route for d

78 xpectedly, these increases did not depend on macroautophagy, as similar increases in vacuole size wer

79 tingtin transgene expression, the absence of macroautophagy (ATG5 or ATG7 expression), an increase in

80 Macroautophagy (autophagy hereafter) degrades and recycl

81 role in the initiation of starvation-induced macroautophagy (autophagy) and is activated by the guani

82 Macroautophagy (autophagy) is a critical cellular stress

83 Macroautophagy (autophagy) is a lysosome-dependent degra

84 Macroautophagy (autophagy) is a process wherein bulk cyt

85 Macroautophagy (autophagy) is a regulated catabolic path

86 The possibility that activation of the macroautophagy (autophagy) pathway may increase beta cel

87 Macroautophagy (autophagy), associated with bulk cytopla

88 ing of damaged mitochondria to lysosomes via macroautophagy (autophagy).

89 for mutants defective in a type of selective macroautophagy/autophagy.

90 a mechanism different from that of a loss of macroautophagy, because death occurred in the absence of

91 Experimental findings that an inhibition of macroautophagy blocks apoptosis do not prove that autoph

92 sing pharmacological and genetic blockage of macroautophagy both in vitro and in vivo, we found that

93 contrast, selectively impeding late steps in macroautophagy by inhibiting cathepsin-mediated proteoly

94 This combination enhances macroautophagy by mTOR-independent (IMPase inhibition by

95 We show that suppression of macroautophagy by multiple means promotes the degradatio

96 ind that alpha-syn aggregates impair overall macroautophagy by reducing autophagosome clearance, whic

97 These results demonstrate that inhibition of macroautophagy can promote or prevent apoptosis in the s

98 Macroautophagy can regulate cell signalling and tumorige

99 s; however, either insufficient or excessive macroautophagy can seriously compromise cell physiology,

100 hsc-70 is pivotal to the process of macroautophagy, chaperone-mediated autophagy, and endoso

101 efficient removal of damaged mitochondria by macroautophagy contributes to Parkinson's disease (PD).

102 ocesses, we determined whether inhibition of macroautophagy could have both pro-apoptotic and anti-ap

103 Macroautophagy-defective RNAi-AtATG18a transgenic plants

104 was accelerated in transgenic mice in which macroautophagy deficiency was restricted to dopaminergic

105 during basal and stress conditions in these macroautophagy-deficient cells.

106 cally deleted in T cells, we have found that macroautophagy-deficient effector Th cells have defectiv

107 when an exogenous energy source is added to macroautophagy-deficient T cells.

108 When triggered by mTOR inactivation, macroautophagy degrades long-lived proteins and organell

109 mary dendritic cells, revealed no detectable macroautophagy-dependent component.

110 DCs operated in a redundant manner, whereas macroautophagy-dependent endogenous loading was essentia

111 encing Beclin-1, Atg7, or p62 indicated that macroautophagy does not protect cells undergoing necrosi

112 tes delayed chaperone-mediated autophagy and macroautophagy dysfunction observed in the hSYN(A53T) mi

113 teract cardiac aging through improvements in macroautophagy (eg, calorie restriction and calorie rest

114 Macroautophagy facilitates degradation of cellular const

115 MHC class II-restricted thymocytes required macroautophagy for a mitochondrial version of a neo-anti

116 -driven tumors have been reported to rely on macroautophagy for growth and survival, suggesting a pot

117 confirm that KRAS-driven tumor lines require macroautophagy for growth.

118 TNF-alpha facilitates antigen processing via macroautophagy for more efficient MHC class II loading.

119 from mice with a knock-out of the essential macroautophagy gene atg5 were treated with activators of

120 study by genetic inhibition of the critical macroautophagy gene autophagy-related 7 (Atg7).

121 Through this basic mechanism, macroautophagy has a critical role in cellular homeostas

122 cently, the lysosomal degradative pathway of macroautophagy has been identified as a regulator of cel

123 Macroautophagy has been implicated as a mechanism of cel

124 Macroautophagy has been proposed to play an important ro

125 adative pathway and cell death is unclear as macroautophagy has been shown recently to protect agains

126 G12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, a

127 Macroautophagy (hereafter autophagy) functions in the no

128 Macroautophagy (hereafter autophagy) is a bulk degradati

129 Macroautophagy (hereafter autophagy) is a catabolic cell

130 Macroautophagy (hereafter autophagy) is a degradative ce

131 Macroautophagy (hereafter autophagy) is a key pathway in

132 Macroautophagy (hereafter autophagy) is a ubiquitous pro

133 Macroautophagy (hereafter autophagy) is an evolutionaril

134 ngulf cellular components for degradation by macroautophagy (hereafter called autophagy).

135 Macroautophagy (hereafter referred to as autophagy) is a

136 Macroautophagy (hereafter referred to as autophagy) is a

137 Macroautophagy (hereafter referred to as autophagy) is a

138 Macroautophagy (hereafter referred to as autophagy) is e

139 compartments that were positive for both the macroautophagy (hereafter referred to as autophagy) mark

140 Macroautophagy (hereafter referred to simply as autophag

141 isolation, immobilization and degradation by macroautophagy (hereafter, mitophagy).

142 nse mechanism is the degradative activity of macroautophagy (herein autophagy), mediated by the coord

143 Macroautophagy (herein referred to as autophagy) is an e

144 Macroautophagy (herein referred to as autophagy) is an e

145 unknown, but many studies suggest a role for macroautophagy (herein termed autophagy), a process by w

146 blish an essential link between mitochondria macroautophagy impairments and DA neuron degeneration in

147 that calcium also mediates the induction of macroautophagy in a Bcl-2 regulated fashion and identifi

148 nase activity resulted in the stimulation of macroautophagy in a non-canonical fashion, independent o

149 , we found that vacuolar hydrolysis inhibits macroautophagy in a target of rapamycin complex 1-depend

150 PROPPINs play a key role in macroautophagy in addition to other functions.

151 r these proteins in the proper initiation of macroautophagy in amino acid-starved human fibroblasts.

152 he caspase-7 cleavage product is mediated by macroautophagy in cell culture and primary neuron models

153 Recent work demonstrated the importance of macroautophagy in dendritic cell (DC) maturation and inn

154 that human immunodeficiency virus-1 inhibits macroautophagy in dendritic cells, attenuating MHC II pr

155 g the regulation and molecular mechanisms of macroautophagy in different organisms; however, many que

156 ycan in inducing Peg3, a master regulator of macroautophagy in endothelial cells.

157 is study reveals a novel regulatory role for macroautophagy in GJ function that is directly dependent

158 Macroautophagy in Leishmania, which is important for the

159 -type alpha-synuclein overexpression impairs macroautophagy in mammalian cells and in transgenic mice

160 that alpha-synuclein overexpression impairs macroautophagy in mammalian cells and in transgenic mice

161 The study of macroautophagy in mammalian cells has described inductio

162 d the effects of alpha-synuclein deletion on macroautophagy in mouse brains.

163 In this study, we show that constitutive macroautophagy in primary cortical neurons is highly eff

164 (RUFY4) as a positive molecular regulator of macroautophagy in primary dendritic cells (DCs).

165 cell decides to undergo either apoptosis or macroautophagy in response to calcium signals.

166 on of ulk1 is not essential for induction of macroautophagy in response to nutrient deprivation or fo

167 To test the requirement for macroautophagy in restriction, we examined the ability o

168 (ATG7) by genome editing completely blocked macroautophagy in several tumor lines with oncogenic mut

169 myopathies, led to a marked up-regulation of macroautophagy in skeletal myocytes.

170 re the importance of both the proteasome and macroautophagy in the clearance of dystonia-associated t

171 It is now clear that macroautophagy in the liver is important for the balance

172 Ethanol-induced macroautophagy in the livers of mice and cultured cells

173 Here, we characterize the role of macroautophagy in thymic epithelial cells (TECs) for neg

174 lanoma cells as antigen donors, we show that macroautophagy in tumor cells is essential for cross-pre

175 Macroautophagy (in this paper referred to as autophagy)

176 FGF19 treatment or feeding inhibits macroautophagy, including lipophagy, but these effects a

177 e of specific lipids in the various steps of macroautophagy, including the signaling processes underl

178 Macroautophagy induced by ethanol seemed to be selective

179 ng to its ligand, p62 acts as a modulator of macroautophagy, inducing autophagosome biogenesis.

180 n, depletion of mutant p53 expression due to macroautophagy inhibition sensitizes the death of dorman

181 antigen (HLA)-DR levels and was reversed by macroautophagy inhibition, suggesting that TNF-alpha fac

182 macological tool to evaluate the response to macroautophagy inhibition.

183 mutation status can predict the efficacy to macroautophagy inhibition.

184 In contrast, macroautophagy inhibitors did not increase HIF-1 activit

185 including the signaling processes underlying macroautophagy initiation, autophagosome biogenesis and

186 to other intracellular trafficking pathways, macroautophagy involves a complex sequence of membrane r

187 Macroautophagy involves lysosomal/vacuolar elimination o

188 Macroautophagy is a bulk clearance mechanism in which th

189 Macroautophagy is a catabolic pathway used for the turno

190 Macroautophagy is a cellular degradation process respons

191 Macroautophagy is a fundamental and evolutionarily conse

192 Macroautophagy is a highly conserved mechanism of lysoso

193 Macroautophagy is a key stress-response pathway that can

194 Macroautophagy is a lysosomal degradative pathway essent

195 Macroautophagy is a major catabolic pathway that impacts

196 Here we present evidence that macroautophagy is a significant pathway for lipid turnov

197 These results suggest that macroautophagy is an actively regulated process in T cel

198 Macroautophagy is an essential cellular pathway mediatin

199 Macroautophagy is an essential degradative pathway that

200 Macroautophagy is an evolutionarily conserved cellular p

201 Macroautophagy is an evolutionarily conserved dynamic pa

202 d with the absence of significant defects in macroautophagy is consistent with lysosomal membrane per

203 We conclude that macroautophagy is constitutively active and highly effic

204 lasticity, and neurodegeneration occurs when macroautophagy is deficient.

205 rt of our current understanding of mammalian macroautophagy is derived from studies of the liver.

206 for survival in glucose starvation, whereas macroautophagy is dispensable.

207 Macroautophagy is essential to cell survival during star

208 We have found that macroautophagy is induced after effector T cell activati

209 ed with respective controls, suggesting that macroautophagy is induced to remove alpha-syn, particula

210 cruited to the phagophore assembly site when macroautophagy is induced.

211 Although macroautophagy is known to be an essential degradative p

212 Macroautophagy is known to play an essential role in the

213 n LC3B levels, indicating that LC3B-mediated macroautophagy is necessary for RCC progression.

214 wn to be autophagic substrates, induction of macroautophagy is not required for insoluble protein for

215 Furthermore, macroautophagy is perturbed after YW3-56 treatment in ca

216 ltapsi(m) and (ii) mTORC1-controlled general macroautophagy is required for mitophagy.

217 Furthermore, lysosomal activity but not macroautophagy is responsible for ALIS clearance.

218 Even after macroautophagy is strongly induced by suppressing mTOR (

219 Activation of macroautophagy is suggested to facilitate degradation of

220 The general principle behind macroautophagy is that cytoplasmic contents can be seque

221 A major function of proteasomes and macroautophagy is to eliminate misfolded potentially tox

222 The macroautophagy is triggered despite activation of Akt, m

223 ting degradation of cytoplasmic materials by macroautophagy, is formed in close proximity to the endo

224 mouse model where Atg7, a critical gene for macroautophagy, is specifically deleted in T cells, we h

225 tem function and only modest inefficiency in macroautophagy late in disease.

226 me formation, we have found that blockage of macroautophagy leads to up-regulation of CMA, even under

227 Loss of macroautophagy led to overactivation of the c-Jun N-term

228 nA protein is degraded primarily through the macroautophagy-lysosome pathway.

229 The ubiquitin-proteasome and macroautophagy-lysosome pathways are major routes for in

230 eins are degraded by both the proteasome and macroautophagy-lysosome pathways.

231 creen exposed MTOR signalling and the entire macroautophagy machinery as key regulators of SQSTM1 and

232 signal for the selective recognition by the macroautophagy machinery.

233 review, we summarize current knowledge about macroautophagy mainly in yeast, including the mechanism

234 However, the precise mechanism behind macroautophagy malfunction in HD is poorly understood.

235 mitochondria abnormalities, characterized by macroautophagy marker-positive cytoplasmic inclusions co

236 and MHC class II expression and suggest that macroautophagy-mediated antigen presentation contributes

237 Macroautophagy mediates the degradation of long-lived pr

238 Macroautophagy mediates the selective degradation of pro

239 These pathways include macroautophagy, microautophagy and chaperone-mediated au

240 Three different types of autophagy-macroautophagy, microautophagy, and chaperone-mediated a

241 Reagents that modify macroautophagy might be developed as therapeutics for pa

242 iates the removal of damaged mitochondria by macroautophagy (mitophagy).

243 thermore, treatments that enhance or inhibit macroautophagy modulated the level of presentation from

244 It is nevertheless unknown whether macroautophagy modulates presynaptic function.

245 A basal level of macroautophagy occurs constitutively, but this process c

246 Therefore, we analyzed macroautophagy of APP in human muscle cell lines and sIB

247 , we analyze the consequences of blockage of macroautophagy on CMA activity.

248 roaches, we confirmed the implication of the macroautophagy on PLK2-mediated alpha-syn turnover, and

249 Macroautophagy (or autophagy) is a conserved degradative

250 pecifically in a process called nonselective macroautophagy, or target specific protein aggregates de

251 We examined flux through the macroautophagy pathway as a determinant of the discrepan

252 Reduced flux through the macroautophagy pathway was found to be coincident with t

253 Phagophore maturation is a key step in the macroautophagy pathway, which is critical in many import

254 uctures for elimination independently of the macroautophagy pathway.

255 tumor suppressor Tid56, is a key mediator of macroautophagy pathway.

256 Increasing macroautophagy pharmacologically reduced hepatotoxicity

257 Macroautophagy plays an important role in the regulation

258 Macroautophagy protects against ethanol-induced toxicity

259 Macroautophagy provides eukaryotes with an adaptive resp

260 Thus, upon AICD induction regulation of macroautophagy, rather than selective mitophagy, ensures

261 Macroautophagy (referred to here as autophagy) is induce

262 Macroautophagy (referred to hereafter as autophagy) is a

263 ning some of the most fundamental aspects of macroautophagy remain unresolved.

264 al processes, the molecular understanding of macroautophagy remains far from complete.

265 Macroautophagy requires membrane trafficking and remodel

266 Here, we show that macroautophagy requires the Alzheimer's disease (AD)-rel

267 Interruption of connexins' macroautophagy resulted in their retention at the plasma

268 Loss of macroautophagy sensitized cells to apoptotic and necroti

269 Loss of macroautophagy sensitized these cells to caspase-depende

270 Selective autophagy and macroautophagy sequester specific organelles/substrates

271 Macroautophagy serves cellular housekeeping and metaboli

272 Macroautophagy serves in intracellular quality control a

273 autophagy and clearance of a well-described macroautophagy substrate, demonstrating the critical rol

274 l requires proteins previously implicated in macroautophagy, such as Beclin1 and hVps34.

275 Our findings suggest that macroautophagy supports central CD4(+) T cell tolerance

276 ve InsP(3)R Ca(2+) signaling is required for macroautophagy suppression in cells in nutrient-replete

277 herefore, both elevated NY-ESO-1 release and macroautophagy targeting could improve melanoma cell rec

278 However, macroautophagy targeting of NY-ESO-1 enhanced MHC class

279 Macroautophagy that follows mTOR inhibition in presynapt

280 After macroautophagy, the antigen is processed through a prote

281 Ubiquilin was recently reported to regulate macroautophagy, the form of autophagy in which cytosolic

282 Alterations in macroautophagy, the main process responsible for bulk au

283 events through which LRRK2 acts to influence macroautophagy, the mammalian target of rapamycin (mTOR)

284 leton scaffolds also have essential roles in macroautophagy, the process by which cellular waste is i

285 Macroautophagy--the process by which cytosolic material

286 eased hepatocyte apoptosis and liver injury; macroautophagy therefore protected cells from the toxic

287 n pathway, possibly linking dysregulation of macroautophagy to a female-dominated COPD disease phenot

288 B lymphocytes exploit macroautophagy to capture cytoplasmic and nuclear protei

289 this work, we focused on the contribution of macroautophagy to connexin degradation.

290 The contribution of macroautophagy to the MHC class II-restricted response m

291 lay important roles in autophagosome-forming macroautophagy under various stress conditions.

292 tream of T-cell receptor signalling inhibits macroautophagy upon AICD induction.

293 ted mice, and feeding-mediated inhibition of macroautophagy was attenuated in FXR-knockout mice.

294 in the RALA255-10G rat hepatocyte line when macroautophagy was inhibited by a short hairpin RNA (shR

295 To further validate these findings, macroautophagy was inhibited chemically in ER-stressed w

296 are three different types of autophagy, but macroautophagy, which involves the formation of double m

297 e models is accompanied by the occurrence of macroautophagy, which is suppressed by Myr-Akt.

298 Suppression of macroautophagy with pharmacologic agents or small interf

299 ulated tumor suppressor acting by inhibiting macroautophagy, with MAP1LC3B (LC3B) as a direct and fun

300 he process of cargo recognition in selective macroautophagy, with the goal of providing insights into